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Aliases for C3AR1 Gene

Aliases for C3AR1 Gene

  • Complement Component 3a Receptor 1 2 3
  • HNFAG09 3 4
  • C3a-R 3 4
  • AZ3B 3 4
  • C3AR 3 4
  • Complement Component 3 Receptor 1 3
  • C3R1 4

External Ids for C3AR1 Gene

Previous GeneCards Identifiers for C3AR1 Gene

  • GC12M007906
  • GC12M008358
  • GC12M008111
  • GC12M008102
  • GC12M008210
  • GC12M008022

Summaries for C3AR1 Gene

GeneCards Summary for C3AR1 Gene

C3AR1 (Complement Component 3a Receptor 1) is a Protein Coding gene. Diseases associated with C3AR1 include complement component 3 deficiency and c3 deficiency. Among its related pathways are Signaling by GPCR and Complement and coagulation cascades. GO annotations related to this gene include G-protein coupled receptor activity and complement component C3a receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for C3AR1 Gene

  • Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production

Gene Wiki entry for C3AR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3AR1 Gene

Genomics for C3AR1 Gene

Regulatory Elements for C3AR1 Gene

Genomic Location for C3AR1 Gene

Chromosome:
12
Start:
8,058,302 bp from pter
End:
8,066,471 bp from pter
Size:
8,170 bases
Orientation:
Minus strand

Genomic View for C3AR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C3AR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3AR1 Gene

Proteins for C3AR1 Gene

  • Protein details for C3AR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16581-C3AR_HUMAN
    Recommended name:
    C3a anaphylatoxin chemotactic receptor
    Protein Accession:
    Q16581
    Secondary Accessions:
    • O43771
    • Q92868

    Protein attributes for C3AR1 Gene

    Size:
    482 amino acids
    Molecular mass:
    53864 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C3AR1 Gene

Proteomics data for C3AR1 Gene at MOPED

Post-translational modifications for C3AR1 Gene

Other Protein References for C3AR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C3AR1 (Complement Component C3a R)

No data available for DME Specific Peptides for C3AR1 Gene

Domains & Families for C3AR1 Gene

Gene Families for C3AR1 Gene

Suggested Antigen Peptide Sequences for C3AR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16581

UniProtKB/Swiss-Prot:

C3AR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with C3AR1: view

Function for C3AR1 Gene

Molecular function for C3AR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production

Gene Ontology (GO) - Molecular Function for C3AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001850 complement component C3a binding IEA --
GO:0004435 phosphatidylinositol phospholipase C activity TAS 8765043
GO:0004876 complement component C3a receptor activity TAS 8765043
GO:0004930 G-protein coupled receptor activity IGI 10571060
GO:0004943 C3a anaphylatoxin receptor activity IEA --
genes like me logo Genes that share ontologies with C3AR1: view
genes like me logo Genes that share phenotypes with C3AR1: view

Animal Models for C3AR1 Gene

MGI Knock Outs for C3AR1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C3AR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for C3AR1 Gene

Localization for C3AR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3AR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C3AR1 Gene COMPARTMENTS Subcellular localization image for C3AR1 gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for C3AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 8702752
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8702752
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with C3AR1: view

Pathways & Interactions for C3AR1 Gene

genes like me logo Genes that share pathways with C3AR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for C3AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway IEA --
GO:0002462 tolerance induction to nonself antigen IEA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response TAS 8765043
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with C3AR1: view

No data available for SIGNOR curated interactions for C3AR1 Gene

Drugs & Compounds for C3AR1 Gene

(13) Drugs for C3AR1 Gene - From: IUPHAR, DGIdb, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]C3a (human) Pharma Full agonist, Agonist 0
C3a Pharma Full agonist, Agonist 0
E7 Pharma Full agonist, Agonist 0
FLPLAR Pharma Full agonist, Agonist 0
FLTChaAR Pharma Antagonist 0

(2) Additional Compounds for C3AR1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Anaphylatoxin
FMLP
genes like me logo Genes that share compounds with C3AR1: view

Transcripts for C3AR1 Gene

mRNA/cDNA for C3AR1 Gene

Unigene Clusters for C3AR1 Gene

Complement component 3a receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C3AR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3AR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c
SP1: -
SP2: -
SP3:

Relevant External Links for C3AR1 Gene

GeneLoc Exon Structure for
C3AR1
ECgene alternative splicing isoforms for
C3AR1

Expression for C3AR1 Gene

mRNA expression in normal human tissues for C3AR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C3AR1 Gene

This gene is overexpressed in Whole Blood (x21.8).

Protein differential expression in normal tissues from HIPED for C3AR1 Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C3AR1 Gene



SOURCE GeneReport for Unigene cluster for C3AR1 Gene Hs.591148

mRNA Expression by UniProt/SwissProt for C3AR1 Gene

Q16581-C3AR_HUMAN
Tissue specificity: Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues
genes like me logo Genes that share expression patterns with C3AR1: view

Protein tissue co-expression partners for C3AR1 Gene

Primer Products

In Situ Assay Products

Orthologs for C3AR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3AR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C3AR1 35
  • 81.59 (n)
  • 71.76 (a)
C3AR1 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C3AR1 35
  • 82.22 (n)
  • 71.25 (a)
C3AR1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C3ar1 35
  • 75.94 (n)
  • 66.03 (a)
C3ar1 16
C3ar1 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C3AR1 35
  • 99.31 (n)
  • 98.55 (a)
C3AR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C3ar1 35
  • 73.87 (n)
  • 61.99 (a)
chicken
(Gallus gallus)
Aves C3AR1 35
  • 56.65 (n)
  • 49.06 (a)
C3AR1 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3AR1 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498174 35
  • 56.01 (n)
  • 45.64 (a)
zebrafish
(Danio rerio)
Actinopterygii c3ar1 35
  • 51.95 (n)
  • 41.81 (a)
C3AR1 36
  • 38 (a)
OneToOne
Species with no ortholog for C3AR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3AR1 Gene

ENSEMBL:
Gene Tree for C3AR1 (if available)
TreeFam:
Gene Tree for C3AR1 (if available)

Paralogs for C3AR1 Gene

(12) SIMAP similar genes for C3AR1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with C3AR1: view

Variants for C3AR1 Gene

Sequence variations from dbSNP and Humsavar for C3AR1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3301 -- 8,058,358(+) ATATC(A/G)ACAAA utr-variant-3-prime
rs7842 -- 8,058,591(-) TATTG(A/G)CATCA utr-variant-3-prime
rs140305760 -- 8,060,717(+) AATCT(A/T)CTGTA intron-variant
rs140285031 -- 8,065,115(+) AGGTC(C/T)GAGGA intron-variant
rs140119047 -- 8,059,916(+) CTGCC(A/G)TAGGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for C3AR1 Gene

Variant ID Type Subtype PubMed ID
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914

Variation tolerance for C3AR1 Gene

Residual Variation Intolerance Score: 44.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3AR1 Gene

HapMap Linkage Disequilibrium report
C3AR1
Human Gene Mutation Database (HGMD)
C3AR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3AR1 Gene

Disorders for C3AR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C3AR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
complement component 3 deficiency
  • c3 deficiency
c3 deficiency
  • complement component 3 deficiency
- elite association
Search C3AR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for C3AR1

Genetic Association Database (GAD)
C3AR1
Human Genome Epidemiology (HuGE) Navigator
C3AR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3AR1
genes like me logo Genes that share disorders with C3AR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C3AR1 Gene

Publications for C3AR1 Gene

  1. Complement fragments C3a and C5a: the salt and pepper of the immune response. (PMID: 20186746) Sacks S.H. (Eur. J. Immunol. 2010) 23 67
  2. Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury. (PMID: 20380727) Wang Y. … Dalle Lucca J.J. (J Neuroinflammation 2010) 23 67
  3. C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation. (PMID: 19265162) Schraufstatter I.U. … Khaldoyanidi S.K. (J. Immunol. 2009) 23 67
  4. Sequence-derived three-dimensional pharmacophore models for G-protein-coupled receptors and their application in virtual screening. (PMID: 19374402) Klabunde T. … Evers A. (J. Med. Chem. 2009) 23 67
  5. c-Jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury. (PMID: 19592465) Luo X. … Khachigian L.M. (Arterioscler. Thromb. Vasc. Biol. 2009) 23 67

Products for C3AR1 Gene

Sources for C3AR1 Gene

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