Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBE2V2 Gene

Aliases for UBE2V2 Gene

  • Ubiquitin-Conjugating Enzyme E2 Variant 2 2 3
  • MMS2 3 4 6
  • UEV2 3 4 6
  • Enterocyte Differentiation-Associated Factor 1 3 4
  • Enterocyte Differentiation-Promoting Factor 1 3 4
  • Vitamin D3-Inducible Protein 3 4
  • MMS2 Homolog 3 4
  • DDVit 1 3 4
  • DDVIT1 3 6
  • EDAF-1 3 4
  • EDPF-1 3 4
  • EDPF1 3 6
  • Methyl Methanesulfonate Sensitive 2, S. Cerevisiae, Homolog Of 3
  • Enterocyte Differentiation-Associated Factor EDAF-1 3
  • Enterocyte Differentiation Promoting Factor 3
  • 1 Alpha,25-Dihydroxyvitamin D3-Inducible 3
  • DDVit-1 3
  • UEV-2 3

External Ids for UBE2V2 Gene

Summaries for UBE2V2 Gene

Entrez Gene Summary for UBE2V2 Gene

  • Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2V2 Gene

UBE2V2 (Ubiquitin-Conjugating Enzyme E2 Variant 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is UBE2V1.

UniProtKB/Swiss-Prot for UBE2V2 Gene

  • Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Gene Wiki entry for UBE2V2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2V2 Gene

Genomics for UBE2V2 Gene

Genomic Location for UBE2V2 Gene

Start:
48,008,400 bp from pter
End:
48,064,708 bp from pter
Size:
56,309 bases
Orientation:
Plus strand

Genomic View for UBE2V2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2V2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2V2 Gene

Regulatory Elements for UBE2V2 Gene

Proteins for UBE2V2 Gene

  • Protein details for UBE2V2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15819-UB2V2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 variant 2
    Protein Accession:
    Q15819
    Secondary Accessions:

    Protein attributes for UBE2V2 Gene

    Size:
    145 amino acids
    Molecular mass:
    16363 Da
    Quaternary structure:
    • Heterodimer with UBE2N. Binds CHFR.

    Three dimensional structures from OCA and Proteopedia for UBE2V2 Gene

neXtProt entry for UBE2V2 Gene

Proteomics data for UBE2V2 Gene at MOPED

Post-translational modifications for UBE2V2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8, Lys66, Lys72, Lys108, and Lys129

Other Protein References for UBE2V2 Gene

No data available for DME Specific Peptides for UBE2V2 Gene

Domains for UBE2V2 Gene

Gene Families for UBE2V2 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2V2 Gene

UniProtKB/Swiss-Prot:

UB2V2_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • Q15819
genes like me logo Genes that share domains with UBE2V2: view

Function for UBE2V2 Gene

Molecular function for UBE2V2 Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme E2 variant 2,expressed in monocytes and in some cancer lines,putatively involved in the control of differentiation
UniProtKB/Swiss-Prot Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
UniProtKB/Swiss-Prot Induction: Up-regulated in cultured fresh blood cells upon treatment with vitamin D3.

Gene Ontology (GO) - Molecular Function for UBE2V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11473255
GO:0016881 acid-amino acid ligase activity --
GO:0019787 ubiquitin-like protein transferase activity IBA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with UBE2V2: view

Phenotypes for UBE2V2 Gene

genes like me logo Genes that share phenotypes with UBE2V2: view

miRNA for UBE2V2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2V2 Gene

Localization for UBE2V2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2V2 Gene COMPARTMENTS Subcellular localization image for UBE2V2 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBE2V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16129784
GO:0005737 cytoplasm TAS 16129784
GO:0031372 UBC13-MMS2 complex IDA 16129784
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UBE2V2: view

Pathways for UBE2V2 Gene

genes like me logo Genes that share pathways with UBE2V2: view

Pathways by source for UBE2V2 Gene

Gene Ontology (GO) - Biological Process for UBE2V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS 10089880
GO:0000729 DNA double-strand break processing IMP 17349954
GO:0006282 regulation of DNA repair TAS 10089880
GO:0006301 postreplication repair IBA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with UBE2V2: view

Transcripts for UBE2V2 Gene

Unigene Clusters for UBE2V2 Gene

Ubiquitin-conjugating enzyme E2 variant 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2V2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: - -

Relevant External Links for UBE2V2 Gene

GeneLoc Exon Structure for
UBE2V2
ECgene alternative splicing isoforms for
UBE2V2

Expression for UBE2V2 Gene

mRNA expression in normal human tissues for UBE2V2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2V2 Gene

SOURCE GeneReport for Unigene cluster for UBE2V2 Gene Hs.491695

mRNA Expression by UniProt/SwissProt for UBE2V2 Gene

Q15819-UB2V2_HUMAN
Tissue specificity: Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.
genes like me logo Genes that share expressions with UBE2V2: view

Orthologs for UBE2V2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2V2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2V2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2V2 36
  • 95.86 (n)
  • 100 (a)
UBE2V2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2V2 36
  • 97.7 (n)
  • 100 (a)
UBE2V2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm10088 37
  • 86 (a)
OneToMany
Ube2v2 36
  • 95.17 (n)
  • 98.62 (a)
Ube2v2 16
Ube2v2 37
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 98 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2V2 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2v2 36
  • 94.48 (n)
  • 99.31 (a)
chicken
(Gallus gallus)
Aves UBE2V2 36
  • 92.59 (n)
  • 97.92 (a)
UBE2V2 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2V2 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ube2v2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.569 36
ube2v2 36
  • 85.75 (n)
  • 93.1 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2250 36
zebrafish
(Danio rerio)
Actinopterygii ube2v2 36
  • 84.83 (n)
  • 93.79 (a)
ube2v2 37
  • 94 (a)
OneToOne
wufb18b11 36
fruit fly
(Drosophila melanogaster)
Insecta Uev1A 37
  • 65 (a)
OneToMany
Uev1A 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea uev-1 37
  • 63 (a)
OneToMany
uev-1 38
  • 63 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL064W 36
  • 49.51 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MMS2 36
  • 57.53 (n)
  • 50.37 (a)
MMS2 37
  • 50 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19119g 36
  • 55.39 (n)
  • 52.21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UEV1D-4 36
  • 53.72 (n)
  • 50.36 (a)
rice
(Oryza sativa)
Liliopsida Os09g0297100 36
  • 53.29 (n)
  • 51.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10477 36
  • 51.69 (n)
  • 52.17 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mms2 36
  • 54.5 (n)
  • 49.64 (a)
Species with no ortholog for UBE2V2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2V2 Gene

ENSEMBL:
Gene Tree for UBE2V2 (if available)
TreeFam:
Gene Tree for UBE2V2 (if available)

Paralogs for UBE2V2 Gene

Paralogs for UBE2V2 Gene

genes like me logo Genes that share paralogs with UBE2V2: view

Variants for UBE2V2 Gene

Sequence variations from dbSNP and Humsavar for UBE2V2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1047604 -- 48,062,730(+) CTACC(C/T)TTTCT utr-variant-3-prime
rs1903082 -- 48,045,969(-) AACTC(C/T)GTCTC intron-variant
rs2382637 -- 48,062,208(+) ATTTT(G/T)TCAAG downstream-variant-500B, utr-variant-3-prime
rs4873773 -- 48,032,695(+) AGGCT(G/T)TAGTG intron-variant
rs4873774 -- 48,033,060(+) CAGAG(C/T)ACAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UBE2V2 Gene

Variant ID Type Subtype PubMed ID
dgv2234e1 CNV Complex 17122850
nsv831309 CNV Loss 17160897
nsv8338 CNV Gain+Loss 18304495
dgv7784n71 CNV Gain 21882294

Relevant External Links for UBE2V2 Gene

HapMap Linkage Disequilibrium report
UBE2V2

Disorders for UBE2V2 Gene

Relevant External Links for UBE2V2

Genetic Association Database (GAD)
UBE2V2
genes like me logo Genes that share disorders with UBE2V2: view

No data available for UniProtKB/Swiss-Prot for UBE2V2 Gene

Publications for UBE2V2 Gene

  1. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. (PMID: 9705497) Xiao W. … Wei Y.-F. (Nucleic Acids Res. 1998) 3 4 23
  2. Molecular Cloning of a 1alpha,25-dihydroxyvitamin D3 inducible transcript (DDVit 1) in human blood monocytes. (PMID: 9199207) Fritsche J. … Kreutz M. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  3. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29- M6 intestinal mucosecretory cells. (PMID: 9418904) Sancho E. … Thomson T.M. (Mol. Cell. Biol. 1998) 2 3
  4. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. (PMID: 10089880) Hofmann R.M. … Pickart C.M. (Cell 1999) 3 4
  5. Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexes. (PMID: 12834344) McKenna S. … Spyracopoulos L. (Biochemistry 2003) 3 23

Products for UBE2V2 Gene

Sources for UBE2V2 Gene

Back to Top

Content