Aliases for UBE2H Gene
- Ubiquitin-Conjugating Enzyme E2H 2 3
- UBCH2 3 4 6
- Ubiquitin-Conjugating Enzyme E2H (Homologous To Yeast UBC8) 2 3
- Ubiquitin-Conjugating Enzyme E2H (UBC8 Homolog, Yeast) 2 3
- Ubiquitin-Conjugating Enzyme E2-20K 3 4
- Ubiquitin Carrier Protein H 3 4
- Ubiquitin-Protein Ligase H 3 4
- EC 22.214.171.124 4 64
- UBC8 3 6
External Ids for UBE2H Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
GeneCards Summary for UBE2H Gene
UBE2H (Ubiquitin-Conjugating Enzyme E2H) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for UBE2H Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.