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Aliases for UBE2H Gene

Aliases for UBE2H Gene

  • Ubiquitin-Conjugating Enzyme E2H 2 3
  • UBCH2 3 4 6
  • Ubiquitin-Conjugating Enzyme E2H (Homologous To Yeast UBC8) 2 3
  • Ubiquitin-Conjugating Enzyme E2H (UBC8 Homolog, Yeast) 2 3
  • Ubiquitin-Conjugating Enzyme E2-20K 3 4
  • Ubiquitin Carrier Protein H 3 4
  • Ubiquitin-Protein Ligase H 3 4
  • EC 4 63
  • UBC8 3 6
  • GID Complex Subunit 3, UBC8 Homolog 3
  • Ubiquitin-Conjugating Enzyme E2 H 3
  • UBC8 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 3 2
  • E2-20K 3
  • GID3 3
  • UBCH 3

External Ids for UBE2H Gene

Summaries for UBE2H Gene

Entrez Gene Summary for UBE2H Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

GeneCards Summary for UBE2H Gene

UBE2H (Ubiquitin-Conjugating Enzyme E2H) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for UBE2H Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.

Gene Wiki entry for UBE2H Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2H Gene

Genomics for UBE2H Gene

Genomic Location for UBE2H Gene

129,830,732 bp from pter
129,952,960 bp from pter
122,229 bases
Minus strand

Genomic View for UBE2H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2H Gene

Regulatory Elements for UBE2H Gene

Proteins for UBE2H Gene

  • Protein details for UBE2H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 H
    Protein Accession:
    Secondary Accessions:
    • A4D1L6
    • C9JY93
    • P37286
    • Q7Z6F4

    Protein attributes for UBE2H Gene

    183 amino acids
    Molecular mass:
    20655 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2H Gene

    Alternative splice isoforms for UBE2H Gene


neXtProt entry for UBE2H Gene

Proteomics data for UBE2H Gene at MOPED

Selected DME Specific Peptides for UBE2H Gene

Post-translational modifications for UBE2H Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys60, Lys64, and Lys147

Other Protein References for UBE2H Gene

Domains for UBE2H Gene

Gene Families for UBE2H Gene

  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2H Gene

Suggested Antigen Peptide Sequences for UBE2H Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-conjugating enzyme family.:
    • P62256
genes like me logo Genes that share domains with UBE2H: view

Function for UBE2H Gene

Molecular function for UBE2H Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme H2A,homolog to yeast UBC8
UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.

Enzyme Numbers (IUBMB) for UBE2H Gene

Gene Ontology (GO) - Molecular Function for UBE2H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 20028976
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2H: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2H Gene

Localization for UBE2H Gene

Subcellular locations from

Jensen Localization Image for UBE2H Gene COMPARTMENTS Subcellular localization image for UBE2H gene
Compartment Confidence
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBE2H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with UBE2H: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2H Gene

Pathways for UBE2H Gene

genes like me logo Genes that share pathways with UBE2H: view

UniProtKB/Swiss-Prot P62256-UBE2H_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8132613
GO:0008152 metabolic process --
GO:0070936 protein K48-linked ubiquitination IDA 20061386
GO:0070979 protein K11-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2H: view

Compounds for UBE2H Gene

(4) HMDB Compounds for UBE2H Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with UBE2H: view

Transcripts for UBE2H Gene

Unigene Clusters for UBE2H Gene

Ubiquitin-conjugating enzyme E2H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2H Gene

No ASD Table

Relevant External Links for UBE2H Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2H Gene

mRNA expression in normal human tissues for UBE2H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2H Gene

SOURCE GeneReport for Unigene cluster for UBE2H Gene Hs.643548

genes like me logo Genes that share expressions with UBE2H: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2H Gene

Orthologs for UBE2H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2H Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBE2H 35
  • 99.82 (n)
  • 100 (a)
UBE2H 36
  • 100 (a)
(Bos Taurus)
Mammalia UBE2H 35
  • 95.08 (n)
  • 100 (a)
UBE2H 36
  • 100 (a)
(Canis familiaris)
Mammalia UBE2H 35
  • 96.72 (n)
  • 100 (a)
UBE2H 36
  • 100 (a)
(Mus musculus)
Mammalia Gm2058 36
  • 99 (a)
Ube2h 35
  • 93.81 (n)
  • 100 (a)
Ube2h 16
Ube2h 36
  • 100 (a)
(Monodelphis domestica)
Mammalia UBE2H 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia UBE2H 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Ube2h 35
  • 93.62 (n)
  • 100 (a)
(Gallus gallus)
Aves UBE2H 35
  • 89.25 (n)
  • 100 (a)
UBE2H 36
  • 100 (a)
(Anolis carolinensis)
Reptilia UBE2H 36
  • 88 (a)
African clawed frog
(Xenopus laevis)
Amphibia ube2h-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5927 35
ube2h 35
  • 87.07 (n)
  • 98.91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1397 35
(Danio rerio)
Actinopterygii ube2h 35
  • 82.33 (n)
  • 98.36 (a)
ube2h 36
  • 98 (a)
wufc07a05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001068 35
  • 70.15 (n)
  • 83.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ubc-E2H 35
  • 65.76 (n)
  • 78.69 (a)
Ubc-E2H 36
  • 79 (a)
Ubc-E2H 37
  • 78 (a)
CG14739 37
  • 43 (a)
(Caenorhabditis elegans)
Secernentea ubc-8 35
  • 62.58 (n)
  • 67.74 (a)
ubc-8 36
  • 52 (a)
ubc-8 37
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL045W 35
  • 55.7 (n)
  • 60.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC8 35
  • 58.99 (n)
  • 59.21 (a)
UBC8 36
  • 46 (a)
UBC8 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11198g 35
  • 58.28 (n)
  • 60 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7729 35
(Glycine max)
eudicotyledons Gma.18138 35
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC4 35
  • 63.5 (n)
  • 59.49 (a)
(Oryza sativa)
Liliopsida Os10g0447100 35
  • 61.15 (n)
  • 61.87 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10046 35
  • 64.79 (n)
  • 67.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc8 35
  • 60.18 (n)
  • 62.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3173 35
Species with no ortholog for UBE2H:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2H Gene

Gene Tree for UBE2H (if available)
Gene Tree for UBE2H (if available)

Paralogs for UBE2H Gene Pseudogenes for UBE2H Gene

genes like me logo Genes that share paralogs with UBE2H: view

No data available for Paralogs for UBE2H Gene

Variants for UBE2H Gene

Sequence variations from dbSNP and Humsavar for UBE2H Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7639 -- 129,833,591(-) TCCTG(C/T)GTATG utr-variant-3-prime
rs8485 -- 129,833,335(-) TTTTT(C/T)TTTTT utr-variant-3-prime
rs8673 -- 129,834,860(-) TTAAA(A/C/G/T)AAAGC utr-variant-3-prime
rs10486 -- 129,834,496(-) AAAAA(C/G)TTGGG utr-variant-3-prime
rs12690 -- 129,831,121(-) GGGAG(A/G)AAGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2H Gene

Variant ID Type Subtype PubMed ID
nsv366414 CNV Loss 16902084
nsv831129 CNV Loss 17160897
esv2735150 CNV Deletion 23290073
nsv510968 CNV Complex 20534489

Relevant External Links for UBE2H Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2H Gene

Disorders for UBE2H Gene

(1) University of Copenhagen DISEASES for UBE2H Gene

Relevant External Links for UBE2H

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UBE2H: view

No data available for UniProtKB/Swiss-Prot for UBE2H Gene

Publications for UBE2H Gene

  1. A human ubiquitin-conjugating enzyme homologous to yeast UBC8. (PMID: 8132613) Kaiser P. … Schneider R. (J. Biol. Chem. 1994) 2 3 4 23
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder. (PMID: 14639049) Vourc'h P. … Andres C. (Psychiatr. Genet. 2003) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4

Products for UBE2H Gene

Sources for UBE2H Gene

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