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Aliases for UBE2D1 Gene

Aliases for UBE2D1 Gene

  • Ubiquitin-Conjugating Enzyme E2D 1 2 3
  • Stimulator Of Fe Transport 2 3 4
  • UBCH5A 3 4 6
  • UBCH5 3 4 6
  • Ubiquitin-Conjugating Enzyme E2D 1 (UBC4/5 Homolog, Yeast) 2 3
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 1 3 4
  • Ubiquitin-Conjugating Enzyme E2(17)KB 1 3 4
  • Ubiquitin Carrier Protein D1 3 4
  • Ubiquitin-Protein Ligase D1 3 4
  • UBC4/5 Homolog 3 4
  • EC 6.3.2.19 4 63
  • SFT 3 4
  • Ubiquitin-Conjugating Enzyme E2 D1 3
  • E2(17)KB1 3
  • UBC4/5 3
  • UBC5A 4

External Ids for UBE2D1 Gene

Previous Symbols for UBE2D1 Gene

  • SFT

Summaries for UBE2D1 Gene

Entrez Gene Summary for UBE2D1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for UBE2D1 Gene

UBE2D1 (Ubiquitin-Conjugating Enzyme E2D 1) is a Protein Coding gene. Diseases associated with UBE2D1 include hemochromatosis and hypoxia. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2D1 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.

Gene Wiki entry for UBE2D1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2D1 Gene

Genomics for UBE2D1 Gene

Genomic Location for UBE2D1 Gene

Start:
58,334,975 bp from pter
End:
58,370,753 bp from pter
Size:
35,779 bases
Orientation:
Plus strand

Genomic View for UBE2D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2D1 Gene

Regulatory Elements for UBE2D1 Gene

Proteins for UBE2D1 Gene

  • Protein details for UBE2D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51668-UB2D1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D1
    Protein Accession:
    P51668
    Secondary Accessions:
    • A6NLF6
    • A8K786

    Protein attributes for UBE2D1 Gene

    Size:
    147 amino acids
    Molecular mass:
    16602 Da
    Quaternary structure:
    • Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with RNF11.

    Three dimensional structures from OCA and Proteopedia for UBE2D1 Gene

neXtProt entry for UBE2D1 Gene

Proteomics data for UBE2D1 Gene at MOPED

Selected DME Specific Peptides for UBE2D1 Gene

Post-translational modifications for UBE2D1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys144

Other Protein References for UBE2D1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UBE2D1 Gene

Gene Families for UBE2D1 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2D1 Gene

Suggested Antigen Peptide Sequences for UBE2D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51668

UniProtKB/Swiss-Prot:

UB2D1_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • P51668
genes like me logo Genes that share domains with UBE2D1: view

Function for UBE2D1 Gene

Molecular function for UBE2D1 Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme E2D1,homologous to yeast UBC4/5,involved in the degradation of cellular proteins,mediating the E6-AP dependent ubiquitination of p53
UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.

Enzyme Numbers (IUBMB) for UBE2D1 Gene

Gene Ontology (GO) - Molecular Function for UBE2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18359941
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2D1: view
genes like me logo Genes that share phenotypes with UBE2D1: view

miRNA for UBE2D1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2D1 Gene

Localization for UBE2D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2D1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2D1 Gene COMPARTMENTS Subcellular localization image for UBE2D1 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for UBE2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 15247280
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 18845142
GO:0005829 cytosol TAS --
GO:0043234 protein complex IDA 22797923
genes like me logo Genes that share ontologies with UBE2D1: view

Pathways for UBE2D1 Gene

SuperPathways for UBE2D1 Gene

Superpath Contained pathways
1 Loss of Function of SMAD2/3 in Cancer
2 CDK-mediated phosphorylation and removal of Cdc6
3 Class I MHC mediated antigen processing and presentation
4 Inactivation of APC/C via direct inhibition of the APC/C complex
5 Cell Cycle, Mitotic
.62
genes like me logo Genes that share pathways with UBE2D1: view

UniProtKB/Swiss-Prot P51668-UB2D1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0000209 protein polyubiquitination IDA 15247280
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with UBE2D1: view

Compounds for UBE2D1 Gene

(5) HMDB Compounds for UBE2D1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Iron
  • Armco iron
7439-89-6
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Novoseek inferred chemical compound relationships for UBE2D1 Gene

Compound -log(P) Hits PubMed IDs
iron 5.22 10
genes like me logo Genes that share compounds with UBE2D1: view

Transcripts for UBE2D1 Gene

Unigene Clusters for UBE2D1 Gene

Ubiquitin-conjugating enzyme E2D 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for UBE2D1 Gene

GeneLoc Exon Structure for
UBE2D1
ECgene alternative splicing isoforms for
UBE2D1

Expression for UBE2D1 Gene

mRNA expression in normal human tissues for UBE2D1 Gene

mRNA differential expression in normal tissues according to GTEx for UBE2D1 Gene

This gene is overexpressed in Whole Blood (7.6) and Muscle - Skeletal (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UBE2D1 Gene

SOURCE GeneReport for Unigene cluster for UBE2D1 Gene Hs.129683

mRNA Expression by UniProt/SwissProt for UBE2D1 Gene

P51668-UB2D1_HUMAN
Tissue specificity: Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis.
genes like me logo Genes that share expressions with UBE2D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UBE2D1 Gene

Orthologs for UBE2D1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2D1 35
  • 100 (n)
  • 100 (a)
UBE2D1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2D1 35
  • 96.15 (n)
  • 100 (a)
UBE2D1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2D1 35
  • 97.28 (n)
  • 100 (a)
UBE2D1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2d1 35
  • 89.34 (n)
  • 100 (a)
Ube2d1 16
Ube2d1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2D1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2D1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2d1 35
  • 87.76 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves UBE2D1 35
  • 89.8 (n)
  • 100 (a)
UBE2D1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2D1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6470 35
ube2d1 35
  • 85.26 (n)
  • 95.24 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2d1b 35
  • 81.63 (n)
  • 94.56 (a)
ube2d1b 36
  • 95 (a)
OneToOne
wufc16h06 35
fruit fly
(Drosophila melanogaster)
Insecta CG10862 37
  • 52 (a)
eff 37
  • 89 (a)
CG2574 37
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea F52C6.12 36
  • 68 (a)
ManyToMany
let-70 37
  • 89 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC29 35
  • 66.21 (n)
  • 74.15 (a)
rice
(Oryza sativa)
Liliopsida Os01g0658400 35
  • 68.25 (n)
  • 77.55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3943 35
Species with no ortholog for UBE2D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2D1 Gene

ENSEMBL:
Gene Tree for UBE2D1 (if available)
TreeFam:
Gene Tree for UBE2D1 (if available)

Paralogs for UBE2D1 Gene

Paralogs for UBE2D1 Gene

genes like me logo Genes that share paralogs with UBE2D1: view

Variants for UBE2D1 Gene

Sequence variations from dbSNP and Humsavar for UBE2D1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1905455 -- 58,355,463(-) TGCTT(A/C)CCACA intron-variant
rs1905456 -- 58,335,383(-) GTCCG(A/G)TGCCC intron-variant
rs1963927 -- 58,347,075(+) ATTAA(G/T)ATTGT intron-variant
rs2306605 -- 58,363,234(-) GCCGT(A/C)ATCAG intron-variant
rs3802699 -- 58,368,604(+) TGATA(C/T)ATGTG intron-variant

Relevant External Links for UBE2D1 Gene

HapMap Linkage Disequilibrium report
UBE2D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UBE2D1 Gene

Disorders for UBE2D1 Gene

(2) MalaCards Diseases for UBE2D1 Gene

Search for UBE2D1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UBE2D1 Gene

(2) Novoseek inferred disease relationships for UBE2D1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 0 1
tumors 0 1

Relevant External Links for UBE2D1

Genetic Association Database (GAD)
UBE2D1
Human Genome Epidemiology (HuGE) Navigator
UBE2D1
genes like me logo Genes that share disorders with UBE2D1: view

No data available for UniProtKB/Swiss-Prot for UBE2D1 Gene

Publications for UBE2D1 Gene

  1. UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up- regulated in hereditary hemochromatosis. (PMID: 12480712) Gehrke S.G. … Stremmel W. (Blood 2003) 3 4 23
  2. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. (PMID: 18042044) Windheim M. … Cohen P. (Biochem. J. 2008) 3 4 23
  3. Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes. (PMID: 18485199) Xu Z. … Misra S. (BMC Struct. Biol. 2008) 3 23
  4. Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. (PMID: 16403807) Morris J.R. … Solomon E. (Hum. Mol. Genet. 2006) 3 23
  5. The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. (PMID: 19240029) Uchiki T. … Goldberg A.L. (J. Biol. Chem. 2009) 3 23

Products for UBE2D1 Gene

Sources for UBE2D1 Gene

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