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Aliases for UBE2B Gene

Aliases for UBE2B Gene

  • Ubiquitin-Conjugating Enzyme E2B 2 3
  • RAD6B 3 4 6
  • Ubiquitin-Conjugating Enzyme E2B (RAD6 Homolog) 2 3
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 3 4
  • Ubiquitin Carrier Protein B 3 4
  • Ubiquitin-Protein Ligase B 3 4
  • RAD6 Homolog B 3 4
  • EC 6.3.2.19 4 64
  • HHR6B 3 4
  • HR6B 3 4
  • Ubiquitin-Conjugating Enzyme E2 B 3
  • E2 Protein 3
  • E2-17kDa 3
  • UBC2 3

External Ids for UBE2B Gene

Summaries for UBE2B Gene

Entrez Gene Summary for UBE2B Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2B Gene

UBE2B (Ubiquitin-Conjugating Enzyme E2B) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2A.

UniProtKB/Swiss-Prot for UBE2B Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at Lys-120 to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes Lys-11-, as well as Lys-48- and Lys-63-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on Lys-164. May be involved in neurite outgrowth.

Gene Wiki entry for UBE2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2B Gene

Genomics for UBE2B Gene

Genomic Location for UBE2B Gene

Start:
134,371,179 bp from pter
End:
134,392,108 bp from pter
Size:
20,930 bases
Orientation:
Plus strand

Genomic View for UBE2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2B Gene

Regulatory Elements for UBE2B Gene

Proteins for UBE2B Gene

  • Protein details for UBE2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63146-UBE2B_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 B
    Protein Accession:
    P63146
    Secondary Accessions:
    • B2R503
    • D3DQA2
    • P23567
    • Q4PJ15
    • Q9D0J6

    Protein attributes for UBE2B Gene

    Size:
    152 amino acids
    Molecular mass:
    17312 Da
    Quaternary structure:
    • Interacts with RAD18, UBR2 and WAC.

    Three dimensional structures from OCA and Proteopedia for UBE2B Gene

neXtProt entry for UBE2B Gene

Proteomics data for UBE2B Gene at MOPED

Post-translational modifications for UBE2B Gene

No Post-translational modifications

Other Protein References for UBE2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UBE2B Gene

Gene Families for UBE2B Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2B Gene

UniProtKB/Swiss-Prot:

UBE2B_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • P63146
genes like me logo Genes that share domains with UBE2B: view

Function for UBE2B Gene

Molecular function for UBE2B Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme E2B,involved in post replication repair,containing a CGG repeat in 5utr
UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at Lys-120 to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes Lys-11-, as well as Lys-48- and Lys-63-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on Lys-164. May be involved in neurite outgrowth.

Enzyme Numbers (IUBMB) for UBE2B Gene

Gene Ontology (GO) - Molecular Function for UBE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 18339854
GO:0005515 protein binding IPI 12776193
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2B: view
genes like me logo Genes that share phenotypes with UBE2B: view

Animal Models for UBE2B Gene

MGI Knock Outs for UBE2B:

miRNA for UBE2B Gene

miRTarBase miRNAs that target UBE2B

No data available for Transcription Factor Targeting and HOMER Transcription for UBE2B Gene

Localization for UBE2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2B Gene

Cell membrane. Nucleus. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2B Gene COMPARTMENTS Subcellular localization image for UBE2B gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISS --
GO:0000790 nuclear chromatin IBA --
GO:0001741 XY body IEA --
GO:0005634 nucleus IDA 18339854
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with UBE2B: view

Pathways for UBE2B Gene

genes like me logo Genes that share pathways with UBE2B: view

Pathways by source for UBE2B Gene

UniProtKB/Swiss-Prot P63146-UBE2B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IMP 18339854
GO:0001666 response to hypoxia IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006281 DNA repair TAS --
GO:0006301 postreplication repair NAS 1559696
genes like me logo Genes that share ontologies with UBE2B: view

Compounds for UBE2B Gene

(4) HMDB Compounds for UBE2B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Novoseek inferred chemical compound relationships for UBE2B Gene

Compound -log(P) Hits PubMed IDs
halothane 33.7 3
genes like me logo Genes that share compounds with UBE2B: view

Transcripts for UBE2B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -

Relevant External Links for UBE2B Gene

GeneLoc Exon Structure for
UBE2B
ECgene alternative splicing isoforms for
UBE2B

Expression for UBE2B Gene

mRNA expression in normal human tissues for UBE2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2B Gene

SOURCE GeneReport for Unigene cluster for UBE2B Gene Hs.612096

genes like me logo Genes that share expressions with UBE2B: view

Orthologs for UBE2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2B 36
  • 100 (n)
  • 100 (a)
UBE2B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2B 36
  • 97.37 (n)
  • 100 (a)
UBE2B 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2B 36
  • 98.46 (n)
  • 100 (a)
UBE2B 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2b 36
  • 95.61 (n)
  • 100 (a)
Ube2b 16
Ube2b 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2B 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2B 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2b 36
  • 92.32 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves LOC100857678 36
  • 87.39 (n)
  • 95.27 (a)
UBE2B 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2B 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17466 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11129 36
ube2b 36
  • 85.75 (n)
  • 98.68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9365 36
zebrafish
(Danio rerio)
Actinopterygii ube2b 36
  • 76.54 (n)
  • 95.39 (a)
ube2b 37
  • 95 (a)
ManyToMany
wufc79h10 36
fruit fly
(Drosophila melanogaster)
Insecta UbcD6 37
  • 86 (a)
OneToMany
UbcD6 38
  • 86 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-1 37
  • 67 (a)
OneToMany
ubc-1 38
  • 84 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR156C 36
  • 57.24 (n)
  • 69.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 36
  • 63.6 (n)
  • 69.08 (a)
RAD6 37
  • 61 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05632g 36
  • 64.02 (n)
  • 70.2 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7559 36
barley
(Hordeum vulgare)
Liliopsida Hv.679 36
corn
(Zea mays)
Liliopsida Zm.3859 36
bread mold
(Neurospora crassa)
Ascomycetes NCU09731 36
  • 61.15 (n)
  • 68.21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhp6 36
  • 63.31 (n)
  • 71.81 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6140 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6239 37
  • 80 (a)
OneToMany
Species with no ortholog for UBE2B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2B Gene

ENSEMBL:
Gene Tree for UBE2B (if available)
TreeFam:
Gene Tree for UBE2B (if available)

Paralogs for UBE2B Gene

Paralogs for UBE2B Gene

genes like me logo Genes that share paralogs with UBE2B: view

Variants for UBE2B Gene

Sequence variations from dbSNP and Humsavar for UBE2B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs167870 -- 134,389,794(-) cgagg(C/T)gggca intron-variant
rs328037 -- 134,390,211(-) AAAGA(A/G)AAGAA intron-variant
rs328038 -- 134,387,103(-) gcatg(C/T)gtgta intron-variant
rs328044 -- 134,373,483(-) tattt(A/T)aaaaa intron-variant
rs1803727 -- 134,380,789(+) TTATC(C/T)AAAAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UBE2B Gene

Variant ID Type Subtype PubMed ID
esv8462 CNV Gain 19470904

Relevant External Links for UBE2B Gene

HapMap Linkage Disequilibrium report
UBE2B
Human Gene Mutation Database (HGMD)
UBE2B

Disorders for UBE2B Gene

(4) Novoseek inferred disease relationships for UBE2B Gene

Disease -log(P) Hits PubMed IDs
hepatitis halothane 81.3 3
mimicry 41.5 2
papilloma 33.7 3
tumors 0 1

Relevant External Links for UBE2B

Genetic Association Database (GAD)
UBE2B
Human Genome Epidemiology (HuGE) Navigator
UBE2B
genes like me logo Genes that share disorders with UBE2B: view

No data available for UniProtKB/Swiss-Prot for UBE2B Gene

Publications for UBE2B Gene

  1. Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. (PMID: 1559696) Koken M.H. … Hoeijmakers J.H. (Genomics 1992) 2 3 23
  2. The human RAD18 gene product interacts with HHR6A and HHR6B. (PMID: 10908344) Xin H. … Wang Z. (Nucleic Acids Res. 2000) 3 4 23
  3. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PMID: 10373550) Pati D. … Plon S.E. (Mol. Cell. Biol. 1999) 3 23
  4. RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. (PMID: 14981545) Lyakhovich A. … Shekhar M.P. (Oncogene 2004) 3 23
  5. Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. (PMID: 17050667) Shekhar M.P. … Gerard B. (Mol. Cancer Res. 2006) 3 23

Products for UBE2B Gene

  • Addgene plasmids for UBE2B

Sources for UBE2B Gene

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