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Aliases for UBE2I Gene

Aliases for UBE2I Gene

  • Ubiquitin-Conjugating Enzyme E2I 2 3
  • Ubiquitin-Conjugating Enzyme E2I (Homologous To Yeast UBC9) 2 3
  • Ubiquitin-Conjugating Enzyme E2I (UBC9 Homolog, Yeast) 2 3
  • Ubiquitin Carrier Protein 9 3 4
  • Ubiquitin Carrier Protein I 3 4
  • Ubiquitin-Protein Ligase I 3 4
  • SUMO-Protein Ligase 3 4
  • UBC9 3 4
  • P18 3 4
  • Ubiquitin-Like Protein SUMO-1 Conjugating Enzyme 3
  • Ubiquitin-Conjugating Enzyme UbcE2A 3
  • Ubiquitin-Conjugating Enzyme E2 I 4
  • Ubiquitin Conjugating Enzyme 9 3
  • SUMO-Conjugating Enzyme UBC9 3
  • Ubiquitin-Protein Ligase E2I 3
  • SUMO-1-Protein Ligase 3
  • EC 6.3.2.- 4
  • C358B7.1 3
  • EC 6.3.2 63
  • UBCE9 4

External Ids for UBE2I Gene

Summaries for UBE2I Gene

Entrez Gene Summary for UBE2I Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2I Gene

UBE2I (Ubiquitin-Conjugating Enzyme E2I) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Cell Cycle, Mitotic. GO annotations related to this gene include transcription factor binding and enzyme binding.

UniProtKB/Swiss-Prot for UBE2I Gene

  • Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at Lys-386.

Gene Wiki entry for UBE2I Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2I Gene

Genomics for UBE2I Gene

Genomic Location for UBE2I Gene

Start:
1,308,880 bp from pter
End:
1,327,018 bp from pter
Size:
18,139 bases
Orientation:
Plus strand

Genomic View for UBE2I Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2I Gene

Regulatory Elements for UBE2I Gene

Transcription factor binding sites by QIAGEN in the UBE2I gene promoter:

Proteins for UBE2I Gene

  • Protein details for UBE2I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63279-UBC9_HUMAN
    Recommended name:
    SUMO-conjugating enzyme UBC9
    Protein Accession:
    P63279
    Secondary Accessions:
    • D3DU69
    • P50550
    • Q15698
    • Q59GX1
    • Q86VB3

    Protein attributes for UBE2I Gene

    Size:
    158 amino acids
    Molecular mass:
    18007 Da
    Quaternary structure:
    • Interacts with SETX (PubMed:24105744). Interacts with HIPK1, HIPK2, PPM1J, RASD2 and TCF3 Interacts with NR2C1; the interaction promotes its sumoylation (By similarity). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1 and PARP. Interacts with various transcription factors such as TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B. Interacts with DNMT1. Interacts with FOXL2. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Interacts with human herpesvirus 6 IE2. Interacts with human adenovirus early E1A protein; this interaction interferes with polysumoylation (Probable). Interacts with DNM1l (via its GTPase and B domains); the interaction promotes sumoylation of DNM1L, mainly in its B domain. Interacts with PML-RARA oncoprotein (via the coiled-colied domain); the interaction is required for sumoylation of the PML-RARA oncoprotein. Interacts with IPO13. Interacts with NFATC2IP; this inhibits formation of poly-SUMO chains. Interacts with FHIT. Interacts with PRKRA and p53/TP53 (By similarity). Interacts with UHRF2. Interacts with NR3C1 and this interaction is enhanced in the presence of RWDD3. Interacts with MTA1.
    SequenceCaution:
    • Sequence=AAH51289.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92225.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2I Gene

neXtProt entry for UBE2I Gene

Proteomics data for UBE2I Gene at MOPED

Post-translational modifications for UBE2I Gene

  • Phosphorylation at Ser-71 significantly enhances SUMOylation activity.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys18, Lys59, and Lys65

Domains for UBE2I Gene

Gene Families for UBE2I Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2I Gene

Suggested Antigen Peptide Sequences for UBE2I Gene

Graphical View of Domain Structure for InterPro Entry

P63279

UniProtKB/Swiss-Prot:

UBC9_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • P63279
genes like me logo Genes that share domains with UBE2I: view

Function for UBE2I Gene

Molecular function for UBE2I Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme E2I,homolog to yeast UBC9,associating with RAD51,RAD52 proteins in the double strand RAD51/RAD52 repair pathway,also associating with UBL1 and PT53,involved in DNA recombination and essential for cell-cycle progression
UniProtKB/Swiss-Prot CatalyticActivity: ATP + SUMO + protein lysine = AMP + diphosphate + protein N-SUMOyllysine
UniProtKB/Swiss-Prot Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at Lys-386.

Enzyme Numbers (IUBMB) for UBE2I Gene

Gene Ontology (GO) - Molecular Function for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 10871618
GO:0005524 ATP binding IEA --
GO:0008022 protein C-terminus binding IEA --
GO:0008134 transcription factor binding IPI 19744555
genes like me logo Genes that share ontologies with UBE2I: view
genes like me logo Genes that share phenotypes with UBE2I: view

Animal Models for UBE2I Gene

MGI Knock Outs for UBE2I:

No data available for Transcription Factor Targeting and HOMER Transcription for UBE2I Gene

Localization for UBE2I Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2I Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2I Gene COMPARTMENTS Subcellular localization image for UBE2I gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex TAS 8610150
GO:0001650 fibrillar center IEA --
GO:0005634 nucleus IDA 14752048
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with UBE2I: view

Pathways for UBE2I Gene

genes like me logo Genes that share pathways with UBE2I: view

UniProtKB/Swiss-Prot P63279-UBC9_HUMAN

  • Pathway: Protein modification; protein sumoylation

Gene Ontology (GO) - Biological Process for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19955185
GO:0006464 cellular protein modification process TAS 8798754
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8565643
GO:0007059 chromosome segregation IEA --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with UBE2I: view

Compounds for UBE2I Gene

(4) HMDB Compounds for UBE2I Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(7) Novoseek inferred chemical compound relationships for UBE2I Gene

Compound -log(P) Hits PubMed IDs
lysine 63.9 5
topotecan 26.5 2
testosterone 4.12 3
atp 0 1
glucose 0 7

(2) PharmGKB related drug/compound annotations for UBE2I Gene

Drug/compound Annotation
cisplatin CA
irinotecan CA
genes like me logo Genes that share compounds with UBE2I: view

Transcripts for UBE2I Gene

Unigene Clusters for UBE2I Gene

Ubiquitin-conjugating enzyme E2I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2I Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - -
SP12: - -
SP13:
SP14:

Relevant External Links for UBE2I Gene

GeneLoc Exon Structure for
UBE2I
ECgene alternative splicing isoforms for
UBE2I

Expression for UBE2I Gene

mRNA expression in normal human tissues for UBE2I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2I Gene

SOURCE GeneReport for Unigene cluster for UBE2I Gene Hs.302903

mRNA Expression by UniProt/SwissProt for UBE2I Gene

P63279-UBC9_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.
genes like me logo Genes that share expressions with UBE2I: view

No data available for mRNA differential expression in normal tissues for UBE2I Gene

Orthologs for UBE2I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2I 35
  • 98.95 (n)
  • 100 (a)
UBE2I 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2I 35
  • 90.72 (n)
  • 100 (a)
UBE2I 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2I 35
  • 91.98 (n)
  • 100 (a)
UBE2I 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2i 35
  • 89.24 (n)
  • 100 (a)
Ube2i 16
Ube2i 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2I 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2I 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2i 35
  • 89.24 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves UBE2I 35
  • 87.13 (n)
  • 100 (a)
UBE2I 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2I 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ube2i-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8764 35
ube2i 35
  • 85.65 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ube2i2 35
  • 81.32 (n)
  • 99.36 (a)
ube2i2 36
  • 99 (a)
OneToMany
ube2i2 36
  • 99 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011076 35
  • 68.99 (n)
  • 82.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta lwr 35
  • 70.89 (n)
  • 85.44 (a)
lwr 36
  • 85 (a)
OneToOne
lwr 37
  • 86 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-9 36
  • 72 (a)
OneToOne
ubc-9 37
  • 76 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER056C 35
  • 56.62 (n)
  • 57.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC9 35
  • 54.91 (n)
  • 56.41 (a)
UBC9 36
  • 56 (a)
OneToOne
UBC9 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05039g 35
  • 57.91 (n)
  • 57.69 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2303 35
thale cress
(Arabidopsis thaliana)
eudicotyledons SCE1 35
  • 62.77 (n)
  • 66.23 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.919 35
corn
(Zea mays)
Liliopsida Zm.4940 35
rice
(Oryza sativa)
Liliopsida Os.9019 35
Os03g0123100 35
  • 62.82 (n)
  • 64.74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04302 35
  • 58.44 (n)
  • 62.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hus5 35
  • 60.3 (n)
  • 66.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for UBE2I:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2I Gene

ENSEMBL:
Gene Tree for UBE2I (if available)
TreeFam:
Gene Tree for UBE2I (if available)

Paralogs for UBE2I Gene

Pseudogenes.org Pseudogenes for UBE2I Gene

genes like me logo Genes that share paralogs with UBE2I: view

No data available for Paralogs for UBE2I Gene

Variants for UBE2I Gene

Sequence variations from dbSNP and Humsavar for UBE2I Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4610 -- 1,314,364(+) ATTCC(A/G)GGAAA reference, synonymous-codon
rs7302 -- 1,325,262(+) CCAGG(G/T)CAGCA utr-variant-3-prime
rs8063 -- 1,324,817(+) CGTCA(A/G)AAGGA utr-variant-3-prime
rs9597 -- 1,324,950(+) GGTCT(C/G)GATTC utr-variant-3-prime
rs12129 -- 1,325,072(+) AAAAT(C/T)ATAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2I Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv471066 CNV Loss 18288195
nsv428316 CNV Gain+Loss 18775914
dgv2505n71 CNV Loss 21882294
dgv2509n71 CNV Loss 21882294
dgv2525n71 CNV Loss 21882294
nsv904950 CNV Loss 21882294
nsv904954 CNV Loss 21882294
nsv833117 CNV Loss 17160897
nsv904962 CNV Gain 21882294
nsv904963 CNV Gain+Loss 21882294
dgv2527n71 CNV Loss 21882294
dgv2528n71 CNV Loss 21882294
dgv2529n71 CNV Loss 21882294
esv22390 CNV Loss 19812545
nsv103725 CNV Loss 16902084

Relevant External Links for UBE2I Gene

HapMap Linkage Disequilibrium report
UBE2I
Human Gene Mutation Database (HGMD)
UBE2I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2I Gene

Disorders for UBE2I Gene

(10) Novoseek inferred disease relationships for UBE2I Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma lung 17.1 2
shock 10.2 1
melanoma 4.02 4
ovarian carcinoma 3.48 2
leukemia 0 1

Relevant External Links for UBE2I

Genetic Association Database (GAD)
UBE2I
Human Genome Epidemiology (HuGE) Navigator
UBE2I
genes like me logo Genes that share disorders with UBE2I: view

No data available for UniProtKB/Swiss-Prot for UBE2I Gene

Publications for UBE2I Gene

  1. Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. (PMID: 8565643) Watanabe T.K. … Shin S. (Cytogenet. Cell Genet. 1996) 2 3 4 23
  2. Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. (PMID: 8610150) Kovalenko O.V. … Golub E.I. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  3. Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. (PMID: 8798754) Wang Z.-Y. … Deuel T.F. (J. Biol. Chem. 1996) 3 4 23
  4. Poly(ADP-ribose) polymerase interacts with a novel human ubiquitin conjugating enzyme: hUbc9. (PMID: 9197546) Masson M. … Niedergang C.P. (Gene 1997) 3 4 23
  5. Ubc9 interacts with the androgen receptor and activates receptor- dependent transcription. (PMID: 10383460) Poukka H. … Jaenne O.A. (J. Biol. Chem. 1999) 3 4 23

Products for UBE2I Gene

  • Addgene plasmids for UBE2I

Sources for UBE2I Gene

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