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Aliases for UBE2I Gene

Aliases for UBE2I Gene

  • Ubiquitin Conjugating Enzyme E2 I 2 3 5
  • Ubiquitin-Conjugating Enzyme E2I (Homologous To Yeast UBC9) 2 3
  • Ubiquitin-Conjugating Enzyme E2I (UBC9 Homolog, Yeast) 2 3
  • RING-Type E3 SUMO Transferase UBC9 3 4
  • Ubiquitin Carrier Protein 9 3 4
  • Ubiquitin Carrier Protein I 3 4
  • Ubiquitin-Protein Ligase I 3 4
  • SUMO-Protein Ligase 3 4
  • UBC9 3 4
  • P18 3 4
  • Ubiquitin-Like Protein SUMO-1 Conjugating Enzyme 3
  • Ubiquitin-Conjugating Enzyme UbcE2A 3
  • Ubiquitin-Conjugating Enzyme E2 I 4
  • Ubiquitin-Conjugating Enzyme E2I 2
  • Ubiquitin Conjugating Enzyme E2I 3
  • Ubiquitin Conjugating Enzyme 9 3
  • SUMO-Conjugating Enzyme UBC9 3
  • Ubiquitin-Protein Ligase E2I 3
  • SUMO-1-Protein Ligase 3
  • EC 2.3.2.- 4
  • C358B7.1 3
  • EC 6.3.2 58
  • UBCE9 4

External Ids for UBE2I Gene

Previous GeneCards Identifiers for UBE2I Gene

  • GC16P001375
  • GC16P001299
  • GC16P001287
  • GC16P001359

Summaries for UBE2I Gene

Entrez Gene Summary for UBE2I Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2I Gene

UBE2I (Ubiquitin Conjugating Enzyme E2 I) is a Protein Coding gene. Diseases associated with UBE2I include Pediatric Fibrosarcoma and Congenital Fibrosarcoma. Among its related pathways are Transport of the SLBP independent Mature mRNA and DNA Double Strand Break Response. GO annotations related to this gene include poly(A) RNA binding and ligase activity.

UniProtKB/Swiss-Prot for UBE2I Gene

  • Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at Lys-386.

Gene Wiki entry for UBE2I Gene

Additional gene information for UBE2I Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2I Gene

Genomics for UBE2I Gene

Regulatory Elements for UBE2I Gene

Enhancers for UBE2I Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001308 1.4 ENCODE dbSUPER 158.6 +1.9 1875 5 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H001271 1.1 ENCODE 133.8 -37.1 -37054 1 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF662 ZNF592 CRAMP1 WDR90 TELO2 IFT140 ENSG00000261505 TSC2 E4F1 WDR24 ENSG00000260646 UBE2I
GH16H000981 1.2 ENCODE dbSUPER 79.7 -327.4 -327405 0 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 KLF7 ZNF548 SP3 MCM3 WDR90 CRAMP1 ENSG00000261505 UBE2I JMJD8 TELO2 ENSG00000260954 UNKL ENSG00000260051 WDR24
GH16H000323 2 FANTOM5 Ensembl ENCODE dbSUPER 41.1 -982.4 -982448 5 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF416 ZNF207 FOS WDR90 LUC7L JMJD8 UBE2I ENSG00000228779 ENSG00000261505 RHOT2 WDR24 ENSG00000262528 MPG
GH16H002147 2 FANTOM5 Ensembl ENCODE dbSUPER 34.7 +846.9 846911 17 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC CRAMP1 ENSG00000260051 ENSG00000261505 TELO2 TBL3 UNKL E4F1 TSC2 SRRM2 ZNF213-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2I on UCSC Golden Path with GeneCards custom track

Promoters for UBE2I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082331 920 2801 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC ZFP41

Transcription factor binding sites by QIAGEN in the UBE2I gene promoter:

Genomic Location for UBE2I Gene

Chromosome:
16
Start:
1,308,880 bp from pter
End:
1,327,018 bp from pter
Size:
18,139 bases
Orientation:
Plus strand

Genomic View for UBE2I Gene

Genes around UBE2I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2I Gene

Proteins for UBE2I Gene

  • Protein details for UBE2I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63279-UBC9_HUMAN
    Recommended name:
    SUMO-conjugating enzyme UBC9
    Protein Accession:
    P63279
    Secondary Accessions:
    • D3DU69
    • P50550
    • Q15698
    • Q59GX1
    • Q86VB3

    Protein attributes for UBE2I Gene

    Size:
    158 amino acids
    Molecular mass:
    18007 Da
    Quaternary structure:
    • Interacts with SETX (PubMed:24105744). Interacts with HIPK1, HIPK2, PPM1J, RASD2 and TCF3 Interacts with NR2C1; the interaction promotes its sumoylation (By similarity). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1 and PARP. Interacts with various transcription factors such as TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B. Interacts with DNMT1. Interacts with FOXL2. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Interacts with human herpesvirus 6 IE2. Interacts with human adenovirus early E1A protein; this interaction interferes with polysumoylation (Probable). Interacts with DNM1l (via its GTPase and B domains); the interaction promotes sumoylation of DNM1L, mainly in its B domain. Interacts with PML-RARA oncoprotein (via the coiled-colied domain); the interaction is required for sumoylation of the PML-RARA oncoprotein. Interacts with IPO13. Interacts with NFATC2IP; this inhibits formation of poly-SUMO chains. Interacts with FHIT. Interacts with PRKRA and p53/TP53 (By similarity). Interacts with UHRF2. Interacts with NR3C1 and this interaction is enhanced in the presence of RWDD3. Interacts with MTA1. Interacts with ZNF451. Identified in a complex with SUMO2 and UBC9, where one ZNF451 interacts with one UBC9 and two SUMO2 chains, one bound to the UBC9 active site and the other to another region of the same UBC9 molecule. Interacts with Epstein-barr virus protein LMP1. Interacts with CPEB3 (By similarity).
    SequenceCaution:
    • Sequence=AAH51289.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92225.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2I Gene

neXtProt entry for UBE2I Gene

Selected DME Specific Peptides for UBE2I Gene

P63279:
  • HPNVYPSGT
  • VAVPTKNPDGTMNLMN
  • PAITIKQILLGIQ
  • PAQAEAYTIYCQNRVEYEKR
  • GIQELLNEPNIQ
  • DWRPAIT

Post-translational modifications for UBE2I Gene

  • Phosphorylation at Ser-71 significantly enhances SUMOylation activity.
  • Ubiquitination at Lys18, posLast=5959, and posLast=6565
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2I (UBC9)

Domains & Families for UBE2I Gene

Gene Families for UBE2I Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for UBE2I Gene

Graphical View of Domain Structure for InterPro Entry

P63279

UniProtKB/Swiss-Prot:

UBC9_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2I: view

Function for UBE2I Gene

Molecular function for UBE2I Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2I,homolog to yeast UBC9,associating with RAD51,RAD52 proteins in the double strand RAD51/RAD52 repair pathway,also associating with UBL1 and PT53,involved in DNA recombination and essential for cell-cycle progression
UniProtKB/Swiss-Prot CatalyticActivity:
SUMOyl-[E2 SUMO-conjugating enzyme]-L-cysteine + [acceptor-protein]-L-lysine = [E2 SUMO-conjugating enzyme]-L-cysteine + N(6)-SUMOyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at Lys-386.

Enzyme Numbers (IUBMB) for UBE2I Gene

Phenotypes From GWAS Catalog for UBE2I Gene

Gene Ontology (GO) - Molecular Function for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 9885291
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with UBE2I: view
genes like me logo Genes that share phenotypes with UBE2I: view

Animal Models for UBE2I Gene

MGI Knock Outs for UBE2I:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2I

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2I
  • Applied Biological Materials Clones for UBE2I
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2I Gene

Localization for UBE2I Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2I Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2I gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex TAS 8610150
GO:0001650 fibrillar center IEA --
GO:0005634 nucleus IEA,IDA 9223278
GO:0005635 nuclear envelope TAS --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with UBE2I: view

Pathways & Interactions for UBE2I Gene

genes like me logo Genes that share pathways with UBE2I: view

UniProtKB/Swiss-Prot P63279-UBC9_HUMAN

  • Pathway: Protein modification; protein sumoylation.

SIGNOR curated interactions for UBE2I Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006464 cellular protein modification process TAS 8798754
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8565643
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
genes like me logo Genes that share ontologies with UBE2I: view

Drugs & Compounds for UBE2I Gene

(10) Drugs for UBE2I Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2823
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1148
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
ATP Nutra Agonist 0

(2) Additional Compounds for UBE2I Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2I: view

Transcripts for UBE2I Gene

Unigene Clusters for UBE2I Gene

Ubiquitin-conjugating enzyme E2I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2I
  • Applied Biological Materials Clones for UBE2I
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2I Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - -
SP12: - -
SP13:
SP14:

Relevant External Links for UBE2I Gene

GeneLoc Exon Structure for
UBE2I
ECgene alternative splicing isoforms for
UBE2I

Expression for UBE2I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2I Gene



Protein tissue co-expression partners for UBE2I Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2I Gene:

UBE2I

SOURCE GeneReport for Unigene cluster for UBE2I Gene:

Hs.302903

mRNA Expression by UniProt/SwissProt for UBE2I Gene:

P63279-UBC9_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.

Evidence on tissue expression from TISSUES for UBE2I Gene

  • Nervous system(4.8)
  • Lung(4.6)
  • Liver(4.4)
  • Stomach(3.3)
  • Intestine(2.9)
  • Pancreas(2.7)
  • Kidney(2.4)
  • Muscle(2.3)
  • Adrenal gland(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with UBE2I: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2I Gene

Orthologs for UBE2I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2I Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia UBE2I 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2I 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2I 33 34
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia UBE2I 33 34
  • 91.98 (n)
cow
(Bos Taurus)
Mammalia UBE2I 33 34
  • 90.72 (n)
mouse
(Mus musculus)
Mammalia Ube2i 33 16 34
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Ube2i 33
  • 89.24 (n)
chicken
(Gallus gallus)
Aves UBE2I 33 34
  • 87.13 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2I 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2i 33
  • 85.65 (n)
Str.8764 33
African clawed frog
(Xenopus laevis)
Amphibia ube2i-prov 33
zebrafish
(Danio rerio)
Actinopterygii ube2i2 33 34 34
  • 81.32 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta lwr 35 33 34
  • 70.89 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011076 33
  • 68.99 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-9 35 34
  • 76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05039g 33
  • 57.91 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER056C 33
  • 56.62 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC9 33 34 36
  • 54.91 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SCE1 33
  • 62.77 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2303 33
rice
(Oryza sativa)
Liliopsida Os03g0123100 33
  • 62.82 (n)
Os.9019 33
barley
(Hordeum vulgare)
Liliopsida Hv.919 33
corn
(Zea mays)
Liliopsida Zm.4940 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 79 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hus5 33
  • 60.3 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04302 33
  • 58.44 (n)
Species where no ortholog for UBE2I was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2I Gene

ENSEMBL:
Gene Tree for UBE2I (if available)
TreeFam:
Gene Tree for UBE2I (if available)

Paralogs for UBE2I Gene

Pseudogenes.org Pseudogenes for UBE2I Gene

genes like me logo Genes that share paralogs with UBE2I: view

No data available for Paralogs for UBE2I Gene

Variants for UBE2I Gene

Sequence variations from dbSNP and Humsavar for UBE2I Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000089291 -- 1,321,158(+) CGCCC(A/G)CCTGT intron-variant, downstream-variant-500B
rs1000094979 -- 1,315,978(+) CAGCT(A/G)ATTGG intron-variant
rs1000282388 -- 1,319,222(+) TGGAA(A/G)CAGCA intron-variant
rs1000290145 -- 1,310,381(+) AGTTG(A/G)TTCTG intron-variant
rs1000393207 -- 1,323,219(+) GAGGC(A/G)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2I Gene

Variant ID Type Subtype PubMed ID
dgv2692n100 CNV gain 25217958
dgv4842n54 CNV loss 21841781
dgv4843n54 CNV gain 21841781
dgv4844n54 CNV gain 21841781
dgv4845n54 CNV gain 21841781
dgv4846n54 CNV gain 21841781
dgv4847n54 CNV gain+loss 21841781
dgv4848n54 CNV gain 21841781
dgv4849n54 CNV gain 21841781
esv22390 CNV loss 19812545
esv2422427 CNV duplication 17116639
esv2762143 CNV gain 21179565
nsv103725 CNV deletion 16902084
nsv1046314 CNV loss 25217958
nsv1069895 CNV deletion 25765185
nsv1143799 CNV deletion 24896259
nsv428316 CNV gain+loss 18775914
nsv471066 CNV loss 18288195
nsv571116 CNV gain 21841781
nsv571117 CNV loss 21841781
nsv571118 CNV loss 21841781
nsv571124 CNV loss 21841781
nsv571134 CNV loss 21841781
nsv571140 CNV loss 21841781
nsv571142 CNV loss 21841781
nsv571143 CNV loss 21841781
nsv833117 CNV loss 17160897
nsv952899 CNV deletion 24416366

Variation tolerance for UBE2I Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2I Gene

Human Gene Mutation Database (HGMD)
UBE2I
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2I Gene

Disorders for UBE2I Gene

MalaCards: The human disease database

(3) MalaCards diseases for UBE2I Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pediatric fibrosarcoma
  • childhood fibrosarcoma
congenital fibrosarcoma
  • infantile fibrosarcoma
split hand-foot malformation
  • lobster-claw deformity
- elite association - COSMIC cancer census association via MalaCards
Search UBE2I in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBE2I

Genetic Association Database (GAD)
UBE2I
Human Genome Epidemiology (HuGE) Navigator
UBE2I
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2I
genes like me logo Genes that share disorders with UBE2I: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2I Gene

Publications for UBE2I Gene

  1. Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. (PMID: 8565643) Watanabe TK … Shin S (Cytogenetics and cell genetics 1996) 2 3 4 22 60
  2. Association of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy. (PMID: 19859084) Han JY … Lee JS (The pharmacogenomics journal 2010) 3 22 45 60
  3. Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade. (PMID: 19358266) Dünnebier T … Hamann U (International journal of cancer 2009) 3 22 45 60
  4. Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: a genetic association study. (PMID: 19765634) Ahn K … Koh YH (Neuroscience letters 2009) 3 22 45 60
  5. Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction. (PMID: 17466333) Capili AD … Lima CD (Journal of molecular biology 2007) 3 4 22 60

Products for UBE2I Gene

  • Addgene plasmids for UBE2I

Sources for UBE2I Gene