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Aliases for TYK2 Gene

Aliases for TYK2 Gene

  • Tyrosine Kinase 2 2 3 5
  • EC 2.7.10.2 4 63
  • EC 2.7.10 63
  • IMD35 3
  • JTK1 3

External Ids for TYK2 Gene

Previous GeneCards Identifiers for TYK2 Gene

  • GC19M010582
  • GC19M010684
  • GC19M010306
  • GC19M010322
  • GC19M010461
  • GC19M010041

Summaries for TYK2 Gene

Entrez Gene Summary for TYK2 Gene

  • This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

GeneCards Summary for TYK2 Gene

TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Lymphomatoid Papulosis. Among its related pathways are Immune response IL-23 signaling pathway and Th17 Differentiation Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot for TYK2 Gene

  • Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Gene Wiki entry for TYK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYK2 Gene

Genomics for TYK2 Gene

Regulatory Elements for TYK2 Gene

Enhancers for TYK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TYK2 on UCSC Golden Path with GeneCards custom track

Promoters for TYK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TYK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TYK2 Gene

Chromosome:
19
Start:
10,350,528 bp from pter
End:
10,380,676 bp from pter
Size:
30,149 bases
Orientation:
Minus strand

Genomic View for TYK2 Gene

Genes around TYK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYK2 Gene

Proteins for TYK2 Gene

  • Protein details for TYK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29597-TYK2_HUMAN
    Recommended name:
    Non-receptor tyrosine-protein kinase TYK2
    Protein Accession:
    P29597
    Secondary Accessions:
    • Q6QB10
    • Q96CH0

    Protein attributes for TYK2 Gene

    Size:
    1187 amino acids
    Molecular mass:
    133650 Da
    Quaternary structure:
    • Interacts with JAKMIP1.

    Three dimensional structures from OCA and Proteopedia for TYK2 Gene

neXtProt entry for TYK2 Gene

Proteomics data for TYK2 Gene at MOPED

Selected DME Specific Peptides for TYK2 Gene

Post-translational modifications for TYK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TYK2 (Tyk2)
  • Abcam antibodies for TYK2

Domains & Families for TYK2 Gene

Gene Families for TYK2 Gene

Suggested Antigen Peptide Sequences for TYK2 Gene

Graphical View of Domain Structure for InterPro Entry

P29597

UniProtKB/Swiss-Prot:

TYK2_HUMAN :
  • The FERM domain mediates interaction with JAKMIP1.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Domain:
  • The FERM domain mediates interaction with JAKMIP1.
  • Contains 1 FERM domain.
  • Contains 2 protein kinase domains.
  • Contains 1 SH2 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
genes like me logo Genes that share domains with TYK2: view

Function for TYK2 Gene

Molecular function for TYK2 Gene

GENATLAS Biochemistry:
tyrosine kinase 2,non receptor type,class III,expressed in lymphoid cells (JAK family),involved in signal transduction of cytokine receptors,mediating the activation of STAT proteins
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Enzyme Numbers (IUBMB) for TYK2 Gene

Gene Ontology (GO) - Molecular Function for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with TYK2: view
genes like me logo Genes that share phenotypes with TYK2: view

Human Phenotype Ontology for TYK2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TYK2 Gene

MGI Knock Outs for TYK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TYK2

miRNA for TYK2 Gene

miRTarBase miRNAs that target TYK2

No data available for Transcription Factor Targets and HOMER Transcription for TYK2 Gene

Localization for TYK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TYK2 Gene COMPARTMENTS Subcellular localization image for TYK2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 4
cytoskeleton 3
mitochondrion 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10502458
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with TYK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TYK2 Gene

Pathways & Interactions for TYK2 Gene

genes like me logo Genes that share pathways with TYK2: view

SIGNOR curated interactions for TYK2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,TAS 2216457
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0030154 cell differentiation IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with TYK2: view

Drugs & Compounds for TYK2 Gene

(24) Drugs for TYK2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Experimental Pharma Target 0
3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile Experimental Pharma Target 0
AT9283 Investigational Pharma inhibitor Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
AZ 960 Pharma JAKs inhibitor 0

(10) Additional Compounds for TYK2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(8) ApexBio Compounds for TYK2 Gene

Compound Action Cas Number
AZ 960 JAKs inhibitor 905586-69-8
Bardoxolone methyl IKK inhibitor, potent antioxidant inflammation modulator 218600-53-4
GLPG0634 JAK1 inhibitor 1206161-97-8
NVP-BSK805 ATP-competitive JAK2 inhibitor 1092499-93-8
Pyridone 6 Pan-JAK inhibitor 457081-03-7
S-Ruxolitinib (INCB018424) JAK1/2 inhibitor,potent and selective 941685-37-6
WHI-P154 JAK3 inhibitor 211555-04-3
ZM 39923 HCl JAK3 inhibitor,potent and selective 1021868-92-7
genes like me logo Genes that share compounds with TYK2: view

Transcripts for TYK2 Gene

Unigene Clusters for TYK2 Gene

Tyrosine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TYK2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - -
SP2: - - -
SP3:
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13:
SP14:
SP15:
SP16:

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c · 21d · 21e ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ·
SP1: - - - - - - -
SP2:
SP3: - - - - - -
SP4:
SP5:
SP6: - -
SP7: -
SP8: - - - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14: -
SP15: -
SP16: - - -

ExUns: 30c · 30d · 30e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TYK2 Gene

GeneLoc Exon Structure for
TYK2
ECgene alternative splicing isoforms for
TYK2

Expression for TYK2 Gene

mRNA expression in normal human tissues for TYK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TYK2 Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for TYK2 Gene

This gene is overexpressed in Liver (42.9) and Spleen (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TYK2 Gene



SOURCE GeneReport for Unigene cluster for TYK2 Gene Hs.75516

mRNA Expression by UniProt/SwissProt for TYK2 Gene

P29597-TYK2_HUMAN
Tissue specificity: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
genes like me logo Genes that share expression patterns with TYK2: view

Protein tissue co-expression partners for TYK2 Gene

- Elite partner

Primer Products

Orthologs for TYK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TYK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TYK2 35
  • 85.28 (n)
  • 82.77 (a)
TYK2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TYK2 35
  • 84.45 (n)
  • 83.25 (a)
TYK2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tyk2 35
  • 80.95 (n)
  • 80.46 (a)
Tyk2 16
Tyk2 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TYK2 35
  • 99.06 (n)
  • 98.67 (a)
TYK2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tyk2 35
  • 80.72 (n)
  • 80.58 (a)
oppossum
(Monodelphis domestica)
Mammalia TYK2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves TYK2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TYK2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3707 35
tyk2 35
  • 63.79 (n)
  • 61.94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12998 35
zebrafish
(Danio rerio)
Actinopterygii tyk2 35
  • 58.14 (n)
  • 52.91 (a)
tyk2 36
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for TYK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYK2 Gene

ENSEMBL:
Gene Tree for TYK2 (if available)
TreeFam:
Gene Tree for TYK2 (if available)

Paralogs for TYK2 Gene

Paralogs for TYK2 Gene

genes like me logo Genes that share paralogs with TYK2: view

Variants for TYK2 Gene

Sequence variations from dbSNP and Humsavar for TYK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12720356 - 10,359,299(-) AGATA(G/T)CATGG reference, missense
rs12720343 - 10,378,396(-) TCTGC(A/C/G)CCACT upstream-variant-2KB, reference, missense
rs12720263 - 10,366,456(-) TCTCC(A/G)CCATG upstream-variant-2KB, reference, missense
rs2304256 - 10,364,976(+) GCCGA(A/C)TGCCT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs2304255 - 10,364,973(+) CTGGC(C/T)GAMTG upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TYK2 Gene

Variant ID Type Subtype PubMed ID
dgv3725n71 CNV Loss 21882294
dgv3726n71 CNV Loss 21882294
nsv470124 CNV Gain 18288195
nsv470125 CNV Loss 18288195
nsv518008 CNV Gain 19592680
nsv2415 CNV Insertion 18451855
esv24860 CNV Gain 19812545

Variation tolerance for TYK2 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TYK2 Gene

Human Gene Mutation Database (HGMD)
TYK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYK2 Gene

Disorders for TYK2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for TYK2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 35
  • tyrosine kinase 2 deficiency
lymphomatoid papulosis
  • lyp
primary cutaneous anaplastic large cell lymphoma
  • primary c-alcl
familial atypical mycobacteriosis, tyk2-related
susceptibility to infection due to tyk2 deficiency
  • autosomal recessive hyper-ige syndrome due to tyk2 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search TYK2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TYK2_HUMAN
  • Immunodeficiency 35 (IMD35) [MIM:611521]: A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. {ECO:0000269 PubMed:17088085}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TYK2

Genetic Association Database (GAD)
TYK2
Human Genome Epidemiology (HuGE) Navigator
TYK2
Tumor Gene Database (TGDB):
TYK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TYK2
genes like me logo Genes that share disorders with TYK2: view

No data available for Genatlas for TYK2 Gene

Publications for TYK2 Gene

  1. Identification and chromosomal mapping of new human tyrosine kinase genes. (PMID: 2156206) Krolewski J.J. … Dalla-Favera R. (Oncogene 1990) 2 3 4 67
  2. Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus. (PMID: 19758313) JAorvinen T.M. … Saarialho-Kere U. (Exp. Dermatol. 2010) 3 23
  3. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. (PMID: 19293837) Ban M. … Compston A. (Eur. J. Hum. Genet. 2009) 3 23
  4. Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. (PMID: 19440814) Kyogoku C. … Kumagai S. (Mod Rheumatol 2009) 3 23
  5. Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus. (PMID: 19567624) Hellquist A. … Kere J. (J. Rheumatol. 2009) 3 23

Products for TYK2 Gene

Sources for TYK2 Gene

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