Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UGT2B7 Gene

Aliases for UGT2B7 Gene

  • UDP Glucuronosyltransferase 2 Family, Polypeptide B7 2 3
  • 3,4-Catechol Estrogen-Specific UDPGT 3 4
  • UDP-Glucuronosyltransferase 2B9 3 4
  • EC 2.4.1.17 4 63
  • UDPGT 2B7 3 4
  • UDPGT 2B9 3 4
  • UDPGTh-2 3 4
  • UGT2B9 3 6
  • UDP Glycosyltransferase 2 Family, Polypeptide B7 2
  • UDP-Glucuronyltransferase, Family 2, Beta-7 3
  • UDP Glucuronosyltransferase 2B7 3
  • UDP-Glucuronosyltransferase 2B7 3
  • 3,4-Catechol Estrogen Specific 3
  • UDPGT2B7 3
  • UDPGTH2 3
  • UGTB2B9 4

External Ids for UGT2B7 Gene

Previous GeneCards Identifiers for UGT2B7 Gene

  • GC04P069872
  • GC04P070010
  • GC04P070166
  • GC04P070277
  • GC04P070142
  • GC04P069962
  • GC04P069917
  • GC04P065757

Summaries for UGT2B7 Gene

Entrez Gene Summary for UGT2B7 Gene

  • The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011]

GeneCards Summary for UGT2B7 Gene

UGT2B7 (UDP Glucuronosyltransferase 2 Family, Polypeptide B7) is a Protein Coding gene. Diseases associated with UGT2B7 include hepatocellular adenoma. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include glucuronosyltransferase activity and retinoic acid binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2B7 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

  • Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).

Gene Wiki entry for UGT2B7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B7 Gene

Genomics for UGT2B7 Gene

Regulatory Elements for UGT2B7 Gene

Genomic Location for UGT2B7 Gene

Start:
69,051,363 bp from pter
End:
69,112,987 bp from pter
Size:
61,625 bases
Orientation:
Plus strand

Genomic View for UGT2B7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT2B7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B7 Gene

Proteins for UGT2B7 Gene

  • Protein details for UGT2B7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16662-UD2B7_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B7
    Protein Accession:
    P16662
    Secondary Accessions:
    • B2R810
    • Q6GTW0

    Protein attributes for UGT2B7 Gene

    Size:
    529 amino acids
    Molecular mass:
    60695 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UGT2B7 Gene

neXtProt entry for UGT2B7 Gene

Proteomics data for UGT2B7 Gene at MOPED

Post-translational modifications for UGT2B7 Gene

  • Glycosylation at Asn67, Asn68, and Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for UGT2B7 Gene

Gene Families for UGT2B7 Gene

Protein Domains for UGT2B7 Gene

Suggested Antigen Peptide Sequences for UGT2B7 Gene

Graphical View of Domain Structure for InterPro Entry

P16662

UniProtKB/Swiss-Prot:

UD2B7_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B7: view

Function for UGT2B7 Gene

Molecular function for UGT2B7 Gene

GENATLAS Biochemistry:
UDP glucuronosyltransferase subfamily 2,liver specific,but expressed in kidney,pancreas and brain,conjugating bile acid,potentially involved in the overall contribution of morphine analgesia
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
UniProtKB/Swiss-Prot Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).

Enzyme Numbers (IUBMB) for UGT2B7 Gene

Gene Ontology (GO) - Molecular Function for UGT2B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity IDA 17442341
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with UGT2B7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UGT2B7

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT2B7 Gene

Localization for UGT2B7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B7 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT2B7 Gene COMPARTMENTS Subcellular localization image for UGT2B7 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
peroxisome 3
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane TAS 2159463
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2B7: view

Pathways for UGT2B7 Gene

genes like me logo Genes that share pathways with UGT2B7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat

Gene Ontology (GO) - Biological Process for UGT2B7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006629 lipid metabolic process TAS 2159463
GO:0008152 metabolic process --
GO:0008209 androgen metabolic process IDA 17442341
GO:0009813 flavonoid biosynthetic process IBA --
genes like me logo Genes that share ontologies with UGT2B7: view

Drugs for UGT2B7 Gene

(31) Drugbank Compounds for UGT2B7 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Codeine
  • (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
76-57-3 5284371 Enzyme substrate approved, illicit
Flunitrazepam
  • Flunitrazepamum
1622-62-4 3380 Enzyme inhibitor approved, illicit
Carbamazepine
  • 5-Carbamoyl-5H-dibenz(b,f)azepine
298-46-4 2554 Enzyme substrate approved, investigational
Etodolac
  • (+-)-1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
41340-25-4 3308 Enzyme substrate approved, investigational
Flurbiprofen
  • (+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid
5104-49-4 3394 Enzyme substrate approved, investigational

(169) HMDB Compounds for UGT2B7 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
(3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronic acid
  • (3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronate
99794-82-8
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
58814-71-4
(3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid
  • Glycocholic acid 3-glucuronide
99794-78-2
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
115075-59-7

(58) Novoseek inferred chemical compound relationships for UGT2B7 Gene

Compound -log(P) Hits PubMed IDs
uridine diphosphate 86.2 4
udp glucuronic acid 85.8 4
morphine-3-glucuronide 81.8 5
glucuronide 81.5 6
hecogenin 81.1 1

(10) PharmGKB related drug/compound annotations for UGT2B7 Gene

Drug/compound Annotation
codeine DrugLabel,Clinical Annotation
efavirenz DrugLabel,Clinical Annotation
eltrombopag DrugLabel,Clinical Annotation
flurbiprofen DrugLabel,Clinical Annotation
lamotrigine DrugLabel,Clinical Annotation
lorazepam DrugLabel,Clinical Annotation
morphine DrugLabel,Clinical Annotation
mycophenolate mofetil DrugLabel,Clinical Annotation
valproic acid DrugLabel,Clinical Annotation
zidovudine DrugLabel,Clinical Annotation
genes like me logo Genes that share compounds with UGT2B7: view

Transcripts for UGT2B7 Gene

Unigene Clusters for UGT2B7 Gene

UDP glucuronosyltransferase 2 family, polypeptide B7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UGT2B7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B7 Gene

No ASD Table

Relevant External Links for UGT2B7 Gene

GeneLoc Exon Structure for
UGT2B7
ECgene alternative splicing isoforms for
UGT2B7

Expression for UGT2B7 Gene

mRNA expression in normal human tissues for UGT2B7 Gene

mRNA differential expression in normal tissues according to GTEx for UGT2B7 Gene

This gene is overexpressed in Liver (29.9) and Kidney - Cortex (19.6).

Protein differential expression in normal tissues for UGT2B7 Gene

This gene is overexpressed in Gallbladder (33.5), Liver (19.3), and Kidney (13.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT2B7 Gene

SOURCE GeneReport for Unigene cluster for UGT2B7 Gene Hs.654424

genes like me logo Genes that share expressions with UGT2B7: view

Expression partners for UGT2B7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UGT2B7 Gene

Orthologs for UGT2B7 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B7 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ugt2b36 35
  • 74.46 (n)
  • 67.49 (a)
Ugt2b35 16
Ugt2b35 36
  • 67 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia UGT2B7 35
  • 99.24 (n)
  • 99.05 (a)
UGT2B7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ugt2b15 35
  • 74.35 (n)
  • 67.67 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 72 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BEST:GH06505 37
  • 31 (a)
BEST:GH09393 37
  • 31 (a)
CG10168 37
  • 23 (a)
CG10170 37
  • 25 (a)
CG10178 37
  • 27 (a)
CG11289 37
  • 33 (a)
CG15661 37
  • 34 (a)
CG17323 37
  • 25 (a)
CG5724 37
  • 23 (a)
CG5999 37
  • 25 (a)
CG6475 37
  • 34 (a)
Dot 37
  • 23 (a)
Ugt35a 37
  • 30 (a)
Ugt35b 37
  • 32 (a)
Ugt36Ba 37
  • 26 (a)
Ugt36Bb 37
  • 28 (a)
Ugt36Bc 37
  • 29 (a)
Ugt37a1 37
  • 31 (a)
Ugt37b1 37
  • 26 (a)
Ugt86Da 37
  • 35 (a)
Ugt86Dc 37
  • 33 (a)
Ugt86Dd 37
  • 30 (a)
Ugt86De 37
  • 28 (a)
Ugt86Dg 37
  • 35 (a)
Ugt86Dh 37
  • 25 (a)
Ugt86Di 37
  • 34 (a)
Ugt86Dj 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea C03A7.11 37
  • 27 (a)
C08B6.1 37
  • 27 (a)
C08F11.8 37
  • 24 (a)
C10H11.4 37
  • 25 (a)
C10H11.5 37
  • 24 (a)
C33A12.6 37
  • 25 (a)
C44H9.1 37
  • 25 (a)
F01D4.1 37
  • 23 (a)
F01D4.2 37
  • 21 (a)
F35H8.6 37
  • 26 (a)
F39G3.1 37
  • 30 (a)
F56B3.7 37
  • 23 (a)
M88.1 37
  • 32 (a)
R04B5.9 37
  • 23 (a)
T01G5.2 37
  • 23 (a)
T03D3.1 37
  • 23 (a)
T19H12.11 37
  • 22 (a)
T25B9.7 37
  • 26 (a)
Y37E11AR.5 37
  • 23 (a)
ZC443.5 37
  • 27 (a)
Species with no ortholog for UGT2B7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B7 Gene

ENSEMBL:
Gene Tree for UGT2B7 (if available)
TreeFam:
Gene Tree for UGT2B7 (if available)

Paralogs for UGT2B7 Gene

genes like me logo Genes that share paralogs with UGT2B7: view

Variants for UGT2B7 Gene

Sequence variations from dbSNP and Humsavar for UGT2B7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3924192 -- 69,105,246(+) CAGAT(A/G)CCCCC intron-variant
rs3924193 -- 69,105,273(+) GAAAT(A/T)TATTA intron-variant
rs3924194 -- 69,105,374(+) TCCAA(C/G)TTTTG intron-variant
rs4257713 -- 69,107,061(+) TTTGA(A/G)TAGTT intron-variant
rs4292394 -- 69,107,231(+) CGGCT(C/G)TACAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UGT2B7 Gene

Variant ID Type Subtype PubMed ID
dgv1628e1 CNV Complex 17122850
essv17788 CNV CNV 17122850
esv2727775 CNV Deletion 23290073
dgv1634e1 CNV Complex 17122850
nsv879379 CNV Loss 21882294
dgv1635e1 CNV Complex 17122850
dgv1636e1 CNV Complex 17122850
nsv522091 CNV Loss 19592680
dgv5608n71 CNV Loss 21882294
dgv891e201 CNV Deletion 23290073
nsv822595 CNV Loss 20364138

Relevant External Links for UGT2B7 Gene

HapMap Linkage Disequilibrium report
UGT2B7
Human Gene Mutation Database (HGMD)
UGT2B7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B7 Gene

Disorders for UGT2B7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for UGT2B7 Gene in MalaCards »

(1) Disease for UGT2B7 Gene

(6) Novoseek inferred disease relationships for UGT2B7 Gene

Disease -log(P) Hits PubMed IDs
hepatitis autoimmune 17.6 1
bladder cancer 13.9 3
breast cancer 6.19 3
cancer 5.02 4
tumors 1.06 1

Relevant External Links for UGT2B7

Genetic Association Database (GAD)
UGT2B7
Human Genome Epidemiology (HuGE) Navigator
UGT2B7
genes like me logo Genes that share disorders with UGT2B7: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for UGT2B7 Gene

Publications for UGT2B7 Gene

  1. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. (PMID: 11186130) Bhasker C.R. … Miners J.O. (Pharmacogenetics 2000) 3 4 23 48
  2. Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. (PMID: 15611481) Takeda S. … Yamada H. (Mol. Pharmacol. 2005) 3 23 25 26
  3. An association of UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism with bladder cancer in benzidine-exposed workers in China. (PMID: 15615884) Lin G.F. … Shen J.H. (Toxicol. Sci. 2005) 3 23 48
  4. Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates. (PMID: 2159463) Ritter J.K. … Owens I.S. (J. Biol. Chem. 1990) 2 3 4
  5. Genetic polymorphisms of MRP2 and UGT2B7 and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid. (PMID: 19730281) Yang J.W. … Min D.I. (Ther Drug Monit 2009) 3 23 48

Products for UGT2B7 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate UGT2B7
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for UGT2B7
    • Block miRNA regulation of UGT2B7 using miScript Target Protectors

    Sources for UGT2B7 Gene

    Back to Top

    Content