Aliases for SFTPA2 Gene
External Ids for SFTPA2 Gene
Previous GeneCards Identifiers for SFTPA2 Gene
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]
GeneCards Summary for SFTPA2 Gene
SFTPA2 (Surfactant Protein A2) is a Protein Coding gene. Diseases associated with SFTPA2 include Pulmonary Fibrosis, Idiopathic and Pulmonary Fibrosis. Among its related pathways are Diseases of metabolism and Phagosome. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is COLEC11.
UniProtKB/Swiss-Prot for SFTPA2 Gene
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.