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Aliases for UBE2D2 Gene

Aliases for UBE2D2 Gene

  • Ubiquitin Conjugating Enzyme E2 D2 2 3 5
  • Ubiquitin-Conjugating Enzyme E2D 2 (Homologous To Yeast UBC4/5) 2 3
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme D2 3 4
  • P53-Regulated Ubiquitin-Conjugating Enzyme 1 3 4
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 2 3 4
  • E2 Ubiquitin-Conjugating Enzyme D2 3 4
  • Ubiquitin Carrier Protein D2 3 4
  • Ubiquitin-Protein Ligase D2 3 4
  • UBCH5B 3 4
  • PUBC1 3 4
  • UBCH4 3 4
  • UBC4 3 4
  • Ubiquitin-Conjugating Enzyme E2D 2 (UBC4/5 Homolog, Yeast) 2
  • Ubiquitin-Conjugating Enzyme E2(17)KB 2 4
  • Ubiquitin-Conjugating Enzyme E2D 2 2
  • Ubiquitin Conjugating Enzyme E2D 2 3
  • Ubiquitin-Conjugating Enzyme E2 D2 3
  • EC 6.3.2.19 58
  • EC 2.3.2.23 4
  • EC 2.3.2.24 4
  • E2(17)KB2 3
  • UBC4/5 3
  • UBC5B 4

External Ids for UBE2D2 Gene

Previous GeneCards Identifiers for UBE2D2 Gene

  • GC05P138764
  • GC05P138923
  • GC05P138969
  • GC05P138920
  • GC05P134083

Summaries for UBE2D2 Gene

Entrez Gene Summary for UBE2D2 Gene

  • Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for UBE2D2 Gene

UBE2D2 (Ubiquitin Conjugating Enzyme E2 D2) is a Protein Coding gene. Diseases associated with UBE2D2 include Smallpox and Retinitis Pigmentosa 42. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Protein processing in endoplasmic reticulum. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2D1.

UniProtKB/Swiss-Prot for UBE2D2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Gene Wiki entry for UBE2D2 Gene

Additional gene information for UBE2D2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2D2 Gene

Genomics for UBE2D2 Gene

Regulatory Elements for UBE2D2 Gene

Enhancers for UBE2D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H138843 0.8 Ensembl ENCODE 4.9 -681.7 -681675 3 OSR2 GATA3 PRDM6 JUND SCRT2 CEBPB LOC105379194 CTNNA1 UBE2D2 GC05P138821 LRRTM2
GH05H139134 0.4 dbSUPER 4.1 -390.8 -390797 2 SCRT2 LOC105379194 MATR3 SIL1 UBE2D2 GC05P139163 GC05P139162 GC05P139102 GC05P139103 GC05P139104 GC05P139106
GH05H139517 1.8 FANTOM5 Ensembl ENCODE 0.4 -8.3 -8256 1 ZFP64 FEZF1 DMAP1 ZNF416 ZNF143 SP3 ZC3H11A MEF2D SSRP1 ZNF610 PURA ANKHD1 MALINC1 IGIP MATR3 DNAJC18 ENSG00000232174 SLC23A1 CTNNA1 PSD2
GH05H139284 0.5 FANTOM5 1.4 -241.7 -241670 0 POLR2A SUPT5H SLC23A1 PAIP2 MATR3 HSPA9 UBE2D2 PIR57006 SIL1
GH05H139523 0.9 ENCODE 0.7 -1.1 -1101 3 PKNOX1 RB1 MLX BATF RARA ATF7 RUNX3 CREM IKZF2 SMARCA5 ENSG00000253965 UBE2D2 PIR33843
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2D2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UBE2D2 gene promoter:

Genomic Location for UBE2D2 Gene

Chromosome:
5
Start:
139,526,431 bp from pter
End:
139,628,434 bp from pter
Size:
102,004 bases
Orientation:
Plus strand

Genomic View for UBE2D2 Gene

Genes around UBE2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2D2 Gene

Proteins for UBE2D2 Gene

  • Protein details for UBE2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62837-UB2D2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D2
    Protein Accession:
    P62837
    Secondary Accessions:
    • D3DQC9
    • P51669
    • Q3MN78
    • Q96RP6

    Protein attributes for UBE2D2 Gene

    Size:
    147 amino acids
    Molecular mass:
    16735 Da
    Quaternary structure:
    • Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3.

    Three dimensional structures from OCA and Proteopedia for UBE2D2 Gene

    Alternative splice isoforms for UBE2D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2D2 Gene

Selected DME Specific Peptides for UBE2D2 Gene

P62837:
  • CSAGPVG
  • DPNPDDPLVP
  • NSNGSICLDIL
  • YPFKPPK
  • PLVPEIA
  • YQGGVFFLT
  • HPNINSNG
  • QWSPALT
  • DREKYNR
  • SLLCDPNP
  • WQATIMGP

Post-translational modifications for UBE2D2 Gene

  • Ubiquitination at posLast=88
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2D2 Gene

Domains & Families for UBE2D2 Gene

Gene Families for UBE2D2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for UBE2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62837

UniProtKB/Swiss-Prot:

UB2D2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2D2: view

Function for UBE2D2 Gene

Molecular function for UBE2D2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Enzyme Numbers (IUBMB) for UBE2D2 Gene

Phenotypes From GWAS Catalog for UBE2D2 Gene

Gene Ontology (GO) - Molecular Function for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS,IDA 18359941
GO:0005515 protein binding IPI 14667819
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBE2D2: view
genes like me logo Genes that share phenotypes with UBE2D2: view

Animal Models for UBE2D2 Gene

MGI Knock Outs for UBE2D2:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2D2

CRISPR Products

miRNA for UBE2D2 Gene

miRTarBase miRNAs that target UBE2D2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBE2D2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2D2 Gene

Localization for UBE2D2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2D2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 15247280
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IDA 22797923
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with UBE2D2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2D2 Gene

Pathways & Interactions for UBE2D2 Gene

genes like me logo Genes that share pathways with UBE2D2: view

UniProtKB/Swiss-Prot P62837-UB2D2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 15247280
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006464 cellular protein modification process TAS 8090726
GO:0006511 ubiquitin-dependent protein catabolic process TAS 7724550
GO:0016567 protein ubiquitination IDA,TAS --
genes like me logo Genes that share ontologies with UBE2D2: view

No data available for SIGNOR curated interactions for UBE2D2 Gene

Drugs & Compounds for UBE2D2 Gene

(4) Drugs for UBE2D2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
(R,R)-2,3-Butanediol Experimental Pharma Target 0
ATP Nutra Agonist 0

(1) Additional Compounds for UBE2D2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2D2: view

Transcripts for UBE2D2 Gene

Unigene Clusters for UBE2D2 Gene

Ubiquitin-conjugating enzyme E2D 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBE2D2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D2 Gene

No ASD Table

Relevant External Links for UBE2D2 Gene

GeneLoc Exon Structure for
UBE2D2
ECgene alternative splicing isoforms for
UBE2D2

Expression for UBE2D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2D2 Gene

This gene is overexpressed in Rectum (15.6), Uterus (12.8), and Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBE2D2 Gene



NURSA nuclear receptor signaling pathways regulating expression of UBE2D2 Gene:

UBE2D2

SOURCE GeneReport for Unigene cluster for UBE2D2 Gene:

Hs.108332

Evidence on tissue expression from TISSUES for UBE2D2 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with UBE2D2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2D2 Gene

Orthologs for UBE2D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2D2 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia UBE2D2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2D2 33 34
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia UBE2D2 33 34
  • 98.64 (n)
dog
(Canis familiaris)
Mammalia UBE2D2 33 34
  • 97.96 (n)
mouse
(Mus musculus)
Mammalia Ube2d2a 33 16 34
  • 97.28 (n)
rat
(Rattus norvegicus)
Mammalia Ube2d2 33
  • 97.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2D2 34
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2D2 33
  • 95.98 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2D2 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2d3 33
  • 87.3 (n)
zebrafish
(Danio rerio)
Actinopterygii ube2d2l 34
  • 97 (a)
OneToMany
zgc:77149 33
  • 83.45 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta eff 35 33 34
  • 77.1 (n)
CG2574 35
  • 51 (a)
CG10862 35
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000145 33
  • 75.74 (n)
worm
(Caenorhabditis elegans)
Secernentea let-70 35 33 34
  • 76.42 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12563g 33
  • 70.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC4 33
  • 68.98 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER173C 33
  • 66.89 (n)
soybean
(Glycine max)
eudicotyledons Gma.6374 33
rice
(Oryza sativa)
Liliopsida Os09g0293400 33
  • 65.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10809 34
  • 85 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc4 33
  • 72.79 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02289 33
  • 66.44 (n)
Species where no ortholog for UBE2D2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2D2 Gene

ENSEMBL:
Gene Tree for UBE2D2 (if available)
TreeFam:
Gene Tree for UBE2D2 (if available)

Paralogs for UBE2D2 Gene

Paralogs for UBE2D2 Gene

Pseudogenes.org Pseudogenes for UBE2D2 Gene

genes like me logo Genes that share paralogs with UBE2D2: view

Variants for UBE2D2 Gene

Sequence variations from dbSNP and Humsavar for UBE2D2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000002977 -- 139,612,990(+) GGTCC(A/C)GTTTT intron-variant
rs1000030439 -- 139,619,949(+) CGGGA(A/G)CTTTT intron-variant
rs1000048009 -- 139,593,329(+) CTAAT(A/G)TTTTA intron-variant
rs1000119430 -- 139,605,429(+) CTACT(A/G)AAAAT intron-variant
rs1000146935 -- 139,587,795(+) TTGCC(A/C)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2D2 Gene

Variant ID Type Subtype PubMed ID
nsv462460 CNV loss 19166990
nsv5028 CNV insertion 18451855
nsv519808 CNV loss 19592680
nsv599820 CNV loss 21841781
nsv830504 CNV gain 17160897
nsv830505 CNV loss 17160897
nsv980732 CNV duplication 23825009

Variation tolerance for UBE2D2 Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2D2 Gene

Disorders for UBE2D2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UBE2D2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smallpox
  • ordinary smallpox
retinitis pigmentosa 42
  • rp42
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UBE2D2

Genetic Association Database (GAD)
UBE2D2
Human Genome Epidemiology (HuGE) Navigator
UBE2D2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2D2
genes like me logo Genes that share disorders with UBE2D2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2D2 Gene

Publications for UBE2D2 Gene

  1. Identification of a family of closely related human ubiquitin conjugating enzymes. (PMID: 8530467) Jensen JP … Weissman AM (The Journal of biological chemistry 1995) 2 3 4 60
  2. Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity. (PMID: 26656854) Wright JD … Day CL (Nature structural & molecular biology 2016) 3 4 60
  3. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme. (PMID: 20525694) Ryan PE … Lipkowitz S (The Journal of biological chemistry 2010) 3 4 60

Products for UBE2D2 Gene

Sources for UBE2D2 Gene

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