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Aliases for UBE2V1 Gene

Aliases for UBE2V1 Gene

  • Ubiquitin Conjugating Enzyme E2 V1 2 3
  • TRAF6-Regulated IKK Activator 1 Beta Uev1A 3 4
  • Ubiquitin Conjugating Enzyme E2 Variant 1 3 5
  • CROC-1 3 4
  • UBE2V 3 4
  • CROC1 3 4
  • UEV-1 3 4
  • UEV1 3 4
  • Ubiquitin-Conjugating Enzyme E2 Variant 1 2
  • DNA-Binding Protein 3
  • UEV1A 3
  • CIR1 3

External Ids for UBE2V1 Gene

Previous HGNC Symbols for UBE2V1 Gene

  • UBE2V

Previous GeneCards Identifiers for UBE2V1 Gene

  • GC20M048426
  • GC20M049336
  • GC20M049383
  • GC20M048132
  • GC20M048698
  • GC20M045447

Summaries for UBE2V1 Gene

Entrez Gene Summary for UBE2V1 Gene

  • Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

GeneCards Summary for UBE2V1 Gene

UBE2V1 (Ubiquitin Conjugating Enzyme E2 V1) is a Protein Coding gene. Among its related pathways are TCR signaling (REACTOME) and MyD88 cascade initiated on plasma membrane. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2V2.

UniProtKB/Swiss-Prot for UBE2V1 Gene

  • Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate Lys-63-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.

Gene Wiki entry for UBE2V1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2V1 Gene

Genomics for UBE2V1 Gene

Regulatory Elements for UBE2V1 Gene

Enhancers for UBE2V1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBE2V1 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2V1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2V1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UBE2V1 gene promoter:

Genomic Location for UBE2V1 Gene

Chromosome:
20
Start:
50,081,124 bp from pter
End:
50,115,959 bp from pter
Size:
34,836 bases
Orientation:
Minus strand

Genomic View for UBE2V1 Gene

Genes around UBE2V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2V1 Gene

Proteins for UBE2V1 Gene

  • Protein details for UBE2V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13404-UB2V1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 variant 1
    Protein Accession:
    Q13404
    Secondary Accessions:
    • E1P629
    • Q13403
    • Q13532
    • Q5TGE0
    • Q5TGE3
    • Q96H34
    • Q9GZT0
    • Q9GZW1
    • Q9H4J3
    • Q9H4J4
    • Q9UKL1
    • Q9UM48
    • Q9UM49
    • Q9UM50

    Protein attributes for UBE2V1 Gene

    Size:
    147 amino acids
    Molecular mass:
    16495 Da
    Quaternary structure:
    • Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific Lys-63-linked polyubiquitination activity. Interacts with TRAF6.
    Miscellaneous:
    • In human, TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein.
    SequenceCaution:
    • Sequence=AAH08944.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC16955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2V1 Gene

    Alternative splice isoforms for UBE2V1 Gene

neXtProt entry for UBE2V1 Gene

Proteomics data for UBE2V1 Gene at MOPED

Post-translational modifications for UBE2V1 Gene

  • Ubiquitination at Lys 142, Lys 148, and Lys 10
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for UBE2V1
  • Abcam antibodies for UEV1A

No data available for DME Specific Peptides for UBE2V1 Gene

Domains & Families for UBE2V1 Gene

Gene Families for UBE2V1 Gene

Protein Domains for UBE2V1 Gene

Suggested Antigen Peptide Sequences for UBE2V1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13404

UniProtKB/Swiss-Prot:

UB2V1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2V1: view

Function for UBE2V1 Gene

Molecular function for UBE2V1 Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2 variant 1,expressed as at least four isoforms,transcriptional activator of FOS promoter,underexpressed in hormone refractory prostate cancer,potentially involved in the control of differentiation
UniProtKB/Swiss-Prot Function:
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate Lys-63-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
UniProtKB/Swiss-Prot Induction:
Down-regulated during differentiation of cultured colon adenocarcinoma cells.

Phenotypes for UBE2V1 Gene

genes like me logo Genes that share phenotypes with UBE2V1: view

Animal Model Products

CRISPR Products

miRNA for UBE2V1 Gene

miRTarBase miRNAs that target UBE2V1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2V1 Gene

Localization for UBE2V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2V1 Gene

Nucleus. Note=Excluded from the nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2V1 Gene COMPARTMENTS Subcellular localization image for UBE2V1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
endosome 1

Gene Ontology (GO) - Cellular Components for UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031371 ubiquitin conjugating enzyme complex IDA 16129784
GO:0035370 UBC13-UEV1A complex IDA 16307917
genes like me logo Genes that share ontologies with UBE2V1: view

Pathways & Interactions for UBE2V1 Gene

genes like me logo Genes that share pathways with UBE2V1: view

SIGNOR curated interactions for UBE2V1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006301 postreplication repair IBA --
GO:0006355 regulation of transcription, DNA-templated TAS 9305758
GO:0030154 cell differentiation NAS 9418904
genes like me logo Genes that share ontologies with UBE2V1: view

Drugs & Compounds for UBE2V1 Gene

(1) Drugs for UBE2V1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NSC697923 Pharma Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective, Selective UBE2N inhibitor 0

(1) ApexBio Compounds for UBE2V1 Gene

Compound Action Cas Number
NSC697923 Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective 343351-67-7
genes like me logo Genes that share compounds with UBE2V1: view

Transcripts for UBE2V1 Gene

Unigene Clusters for UBE2V1 Gene

Ubiquitin-conjugating enzyme E2 variant 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2V1 Gene

No ASD Table

Relevant External Links for UBE2V1 Gene

GeneLoc Exon Structure for
UBE2V1
ECgene alternative splicing isoforms for
UBE2V1

Expression for UBE2V1 Gene

mRNA expression in normal human tissues for UBE2V1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2V1 Gene



SOURCE GeneReport for Unigene cluster for UBE2V1 Gene Hs.420529

mRNA Expression by UniProt/SwissProt for UBE2V1 Gene

Q13404-UB2V1_HUMAN
Tissue specificity: Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.
genes like me logo Genes that share expression patterns with UBE2V1: view

Protein tissue co-expression partners for UBE2V1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for UBE2V1 Gene

Orthologs for UBE2V1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2V1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2V1 35
  • 99.55 (n)
  • 100 (a)
UBE2V1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2V1 35
  • 98.41 (n)
  • 100 (a)
UBE2V1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2v1 35
  • 87.07 (n)
  • 93.88 (a)
Ube2v1 16
Gm5830 36
  • 87 (a)
OneToMany
Gm8325 36
  • 88 (a)
OneToMany
Ube2v1 36
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia UBE2V1 35
  • 100 (n)
  • 100 (a)
-- 36
  • 94 (a)
OneToMany
UBE2V1 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100912618 35
  • 87.3 (n)
  • 93.88 (a)
chicken
(Gallus gallus)
Aves UBE2V1 35
  • 91.72 (n)
  • 99.31 (a)
UBE2V1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2V1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6054 35
ube2v1 35
  • 87.76 (n)
  • 95.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15969 35
zebrafish
(Danio rerio)
Actinopterygii ube2v1 35
  • 74.6 (n)
  • 88.44 (a)
ube2v1 36
  • 85 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Uev1A 37
  • 67 (a)
Uev1A 35
  • 59.31 (n)
  • 66.9 (a)
Uev1A 36
  • 65 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006937 35
  • 62.83 (n)
  • 70.5 (a)
worm
(Caenorhabditis elegans)
Secernentea uev-1 37
  • 66 (a)
uev-1 35
  • 60.58 (n)
  • 67.15 (a)
uev-1 36
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MMS2 36
  • 50 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os12g0605400 35
  • 55.48 (n)
  • 51.05 (a)
Species with no ortholog for UBE2V1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2V1 Gene

ENSEMBL:
Gene Tree for UBE2V1 (if available)
TreeFam:
Gene Tree for UBE2V1 (if available)

Paralogs for UBE2V1 Gene

Paralogs for UBE2V1 Gene

(2) SIMAP similar genes for UBE2V1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBE2V1: view

Variants for UBE2V1 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBE2V1 Gene

Variant ID Type Subtype PubMed ID
nsv833999 CNV Loss 17160897
nsv834000 CNV Gain+Loss 17160897

Variation tolerance for UBE2V1 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for UBE2V1 Gene

Disorders for UBE2V1 Gene

Relevant External Links for UBE2V1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2V1

No disorders were found for UBE2V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2V1 Gene

Publications for UBE2V1 Gene

  1. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29- M6 intestinal mucosecretory cells. (PMID: 9418904) Sancho E. … Thomson T.M. (Mol. Cell. Biol. 1998) 2 3 4 67
  2. Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. (PMID: 17709375) Petroski M.D. … Huang J. (J. Biol. Chem. 2007) 3 23
  3. Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexes. (PMID: 12834344) McKenna S. … Spyracopoulos L. (Biochemistry 2003) 3 23
  4. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. (PMID: 11057907) Deng L. … Chen Z.J. (Cell 2000) 3 23
  5. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson T.M. … Guigo R. (Genome Res. 2000) 3 23

Products for UBE2V1 Gene

Sources for UBE2V1 Gene

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