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Aliases for TTF1 Gene

Aliases for TTF1 Gene

  • Transcription Termination Factor 1 2 3 5
  • Transcription Termination Factor, RNA Polymerase I 2 3
  • TTF-1 3 4
  • TTF-I 3 4
  • RNA Polymerase I Termination Factor 4
  • Transcription Termination Factor I 4

External Ids for TTF1 Gene

Previous GeneCards Identifiers for TTF1 Gene

  • GC09M126276
  • GC09M126808
  • GC09M128604
  • GC09M130526
  • GC09M132280
  • GC09M134240
  • GC09M135250
  • GC09M104744

Summaries for TTF1 Gene

Entrez Gene Summary for TTF1 Gene

  • This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]

CIViC summary for TTF1 Gene

GeneCards Summary for TTF1 Gene

TTF1 (Transcription Termination Factor 1) is a Protein Coding gene. Diseases associated with TTF1 include Neuroendocrine Cell Hyperplasia Of Infancy and Pulmonary Surfactant Metabolism Dysfunction. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Diseases of metabolism. GO annotations related to this gene include chromatin binding. An important paralog of this gene is DMTF1.

UniProtKB/Swiss-Prot for TTF1 Gene

  • Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.

Gene Wiki entry for TTF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTF1 Gene

Genomics for TTF1 Gene

Regulatory Elements for TTF1 Gene

Enhancers for TTF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G133112 2.2 FANTOM5 Ensembl ENCODE dbSUPER 42.2 -722.1 -722102 33.8 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 RALGDS TTF1 TSC1 GTF3C4 LINC00094 GBGT1 REXO4 EEF1A1P5 SLC2A6 SURF6
GH09G133029 1.2 ENCODE 56.4 -623.8 -623836 2.5 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 TTF1 TSC1 SETX LINC00094 MED27 AK8 GTF3C4 SURF6 RALGDS GTF3C5
GH09G133105 1 dbSUPER 42.2 -701.5 -701507 5.0 ATF1 PKNOX1 ARNT ZNF493 ZFP64 FEZF1 TCF12 ZNF121 GLIS2 GATA2 TSC1 TTF1 GTF3C4 LINC00094 EEF1A1P5 SURF6 STKLD1 SETX LOC100130548 REXO4
GH09G132943 1.2 ENCODE 21.4 -537.7 -537664 2.5 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D TTF1 SETX MED27 TSC1 AK8 GFI1B
GH09G132019 1.2 ENCODE dbSUPER 21.4 +386.3 386270 2.0 FOXA2 SIN3A FEZF1 ZNF2 GLIS2 FOS DEK YY2 TSHZ1 REST MED27 TTF1 SETX PIR57956
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTF1 on UCSC Golden Path with GeneCards custom track

Promoters for TTF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242475 271 1201 PKNOX1 ARNT WRNIP1 ARID4B SIN3A ZNF2 ZNF143 ZNF263 MXD4 REST

Genomic Location for TTF1 Gene

Chromosome:
9
Start:
132,375,548 bp from pter
End:
132,406,871 bp from pter
Size:
31,324 bases
Orientation:
Minus strand

Genomic View for TTF1 Gene

Genes around TTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTF1 Gene

Proteins for TTF1 Gene

  • Protein details for TTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15361-TTF1_HUMAN
    Recommended name:
    Transcription termination factor 1
    Protein Accession:
    Q15361
    Secondary Accessions:
    • A1L160
    • Q4VXF3
    • Q58EY2
    • Q6P5T5

    Protein attributes for TTF1 Gene

    Size:
    905 amino acids
    Molecular mass:
    103051 Da
    Quaternary structure:
    • Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments. Interacts with BAZ2A/TIP5.
    SequenceCaution:
    • Sequence=AAH62692.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI04640.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI27670.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAI27671.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAI43049.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAI43050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAA58807.1; Type=Frameshift; Positions=875; Evidence={ECO:0000305}; Sequence=CAA58807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

neXtProt entry for TTF1 Gene

Post-translational modifications for TTF1 Gene

  • Ubiquitination at posLast=765765
  • Modification sites at PhosphoSitePlus

Other Protein References for TTF1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TTF1

No data available for DME Specific Peptides for TTF1 Gene

Domains & Families for TTF1 Gene

Gene Families for TTF1 Gene

Protein Domains for TTF1 Gene

Suggested Antigen Peptide Sequences for TTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15361

UniProtKB/Swiss-Prot:

TTF1_HUMAN :
  • The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.
Domain:
  • The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.
genes like me logo Genes that share domains with TTF1: view

Function for TTF1 Gene

Molecular function for TTF1 Gene

UniProtKB/Swiss-Prot Function:
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.

Gene Ontology (GO) - Molecular Function for TTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with TTF1: view
genes like me logo Genes that share phenotypes with TTF1: view

Animal Model Products

CRISPR Products

miRNA for TTF1 Gene

miRTarBase miRNAs that target TTF1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TTF1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTF1 Gene

Localization for TTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTF1 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTF1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for TTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7597036
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA,IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with TTF1: view

Pathways & Interactions for TTF1 Gene

genes like me logo Genes that share pathways with TTF1: view

SIGNOR curated interactions for TTF1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006353 DNA-templated transcription, termination NAS 7597036
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with TTF1: view

Transcripts for TTF1 Gene

Unigene Clusters for TTF1 Gene

Transcription termination factor, RNA polymerase I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TTF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTF1 Gene

No ASD Table

Relevant External Links for TTF1 Gene

GeneLoc Exon Structure for
TTF1
ECgene alternative splicing isoforms for
TTF1

Expression for TTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTF1 Gene

Protein differential expression in normal tissues from HIPED for TTF1 Gene

This gene is overexpressed in Lung (50.1), Blymphocyte (8.3), and Adipocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTF1 Gene



Protein tissue co-expression partners for TTF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TTF1 Gene:

TTF1

SOURCE GeneReport for Unigene cluster for TTF1 Gene:

Hs.54780

Evidence on tissue expression from TISSUES for TTF1 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with TTF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTF1 Gene

Orthologs for TTF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTF1 34 35
  • 98.54 (n)
dog
(Canis familiaris)
Mammalia TTF1 34 35
  • 77.82 (n)
cow
(Bos Taurus)
Mammalia TTF1 34 35
  • 77.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTF1 35
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttf1 35
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTF1 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTF1 35
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TTF1 (2 of 6) 35
  • 34 (a)
OneToMany
TTF1 (5 of 6) 35
  • 31 (a)
OneToMany
TTF1 (6 of 6) 35
  • 31 (a)
OneToMany
TTF1 (3 of 6) 35
  • 29 (a)
OneToMany
ttf1 35 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
OneToMany
Species where no ortholog for TTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTF1 Gene

ENSEMBL:
Gene Tree for TTF1 (if available)
TreeFam:
Gene Tree for TTF1 (if available)

Paralogs for TTF1 Gene

Paralogs for TTF1 Gene

genes like me logo Genes that share paralogs with TTF1: view

Variants for TTF1 Gene

Sequence variations from dbSNP and Humsavar for TTF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000453968 -- 132,392,796(+) ACTTT(A/G)AGAAT intron-variant
rs1000562475 -- 132,381,693(+) GACCA(C/T)GGCAT intron-variant
rs1000651619 -- 132,375,785(+) TCAAG(A/C)AATTC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000677138 -- 132,398,096(+) TATGG(C/G)TGGAA intron-variant
rs1000696939 -- 132,386,480(+) CTGTA(A/G)GATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTF1 Gene

Variant ID Type Subtype PubMed ID
dgv4531e59 CNV duplication 20981092
esv2678054 CNV deletion 23128226
esv2739127 CNV deletion 23290073
esv2739129 CNV deletion 23290073
esv2739130 CNV deletion 23290073
nsv1078091 CNV duplication 25765185
nsv1110583 CNV duplication 24896259
nsv1117528 CNV tandem duplication 24896259
nsv1139373 CNV deletion 24896259
nsv1141035 CNV deletion 24896259
nsv1141650 CNV duplication 24896259
nsv1148188 CNV insertion 26484159
nsv6741 CNV deletion 18451855

Variation tolerance for TTF1 Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTF1 Gene

Disorders for TTF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TTF1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroendocrine cell hyperplasia of infancy
  • nchi
pulmonary surfactant metabolism dysfunction
  • interstitial lung disease
- elite association - COSMIC cancer census association via MalaCards
Search TTF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTF1

Genetic Association Database (GAD)
TTF1
Human Genome Epidemiology (HuGE) Navigator
TTF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTF1
genes like me logo Genes that share disorders with TTF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTF1 Gene

Publications for TTF1 Gene

  1. Molecular evolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-1. (PMID: 7597036) Evers R. … Grummt I. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The mitotically phosphorylated form of the transcription termination factor TTF-1 is associated with the repressed rDNA transcription machinery. (PMID: 10504331) Sirri V. … Hernandez-Verdun D. (J. Cell. Sci. 1999) 3 22 64
  4. Immunophenotypic and prognostic analysis of PAX8 and TTF-1 expressions in neuroendocrine carcinomas of thymic origin: A comparative study with their pulmonary counterparts. (PMID: 27761900) Bi Y. … Meng Y. (J Surg Oncol 2016) 3 64
  5. Expression pattern of ISL-1, TTF-1 and PAX5 in olfactory neuroblastoma. (PMID: 27543867) Czapiewski P. … Biernat W. (Pol J Pathol 2016) 3 64

Products for TTF1 Gene

Sources for TTF1 Gene

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