Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UGT2B10 Gene

Aliases for UGT2B10 Gene

  • UDP Glucuronosyltransferase Family 2 Member B10 2 3
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B10 3 5
  • EC 2.4.1.17 4 63
  • UDPGT 2B10 3 4
  • UDP Glycosyltransferase 2 Family, Polypeptide B10 2
  • UDPGT2B10 3

External Ids for UGT2B10 Gene

Previous GeneCards Identifiers for UGT2B10 Gene

  • GC04P069592
  • GC04P069730
  • GC04P069931
  • GC04P069997
  • GC04P069862
  • GC04P065477

Summaries for UGT2B10 Gene

GeneCards Summary for UGT2B10 Gene

UGT2B10 (UDP Glucuronosyltransferase Family 2 Member B10) is a Protein Coding gene. Among its related pathways are Porphyrin and chlorophyll metabolism and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2B10 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Gene Wiki entry for UGT2B10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B10 Gene

Genomics for UGT2B10 Gene

Regulatory Elements for UGT2B10 Gene

Enhancers for UGT2B10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UGT2B10 on UCSC Golden Path with GeneCards custom track

Promoters for UGT2B10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UGT2B10 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT2B10 Gene

Chromosome:
4
Start:
68,815,993 bp from pter
End:
68,832,017 bp from pter
Size:
16,025 bases
Orientation:
Plus strand

Genomic View for UGT2B10 Gene

Genes around UGT2B10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B10 Gene

Proteins for UGT2B10 Gene

  • Protein details for UGT2B10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36537-UDB10_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B10
    Protein Accession:
    P36537
    Secondary Accessions:
    • A8K9M3
    • B4DPP1
    • Q14CR8

    Protein attributes for UGT2B10 Gene

    Size:
    528 amino acids
    Molecular mass:
    60774 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT2B10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2B10 Gene

Proteomics data for UGT2B10 Gene at MOPED

Post-translational modifications for UGT2B10 Gene

  • Glycosylation at Asn 66, Asn 314, and Asn 481
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B10 Gene

Domains & Families for UGT2B10 Gene

Gene Families for UGT2B10 Gene

Protein Domains for UGT2B10 Gene

Suggested Antigen Peptide Sequences for UGT2B10 Gene

Graphical View of Domain Structure for InterPro Entry

P36537

UniProtKB/Swiss-Prot:

UDB10_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B10: view

Function for UGT2B10 Gene

Molecular function for UGT2B10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Enzyme Numbers (IUBMB) for UGT2B10 Gene

Gene Ontology (GO) - Molecular Function for UGT2B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B10: view
genes like me logo Genes that share phenotypes with UGT2B10: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B10 Gene

Localization for UGT2B10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B10 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2B10 Gene COMPARTMENTS Subcellular localization image for UGT2B10 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
peroxisome 3
cytoskeleton 1
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT2B10: view

Pathways & Interactions for UGT2B10 Gene

genes like me logo Genes that share pathways with UGT2B10: view

Pathways by source for UGT2B10 Gene

Interacting Proteins for UGT2B10 Gene

Gene Ontology (GO) - Biological Process for UGT2B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052696 flavonoid glucuronidation IBA --
genes like me logo Genes that share ontologies with UGT2B10: view

No data available for SIGNOR curated interactions for UGT2B10 Gene

Drugs & Compounds for UGT2B10 Gene

(14) Drugs for UGT2B10 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Antagonist 990
Codeine Approved, Illicit Pharma Full agonist, Agonist 69
Estradiol Approved, Investigational Pharma Sex hormone 1235
Estriol Approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 19

(39) Additional Compounds for UGT2B10 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
15-Hydroxynorandrostene-3,17-dione glucuronide
  • 15-HNADG
  • 15-Hydroxynorandrostene-3,17-dione glucuronoside
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronide
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronoside
  • Androst-4-ene-3,17-dione, 15-hydroxy glucuronide
131749-23-0
17-beta-Estradiol-3-glucuronide
  • 17-b-Estradiol-3-glucuronide
  • 17-beta-Estradiol-3-glucuronide
  • 17beta-Estradiol 3-(beta-D-glucuronide)
  • 17beta-Estradiol 3-(beta-delta-glucuronide)
  • 17beta-estradiol 3-glucosiduronic acid
17-Hydroxyandrostane-3-glucuronide
  • (3alpha,5alpha,17beta)-17-hydroxyandrostan-3-yl-beta-D-Glucopyranosiduronic acid
  • (3alpha,5alpha,17beta)-17-hydroxyandrostan-3-yl-beta-delta-Glucopyranosiduronic acid
  • 17-Hydroxyandrostane-3-glucuronoside
  • 17beta-hydroxy-5alpha-androstan-3alpha-yl-Glucosiduronic acid
65535-18-4
genes like me logo Genes that share compounds with UGT2B10: view

Transcripts for UGT2B10 Gene

mRNA/cDNA for UGT2B10 Gene

Unigene Clusters for UGT2B10 Gene

UDP glucuronosyltransferase 2 family, polypeptide B10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B10 Gene

No ASD Table

Relevant External Links for UGT2B10 Gene

GeneLoc Exon Structure for
UGT2B10
ECgene alternative splicing isoforms for
UGT2B10

Expression for UGT2B10 Gene

mRNA expression in normal human tissues for UGT2B10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B10 Gene

This gene is overexpressed in Liver (x52.6).

Protein differential expression in normal tissues from HIPED for UGT2B10 Gene

This gene is overexpressed in Liver (43.8) and Gallbladder (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT2B10 Gene



SOURCE GeneReport for Unigene cluster for UGT2B10 Gene Hs.201634

genes like me logo Genes that share expression patterns with UGT2B10: view

Protein tissue co-expression partners for UGT2B10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UGT2B10 Gene

Orthologs for UGT2B10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UGT2B10 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ugt2b34 35
  • 76.9 (n)
  • 68.52 (a)
Ugt2b34 16
Ugt2b5 36
  • 64 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia UGT2B10 35
  • 99.05 (n)
  • 98.48 (a)
UGT2B10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ugt2b10 35
  • 75.82 (n)
  • 68.71 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 69 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
Species with no ortholog for UGT2B10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UGT2B10 Gene

ENSEMBL:
Gene Tree for UGT2B10 (if available)
TreeFam:
Gene Tree for UGT2B10 (if available)

Paralogs for UGT2B10 Gene

genes like me logo Genes that share paralogs with UGT2B10: view

Variants for UGT2B10 Gene

Sequence variations from dbSNP and Humsavar for UGT2B10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs294771 -- 68,829,163(+) ttatc(A/C)atcaa intron-variant
rs294772 -- 68,829,223(+) aaata(A/G)acact intron-variant
rs294775 -- 68,815,215(+) atgtc(C/T)atcca upstream-variant-2KB
rs294776 -- 68,815,957(+) GATTT(A/T)TCTCT upstream-variant-2KB
rs294777 -- 68,816,753(+) TTTCA(A/G)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B10 Gene

Variant ID Type Subtype PubMed ID
dgv1628e1 CNV Complex 17122850
nsv829961 CNV Loss 17160897
essv17788 CNV CNV 17122850
dgv5607n71 CNV Loss 21882294
esv2727775 CNV Deletion 23290073
esv2672025 CNV Deletion 23128226
esv2421961 CNV Duplication 20811451
esv21679 CNV Gain 19812545
nsv441886 CNV CNV 18776908
nsv461547 CNV Loss 19166990
dgv1633e1 CNV Complex 17122850
esv2660681 CNV Deletion 23128226
essv17383 CNV CNV 17122850
dgv1634e1 CNV Complex 17122850
nsv829962 CNV Gain 17160897
essv22808 CNV CNV 17122850
nsv879379 CNV Loss 21882294
nsv10521 CNV Loss 18304495

Variation tolerance for UGT2B10 Gene

Gene Damage Index Score: 4.78; 66.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2B10 Gene

HapMap Linkage Disequilibrium report
UGT2B10
Human Gene Mutation Database (HGMD)
UGT2B10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B10 Gene

Disorders for UGT2B10 Gene

Relevant External Links for UGT2B10

Genetic Association Database (GAD)
UGT2B10
Human Genome Epidemiology (HuGE) Navigator
UGT2B10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2B10

No disorders were found for UGT2B10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2B10 Gene

Publications for UGT2B10 Gene

  1. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. (PMID: 8333863) Jin C.-J. … McKenzie P.I. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 67
  2. Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. (PMID: 17576790) Kaivosaari S. … Finel M. (Mol. Pharmacol. 2007) 3 23 26
  3. Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines. (PMID: 18300939) Chen G. … Lazarus P. (Pharmacogenet. Genomics 2008) 3 23
  4. Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. (PMID: 10024527) Strassburg C.P. … Tukey R.H. (Biochem. J. 1999) 3 23
  5. The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. (PMID: 25293881) Patel Y.M. … Murphy S.E. (Cancer Epidemiol. Biomarkers Prev. 2015) 3

Products for UGT2B10 Gene

Sources for UGT2B10 Gene

Content