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Aliases for UBE2G2 Gene

Aliases for UBE2G2 Gene

  • Ubiquitin-Conjugating Enzyme E2G 2 2 3
  • Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7) 2 3
  • Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog, Yeast) 2 3
  • Ubiquitin Carrier Protein G2 3 4
  • Ubiquitin-Protein Ligase G2 3 4
  • EC 6.3.2.19 4 63
  • UBC7 3 6
  • Ubiquitin-Conjugating Enzyme E2 G2 3
  • Ubiquitin Conjugating Enzyme G2 3
  • Ubiquitin Conjugating Enzyme 7 3

External Ids for UBE2G2 Gene

Previous GeneCards Identifiers for UBE2G2 Gene

  • GC21M042698
  • GC21M045045
  • GC21M045013
  • GC21M046188
  • GC21M031563

Summaries for UBE2G2 Gene

Entrez Gene Summary for UBE2G2 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for UBE2G2 Gene

UBE2G2 (Ubiquitin-Conjugating Enzyme E2G 2) is a Protein Coding gene. Diseases associated with UBE2G2 include cri-du-chat syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2R2.

UniProtKB/Swiss-Prot for UBE2G2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).

Gene Wiki entry for UBE2G2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2G2 Gene

Genomics for UBE2G2 Gene

Regulatory Elements for UBE2G2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2G2 Gene

Start:
44,768,580 bp from pter
End:
44,802,019 bp from pter
Size:
33,440 bases
Orientation:
Minus strand

Genomic View for UBE2G2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2G2 Gene

Proteins for UBE2G2 Gene

  • Protein details for UBE2G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60604-UB2G2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 G2
    Protein Accession:
    P60604
    Secondary Accessions:
    • A6NMQ7
    • A8K3L4
    • D3DSL7
    • P56554

    Protein attributes for UBE2G2 Gene

    Size:
    165 amino acids
    Molecular mass:
    18566 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2G2 Gene

    Alternative splice isoforms for UBE2G2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2G2 Gene

Proteomics data for UBE2G2 Gene at MOPED

Selected DME Specific Peptides for UBE2G2 Gene

Post-translational modifications for UBE2G2 Gene

  • Ubiquitination at Lys7, Lys153, and Lys156
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2G2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for UBE2G2 Gene

Gene Families for UBE2G2 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2G2 Gene

Suggested Antigen Peptide Sequences for UBE2G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60604

UniProtKB/Swiss-Prot:

UB2G2_HUMAN :
  • P60604
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2G2: view

Function for UBE2G2 Gene

Molecular function for UBE2G2 Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme,homolog to yeast UBC7,with two transcript,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).

Enzyme Numbers (IUBMB) for UBE2G2 Gene

Gene Ontology (GO) - Molecular Function for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 17681147
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2G2: view
genes like me logo Genes that share phenotypes with UBE2G2: view

Animal Model Products

CRISPR Products

miRNA for UBE2G2 Gene

miRTarBase miRNAs that target UBE2G2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2G2 Gene

Localization for UBE2G2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2G2 Gene COMPARTMENTS Subcellular localization image for UBE2G2 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0005829 cytosol IDA 16780588
genes like me logo Genes that share ontologies with UBE2G2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2G2 Gene

Pathways for UBE2G2 Gene

genes like me logo Genes that share pathways with UBE2G2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P60604-UB2G2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS 9693041
GO:0008152 metabolic process --
GO:0018279 protein N-linked glycosylation via asparagine IMP 22607976
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 22607976
GO:0044257 cellular protein catabolic process IDA 21628527
genes like me logo Genes that share ontologies with UBE2G2: view

Compounds for UBE2G2 Gene

(4) HMDB Compounds for UBE2G2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2G2: view

Transcripts for UBE2G2 Gene

Unigene Clusters for UBE2G2 Gene

Ubiquitin-conjugating enzyme E2G 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2G2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - -
SP5:
SP6: - - - -
SP7:
SP8:

Relevant External Links for UBE2G2 Gene

GeneLoc Exon Structure for
UBE2G2
ECgene alternative splicing isoforms for
UBE2G2

Expression for UBE2G2 Gene

mRNA expression in normal human tissues for UBE2G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2G2 Gene

SOURCE GeneReport for Unigene cluster for UBE2G2 Gene Hs.529420

genes like me logo Genes that share expressions with UBE2G2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2G2 Gene

Orthologs for UBE2G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2G2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2G2 35
  • 99.39 (n)
  • 100 (a)
UBE2G2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2G2 35
  • 91.52 (n)
  • 99.39 (a)
UBE2G2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2G2 35
  • 90.71 (n)
  • 95.76 (a)
UBE2G2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2g2 35
  • 89.49 (n)
  • 100 (a)
Ube2g2 16
Ube2g2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2G2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2G2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2g2 35
  • 89.49 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves UBE2G2 35
  • 82.42 (n)
  • 98.18 (a)
UBE2G2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2G2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2g2 35
  • 82.22 (n)
  • 96.36 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ube2g2 35
  • 78.18 (n)
  • 92.73 (a)
ube2g2 36
  • 94 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002169 35
  • 70.91 (n)
  • 82.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta crl 35
  • 71.72 (n)
  • 81.82 (a)
crl 36
  • 81 (a)
OneToOne
crl 37
  • 80 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-14 35
  • 65.05 (n)
  • 76.97 (a)
ubc-14 36
  • 75 (a)
OneToOne
ubc-14 37
  • 74 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR059W 35
  • 60.61 (n)
  • 62.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC7 35
  • 56.57 (n)
  • 62.42 (a)
UBC7 36
  • 62 (a)
OneToMany
UBC7 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07745g 35
  • 57.17 (n)
  • 59.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03623 35
  • 59.71 (n)
  • 63.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc7 35
  • 60.25 (n)
  • 68.32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3185 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for UBE2G2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2G2 Gene

ENSEMBL:
Gene Tree for UBE2G2 (if available)
TreeFam:
Gene Tree for UBE2G2 (if available)

Paralogs for UBE2G2 Gene

Paralogs for UBE2G2 Gene

genes like me logo Genes that share paralogs with UBE2G2: view

Variants for UBE2G2 Gene

Sequence variations from dbSNP and Humsavar for UBE2G2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs8103 -- 44,769,315(-) ACCTA(A/T)GTTGT utr-variant-3-prime
rs11569 -- 44,771,355(-) GGCGC(A/G)CACAC utr-variant-3-prime
rs170959 -- 44,794,793(-) cactt(C/T)gtggg intron-variant
rs170964 -- 44,776,883(-) ctaat(A/G)aagac intron-variant
rs173097 -- 44,771,202(-) TGAAA(C/T)GATGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2G2 Gene

Variant ID Type Subtype PubMed ID
dgv4775n71 CNV Loss 21882294
nsv913959 CNV Loss 21882294
dgv4776n71 CNV Loss 21882294
nsv913963 CNV Loss 21882294
nsv459298 CNV Loss 19166990
dgv4777n71 CNV Loss 21882294

Relevant External Links for UBE2G2 Gene

HapMap Linkage Disequilibrium report
UBE2G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2G2 Gene

Disorders for UBE2G2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UBE2G2 Gene including...

Search for UBE2G2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UBE2G2 Gene

Relevant External Links for UBE2G2

Genetic Association Database (GAD)
UBE2G2
genes like me logo Genes that share disorders with UBE2G2: view

No data available for UniProtKB/Swiss-Prot for UBE2G2 Gene

Publications for UBE2G2 Gene

  1. Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae UBC7 gene. (PMID: 9693041) Katsanis N. … Fisher E.M.C. (Genomics 1998) 2 3 4 23
  2. Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). (PMID: 16582478) Arai R. … Yokoyama S. (Acta Crystallogr. F 2006) 3 4 23
  3. A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. (PMID: 17310145) Li W. … Ye Y. (Nature 2007) 3 23
  4. Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2. (PMID: 20014027) Ju T. … Tolman J.R. (Proteins 2010) 3 23
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4

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Sources for UBE2G2 Gene

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