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Aliases for UBE2E2 Gene

Aliases for UBE2E2 Gene

  • Ubiquitin-Conjugating Enzyme E2E 2 2 3
  • Ubiquitin-Conjugating Enzyme E2E 2 (Homologous To Yeast UBC4/5) 2 3
  • Ubiquitin-Conjugating Enzyme E2E 2 (UBC4/5 Homolog, Yeast) 2 3
  • E2 Ubiquitin-Conjugating Enzyme E2 3 4
  • Ubiquitin Carrier Protein E2 3 4
  • Ubiquitin-Protein Ligase E2 3 4
  • UBCH8 3 4
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4

External Ids for UBE2E2 Gene

Previous GeneCards Identifiers for UBE2E2 Gene

  • GC03U990078
  • GC03P023220

Summaries for UBE2E2 Gene

GeneCards Summary for UBE2E2 Gene

UBE2E2 (Ubiquitin-Conjugating Enzyme E2E 2) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2E2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene Wiki entry for UBE2E2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2E2 Gene

Genomics for UBE2E2 Gene

Regulatory Elements for UBE2E2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2E2 Gene

Chromosome:
3
Start:
23,203,007 bp from pter
End:
23,591,793 bp from pter
Size:
388,787 bases
Orientation:
Plus strand

Genomic View for UBE2E2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for UBE2E2 Gene

Proteins for UBE2E2 Gene

  • Protein details for UBE2E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LR5-UB2E2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 E2
    Protein Accession:
    Q96LR5

    Protein attributes for UBE2E2 Gene

    Size:
    201 amino acids
    Molecular mass:
    22255 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2E2 Gene

neXtProt entry for UBE2E2 Gene

Proteomics data for UBE2E2 Gene at MOPED

Post-translational modifications for UBE2E2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBE2E2 Gene

Antibody Products

Domains & Families for UBE2E2 Gene

Gene Families for UBE2E2 Gene

Protein Domains for UBE2E2 Gene

Suggested Antigen Peptide Sequences for UBE2E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LR5

UniProtKB/Swiss-Prot:

UB2E2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2E2: view

Function for UBE2E2 Gene

Molecular function for UBE2E2 Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2E2,homologous to yeast UBC4/5,ubiquitously expressed, involved in selective protein degradation
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.

Enzyme Numbers (IUBMB) for UBE2E2 Gene

Gene Ontology (GO) - Molecular Function for UBE2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 19549727
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity --
GO:0042296 ISG15 transferase activity IDA 16428300
genes like me logo Genes that share ontologies with UBE2E2: view
genes like me logo Genes that share phenotypes with UBE2E2: view

Animal Model Products

miRNA for UBE2E2 Gene

miRTarBase miRNAs that target UBE2E2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2E2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2E2 Gene

Localization for UBE2E2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2E2 Gene COMPARTMENTS Subcellular localization image for UBE2E2 gene
Compartment Confidence
lysosome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBE2E2 Gene

Pathways & Interactions for UBE2E2 Gene

genes like me logo Genes that share pathways with UBE2E2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q96LR5-UB2E2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 21628527
GO:0008152 metabolic process --
GO:0032020 ISG15-protein conjugation IDA 16428300
GO:0070534 protein K63-linked ubiquitination IDA 20061386
GO:0070936 protein K48-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2E2: view

No data available for SIGNOR curated interactions for UBE2E2 Gene

Drugs & Compounds for UBE2E2 Gene

(3) Drugs for UBE2E2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2E2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2E2: view

Transcripts for UBE2E2 Gene

Unigene Clusters for UBE2E2 Gene

Ubiquitin-conjugating enzyme E2E 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2E2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2E2 Gene

No ASD Table

Relevant External Links for UBE2E2 Gene

GeneLoc Exon Structure for
UBE2E2
ECgene alternative splicing isoforms for
UBE2E2

Expression for UBE2E2 Gene

mRNA expression in normal human tissues for UBE2E2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2E2 Gene

This gene is overexpressed in Testis (12.2), Uterus (10.0), Pancreatic juice (8.7), and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2E2 Gene



SOURCE GeneReport for Unigene cluster for UBE2E2 Gene Hs.475688

genes like me logo Genes that share expression patterns with UBE2E2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for UBE2E2 Gene

Orthologs for UBE2E2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBE2E2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2E2 35
  • 91.87 (n)
  • 99.5 (a)
UBE2E2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2E2 35
  • 97.01 (n)
  • 100 (a)
UBE2E2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2e2 35
  • 91.87 (n)
  • 99.5 (a)
Ube2e2 16
Ube2e2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2E2 35
  • 99.83 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Ube2e2 35
  • 91.49 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2E2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2E2 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2E2 35
  • 87.86 (n)
  • 97.28 (a)
lizard
(Anolis carolinensis)
Reptilia UBE2E2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2e2 35
  • 82.59 (n)
  • 96.02 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2e2 35
  • 79.6 (n)
  • 89.55 (a)
ube2e1 36
  • 82 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007952 35
  • 65.45 (n)
  • 78.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta UbcD2 35
  • 69.34 (n)
  • 87.65 (a)
CG2574 36
  • 38 (a)
ManyToMany
CG5440 36
  • 65 (a)
ManyToMany
UbcD2 36
  • 63 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6406 36
  • 70 (a)
OneToMany
Species with no ortholog for UBE2E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2E2 Gene

ENSEMBL:
Gene Tree for UBE2E2 (if available)
TreeFam:
Gene Tree for UBE2E2 (if available)

Paralogs for UBE2E2 Gene

Paralogs for UBE2E2 Gene

genes like me logo Genes that share paralogs with UBE2E2: view

Variants for UBE2E2 Gene

Sequence variations from dbSNP and Humsavar for UBE2E2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs704533 -- 23,443,336(+) ATCCC(A/G)AGAAG intron-variant
rs704534 -- 23,431,855(-) AAAAT(A/G)TTTTG intron-variant
rs704535 -- 23,394,906(+) TACAC(C/T)AGCCT intron-variant
rs716456 -- 23,338,799(+) tcaaa(C/G)gggag intron-variant
rs716457 -- 23,338,828(+) GCCAT(A/G)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2E2 Gene

Variant ID Type Subtype PubMed ID
nsv834636 CNV Gain+Loss 17160897
nsv3731 CNV Insertion 18451855
esv270258 CNV Insertion 20981092
nsv876624 CNV Loss 21882294
nsv876625 CNV Gain 21882294
nsv236860 CNV Loss 16902084
esv25457 CNV Loss 19812545
esv2669216 CNV Deletion 23128226
esv268283 CNV Insertion 20981092
nsv526739 CNV Loss 19592680
esv2725037 CNV Deletion 23290073
esv2674431 CNV Deletion 23128226
nsv460479 CNV Gain 19166990

Variation tolerance for UBE2E2 Gene

Residual Variation Intolerance Score: 35.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2E2 Gene

HapMap Linkage Disequilibrium report
UBE2E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2E2 Gene

Disorders for UBE2E2 Gene

Relevant External Links for UBE2E2

Genetic Association Database (GAD)
UBE2E2
Human Genome Epidemiology (HuGE) Navigator
UBE2E2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2E2
genes like me logo Genes that share disorders with UBE2E2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2E2 Gene

Publications for UBE2E2 Gene

  1. cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme. (PMID: 9371400) Kimura M. … Okano Y. (Cytogenet. Cell Genet. 1997) 2 23 67
  2. ISG15 and immune diseases. (PMID: 20153823) Jeon Y.J. … Chung C.H. (Biochim. Biophys. Acta 2010) 23 67
  3. Identification and characterization of a novel endogenous murine parkin mutation. (PMID: 20089136) Ramsey C.P. … Giasson B.I. (J. Neurochem. 2010) 23 67
  4. ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. (PMID: 19073728) Giannakopoulos N.V. … Virgin H.W. (J. Virol. 2009) 23 67
  5. UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I. (PMID: 17719635) Arimoto K. … Shimotohno K. (Mol. Immunol. 2008) 23 67

Products for UBE2E2 Gene

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