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Aliases for UBE2D2 Gene

Aliases for UBE2D2 Gene

  • Ubiquitin Conjugating Enzyme E2 D2 2 3
  • Ubiquitin-Conjugating Enzyme E2D 2 (Homologous To Yeast UBC4/5) 2 3
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme D2 3 4
  • P53-Regulated Ubiquitin-Conjugating Enzyme 1 3 4
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 2 3 4
  • Ubiquitin Conjugating Enzyme E2D 2 3 5
  • E2 Ubiquitin-Conjugating Enzyme D2 3 4
  • Ubiquitin Carrier Protein D2 3 4
  • Ubiquitin-Protein Ligase D2 3 4
  • UBCH5B 3 4
  • PUBC1 3 4
  • UBCH4 3 4
  • UBC4 3 4
  • Ubiquitin-Conjugating Enzyme E2D 2 (UBC4/5 Homolog, Yeast) 2
  • Ubiquitin-Conjugating Enzyme E2(17)KB 2 4
  • Ubiquitin-Conjugating Enzyme E2D 2 2
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • EC 2.3.2.24 4
  • E2(17)KB2 3
  • UBC4/5 3
  • UBC5B 4

External Ids for UBE2D2 Gene

Previous GeneCards Identifiers for UBE2D2 Gene

  • GC05P138764
  • GC05P138923
  • GC05P138969
  • GC05P138920
  • GC05P134083

Summaries for UBE2D2 Gene

Entrez Gene Summary for UBE2D2 Gene

  • Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for UBE2D2 Gene

UBE2D2 (Ubiquitin Conjugating Enzyme E2 D2) is a Protein Coding gene. Diseases associated with UBE2D2 include tauopathy. Among its related pathways are Immune System and Cellular Senescence. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2D2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Gene Wiki entry for UBE2D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2D2 Gene

Genomics for UBE2D2 Gene

Regulatory Elements for UBE2D2 Gene

Promoters for UBE2D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2D2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UBE2D2 gene promoter:

Genomic Location for UBE2D2 Gene

Chromosome:
5
Start:
139,526,431 bp from pter
End:
139,628,434 bp from pter
Size:
102,004 bases
Orientation:
Plus strand

Genomic View for UBE2D2 Gene

Genes around UBE2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2D2 Gene

Proteins for UBE2D2 Gene

  • Protein details for UBE2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62837-UB2D2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D2
    Protein Accession:
    P62837
    Secondary Accessions:
    • D3DQC9
    • P51669
    • Q3MN78
    • Q96RP6

    Protein attributes for UBE2D2 Gene

    Size:
    147 amino acids
    Molecular mass:
    16735 Da
    Quaternary structure:
    • Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3.

    Three dimensional structures from OCA and Proteopedia for UBE2D2 Gene

    Alternative splice isoforms for UBE2D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2D2 Gene

Proteomics data for UBE2D2 Gene at MOPED

Post-translational modifications for UBE2D2 Gene

  • Ubiquitination at Lys 8
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2D2 Gene

Antibody Products

  • R&D Systems Antibodies for UBE2D2 (UbcH5b/UBE2D2)

Domains & Families for UBE2D2 Gene

Gene Families for UBE2D2 Gene

Protein Domains for UBE2D2 Gene

Suggested Antigen Peptide Sequences for UBE2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62837

UniProtKB/Swiss-Prot:

UB2D2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2D2: view

Function for UBE2D2 Gene

Molecular function for UBE2D2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Enzyme Numbers (IUBMB) for UBE2D2 Gene

Gene Ontology (GO) - Molecular Function for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBE2D2: view
genes like me logo Genes that share phenotypes with UBE2D2: view

Animal Models for UBE2D2 Gene

MGI Knock Outs for UBE2D2:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2D2

miRNA for UBE2D2 Gene

miRTarBase miRNAs that target UBE2D2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2D2 Gene

Localization for UBE2D2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2D2 Gene COMPARTMENTS Subcellular localization image for UBE2D2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 4
endosome 3
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with UBE2D2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2D2 Gene

Pathways & Interactions for UBE2D2 Gene

genes like me logo Genes that share pathways with UBE2D2: view

UniProtKB/Swiss-Prot P62837-UB2D2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 15247280
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006511 ubiquitin-dependent protein catabolic process TAS 7724550
GO:0034142 toll-like receptor 4 signaling pathway TAS --
genes like me logo Genes that share ontologies with UBE2D2: view

No data available for SIGNOR curated interactions for UBE2D2 Gene

Drugs & Compounds for UBE2D2 Gene

(4) Drugs for UBE2D2 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
(R,R)-2,3-Butanediol Experimental Pharma Target 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2D2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2D2: view

Transcripts for UBE2D2 Gene

Unigene Clusters for UBE2D2 Gene

Ubiquitin-conjugating enzyme E2D 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D2 Gene

No ASD Table

Relevant External Links for UBE2D2 Gene

GeneLoc Exon Structure for
UBE2D2
ECgene alternative splicing isoforms for
UBE2D2

Expression for UBE2D2 Gene

mRNA expression in normal human tissues for UBE2D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2D2 Gene

This gene is overexpressed in Rectum (15.6), Uterus (12.8), and Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBE2D2 Gene



SOURCE GeneReport for Unigene cluster for UBE2D2 Gene Hs.108332

genes like me logo Genes that share expression patterns with UBE2D2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for UBE2D2 Gene

Orthologs for UBE2D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2D2 35
  • 98.64 (n)
  • 100 (a)
UBE2D2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2D2 35
  • 97.96 (n)
  • 100 (a)
UBE2D2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2d2a 35
  • 97.28 (n)
  • 100 (a)
Ube2d2a 16
Ube2d2a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2D2 35
  • 99.77 (n)
  • 100 (a)
UBE2D2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2d2 35
  • 97.28 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2D2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2D2 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2D2 35
  • 95.98 (n)
  • 98.58 (a)
lizard
(Anolis carolinensis)
Reptilia UBE2D2 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2d3 35
  • 87.3 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
zgc:77149 35
  • 83.45 (n)
  • 98.64 (a)
ube2d2l 36
  • 97 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10862 37
  • 50 (a)
CG2574 37
  • 51 (a)
eff 37
  • 94 (a)
eff 35
  • 77.1 (n)
  • 94.56 (a)
eff 36
  • 95 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000145 35
  • 75.74 (n)
  • 94.56 (a)
worm
(Caenorhabditis elegans)
Secernentea let-70 37
  • 93 (a)
let-70 35
  • 76.42 (n)
  • 93.88 (a)
let-70 36
  • 94 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER173C 35
  • 66.89 (n)
  • 80.95 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12563g 35
  • 70.32 (n)
  • 80.82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC4 35
  • 68.98 (n)
  • 80.56 (a)
soybean
(Glycine max)
eudicotyledons Gma.6374 35
rice
(Oryza sativa)
Liliopsida Os09g0293400 35
  • 65.76 (n)
  • 77.55 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02289 35
  • 66.44 (n)
  • 82.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc4 35
  • 72.79 (n)
  • 84.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10809 36
  • 85 (a)
OneToMany
Species with no ortholog for UBE2D2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2D2 Gene

ENSEMBL:
Gene Tree for UBE2D2 (if available)
TreeFam:
Gene Tree for UBE2D2 (if available)

Paralogs for UBE2D2 Gene

Pseudogenes.org Pseudogenes for UBE2D2 Gene

genes like me logo Genes that share paralogs with UBE2D2: view

Variants for UBE2D2 Gene

Sequence variations from dbSNP and Humsavar for UBE2D2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10241 -- 139,627,424(-) TAGGG(A/T)GATGT utr-variant-3-prime
rs149308 -- 139,568,067(-) accgc(A/G)cccag intron-variant
rs187144 -- 139,586,225(+) CATAT(G/T)GGTTT intron-variant
rs166363 -- 139,564,356(-) gccaa(C/G)atggt intron-variant
rs187780 -- 139,568,142(-) ggtct(C/T)gaact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2D2 Gene

Variant ID Type Subtype PubMed ID
nsv519808 CNV Loss 19592680
nsv830504 CNV Gain 17160897
nsv882941 CNV Loss 21882294
nsv882942 CNV Loss 21882294
nsv5028 CNV Insertion 18451855
nsv882943 CNV Loss 21882294
nsv830505 CNV Loss 17160897
nsv462460 CNV Loss 19166990

Variation tolerance for UBE2D2 Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2D2 Gene

HapMap Linkage Disequilibrium report
UBE2D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2D2 Gene

Disorders for UBE2D2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBE2D2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tauopathy
  • tauopathies
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UBE2D2

Genetic Association Database (GAD)
UBE2D2
Human Genome Epidemiology (HuGE) Navigator
UBE2D2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2D2
genes like me logo Genes that share disorders with UBE2D2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2D2 Gene

Publications for UBE2D2 Gene

  1. Identification of a family of closely related human ubiquitin conjugating enzymes. (PMID: 8530467) Jensen J.P. … Weissman A.M. (J. Biol. Chem. 1995) 2 3 4 67
  2. E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity. (PMID: 18996392) Huang A. … Boelens R. (J. Mol. Biol. 2009) 3 23
  3. Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity. (PMID: 17206147) Sakata E. … Kato K. (Nat. Struct. Mol. Biol. 2007) 3 23
  4. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  5. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26

Products for UBE2D2 Gene

Sources for UBE2D2 Gene

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