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Aliases for CCR2 Gene

Aliases for CCR2 Gene

  • C-C Motif Chemokine Receptor 2 2 3 5
  • Monocyte Chemoattractant Protein 1 Receptor 3 4
  • Chemokine (C-C Motif) Receptor 2 2 3
  • CC-CKR-2 3 4
  • MCP-1-R 3 4
  • CMKBR2 3 4
  • CCR-2 3 4
  • Monocyte Chemotactic Protein 1 Receptor 3
  • C-C Chemokine Receptor Type 2 3
  • MCP-1 Receptor 3
  • CD192 Antigen 4
  • C-C CKR-2 4
  • CCR2A 3
  • CCR2B 3
  • CD192 3
  • CKR2A 3
  • CKR2B 3
  • CKR2 3

External Ids for CCR2 Gene

Previous HGNC Symbols for CCR2 Gene

  • CMKBR2

Previous GeneCards Identifiers for CCR2 Gene

  • GC03P045636
  • GC03P046214
  • GC03P9F0042
  • GC03P9K0042

Summaries for CCR2 Gene

Entrez Gene Summary for CCR2 Gene

  • The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]

GeneCards Summary for CCR2 Gene

CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Idiopathic Anterior Uveitis and Cd3zeta Deficiency. Among its related pathways are Cytokine Signaling in Immune system and Defensins. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot for CCR2 Gene

  • Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable).

  • (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Tocris Summary for CCR2 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Additional gene information for CCR2 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR2 Gene

Genomics for CCR2 Gene

GeneHancer (GH) Regulatory Elements for CCR2 Gene

Promoters and enhancers for CCR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I046353 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 558.2 +0.3 270 1.3 CEBPG CCR2 CCR1 CCR5
GH03I046297 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.2 -54.0 -54045 4.5 PKNOX1 EBF1 BATF IRF4 RELA ZFHX2 ZNF316 POLR2A VEZF1 ATF7 CCR1 CCR2 CCR5 CCRL2 TDGF1 LRRC2 FYCO1 GC03M046310
GH03I046404 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +52.9 52864 4.8 HDGF PKNOX1 SMAD1 ARNT IRF4 POLR2B ZNF766 CBX5 FOS ZNF592 CCRL2 LOC102724297 CCR1 CCR2 RTP3 CCR5 LIMD1 LRRC2 TDGF1 PRSS45
GH03I046392 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.8 +41.0 41039 5.3 PKNOX1 ATF1 ARNT GTF3C2 ZNF143 ATF7 RUNX3 REST ATF4 SMARCA4 CCRL2 CCR5 CCR1 CCR2 LOC102724297 LRRC2 TDGF1 GC03P046375
GH03I046320 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 19.6 -32.2 -32232 1.6 TRIM22 CHD4 BMI1 DPF2 ATF2 HDAC2 IKZF1 BCLAF1 RUNX3 IKZF2 CCR1 CCR2 CCRL2 CCR5 UQCRC2P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCR2 gene promoter:

Genomic Locations for CCR2 Gene

Genomic Locations for CCR2 Gene
chr3:46,353,734-46,360,940
(GRCh38/hg38)
Size:
7,207 bases
Orientation:
Plus strand
chr3:46,395,225-46,402,419
(GRCh37/hg19)

Genomic View for CCR2 Gene

Genes around CCR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR2 Gene

Proteins for CCR2 Gene

  • Protein details for CCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41597-CCR2_HUMAN
    Recommended name:
    C-C chemokine receptor type 2
    Protein Accession:
    P41597
    Secondary Accessions:
    • A0AVQ3
    • B2RMT0
    • O95950
    • Q4VBL2

    Protein attributes for CCR2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41915 Da
    Quaternary structure:
    • Interacts with ARRB1 (PubMed:9501202). Interacts (via extracellular N-terminal region) with beta-defensin DEFB106A/DEFB106B; this interaction may preferentially require specific tyrosine sulfation on CCR2 (PubMed:23938203). Interacts with NUP85; the interaction is required for CCR2 clusters formation on the cell membrane and CCR2 signaling (PubMed:15995708, PubMed:25283965).
    • (Microbial infection) Binds to HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for CCR2 Gene

    Alternative splice isoforms for CCR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR2 Gene

Post-translational modifications for CCR2 Gene

  • N-glycosylated.
  • Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.
  • Glycosylation at Asn14

Other Protein References for CCR2 Gene

No data available for DME Specific Peptides for CCR2 Gene

Domains & Families for CCR2 Gene

Gene Families for CCR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • G-protein coupled receptors
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P41597

UniProtKB/Swiss-Prot:

CCR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR2: view

Function for CCR2 Gene

Molecular function for CCR2 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 2,with high affinity binding for monocyte chemoattractant protein 1 (MCP1),dimerizing in response to MCP1,G protein coupled receptor superfamily,involved in HIV-1 infection and AIDS symptom onset,with a dominant protective effect of the CCR2-64I mutation
UniProtKB/Swiss-Prot Function:
Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.
UniProtKB/Swiss-Prot Induction:
Up-regulated by CREB3 (PubMed:18587271). In NK cells, induced by IL2 (PubMed:9058802).

Phenotypes From GWAS Catalog for CCR2 Gene

Gene Ontology (GO) - Molecular Function for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 10623817
GO:0005515 protein binding IPI 23938203
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR2: view
genes like me logo Genes that share phenotypes with CCR2: view

Animal Models for CCR2 Gene

MGI Knock Outs for CCR2:

Animal Model Products

Clone Products

  • Addgene plasmids for CCR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCR2 Gene

Localization for CCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR2 Gene

Cell membrane; Multi-pass membrane protein. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. {ECO:0000269 PubMed:15995708}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR2 gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 2
cytoskeleton 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15995708
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8146186
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CCR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCR2 Gene

Pathways & Interactions for CCR2 Gene

genes like me logo Genes that share pathways with CCR2: view

Gene Ontology (GO) - Biological Process for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling ISS --
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0002548 monocyte chemotaxis IEA --
GO:0002827 positive regulation of T-helper 1 type immune response IEA,ISS --
GO:0002829 negative regulation of type 2 immune response ISS,IEA --
genes like me logo Genes that share ontologies with CCR2: view

No data available for SIGNOR curated interactions for CCR2 Gene

Drugs & Compounds for CCR2 Gene

(38) Drugs for CCR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
INCB3284 Investigational Pharma Target, antagonist 0
CCX915 Investigational Pharma Target 0
Plozalizumab Investigational Pharma Target 0
MK-0812 Investigational Pharma antagonist of chemokine receptor CCR-2 0

(2) Additional Compounds for CCR2 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL2
Full agonist, Agonist
vMIP-II
Antagonist

(5) Tocris Compounds for CCR2 Gene

Compound Action Cas Number
DAPTA Chemokine receptor 5 (CCR5) antagonist 106362-34-9
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3
ZK 756326 Selective, non-peptide CCR8 agonist 874911-96-3

(8) ApexBio Compounds for CCR2 Gene

Compound Action Cas Number
BMS CCR2 22 445479-97-0
INCB 3284 dimesylate HCCR2 antagonist 887401-93-6
INCB3344 CCR2 chemokine receptor antagonist 1262238-11-8
INCB8761(PF-4136309) 1341224-83-6
MK-0812 antagonist of chemokine receptor CCR-2 624733-88-6
RS 102895 hydrochloride 1173022-16-6
RS 504393 CCR2 chemokine receptor antagonist 300816-15-3
Teijin compound 1 1313730-14-1
genes like me logo Genes that share compounds with CCR2: view

Drug Products

Transcripts for CCR2 Gene

mRNA/cDNA for CCR2 Gene

(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

  • Addgene plasmids for CCR2

Alternative Splicing Database (ASD) splice patterns (SP) for CCR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for CCR2 Gene

GeneLoc Exon Structure for
CCR2
ECgene alternative splicing isoforms for
CCR2

Expression for CCR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR2 Gene

This gene is overexpressed in Whole Blood (x25.7) and Spleen (x7.2).

Protein differential expression in normal tissues from HIPED for CCR2 Gene

This gene is overexpressed in Monocytes (35.2) and Peripheral blood mononuclear cells (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR2 Gene



Protein tissue co-expression partners for CCR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCR2 Gene:

CCR2

SOURCE GeneReport for Unigene cluster for CCR2 Gene:

Hs.511794

mRNA Expression by UniProt/SwissProt for CCR2 Gene:

P41597-CCR2_HUMAN
Tissue specificity: Expressed by monocytes and IL2-activated NK cells.

Evidence on tissue expression from TISSUES for CCR2 Gene

  • Blood(3.4)
  • Spleen(3.1)
  • Lymph node(3)
  • Bone marrow(2.6)
  • Nervous system(2.5)
  • Lung(2.4)
  • Skin(2.4)
  • Intestine(2.3)
  • Heart(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CCR2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR2 Gene

Orthologs for CCR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR2 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCR2 33 34
  • 84.54 (n)
mouse
(Mus musculus)
Mammalia Ccr2 33 16 34
  • 80.74 (n)
Ccr5 34
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCR2 33 34
  • 80.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCR5 33 34
  • 66.48 (n)
CCR2 34
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 57 (a)
ManyToMany
-- 34
  • 54 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100329767 33
  • 53.29 (n)
Species where no ortholog for CCR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR2 Gene

ENSEMBL:
Gene Tree for CCR2 (if available)
TreeFam:
Gene Tree for CCR2 (if available)

Paralogs for CCR2 Gene

Variants for CCR2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCR2 Gene

CCR2_HUMAN-P41597
Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].

Sequence variations from dbSNP and Humsavar for CCR2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1799864 protective, Human immunodeficiency virus type 1, susceptibility to 46,357,717(+) G/A coding_sequence_variant, missense_variant
rs1000130725 -- 46,359,261(+) T/C 3_prime_UTR_variant, intron_variant
rs1000199976 -- 46,354,122(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000908711 -- 46,357,393(+) T/C intron_variant
rs1001267279 -- 46,355,467(+) G/C intron_variant

Variation tolerance for CCR2 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCR2 Gene

Human Gene Mutation Database (HGMD)
CCR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR2

No data available for Structural Variations from Database of Genomic Variants (DGV) for CCR2 Gene

Disorders for CCR2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CCR2 Gene - From: HGMD, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
idiopathic anterior uveitis
  • anterior uveitis idiopathic
cd3zeta deficiency
purulent labyrinthitis
  • acute suppurative labyrinthitis
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
cytomegalovirus retinitis
  • cmv retinitis
- elite association - COSMIC cancer census association via MalaCards
Search CCR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR2 Gene

Publications for CCR2 Gene

  1. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. (PMID: 8146186) Charo IF … Coughlin SR (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 58
  2. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. (PMID: 27926736) Zheng Y … Handel TM (Nature 2016) 3 4 58
  3. Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT. (PMID: 25283965) Esaki K … Terasawa H (The FEBS journal 2014) 3 4 58
  4. Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1). (PMID: 23408426) Tan JH … Stone MJ (The Journal of biological chemistry 2013) 3 4 58
  5. Structural basis for the interaction of human β-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles. (PMID: 23938203) De Paula VS … Valente AP (Journal of molecular biology 2013) 3 4 58

Products for CCR2 Gene

  • Addgene plasmids for CCR2

Sources for CCR2 Gene

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