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Aliases for CCR2 Gene

Aliases for CCR2 Gene

  • Chemokine (C-C Motif) Receptor 2 2 3
  • CMKBR2 3 4 6
  • Monocyte Chemoattractant Protein 1 Receptor 3 4
  • CC-CKR-2 3 4
  • MCP-1-R 3 4
  • CCR-2 3 4
  • Monocyte Chemotactic Protein 1 Receptor 3
  • C-C Chemokine Receptor Type 2 3
  • MCP-1 Receptor 3
  • CD192 Antigen 4
  • C-C CKR-2 4
  • CCR2A 3
  • CCR2B 3
  • CD192 3
  • CKR2A 3
  • CKR2B 3
  • CKR2 3

External Ids for CCR2 Gene

Previous HGNC Symbols for CCR2 Gene

  • CMKBR2

Previous GeneCards Identifiers for CCR2 Gene

  • GC03P045636
  • GC03P046214
  • GC03P9F0042
  • GC03P9K0042

Summaries for CCR2 Gene

Entrez Gene Summary for CCR2 Gene

  • This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for CCR2 Gene

CCR2 (Chemokine (C-C Motif) Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include anterior uveitis and idiopathic anterior uveitis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include protein homodimerization activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR2 Gene

  • Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.

Tocris Summary for CCR2 Gene

  • Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorised into four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are classified according to the class of chemokines that they bind. The major function of chemokines is to regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by cytotoxic T-cells and macrophages.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR2 Gene

Genomics for CCR2 Gene

Regulatory Elements for CCR2 Gene

Genomic Location for CCR2 Gene

Start:
46,353,734 bp from pter
End:
46,360,928 bp from pter
Size:
7,195 bases
Orientation:
Plus strand

Genomic View for CCR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR2 Gene

Proteins for CCR2 Gene

  • Protein details for CCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41597-CCR2_HUMAN
    Recommended name:
    C-C chemokine receptor type 2
    Protein Accession:
    P41597
    Secondary Accessions:
    • A0AVQ3
    • B2RMT0
    • Q4VBL2

    Protein attributes for CCR2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41915 Da
    Quaternary structure:
    • Binds to HIV-1 Tat. Interacts with ARRB1.

    Three dimensional structures from OCA and Proteopedia for CCR2 Gene

    Alternative splice isoforms for CCR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR2 Gene

Proteomics data for CCR2 Gene at MOPED

Post-translational modifications for CCR2 Gene

  • N-glycosylated.
  • Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.
  • Glycosylation at Asn14
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCR2 (CCR2)

No data available for DME Specific Peptides for CCR2 Gene

Domains for CCR2 Gene

Gene Families for CCR2 Gene

HGNC:
  • CD :CD molecules
  • CCR :GPCR / Class A : Chemokine receptors : C-C motif
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P41597

UniProtKB/Swiss-Prot:

CCR2_HUMAN :
  • P41597
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR2: view

Function for CCR2 Gene

Molecular function for CCR2 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 2,with high affinity binding for monocyte chemoattractant protein 1 (MCP1),dimerizing in response to MCP1,G protein coupled receptor superfamily,involved in HIV-1 infection and AIDS symptom onset,with a dominant protective effect of the CCR2-64I mutation
UniProtKB/Swiss-Prot Function:
Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
UniProtKB/Swiss-Prot Induction:
Up-regulated by CREB3.

Gene Ontology (GO) - Molecular Function for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 10623817
GO:0016493 C-C chemokine receptor activity IEA --
GO:0031727 CCR2 chemokine receptor binding IDA 15995708
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with CCR2: view
genes like me logo Genes that share phenotypes with CCR2: view

Animal Models for CCR2 Gene

MGI Knock Outs for CCR2:

Animal Model Products

miRNA for CCR2 Gene

miRTarBase miRNAs that target CCR2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCR2 Gene

Localization for CCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR2 Gene COMPARTMENTS Subcellular localization image for CCR2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15995708
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8146186
GO:0016021 integral component of membrane TAS 8530354
genes like me logo Genes that share ontologies with CCR2: view

Pathways for CCR2 Gene

genes like me logo Genes that share pathways with CCR2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling ISS --
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0002827 positive regulation of T-helper 1 type immune response ISS --
GO:0002829 negative regulation of type 2 immune response ISS --
GO:0006874 cellular calcium ion homeostasis ISS --
genes like me logo Genes that share ontologies with CCR2: view

Compounds for CCR2 Gene

(5) Tocris Compounds for CCR2 Gene

Compound Action Cas Number
AMD 3100 octahydrochloride Highly selective CXCR4 antagonist [155148-31-5]
AMD 3465 hexahydrobromide Potent, selective CXCR4 antagonist [185991-07-5]
RS 504393 Highly selective CCR2 chemokine receptor antagonist [300816-15-3]
SB 225002 Potent and selective CXCR2 antagonist [182498-32-4]
SB 328437 Potent and selective CCR3 antagonist [247580-43-4]

(1) ApexBio Compounds for CCR2 Gene

Compound Action Cas Number
INCB3344 CCR2 chemokine receptor antagonist [1262238-11-8]

(1) HMDB Compounds for CCR2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(21) IUPHAR Ligand for CCR2 Gene

Ligand Type Action Affinity Pubmed IDs
CCL11 Antagonist Antagonist 10
CCL24 Agonist Full agonist 9.4
[125I]CCL2 Agonist Full agonist 9.4
[125I]CCL7 (human) Agonist Full agonist 9.2
CCL26 Agonist Full agonist 8.9
MC148R Antagonist Antagonist 8.8
RS-136270 Antagonist Antagonist 8.5
vMIP-II Antagonist Antagonist 8.1
CCL7 Agonist Full agonist 8.1
CCL16 Agonist Full agonist 8.1
CCL2 Agonist Full agonist 7.8
GSK Compound 34 Antagonist Antagonist 7.6
TAK-779 Antagonist Antagonist 7.5
HIV-Tat Agonist Full agonist 7.2
vCCL4 Agonist Full agonist 7.1
SB-282241 Antagonist Antagonist 7
RS-504393 Antagonist Antagonist 6.7
Teijin-lead_cmp_5 Antagonist Antagonist 6.5
RS-102895 Antagonist Antagonist 6.3
CCL13 Agonist Agonist
CCL8 Agonist Agonist
genes like me logo Genes that share compounds with CCR2: view

Transcripts for CCR2 Gene

mRNA/cDNA for CCR2 Gene

(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for CCR2 Gene

GeneLoc Exon Structure for
CCR2
ECgene alternative splicing isoforms for
CCR2

Expression for CCR2 Gene

mRNA expression in normal human tissues for CCR2 Gene

mRNA differential expression in normal tissues according to GTEx for CCR2 Gene

This gene is overexpressed in Whole Blood (25.7) and Spleen (7.2).

Protein differential expression in normal tissues for CCR2 Gene

This gene is overexpressed in Monocytes (35.2) and Peripheral blood mononuclear cells (28.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCR2 Gene

SOURCE GeneReport for Unigene cluster for CCR2 Gene Hs.511794

genes like me logo Genes that share expressions with CCR2: view

Expression partners for CCR2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CCR2 Gene

Orthologs for CCR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCR2 35
  • 84.54 (n)
  • 80 (a)
CCR2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR2 35
  • 80.59 (n)
  • 77.72 (a)
CCR2 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr2 35
  • 80.74 (n)
  • 79.72 (a)
Ccr2 16
Ccr2 36
  • 68 (a)
OneToMany
Ccr5 36
  • 67 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CCR2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCR5 35
  • 66.48 (n)
  • 62 (a)
CCR2 36
  • 53 (a)
ManyToMany
CCR5 36
  • 54 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100329767 35
  • 53.29 (n)
  • 42.07 (a)
Species with no ortholog for CCR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR2 Gene

ENSEMBL:
Gene Tree for CCR2 (if available)
TreeFam:
Gene Tree for CCR2 (if available)

Paralogs for CCR2 Gene

genes like me logo Genes that share paralogs with CCR2: view

Variants for CCR2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCR2 Gene

P41597-CCR2_HUMAN
Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423]

Sequence variations from dbSNP and Humsavar for CCR2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs743660 -- 46,360,527(+) ATCAA(A/G)TTGGC utr-variant-3-prime
rs762788 -- 46,361,073(+) CCCCA(C/T)GCCCT downstream-variant-500B
rs762789 -- 46,361,136(+) CAAGC(A/G)GAGCC downstream-variant-500B
rs762790 -- 46,361,197(+) GCGCC(C/G)TGGTG downstream-variant-500B
rs1042100 -- 46,360,132(+) GAGTT(A/G)CTATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCR2 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294

Relevant External Links for CCR2 Gene

HapMap Linkage Disequilibrium report
CCR2
Human Gene Mutation Database (HGMD)
CCR2

Disorders for CCR2 Gene

Relevant External Links for CCR2

Genetic Association Database (GAD)
CCR2
Human Genome Epidemiology (HuGE) Navigator
CCR2
genes like me logo Genes that share disorders with CCR2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CCR2 Gene

Publications for CCR2 Gene

  1. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. (PMID: 8146186) Charo I.F. … Coughlin S.R. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  2. cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. (PMID: 8048929) Yamagami S. … Endo N. (Biochem. Biophys. Res. Commun. 1994) 3 4
  3. Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking. (PMID: 8995400) Wong L.-M. … Charo I.F. (J. Biol. Chem. 1997) 3 4
  4. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. (PMID: 9252328) Smith M.W. … O'Brien S.J. (Science 1997) 3 4
  5. Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. (PMID: 9501202) Aragay A.M. … Mayor F. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4

Products for CCR2 Gene

Sources for CCR2 Gene

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