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Aliases for C5AR1 Gene

Aliases for C5AR1 Gene

  • Complement Component 5a Receptor 1 2 3
  • C5R1 3 4 6
  • C5AR 3 4 6
  • C5a-R 3 4
  • Complement Component 5 Receptor 1 (C5a Ligand) 2
  • C5a Anaphylatoxin Chemotactic Receptor 1 3
  • C5a Anaphylatoxin Chemotactic Receptor 4
  • Complement Component 5 Receptor 1 3
  • C5a Anaphylatoxin Receptor 3
  • CD88 Antigen 4
  • C5a Ligand 3
  • CD88 3
  • C5A 3

External Ids for C5AR1 Gene

Previous HGNC Symbols for C5AR1 Gene

  • C5R1

Previous GeneCards Identifiers for C5AR1 Gene

  • GC19P052505
  • GC19P047813
  • GC19P044237

Summaries for C5AR1 Gene

GeneCards Summary for C5AR1 Gene

C5AR1 (Complement Component 5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include hypersensitivity reaction type iii disease and leukostasis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include N-formyl peptide receptor activity and complement component C5a binding. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for C5AR1 Gene

  • Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Tocris Summary for C5AR1 Gene

  • The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis, triggering inflammation and immune clearance. There are three pathways that can activate the complement system; the classical complement pathway (in response to IgG- or IgM-antigen complexes), the alternative complement pathway (spontaneous activation) and the mannose-binding lectin pathway (in response to lectin residues on pathogen cell surface membranes). All three pathway generate variants of C3 convertase, which cleaves C3 into C3a and C3b. C3a and C3b activate a series of further cleavage events that activates the complement cascade. This leads to immune defence responses such as degranulation of mast cells, increasing vascular permeability and initiation of the membrane attack pathway. Deregulation of the complement system would be extremely damaging to the host, so it is tightly regulated by complement control proteins. These regulatory proteins are found in much higher concentrations that complement proteins themselves and prevent complement system activation in 'self' tissues. The complement system has been implicated in many autoimmune disorders, including systemic lupus erythematosus, multiple sclerosis and arthritis, and more recently has been suggested to have a pathophysiological role in Alzheimer's and other neurodegenerative disorders.

Gene Wiki entry for C5AR1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5AR1 Gene

Genomics for C5AR1 Gene

Regulatory Elements for C5AR1 Gene

Genomic Location for C5AR1 Gene

Start:
47,290,023 bp from pter
End:
47,322,070 bp from pter
Size:
32,048 bases
Orientation:
Plus strand

Genomic View for C5AR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C5AR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5AR1 Gene

Proteins for C5AR1 Gene

  • Protein details for C5AR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21730-C5AR1_HUMAN
    Recommended name:
    C5a anaphylatoxin chemotactic receptor 1
    Protein Accession:
    P21730
    Secondary Accessions:

    Protein attributes for C5AR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    39336 Da
    Quaternary structure:
    • Homodimer. May also form higher-order oligmers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600). Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response (PubMed:15153520, PubMed:15542591, PubMed:21706042).

neXtProt entry for C5AR1 Gene

Proteomics data for C5AR1 Gene at MOPED

Post-translational modifications for C5AR1 Gene

  • Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338.
  • Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042).
  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for C5AR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C5AR1 (Complement Component C5a R1)

No data available for DME Specific Peptides for C5AR1 Gene

Domains for C5AR1 Gene

Gene Families for C5AR1 Gene

HGNC:
  • CD :CD molecules
  • CNAR :GPCR / Class A : Complement component receptors
  • complement :Complement system
IUPHAR :

Suggested Antigen Peptide Sequences for C5AR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21730

UniProtKB/Swiss-Prot:

C5AR1_HUMAN :
  • P21730
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with C5AR1: view

Function for C5AR1 Gene

Molecular function for C5AR1 Gene

UniProtKB/Swiss-Prot Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Gene Ontology (GO) - Molecular Function for C5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001856 complement component C5a binding IEA --
GO:0004878 complement component C5a receptor activity IDA 22496247
GO:0004930 G-protein coupled receptor activity --
GO:0004944 C5a anaphylatoxin receptor activity IDA 22496247
genes like me logo Genes that share ontologies with C5AR1: view
genes like me logo Genes that share phenotypes with C5AR1: view

Animal Models for C5AR1 Gene

MGI Knock Outs for C5AR1:

Animal Model Products

CRISPR Products

miRNA for C5AR1 Gene

miRTarBase miRNAs that target C5AR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C5AR1

Clone Products

  • Addgene plasmids for C5AR1
  • R&D Systems cDNA Clones for C5AR1 (Complement Component C5a R1)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for C5AR1 Gene

Localization for C5AR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5AR1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269 PubMed:12464600}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C5AR1 Gene COMPARTMENTS Subcellular localization image for C5AR1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
extracellular 2
lysosome 2
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2007135
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with C5AR1: view

Pathways for C5AR1 Gene

genes like me logo Genes that share pathways with C5AR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antifungal Response in human,mouse,rat
    • Cell Surface Markers in human,mouse,rat
    • Chemokines & Receptors in human,mouse,rat
    • G Protein Coupled Receptors 384HT in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat

Gene Ontology (GO) - Biological Process for C5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 7649993
GO:0002430 complement receptor mediated signaling pathway --
GO:0006915 apoptotic process IEA --
GO:0006935 chemotaxis TAS 10352266
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with C5AR1: view

Compounds for C5AR1 Gene

(4) Tocris Compounds for C5AR1 Gene

Compound Action Cas Number
Compstatin C3-binding protein, inhibits complement activation [206645-99-0]
Compstatin control peptide Control peptide for Compstatin (Cat. No. 2585) [301544-78-5]
NDT 9513727 Potent, selective human C5a receptor antagonist [439571-48-9]
PMX 205 Potent C5a receptor peptide antagonist [514814-49-4]

(1) HMDB Compounds for C5AR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(17) IUPHAR Ligand for C5AR1 Gene

Ligand Type Action Affinity Pubmed IDs
CHIPS Antagonist Antagonist 9
C5a Agonist Full agonist 9
[125I]C5a (human) Agonist Full agonist 8.7
W54011 Antagonist Antagonist 8.7
AcPhe-Orn-Pro-D-Cha-Trp-Arg Antagonist Antagonist 7.9
PMX53 Antagonist Antagonist 7.7
N-methyl-Phe-Lys-Pro-D-Cha-Cha-D-Arg-CO2H Agonist Full agonist 7.6
PMX205 Antagonist Antagonist 7.51
NDT9520492 Antagonist Antagonist 7.5
N-methyl-Phe-Lys-Pro-D-Cha-Trp-D-Arg-CO2H Antagonist Antagonist 7.2
JPE1375 Antagonist Antagonist 7
C089 Antagonist Antagonist 6.7
YSFKPMPLaR Agonist Full agonist 6.7
C5a des-Arg Agonist Partial agonist 6.4
RPR121154 Antagonist Antagonist 6.1
L-156,602 Antagonist Antagonist 5.7
ribosomal protein S19 Agonist Full agonist

(70) Novoseek inferred chemical compound relationships for C5AR1 Gene

Compound -log(P) Hits PubMed IDs
anaphylatoxin 97.5 129
fmlp 83.7 93
fmlpl 82 5
leukotriene b4 72.6 40
n-formylmethionyl-leucylphenylalanine 70.4 15
genes like me logo Genes that share compounds with C5AR1: view

Transcripts for C5AR1 Gene

mRNA/cDNA for C5AR1 Gene

(4) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C5AR1 Gene

Complement component 5a receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C5AR1

Clone Products

  • Addgene plasmids for C5AR1
  • R&D Systems cDNA Clones for C5AR1 (Complement Component C5a R1)

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5AR1 Gene

No ASD Table

Relevant External Links for C5AR1 Gene

GeneLoc Exon Structure for
C5AR1
ECgene alternative splicing isoforms for
C5AR1

Expression for C5AR1 Gene

mRNA expression in normal human tissues for C5AR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C5AR1 Gene

This gene is overexpressed in Whole Blood (31.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C5AR1 Gene

SOURCE GeneReport for Unigene cluster for C5AR1 Gene Hs.2161

genes like me logo Genes that share expressions with C5AR1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for C5AR1 Gene

Orthologs for C5AR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5AR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5AR1 35
  • 98.86 (n)
  • 97.71 (a)
C5AR1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5AR1 35
  • 77.08 (n)
  • 71.92 (a)
C5AR1 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5AR1 35
  • 75.74 (n)
  • 69.63 (a)
C5AR1 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C5ar1 35
  • 73.37 (n)
  • 68.05 (a)
C5ar1 16
C5ar1 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C5AR1 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C5AR1 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C5ar1 35
  • 72.01 (n)
  • 69.44 (a)
chicken
(Gallus gallus)
Aves C5AR1 35
  • 53.95 (n)
  • 39.64 (a)
C5AR1 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C5AR1 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c5ar1 35
  • 51.35 (n)
  • 45.65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5490 35
zebrafish
(Danio rerio)
Actinopterygii C5AR1 36
  • 37 (a)
OneToOne
Species with no ortholog for C5AR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5AR1 Gene

ENSEMBL:
Gene Tree for C5AR1 (if available)
TreeFam:
Gene Tree for C5AR1 (if available)

Paralogs for C5AR1 Gene

Selected SIMAP similar genes for C5AR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C5AR1: view

Variants for C5AR1 Gene

Sequence variations from dbSNP and Humsavar for C5AR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_049377 -
VAR_049378 -

Structural Variations from Database of Genomic Variants (DGV) for C5AR1 Gene

Variant ID Type Subtype PubMed ID
nsv912200 CNV Loss 21882294

Relevant External Links for C5AR1 Gene

HapMap Linkage Disequilibrium report
C5AR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5AR1 Gene

Disorders for C5AR1 Gene

(52) Novoseek inferred disease relationships for C5AR1 Gene

Disease -log(P) Hits PubMed IDs
leukemia basophilic 56.6 4
inflammation 54.6 27
immune complex diseases 35.8 2
necrosis 31.5 21
shock septic 28 4

Relevant External Links for C5AR1

Genetic Association Database (GAD)
C5AR1
Human Genome Epidemiology (HuGE) Navigator
C5AR1
genes like me logo Genes that share disorders with C5AR1: view

No data available for UniProtKB/Swiss-Prot for C5AR1 Gene

Publications for C5AR1 Gene

  1. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PMID: 1612600) Bao L. … Gerard C. (Genomics 1992) 2 3 23
  2. Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. (PMID: 2007135) Boulay F. … Vignais P. (Biochemistry 1991) 3 4 23
  3. Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. (PMID: 7642584) Giannini E. … Boulay F. (J. Biol. Chem. 1995) 3 4 23
  4. Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene. (PMID: 8383526) Gerard N.P. … Gerard C. (Biochemistry 1993) 3 4 23
  5. The chemotactic receptor for human C5a anaphylatoxin. (PMID: 1847994) Gerard N.P. … Gerard C. (Nature 1991) 3 4 23

Products for C5AR1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antifungal Response in human,mouse,rat
    • Cell Surface Markers in human,mouse,rat
    • Chemokines & Receptors in human,mouse,rat
    • G Protein Coupled Receptors 384HT in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate C5AR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for C5AR1
    • Block miRNA regulation of C5AR1 using miScript Target Protectors
    • Addgene plasmids for C5AR1

    Sources for C5AR1 Gene

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