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Aliases for TRPC5 Gene

Aliases for TRPC5 Gene

  • Transient Receptor Potential Cation Channel Subfamily C Member 5 2 3
  • Transient Receptor Potential Cation Channel, Subfamily C, Member 5 2 3 5
  • Transient Receptor Protein 5 3 4
  • TRP-5 3 4
  • HTRP5 3 4
  • TRP5 3 4
  • Protein Phosphatase 1, Regulatory Subunit 159 3
  • Transient Receptor Potential Channel 5 3
  • Regulatory Subunit 159 2
  • Protein Phosphatase 1 2
  • PPP1R159 3
  • HTRP-5 4
  • TrpC5 4

External Ids for TRPC5 Gene

Previous GeneCards Identifiers for TRPC5 Gene

  • GC0XM106320
  • GC0XM108164
  • GC0XM109042
  • GC0XM109781
  • GC0XM110823
  • GC0XM110904
  • GC0XM111017
  • GC0XM100639

Summaries for TRPC5 Gene

Entrez Gene Summary for TRPC5 Gene

  • This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]

GeneCards Summary for TRPC5 Gene

TRPC5 (Transient Receptor Potential Cation Channel Subfamily C Member 5) is a Protein Coding gene. Diseases associated with TRPC5 include hypertrophic pyloric stenosis and pyloric stenosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Developmental Biology. GO annotations related to this gene include ion channel activity and store-operated calcium channel activity. An important paralog of this gene is TRPC6.

UniProtKB/Swiss-Prot for TRPC5 Gene

  • Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.

Gene Wiki entry for TRPC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC5 Gene

Genomics for TRPC5 Gene

Regulatory Elements for TRPC5 Gene

Genomic Location for TRPC5 Gene

Chromosome:
X
Start:
111,774,314 bp from pter
End:
112,082,776 bp from pter
Size:
308,463 bases
Orientation:
Minus strand

Genomic View for TRPC5 Gene

Genes around TRPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC5 Gene

Proteins for TRPC5 Gene

  • Protein details for TRPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL62-TRPC5_HUMAN
    Recommended name:
    Short transient receptor potential channel 5
    Protein Accession:
    Q9UL62
    Secondary Accessions:
    • B2RP53
    • O75233
    • Q5JXY8
    • Q9Y514

    Protein attributes for TRPC5 Gene

    Size:
    973 amino acids
    Molecular mass:
    111412 Da
    Quaternary structure:
    • Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C-terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1 repeat).

neXtProt entry for TRPC5 Gene

Proteomics data for TRPC5 Gene at MOPED

Post-translational modifications for TRPC5 Gene

  • Glycosylation at Asn 461
  • Modification sites at PhosphoSitePlus

Other Protein References for TRPC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRPC5 Gene

Domains & Families for TRPC5 Gene

Suggested Antigen Peptide Sequences for TRPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL62

UniProtKB/Swiss-Prot:

TRPC5_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.
  • Contains 4 ANK repeats.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with TRPC5: view

Function for TRPC5 Gene

Molecular function for TRPC5 Gene

GENATLAS Biochemistry:
transient receptor potential non voltage-channel 5,Drosophila store-operated calcium channel (Soc) homolog,ubiquitous but predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion component of the capacitative calcium entry channels (homo or heterotetramer),involved in mental retardation
UniProtKB/Swiss-Prot EnzymeRegulation:
Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.
UniProtKB/Swiss-Prot Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.

Gene Ontology (GO) - Molecular Function for TRPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070679 inositol 1,4,5 trisphosphate binding IEA --
genes like me logo Genes that share ontologies with TRPC5: view
genes like me logo Genes that share phenotypes with TRPC5: view

Animal Models for TRPC5 Gene

MGI Knock Outs for TRPC5:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPC5 Gene

Localization for TRPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPC5 Gene COMPARTMENTS Subcellular localization image for TRPC5 gene
Compartment Confidence
plasma membrane 5
cytosol 4
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRPC5: view

Pathways & Interactions for TRPC5 Gene

genes like me logo Genes that share pathways with TRPC5: view

Pathways by source for TRPC5 Gene

Gene Ontology (GO) - Biological Process for TRPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006828 manganese ion transport IBA --
GO:0007411 axon guidance TAS --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with TRPC5: view

No data available for SIGNOR curated interactions for TRPC5 Gene

Drugs & Compounds for TRPC5 Gene

(18) Drugs for TRPC5 Gene - From: IUPHAR, DGIdb, Novoseek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorpromazine Approved Pharma Antagonist, antagonist 13
Progesterone Approved Pharma Full agonist, Activator, inhibitor Endogenous progesterone receptor agonist 500
Rosiglitazone Approved, Investigational Pharma Full agonist, Agonist, agonist Potent PPARγ agonist 220
Flufenamic acid Experimental Pharma Channel blocker Activates TRPC6; NSAID 0
Genistein Investigational Pharma Potentiation, Activator, agonist AR agonist, EGFR kinase inhibitor. Also estrogen and PPARgamma ligand 54

(7) Additional Compounds for TRPC5 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7,4-dihydroxyisoflavone
Agonist
genes like me logo Genes that share compounds with TRPC5: view

Transcripts for TRPC5 Gene

mRNA/cDNA for TRPC5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRPC5 Gene

Transient receptor potential cation channel, subfamily C, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC5 Gene

No ASD Table

Relevant External Links for TRPC5 Gene

GeneLoc Exon Structure for
TRPC5
ECgene alternative splicing isoforms for
TRPC5

Expression for TRPC5 Gene

mRNA expression in normal human tissues for TRPC5 Gene

mRNA differential expression in normal tissues according to GTEx for TRPC5 Gene

This gene is overexpressed in Brain - Hypothalamus (x7.4), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Frontal Cortex (BA9) (x6.1), and Brain - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for TRPC5 Gene

This gene is overexpressed in Fetal heart (27.3), Retina (18.5), and Frontal cortex (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRPC5 Gene



SOURCE GeneReport for Unigene cluster for TRPC5 Gene Hs.657709

mRNA Expression by UniProt/SwissProt for TRPC5 Gene

Q9UL62-TRPC5_HUMAN
Tissue specificity: Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.
genes like me logo Genes that share expression patterns with TRPC5: view

Protein tissue co-expression partners for TRPC5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRPC5 Gene

Orthologs for TRPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPC5 36
  • 100 (a)
OneToOne
TRPC5 35
  • 93.75 (n)
  • 92.54 (a)
cow
(Bos Taurus)
Mammalia TRPC5 35
  • 93.9 (n)
  • 98.36 (a)
TRPC5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPC5 35
  • 93.66 (n)
  • 98.05 (a)
TRPC5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpc5 36
  • 97 (a)
OneToOne
Trpc5 16
Trpc5 35
  • 90.41 (n)
  • 96.92 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TRPC5 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpc5 35
  • 91.3 (n)
  • 97.43 (a)
chicken
(Gallus gallus)
Aves TRPC5 35
  • 79 (n)
  • 86.13 (a)
TRPC5 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPC5 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpc5 35
  • 75.72 (n)
  • 84.35 (a)
zebrafish
(Danio rerio)
Actinopterygii trpc5a 36
  • 71 (a)
OneToMany
trpc5b 36
  • 56 (a)
OneToMany
LOC555897 35
  • 69.78 (n)
  • 74.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta trp 37
  • 43 (a)
trpgamma 37
  • 49 (a)
trpl 37
  • 44 (a)
trp 36
  • 30 (a)
ManyToMany
trpgamma 36
  • 37 (a)
ManyToMany
trpl 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trp-1 37
  • 39 (a)
trp-2 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
Species with no ortholog for TRPC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPC5 Gene

ENSEMBL:
Gene Tree for TRPC5 (if available)
TreeFam:
Gene Tree for TRPC5 (if available)

Paralogs for TRPC5 Gene

Paralogs for TRPC5 Gene

(6) SIMAP similar genes for TRPC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRPC5: view

Variants for TRPC5 Gene

Sequence variations from dbSNP and Humsavar for TRPC5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs36047478 - 111,781,202(-) GGAAC(A/G)CAATG reference, missense
VAR_069415 -
rs1009560 -- 111,991,013(+) CCACT(A/G)AATGA intron-variant
rs1019052 -- 111,942,860(+) tgatg(C/T)ttaaa intron-variant
rs1019053 -- 111,942,965(+) ATTAG(C/T)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC5 Gene

Variant ID Type Subtype PubMed ID
nsv7039 CNV Loss 18451855
nsv7040 CNV Loss 18451855
nsv520386 CNV Gain 19592680
nsv526892 CNV Gain 19592680
esv2675427 CNV Deletion 23128226
esv268206 CNV Insertion 20981092

Variation tolerance for TRPC5 Gene

Residual Variation Intolerance Score: 9.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPC5 Gene

HapMap Linkage Disequilibrium report
TRPC5
Human Gene Mutation Database (HGMD)
TRPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC5 Gene

Disorders for TRPC5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRPC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypertrophic pyloric stenosis
  • congenital hypertrophic pyloric stenosis
pyloric stenosis
- elite association - COSMIC cancer census association via MalaCards
Search TRPC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRPC5

Genetic Association Database (GAD)
TRPC5
Human Genome Epidemiology (HuGE) Navigator
TRPC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPC5
genes like me logo Genes that share disorders with TRPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPC5 Gene

Publications for TRPC5 Gene

  1. Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca(2+) entry channel. (PMID: 10493832) Sossey-Alaoui K. … Srivastava A.K. (Genomics 1999) 2 3 4 23 67
  2. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PMID: 20164195) Miehe S. … Strubing C. (J. Biol. Chem. 2010) 3 23
  3. Molecular determinant of sensing extracellular pH in classical transient receptor potential channel 5. (PMID: 17981154) Kim M.J. … So I. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Potentiation of TRPC5 by protons. (PMID: 17884814) Semtner M. … Plant T.D. (J. Biol. Chem. 2007) 3 23
  5. Canonical transient receptor potential 5. (PMID: 17217053) Beech D.J. (Handb Exp Pharmacol 2007) 3 23

Products for TRPC5 Gene

Sources for TRPC5 Gene

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