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Aliases for CCR2 Gene

Aliases for CCR2 Gene

  • C-C Motif Chemokine Receptor 2 2 3
  • Chemokine (C-C Motif) Receptor 2 2 3 5
  • Monocyte Chemoattractant Protein 1 Receptor 3 4
  • CC-CKR-2 3 4
  • MCP-1-R 3 4
  • CMKBR2 3 4
  • CCR-2 3 4
  • Monocyte Chemotactic Protein 1 Receptor 3
  • MCP-1 Receptor 3
  • CD192 Antigen 4
  • C-C CKR-2 4
  • CCR2A 3
  • CCR2B 3
  • CD192 3
  • CKR2A 3
  • CKR2B 3
  • CKR2 3

External Ids for CCR2 Gene

Previous HGNC Symbols for CCR2 Gene

  • CMKBR2

Previous GeneCards Identifiers for CCR2 Gene

  • GC03P045636
  • GC03P046214
  • GC03P9F0042
  • GC03P9K0042

Summaries for CCR2 Gene

Entrez Gene Summary for CCR2 Gene

  • This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for CCR2 Gene

CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Idiopathic Anterior Uveitis and Cd3zeta Deficiency. Among its related pathways are Peptide ligand-binding receptors and ERK Signaling. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CCR2 Gene

  • Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.

Tocris Summary for CCR2 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR2 Gene

Genomics for CCR2 Gene

Regulatory Elements for CCR2 Gene

Enhancers for CCR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCR2 on UCSC Golden Path with GeneCards custom track

Promoters for CCR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCR2 Gene

Chromosome:
3
Start:
46,353,734 bp from pter
End:
46,360,940 bp from pter
Size:
7,207 bases
Orientation:
Plus strand

Genomic View for CCR2 Gene

Genes around CCR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR2 Gene

Proteins for CCR2 Gene

  • Protein details for CCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41597-CCR2_HUMAN
    Recommended name:
    C-C chemokine receptor type 2
    Protein Accession:
    P41597
    Secondary Accessions:
    • A0AVQ3
    • B2RMT0
    • Q4VBL2

    Protein attributes for CCR2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41915 Da
    Quaternary structure:
    • Binds to HIV-1 Tat. Interacts with ARRB1.

    Three dimensional structures from OCA and Proteopedia for CCR2 Gene

    Alternative splice isoforms for CCR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR2 Gene

Proteomics data for CCR2 Gene at MOPED

Post-translational modifications for CCR2 Gene

  • N-glycosylated.
  • Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.
  • Glycosylation at Asn 14
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCR2 (CCR2)
  • Abcam antibodies for CCR2

No data available for DME Specific Peptides for CCR2 Gene

Domains & Families for CCR2 Gene

Gene Families for CCR2 Gene

Graphical View of Domain Structure for InterPro Entry

P41597

UniProtKB/Swiss-Prot:

CCR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR2: view

Function for CCR2 Gene

Molecular function for CCR2 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 2,with high affinity binding for monocyte chemoattractant protein 1 (MCP1),dimerizing in response to MCP1,G protein coupled receptor superfamily,involved in HIV-1 infection and AIDS symptom onset,with a dominant protective effect of the CCR2-64I mutation
UniProtKB/Swiss-Prot Function:
Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
UniProtKB/Swiss-Prot Induction:
Up-regulated by CREB3.
genes like me logo Genes that share phenotypes with CCR2: view

Animal Models for CCR2 Gene

MGI Knock Outs for CCR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCR2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCR2 Gene

Localization for CCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR2 Gene COMPARTMENTS Subcellular localization image for CCR2 gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 2
endosome 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,ISS --
GO:0030425 dendrite ISS --
GO:0043025 neuronal cell body ISS --
genes like me logo Genes that share ontologies with CCR2: view

Pathways & Interactions for CCR2 Gene

genes like me logo Genes that share pathways with CCR2: view

Gene Ontology (GO) - Biological Process for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0002827 positive regulation of T-helper 1 type immune response ISS --
GO:0002829 negative regulation of type 2 immune response ISS --
GO:0006935 chemotaxis TAS 10623817
genes like me logo Genes that share ontologies with CCR2: view

No data available for SIGNOR curated interactions for CCR2 Gene

Drugs & Compounds for CCR2 Gene

(30) Drugs for CCR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
INCB3284 Investigational Pharma antagonist, Target 0
MLN-1202 Investigational Pharma Target 0
CCX915 Investigational Pharma Target 0
RS-504393 Pharma Antagonist, antagonist, inhibitor Highly selective CCR2 chemokine receptor antagonist 0
[<sup>125</sup>I]CCL7 (human) Pharma Full agonist, Agonist 0

(5) Additional Compounds for CCR2 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL2
Full agonist, Agonist
vMIP-II
Antagonist
DAPTA
106362-34-9
J 113863
353791-85-2
RS 102895 hydrochloride
1173022-16-6

(5) Tocris Compounds for CCR2 Gene

Compound Action Cas Number
DAPTA Chemokine receptor 5 (CCR5) antagonist 106362-34-9
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3
ZK 756326 Selective, non-peptide CCR8 agonist 874911-96-3

(1) ApexBio Compounds for CCR2 Gene

Compound Action Cas Number
INCB3344 CCR2 chemokine receptor antagonist 1262238-11-8
genes like me logo Genes that share compounds with CCR2: view

Transcripts for CCR2 Gene

mRNA/cDNA for CCR2 Gene

(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CCR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for CCR2 Gene

GeneLoc Exon Structure for
CCR2
ECgene alternative splicing isoforms for
CCR2

Expression for CCR2 Gene

mRNA expression in normal human tissues for CCR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR2 Gene

This gene is overexpressed in Whole Blood (x25.7) and Spleen (x7.2).

Protein differential expression in normal tissues from HIPED for CCR2 Gene

This gene is overexpressed in Monocytes (35.2) and Peripheral blood mononuclear cells (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR2 Gene



SOURCE GeneReport for Unigene cluster for CCR2 Gene Hs.511794

genes like me logo Genes that share expression patterns with CCR2: view

Protein tissue co-expression partners for CCR2 Gene

- Elite partner

No data available for mRNA Expression by UniProt/SwissProt for CCR2 Gene

Orthologs for CCR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCR2 35
  • 84.54 (n)
  • 80 (a)
CCR2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR2 35
  • 80.59 (n)
  • 77.72 (a)
CCR2 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr2 35
  • 80.74 (n)
  • 79.72 (a)
Ccr2 16
Ccr2 36
  • 68 (a)
OneToMany
Ccr5 36
  • 67 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CCR2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCR5 35
  • 66.48 (n)
  • 62 (a)
CCR2 36
  • 53 (a)
ManyToMany
CCR5 36
  • 54 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100329767 35
  • 53.29 (n)
  • 42.07 (a)
Species with no ortholog for CCR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR2 Gene

ENSEMBL:
Gene Tree for CCR2 (if available)
TreeFam:
Gene Tree for CCR2 (if available)

Paralogs for CCR2 Gene

genes like me logo Genes that share paralogs with CCR2: view

Variants for CCR2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCR2 Gene

CCR2_HUMAN-P41597
Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].

Sequence variations from dbSNP and Humsavar for CCR2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1799864 - 46,357,717(+) TGGTC(A/G)TCCTC reference, missense
rs3918387 - 46,359,799(+) TCGTG(A/G)AAAAG downstream-variant-500B, reference, missense, utr-variant-3-prime
rs4987052 - 46,357,660(+) AACTC(C/G)TGCCT reference, missense
rs743660 -- 46,360,527(+) ATCAA(A/G)TTGGC utr-variant-3-prime
rs762788 -- 46,361,073(+) CCCCA(C/T)GCCCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CCR2 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294

Variation tolerance for CCR2 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR2 Gene

Human Gene Mutation Database (HGMD)
CCR2

Disorders for CCR2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CCR2 Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
idiopathic anterior uveitis
  • anterior uveitis idiopathic
cd3zeta deficiency
hiv-1
  • aids, slow progression to
acquired immunodeficiency syndrome
  • aids
cytomegalovirus retinitis
- elite association - COSMIC cancer census association via MalaCards
Search CCR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR2

Genetic Association Database (GAD)
CCR2
Human Genome Epidemiology (HuGE) Navigator
CCR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR2
genes like me logo Genes that share disorders with CCR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR2 Gene

Publications for CCR2 Gene

  1. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. (PMID: 8146186) Charo I.F. … Coughlin S.R. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 67
  2. Intermediate monocytes contribute to pathologic immune response in Leishmania braziliensis infections. (PMID: 25139016) Passos S. … Scott P. (J. Infect. Dis. 2015) 3
  3. Genetic variants of chemokine CCL2 and chemokine receptor CCR2 genes and risk of prostate cancer. (PMID: 25266801) Mandal R.K. … Mittal R.D. (Tumour Biol. 2015) 3
  4. The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion. (PMID: 25312961) He S. … Wong R.J. (Mol. Cancer Res. 2015) 3
  5. MCP-1 and CCR2 gene polymorphisms in Parkinson's disease in a Han Chinese cohort. (PMID: 25370917) Gao L. … Wang L. (Neurol. Sci. 2015) 3

Products for CCR2 Gene

Sources for CCR2 Gene

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