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Aliases for UGT2B10 Gene

Aliases for UGT2B10 Gene

  • UDP Glucuronosyltransferase Family 2 Member B10 2 3 5
  • EC 2.4.1.17 4 58
  • UDPGT 2B10 3 4
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B10 3
  • UDP Glycosyltransferase 2 Family, Polypeptide B10 2
  • UDP-Glucuronosyltransferase 2B10 3
  • UDPGT2B10 3

External Ids for UGT2B10 Gene

Previous GeneCards Identifiers for UGT2B10 Gene

  • GC04P069592
  • GC04P069730
  • GC04P069931
  • GC04P069997
  • GC04P069862
  • GC04P065477

Summaries for UGT2B10 Gene

GeneCards Summary for UGT2B10 Gene

UGT2B10 (UDP Glucuronosyltransferase Family 2 Member B10) is a Protein Coding gene. Among its related pathways are Metabolism and Drug metabolism - cytochrome P450. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B11.

UniProtKB/Swiss-Prot for UGT2B10 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Gene Wiki entry for UGT2B10 Gene

Additional gene information for UGT2B10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B10 Gene

Genomics for UGT2B10 Gene

Regulatory Elements for UGT2B10 Gene

Enhancers for UGT2B10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H068731 1.3 FANTOM5 ENCODE 3.2 -81.7 -81729 5 FOXA2 ATF1 MLX ARID4B YY1 SP5 REST MIER2 PPARG KAT8 LOC100422026 TMPRSS11E UGT2A3 UGT2B7 ENSG00000272626 UGT2B10 UGT2B11 UGT2B15 LOC728811
GH04H068946 1.6 FANTOM5 ENCODE dbSUPER 1.5 +134.7 134718 7 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 TCF12 ATF7 PAF1 SP5 LOC105377267 UGT2B7 UGT2B28 UGT2A3 UGT2B11 UGT2B15 UGT2B10 LOC101927264
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UGT2B10 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT2B10 Gene

Chromosome:
4
Start:
68,815,993 bp from pter
End:
68,832,017 bp from pter
Size:
16,025 bases
Orientation:
Plus strand

Genomic View for UGT2B10 Gene

Genes around UGT2B10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B10 Gene

Proteins for UGT2B10 Gene

  • Protein details for UGT2B10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36537-UDB10_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B10
    Protein Accession:
    P36537
    Secondary Accessions:
    • A8K9M3
    • B4DPP1
    • Q14CR8

    Protein attributes for UGT2B10 Gene

    Size:
    528 amino acids
    Molecular mass:
    60774 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT2B10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2B10 Gene

Selected DME Specific Peptides for UGT2B10 Gene

P36537:
  • AFITHGG
  • HKGAKHLR
  • LLGHPKT
  • PQNDLLGHP
  • FVQSSGE
  • CKDVVSNK
  • KPLDRAVFWIE
  • KLQESRFD
  • AAHNLTW
  • YEAIYHG
  • RGHEVTVL
  • FVGGLHC
  • DVIGFLL
  • KKWDQFYSEVLGRPTTL
  • WIPQNDLLG
  • PPSYVPV
  • FLLACVA
  • IPQKVLW
  • DQPDNIAHMK
  • THGGANG
  • DLLNALK
  • GHPKTRAFITH
  • FPHPFLPN
  • VVFSLGSMV
  • WMNMKTIL
  • VMRHKGA
  • MTFMERV
  • CGKVLVW
  • TMSSTDL
  • QYHSLDV
  • NALKTVINDP
  • NTRLYKW
  • ELLAELFNIP

Post-translational modifications for UGT2B10 Gene

  • Glycosylation at posLast=6666, Asn314, and posLast=481481
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B10 Gene

Antibody Products

  • Abcam antibodies for UGT2B10
  • Santa Cruz Biotechnology (SCBT) Antibodies for UGT2B10

Domains & Families for UGT2B10 Gene

Gene Families for UGT2B10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT2B10 Gene

Suggested Antigen Peptide Sequences for UGT2B10 Gene

Graphical View of Domain Structure for InterPro Entry

P36537

UniProtKB/Swiss-Prot:

UDB10_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B10: view

Function for UGT2B10 Gene

Molecular function for UGT2B10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Enzyme Numbers (IUBMB) for UGT2B10 Gene

Phenotypes From GWAS Catalog for UGT2B10 Gene

Gene Ontology (GO) - Molecular Function for UGT2B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B10: view
genes like me logo Genes that share phenotypes with UGT2B10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UGT2B10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B10 Gene

Localization for UGT2B10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B10 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2B10 gene
Compartment Confidence
endoplasmic reticulum 4
peroxisome 3
golgi apparatus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UGT2B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2B10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT2B10 Gene

Pathways & Interactions for UGT2B10 Gene

genes like me logo Genes that share pathways with UGT2B10: view

Pathways by source for UGT2B10 Gene

Gene Ontology (GO) - Biological Process for UGT2B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 8333863
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with UGT2B10: view

No data available for SIGNOR curated interactions for UGT2B10 Gene

Drugs & Compounds for UGT2B10 Gene

(16) Drugs for UGT2B10 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Antagonist 1148
Codeine Approved, Illicit Pharma Full agonist, Agonist 83
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1357
Estriol Approved, Vet_approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 22

(38) Additional Compounds for UGT2B10 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
15-Hydroxynorandrostene-3,17-dione glucuronide
  • 15-HNADG
  • 15-Hydroxynorandrostene-3,17-dione glucuronoside
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronide
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronoside
  • Androst-4-ene-3,17-dione, 15-hydroxy glucuronide
131749-23-0
17-beta-Estradiol-3-glucuronide
  • 17-b-Estradiol-3-glucuronide
  • 17-beta-Estradiol-3-glucuronide
  • 17beta-Estradiol 3-(beta-D-glucuronide)
  • 17beta-Estradiol 3-(beta-delta-glucuronide)
  • 17beta-estradiol 3-glucosiduronic acid
17-Hydroxyandrostane-3-glucuronide
  • (3alpha,5alpha,17beta)-17-hydroxyandrostan-3-yl-beta-D-Glucopyranosiduronic acid
  • (3alpha,5alpha,17beta)-17-hydroxyandrostan-3-yl-beta-delta-Glucopyranosiduronic acid
  • 17-Hydroxyandrostane-3-glucuronoside
  • 17beta-hydroxy-5alpha-androstan-3alpha-yl-Glucosiduronic acid
65535-18-4
genes like me logo Genes that share compounds with UGT2B10: view

Transcripts for UGT2B10 Gene

mRNA/cDNA for UGT2B10 Gene

Unigene Clusters for UGT2B10 Gene

UDP glucuronosyltransferase 2 family, polypeptide B10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UGT2B10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B10 Gene

No ASD Table

Relevant External Links for UGT2B10 Gene

GeneLoc Exon Structure for
UGT2B10
ECgene alternative splicing isoforms for
UGT2B10

Expression for UGT2B10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGT2B10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B10 Gene

This gene is overexpressed in Liver (x52.6).

Protein differential expression in normal tissues from HIPED for UGT2B10 Gene

This gene is overexpressed in Liver (43.8) and Gallbladder (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGT2B10 Gene



Protein tissue co-expression partners for UGT2B10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UGT2B10 Gene:

UGT2B10

SOURCE GeneReport for Unigene cluster for UGT2B10 Gene:

Hs.201634

Evidence on tissue expression from TISSUES for UGT2B10 Gene

  • Liver(4.7)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with UGT2B10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2B10 Gene

Orthologs for UGT2B10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UGT2B10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2B10 33 34
  • 99.05 (n)
mouse
(Mus musculus)
Mammalia Ugt2b34 33 16
  • 76.9 (n)
Ugt2b5 34
  • 64 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ugt2b10 33
  • 75.82 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 69 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 64 (a)
OneToMany
Species where no ortholog for UGT2B10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UGT2B10 Gene

ENSEMBL:
Gene Tree for UGT2B10 (if available)
TreeFam:
Gene Tree for UGT2B10 (if available)

Paralogs for UGT2B10 Gene

genes like me logo Genes that share paralogs with UGT2B10: view

Variants for UGT2B10 Gene

Sequence variations from dbSNP and Humsavar for UGT2B10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs61750900 drug-response 68,816,218(+) CCAAC(A/G/T)ACTCA intron-variant, reference, missense
rs1000255399 -- 68,818,601(+) ATTAT(A/G)TAAAA intron-variant
rs1000287961 -- 68,818,880(+) TTTAT(C/T)AAGAA intron-variant
rs1000537771 -- 68,814,112(+) ATAAT(G/T)ATACT upstream-variant-2KB
rs1000594404 -- 68,817,519(+) AAATG(-/AGT)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B10 Gene

Variant ID Type Subtype PubMed ID
dgv1004e214 CNV loss 21293372
dgv5291n100 CNV gain 25217958
dgv5292n100 CNV loss 25217958
dgv5293n100 CNV gain 25217958
esv21679 CNV gain 19812545
esv2421961 CNV duplication 20811451
esv2660681 CNV deletion 23128226
esv2672025 CNV deletion 23128226
esv2727775 CNV deletion 23290073
esv2759258 CNV gain+loss 17122850
esv2760902 CNV gain 21179565
esv3368609 OTHER inversion 20981092
esv3569505 CNV loss 25503493
esv3600886 CNV gain 21293372
esv3600887 CNV loss 21293372
esv3600890 CNV gain 21293372
esv3893952 CNV loss 25118596
nsv1001923 CNV gain 25217958
nsv1004225 CNV gain+loss 25217958
nsv10521 CNV loss 18304495
nsv1074180 CNV deletion 25765185
nsv1122086 CNV deletion 24896259
nsv1145032 CNV deletion 24896259
nsv441886 CNV gain 18776908
nsv461547 CNV loss 19166990
nsv594580 CNV loss 21841781
nsv594581 CNV loss 21841781
nsv594582 CNV loss 21841781
nsv829962 CNV gain 17160897
nsv980211 CNV duplication 23825009
nsv980213 CNV duplication 23825009
nsv999654 CNV gain 25217958

Variation tolerance for UGT2B10 Gene

Gene Damage Index Score: 4.78; 66.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2B10 Gene

Human Gene Mutation Database (HGMD)
UGT2B10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2B10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B10 Gene

Disorders for UGT2B10 Gene

Relevant External Links for UGT2B10

Genetic Association Database (GAD)
UGT2B10
Human Genome Epidemiology (HuGE) Navigator
UGT2B10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT2B10

No disorders were found for UGT2B10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2B10 Gene

Publications for UGT2B10 Gene

  1. Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines. (PMID: 18300939) Chen G … Lazarus P (Pharmacogenetics and genomics 2008) 3 22 45 60
  2. Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. (PMID: 17576790) Kaivosaari S … Finel M (Molecular pharmacology 2007) 3 22 25 60
  3. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. (PMID: 8333863) Jin CJ … Mackenzie PI (Biochemical and biophysical research communications 1993) 2 3 4 60
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for UGT2B10 Gene

Sources for UGT2B10 Gene

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