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Aliases for TRPC5 Gene

Aliases for TRPC5 Gene

  • Transient Receptor Potential Cation Channel, Subfamily C, Member 5 2 3
  • TRP5 3 4 6
  • Transient Receptor Protein 5 3 4
  • TRP-5 3 4
  • HTRP5 3 4
  • Protein Phosphatase 1, Regulatory Subunit 159 3
  • Short Transient Receptor Potential Channel 5 3
  • Transient Receptor Potential Channel 5 3
  • Regulatory Subunit 159 2
  • Protein Phosphatase 1 2
  • PPP1R159 3
  • HTRP-5 4
  • TrpC5 4

External Ids for TRPC5 Gene

Summaries for TRPC5 Gene

Entrez Gene Summary for TRPC5 Gene

  • This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]

GeneCards Summary for TRPC5 Gene

TRPC5 (Transient Receptor Potential Cation Channel, Subfamily C, Member 5) is a Protein Coding gene. Among its related pathways are L1CAM interactions and GPCR Pathway. GO annotations related to this gene include calcium channel activity and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is TRPC6.

UniProtKB/Swiss-Prot for TRPC5 Gene

  • Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.

Gene Wiki entry for TRPC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC5 Gene

Genomics for TRPC5 Gene

Genomic Location for TRPC5 Gene

111,774,314 bp from pter
112,082,776 bp from pter
308,463 bases
Minus strand

Genomic View for TRPC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC5 Gene

Regulatory Elements for TRPC5 Gene

Proteins for TRPC5 Gene

  • Protein details for TRPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Short transient receptor potential channel 5
    Protein Accession:
    Secondary Accessions:
    • B2RP53
    • O75233
    • Q5JXY8
    • Q9Y514

    Protein attributes for TRPC5 Gene

    973 amino acids
    Molecular mass:
    111412 Da
    Quaternary structure:
    • Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C-terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1 repeat).

neXtProt entry for TRPC5 Gene

Proteomics data for TRPC5 Gene at MOPED

Post-translational modifications for TRPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn461

Other Protein References for TRPC5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TRPC5 Gene

Domains for TRPC5 Gene

Gene Families for TRPC5 Gene

  • TRP :Voltage-gated ion channels / Transient receptor potential cation channels


  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.:
    • Q9UL62
  • Contains 4 ANK repeats.:
    • Q9UL62
genes like me logo Genes that share domains with TRPC5: view

Function for TRPC5 Gene

Molecular function for TRPC5 Gene

GENATLAS Biochemistry: transient receptor potential non voltage-channel 5,Drosophila store-operated calcium channel (Soc) homolog,ubiquitous but predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion component of the capacitative calcium entry channels (homo or heterotetramer),involved in mental retardation
UniProtKB/Swiss-Prot EnzymeRegulation: Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.
UniProtKB/Swiss-Prot Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.

Gene Ontology (GO) - Molecular Function for TRPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005262 calcium channel activity IDA 20164195
GO:0005515 protein binding IPI 20164195
GO:0015279 store-operated calcium channel activity TAS 10493832
GO:0070679 inositol 1,4,5 trisphosphate binding IBA --
genes like me logo Genes that share ontologies with TRPC5: view
genes like me logo Genes that share phenotypes with TRPC5: view

Animal Models for TRPC5 Gene

MGI Knock Outs for TRPC5:

miRNA for TRPC5 Gene

miRTarBase miRNAs that target TRPC5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRPC5 Gene

Localization for TRPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TRPC5 Gene COMPARTMENTS Subcellular localization image for TRPC5 gene
Compartment Confidence
plasma membrane 5
cytosol 2
endoplasmic reticulum 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10493832
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0034704 calcium channel complex IDA 20164195
genes like me logo Genes that share ontologies with TRPC5: view

Pathways for TRPC5 Gene

genes like me logo Genes that share pathways with TRPC5: view

Gene Ontology (GO) - Biological Process for TRPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006816 calcium ion transport TAS 10493832
GO:0006828 manganese ion transport IBA --
GO:0007399 nervous system development TAS 10493832
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with TRPC5: view

Compounds for TRPC5 Gene

(1) HMDB Compounds for TRPC5 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(17) IUPHAR Ligand for TRPC5 Gene

Ligand Type Action Affinity Pubmed IDs
BTP2 Pore Blocker Antagonist 6.7
ML204 Channel blocker None 5.5
progesterone Pore Blocker Inhibition 5.3
Ca2+ Antagonist Antagonist
KB-R7943 Channel blocker None
2-APB Channel blocker None
rosiglitazone Channel blocker None
SKF96365 Channel blocker None
genistein Activator None
7,4-dihydroxyisoflavone Activator None
GsMTx-4 Channel blocker None
flufenamic acid Channel blocker None
lysophosphatidylcholine Activator None
chlorpromazine Channel blocker None
Gd3+ Channel blocker None
Pb2+ Activator None
La3+ Channel blocker None

(7) Novoseek inferred chemical compound relationships for TRPC5 Gene

Compound -log(P) Hits PubMed IDs
2-aminoethoxydiphenylborane 90.9 1
1-oleoyl-2-acetyl-sn-glycerol 79.2 5
calcium 54.9 8
thapsigargin 53.9 1
inositol 1,4,5 trisphosphate 44.4 1
genes like me logo Genes that share compounds with TRPC5: view

Transcripts for TRPC5 Gene

mRNA/cDNA for TRPC5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRPC5 Gene

Transient receptor potential cation channel, subfamily C, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC5 Gene

No ASD Table

Relevant External Links for TRPC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRPC5 Gene

mRNA expression in normal human tissues for TRPC5 Gene

mRNA differential expression in normal tissues according to GTEx for TRPC5 Gene

This gene is overexpressed in Brain - Hypothalamus (7.4), Brain - Anterior cingulate cortex (BA24) (6.5), Brain - Frontal Cortex (BA9) (6.1), and Brain - Cortex (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRPC5 Gene

SOURCE GeneReport for Unigene cluster for TRPC5 Gene Hs.657709

mRNA Expression by UniProt/SwissProt for TRPC5 Gene

Tissue specificity: Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.
genes like me logo Genes that share expressions with TRPC5: view

Orthologs for TRPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRPC5 36
  • 93.75 (n)
  • 92.54 (a)
TRPC5 37
  • 100 (a)
(Bos Taurus)
Mammalia TRPC5 36
  • 93.9 (n)
  • 98.36 (a)
TRPC5 37
  • 98 (a)
(Canis familiaris)
Mammalia TRPC5 36
  • 93.66 (n)
  • 98.05 (a)
TRPC5 37
  • 98 (a)
(Mus musculus)
Mammalia Trpc5 36
  • 90.41 (n)
  • 96.92 (a)
Trpc5 16
Trpc5 37
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 97 (a)
-- 37
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TRPC5 37
  • 79 (a)
(Rattus norvegicus)
Mammalia Trpc5 36
  • 91.3 (n)
  • 97.43 (a)
(Gallus gallus)
Aves TRPC5 36
  • 79 (n)
  • 86.13 (a)
TRPC5 37
  • 85 (a)
(Anolis carolinensis)
Reptilia TRPC5 37
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trpc5 36
  • 75.72 (n)
  • 84.35 (a)
(Danio rerio)
Actinopterygii LOC555897 36
  • 69.78 (n)
  • 74.55 (a)
trpc5a 37
  • 71 (a)
trpc5b 37
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta trp 37
  • 30 (a)
trpgamma 37
  • 37 (a)
trpl 37
  • 34 (a)
trpgamma 38
  • 49 (a)
trpl 38
  • 44 (a)
trp 38
  • 43 (a)
(Caenorhabditis elegans)
Secernentea trp-2 37
  • 41 (a)
trp-1 38
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
Species with no ortholog for TRPC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPC5 Gene

Gene Tree for TRPC5 (if available)
Gene Tree for TRPC5 (if available)

Paralogs for TRPC5 Gene

Paralogs for TRPC5 Gene

Selected SIMAP similar genes for TRPC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRPC5: view

Variants for TRPC5 Gene

Sequence variations from dbSNP and Humsavar for TRPC5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs715154 -- 112,068,987(+) aaggt(C/T)ttatg intron-variant
rs740357 -- 111,917,465(+) CTCCA(G/T)ATTCC intron-variant
rs758030 -- 111,857,951(+) ATATA(A/C)CATCC intron-variant
rs767034 -- 111,925,601(+) TGAGC(C/T)AAACC intron-variant
rs886851 -- 111,857,407(+) ggagg(C/G)aggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC5 Gene

Variant ID Type Subtype PubMed ID
nsv7039 CNV Loss 18451855
nsv7040 CNV Loss 18451855
nsv520386 CNV Gain 19592680
nsv526892 CNV Gain 19592680
esv2675427 CNV Deletion 23128226
esv268206 CNV Insertion 20981092

Relevant External Links for TRPC5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for TRPC5 Gene

(2) Novoseek inferred disease relationships for TRPC5 Gene

Disease -log(P) Hits PubMed IDs
essential hypertension 18.1 3
mental retardation 16.2 3

Relevant External Links for TRPC5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRPC5: view

No data available for UniProtKB/Swiss-Prot for TRPC5 Gene

Publications for TRPC5 Gene

  1. Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca(2+) entry channel. (PMID: 10493832) Sossey-Alaoui K. … Srivastava A.K. (Genomics 1999) 2 3 4 23
  2. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PMID: 20164195) Miehe S. … Strubing C. (J. Biol. Chem. 2010) 3 4 23
  3. Subunit composition of mammalian transient receptor potential channels in living cells. (PMID: 12032305) Hofmann T. … Gudermann T. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  4. MxA, a member of the dynamin superfamily, interacts with the ankyrin- like repeat domain of TRPC. (PMID: 15757897) Lussier M.P. … Boulay G. (J. Biol. Chem. 2005) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for TRPC5 Gene

Sources for TRPC5 Gene

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