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Aliases for UGT2B7 Gene

Aliases for UGT2B7 Gene

  • UDP Glucuronosyltransferase 2 Family, Polypeptide B7 2 3
  • 3,4-Catechol Estrogen-Specific UDPGT 3 4
  • UDP-Glucuronosyltransferase 2B9 3 4
  • EC 2.4.1.17 4 64
  • UDPGT 2B7 3 4
  • UDPGT 2B9 3 4
  • UDPGTh-2 3 4
  • UGT2B9 3 6
  • UDP Glycosyltransferase 2 Family, Polypeptide B7 2
  • UDP-Glucuronyltransferase, Family 2, Beta-7 3
  • UDP Glucuronosyltransferase 2B7 3
  • UDP-Glucuronosyltransferase 2B7 3
  • 3,4-Catechol Estrogen Specific 3
  • UDPGT2B7 3
  • UDPGTH2 3
  • UGTB2B9 4

External Ids for UGT2B7 Gene

Summaries for UGT2B7 Gene

Entrez Gene Summary for UGT2B7 Gene

  • The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011]

GeneCards Summary for UGT2B7 Gene

UGT2B7 (UDP Glucuronosyltransferase 2 Family, Polypeptide B7) is a Protein Coding gene. Diseases associated with UGT2B7 include hepatocellular adenoma. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include glucuronosyltransferase activity and retinoic acid binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2B7 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

  • Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).

Gene Wiki entry for UGT2B7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B7 Gene

Genomics for UGT2B7 Gene

Genomic Location for UGT2B7 Gene

Start:
69,051,363 bp from pter
End:
69,112,987 bp from pter
Size:
61,625 bases
Orientation:
Plus strand

Genomic View for UGT2B7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT2B7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B7 Gene

Regulatory Elements for UGT2B7 Gene

Proteins for UGT2B7 Gene

  • Protein details for UGT2B7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16662-UD2B7_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B7
    Protein Accession:
    P16662
    Secondary Accessions:
    • B2R810
    • Q6GTW0

    Protein attributes for UGT2B7 Gene

    Size:
    529 amino acids
    Molecular mass:
    60695 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UGT2B7 Gene

neXtProt entry for UGT2B7 Gene

Proteomics data for UGT2B7 Gene at MOPED

Post-translational modifications for UGT2B7 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn67, Asn68, and Asn315

Other Protein References for UGT2B7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UGT2B7 Gene

Gene Families for UGT2B7 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT2B7 Gene

UniProtKB/Swiss-Prot:

UD2B7_HUMAN
Family:
  • Belongs to the UDP-glycosyltransferase family.:
    • P16662
genes like me logo Genes that share domains with UGT2B7: view

Function for UGT2B7 Gene

Molecular function for UGT2B7 Gene

GENATLAS Biochemistry: UDP glucuronosyltransferase subfamily 2,liver specific,but expressed in kidney,pancreas and brain,conjugating bile acid,potentially involved in the overall contribution of morphine analgesia
UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
UniProtKB/Swiss-Prot Function: Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).

Enzyme Numbers (IUBMB) for UGT2B7 Gene

Gene Ontology (GO) - Molecular Function for UGT2B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity IDA 17442341
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with UGT2B7: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT2B7 Gene

Localization for UGT2B7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B7 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2B7 Gene COMPARTMENTS Subcellular localization image for UGT2B7 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
peroxisome 3
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane TAS 2159463
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2B7: view

Pathways for UGT2B7 Gene

genes like me logo Genes that share pathways with UGT2B7: view

Gene Ontology (GO) - Biological Process for UGT2B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006629 lipid metabolic process TAS 2159463
GO:0008152 metabolic process --
GO:0008209 androgen metabolic process IDA 17442341
GO:0009813 flavonoid biosynthetic process IBA --
genes like me logo Genes that share ontologies with UGT2B7: view

Compounds for UGT2B7 Gene

(86) HMDB Compounds for UGT2B7 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
Not Available
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • Ibuprofen acyl glucuronide
115075-59-7
11-beta-hydroxyandrosterone-3-glucuronide
  • 11-beta-hydroxyetiocholanolone-3-glucuronide
Not Available
11-Hydroxyprogesterone 11-glucuronide
  • 11-hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-etiocholanolone glucuronide
Not Available

(30) Drugbank Compounds for UGT2B7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Atorvastatin
134523-00-5 enzyme substrate
Carbamazepine
  • Carbamezepine
298-46-4 enzyme substrate
Chenodeoxycholic acid
  • Chenocholic acid
474-25-9 enzyme inhibitor
Codeine
  • Codeine anhydrous
76-57-3 enzyme substrate
Dabigatran etexilate
  • Dabigatran
211915-06-9 enzyme

(58) Novoseek inferred chemical compound relationships for UGT2B7 Gene

Compound -log(P) Hits PubMed IDs
uridine diphosphate 86.2 4
udp glucuronic acid 85.8 4
morphine-3-glucuronide 81.8 5
glucuronide 81.5 6
hecogenin 81.1 1

(8) PharmGKB related drug/compound annotations for UGT2B7 Gene

genes like me logo Genes that share compounds with UGT2B7: view

Transcripts for UGT2B7 Gene

Unigene Clusters for UGT2B7 Gene

UDP glucuronosyltransferase 2 family, polypeptide B7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B7 Gene

No ASD Table

Relevant External Links for UGT2B7 Gene

GeneLoc Exon Structure for
UGT2B7
ECgene alternative splicing isoforms for
UGT2B7

Expression for UGT2B7 Gene

mRNA expression in normal human tissues for UGT2B7 Gene

mRNA differential expression in normal tissues according to GTEx for UGT2B7 Gene

This gene is overexpressed in Liver (29.9) and Kidney - Cortex (19.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT2B7 Gene

SOURCE GeneReport for Unigene cluster for UGT2B7 Gene Hs.654424

genes like me logo Genes that share expressions with UGT2B7: view

Orthologs for UGT2B7 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2B7 36
  • 99.24 (n)
  • 99.05 (a)
UGT2B7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 72 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 81 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ugt2b35 16
Ugt2b35 37
  • 67 (a)
ManyToMany
Ugt2b36 36
  • 74.46 (n)
  • 67.49 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ugt2b15 36
  • 74.35 (n)
  • 67.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10178 38
  • 27 (a)
BEST:GH09393 38
  • 31 (a)
Ugt86Da 38
  • 35 (a)
Dot 38
  • 23 (a)
CG10168 38
  • 23 (a)
Ugt36Bb 38
  • 28 (a)
Ugt86De 38
  • 28 (a)
CG11289 38
  • 33 (a)
Ugt36Bc 38
  • 29 (a)
CG10170 38
  • 25 (a)
CG5999 38
  • 25 (a)
Ugt86Di 38
  • 34 (a)
Ugt86Dd 38
  • 30 (a)
Ugt35b 38
  • 32 (a)
CG15661 38
  • 34 (a)
Ugt86Dh 38
  • 25 (a)
Ugt36Ba 38
  • 26 (a)
Ugt37b1 38
  • 26 (a)
BEST:GH06505 38
  • 31 (a)
Ugt86Dc 38
  • 33 (a)
Ugt35a 38
  • 30 (a)
CG5724 38
  • 23 (a)
Ugt37a1 38
  • 31 (a)
CG6475 38
  • 34 (a)
CG17323 38
  • 25 (a)
Ugt86Dg 38
  • 35 (a)
Ugt86Dj 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea F56B3.7 38
  • 23 (a)
C08F11.8 38
  • 24 (a)
Y37E11AR.5 38
  • 23 (a)
ZC443.5 38
  • 27 (a)
T03D3.1 38
  • 23 (a)
C08B6.1 38
  • 27 (a)
F35H8.6 38
  • 26 (a)
F01D4.2 38
  • 21 (a)
R04B5.9 38
  • 23 (a)
C03A7.11 38
  • 27 (a)
C44H9.1 38
  • 25 (a)
T01G5.2 38
  • 23 (a)
T25B9.7 38
  • 26 (a)
C10H11.4 38
  • 25 (a)
C33A12.6 38
  • 25 (a)
F39G3.1 38
  • 30 (a)
M88.1 38
  • 32 (a)
C10H11.5 38
  • 24 (a)
T19H12.11 38
  • 22 (a)
F01D4.1 38
  • 23 (a)
Species with no ortholog for UGT2B7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B7 Gene

ENSEMBL:
Gene Tree for UGT2B7 (if available)
TreeFam:
Gene Tree for UGT2B7 (if available)

Paralogs for UGT2B7 Gene

genes like me logo Genes that share paralogs with UGT2B7: view

Variants for UGT2B7 Gene

Sequence variations from dbSNP and Humsavar for UGT2B7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3924192 -- 69,105,246(+) CAGAT(A/G)CCCCC intron-variant
rs3924193 -- 69,105,273(+) GAAAT(A/T)TATTA intron-variant
rs3924194 -- 69,105,374(+) TCCAA(C/G)TTTTG intron-variant
rs4257713 -- 69,107,061(+) TTTGA(A/G)TAGTT intron-variant
rs4292394 -- 69,107,231(+) CGGCT(C/G)TACAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UGT2B7 Gene

Variant ID Type Subtype PubMed ID
dgv1628e1 CNV Complex 17122850
essv17788 CNV CNV 17122850
esv2727775 CNV Deletion 23290073
dgv1634e1 CNV Complex 17122850
nsv879379 CNV Loss 21882294
dgv1635e1 CNV Complex 17122850
dgv1636e1 CNV Complex 17122850
nsv522091 CNV Loss 19592680
dgv5608n71 CNV Loss 21882294
dgv891e201 CNV Deletion 23290073
nsv822595 CNV Loss 20364138

Relevant External Links for UGT2B7 Gene

HapMap Linkage Disequilibrium report
UGT2B7
Human Gene Mutation Database (HGMD)
UGT2B7

Disorders for UGT2B7 Gene

(1) MalaCards Diseases for UGT2B7 Gene

Search for UGT2B7 Gene in MalaCards »

(6) Novoseek inferred disease relationships for UGT2B7 Gene

Disease -log(P) Hits PubMed IDs
hepatitis autoimmune 17.6 1
bladder cancer 13.9 3
breast cancer 6.19 3
cancer 5.02 4
tumors 1.06 1

Relevant External Links for UGT2B7

Genetic Association Database (GAD)
UGT2B7
Human Genome Epidemiology (HuGE) Navigator
UGT2B7
genes like me logo Genes that share disorders with UGT2B7: view

No data available for UniProtKB/Swiss-Prot for UGT2B7 Gene

Publications for UGT2B7 Gene

  1. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. (PMID: 11186130) Bhasker C.R. … Miners J.O. (Pharmacogenetics 2000) 3 4 23 49
  2. Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. (PMID: 12629580) Holthe M. … Skorpen F. (Pharmacogenomics J. 2003) 3 23 49
  3. A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity. (PMID: 15001974) Duguay Y. … Guillemette C. (Clin. Pharmacol. Ther. 2004) 3 23 49
  4. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. (PMID: 15318931) Sparks R. … McTiernan A. (Breast Cancer Res. 2004) 3 23 49
  5. Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. (PMID: 15319348) Saeki M. … Sawada J. (Drug Metab. Dispos. 2004) 3 23 49

Products for UGT2B7 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate UGT2B7
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for UGT2B7
    • Block miRNA regulation of UGT2B7 using miScript Target Protectors

    Sources for UGT2B7 Gene

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