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Aliases for DNAJC7 Gene

Aliases for DNAJC7 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 7 2 3
  • TTC2 3 4 6
  • TPR2 3 4 6
  • Tetratricopeptide Repeat Protein 2 3 4
  • TPR Repeat Protein 2 3 4
  • DnaJ Homolog Subfamily C Member 7 3
  • Tetratricopeptide Repeat Domain 2 3
  • DANJC7 6
  • DJ11 3
  • DJC7 3

External Ids for DNAJC7 Gene

Previous HGNC Symbols for DNAJC7 Gene

  • TTC2

Previous GeneCards Identifiers for DNAJC7 Gene

  • GC17M039682
  • GC17M042284
  • GC17M040037
  • GC17M040501
  • GC17M037382
  • GC17M040128
  • GC17M035893

Summaries for DNAJC7 Gene

Entrez Gene Summary for DNAJC7 Gene

  • This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for DNAJC7 Gene

DNAJC7 (DnaJ (Hsp40) Homolog, Subfamily C, Member 7) is a Protein Coding gene. GO annotations related to this gene include heat shock protein binding. An important paralog of this gene is DNAJC3.

UniProtKB/Swiss-Prot for DNAJC7 Gene

  • Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).

Gene Wiki entry for DNAJC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC7 Gene

Genomics for DNAJC7 Gene

Regulatory Elements for DNAJC7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJC7 Gene

Start:
41,976,421 bp from pter
End:
42,021,376 bp from pter
Size:
44,956 bases
Orientation:
Minus strand

Genomic View for DNAJC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC7 Gene

Proteins for DNAJC7 Gene

  • Protein details for DNAJC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99615-DNJC7_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 7
    Protein Accession:
    Q99615
    Secondary Accessions:
    • Q7Z784

    Protein attributes for DNAJC7 Gene

    Size:
    494 amino acids
    Molecular mass:
    56441 Da
    Quaternary structure:
    • Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1. Interacts with NR1I3. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). Interacts with HSPA8.
    SequenceCaution:
    • Sequence=AAB36872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH33772.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC7 Gene

Proteomics data for DNAJC7 Gene at MOPED

Post-translational modifications for DNAJC7 Gene

  • Ubiquitination at Lys60, Lys128, Lys182, Lys273, Lys329, Lys368, Lys384, and Lys390
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DNAJC7 Gene

Domains for DNAJC7 Gene

Gene Families for DNAJC7 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for DNAJC7 Gene

Suggested Antigen Peptide Sequences for DNAJC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q99615

UniProtKB/Swiss-Prot:

DNJC7_HUMAN :
  • Q99615
Domain:
  • Contains 1 J domain.
Similarity:
  • Contains 9 TPR repeats.
genes like me logo Genes that share domains with DNAJC7: view

Function for DNAJC7 Gene

Molecular function for DNAJC7 Gene

UniProtKB/Swiss-Prot Function: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).

Gene Ontology (GO) - Molecular Function for DNAJC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0031072 heat shock protein binding IPI 12853476
genes like me logo Genes that share ontologies with DNAJC7: view

Phenotypes for DNAJC7 Gene

genes like me logo Genes that share phenotypes with DNAJC7: view

Animal Model Products

CRISPR Products

miRNA for DNAJC7 Gene

miRTarBase miRNAs that target DNAJC7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJC7 Gene

Localization for DNAJC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC7 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC7 Gene COMPARTMENTS Subcellular localization image for DNAJC7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAJC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with DNAJC7: view

Pathways for DNAJC7 Gene

SuperPathways for DNAJC7 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 8836031
GO:0034605 cellular response to heat TAS --
GO:0070389 chaperone cofactor-dependent protein refolding IDA 12853476
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with DNAJC7: view

No data available for Pathways by source for DNAJC7 Gene

Transcripts for DNAJC7 Gene

Unigene Clusters for DNAJC7 Gene

DnaJ (Hsp40) homolog, subfamily C, member 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for DNAJC7 Gene

GeneLoc Exon Structure for
DNAJC7
ECgene alternative splicing isoforms for
DNAJC7

Expression for DNAJC7 Gene

mRNA expression in normal human tissues for DNAJC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC7 Gene

SOURCE GeneReport for Unigene cluster for DNAJC7 Gene Hs.500156

genes like me logo Genes that share expressions with DNAJC7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC7 Gene

Orthologs for DNAJC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC7 35
  • 99.85 (n)
  • 99.77 (a)
DNAJC7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC7 35
  • 94.2 (n)
  • 98.18 (a)
DNAJC7 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC7 35
  • 94.8 (n)
  • 98.38 (a)
DNAJC7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc7 35
  • 91.63 (n)
  • 97.17 (a)
Dnajc7 16
Dnajc7 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC7 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC7 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc7 35
  • 91.43 (n)
  • 97.17 (a)
chicken
(Gallus gallus)
Aves DNAJC7 35
  • 83.54 (n)
  • 93.7 (a)
DNAJC7 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC7 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33412 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc7 35
  • 76.81 (n)
  • 84.79 (a)
Str.6019 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9695 35
zebrafish
(Danio rerio)
Actinopterygii dnajc7 35
  • 73.46 (n)
  • 83.23 (a)
dnajc7 36
  • 77 (a)
OneToMany
dnajc7 36
  • 77 (a)
OneToMany
wufa20d06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008985 35
  • 52.21 (n)
  • 49.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tpr2 35
  • 53.21 (n)
  • 47.01 (a)
Tpr2 36
  • 44 (a)
OneToOne
Tpr2 37
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons P58IPK 35
  • 44.15 (n)
  • 30.73 (a)
rice
(Oryza sativa)
Liliopsida Os02g0195300 35
  • 49.31 (n)
  • 38.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00170 35
  • 48.25 (n)
  • 39.95 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC543.02c 35
  • 49.27 (n)
  • 43.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for DNAJC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC7 Gene

ENSEMBL:
Gene Tree for DNAJC7 (if available)
TreeFam:
Gene Tree for DNAJC7 (if available)

Paralogs for DNAJC7 Gene

Paralogs for DNAJC7 Gene

Pseudogenes.org Pseudogenes for DNAJC7 Gene

genes like me logo Genes that share paralogs with DNAJC7: view

Variants for DNAJC7 Gene

Sequence variations from dbSNP and Humsavar for DNAJC7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1127182 -- 41,990,284(-) TATCC(A/G)GAAGC reference, synonymous-codon, nc-transcript-variant
rs4239268 -- 42,002,759(+) AATTA(A/G)TCTGT intron-variant
rs4378665 -- 41,991,918(+) tcaag(C/T)gatcc intron-variant
rs4534906 -- 42,005,139(+) TCTCT(C/G)AATTC intron-variant
rs4796624 -- 41,985,787(+) TACTT(C/T)TTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC7 Gene

Variant ID Type Subtype PubMed ID
nsv509658 CNV Insertion 20534489
nsv908239 CNV Gain 21882294

Relevant External Links for DNAJC7 Gene

HapMap Linkage Disequilibrium report
DNAJC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC7 Gene

Disorders for DNAJC7 Gene

No disorders were found for DNAJC7 Gene.

No data available for UniProtKB/Swiss-Prot for DNAJC7 Gene

Publications for DNAJC7 Gene

  1. Identification and characterization of two novel tetratricopeptide repeat-containing genes. (PMID: 8836031) Murthy A.E. … Gusella J.F. (DNA Cell Biol. 1996) 2 3 4 23
  2. The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. (PMID: 11573955) Xiang S.L. … Yamamoto K.C. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  3. Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats. (PMID: 10567422) Liu F.H. … Wang C. (J. Biol. Chem. 1999) 3 4
  4. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PMID: 12853476) Brychzy A. … Obermann W.M. (EMBO J. 2003) 3 4
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3

Products for DNAJC7 Gene

Sources for DNAJC7 Gene

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