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Aliases for TRAF5 Gene

Aliases for TRAF5 Gene

  • TNF Receptor-Associated Factor 5 2 3
  • RING Finger Protein 84 3 4
  • RNF84 3 4
  • MGC:39780 3

External Ids for TRAF5 Gene

Previous GeneCards Identifiers for TRAF5 Gene

  • GC01P210231
  • GC01P207335
  • GC01P208139
  • GC01P208579
  • GC01P207888
  • GC01P209566
  • GC01P211499
  • GC01P182176

Summaries for TRAF5 Gene

Entrez Gene Summary for TRAF5 Gene

  • The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRAF5 Gene

TRAF5 (TNF Receptor-Associated Factor 5) is a Protein Coding gene. Among its related pathways are Pathways in cancer and NF-KappaB Family Pathway. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin protein ligase binding. An important paralog of this gene is TRAF6.

UniProtKB/Swiss-Prot for TRAF5 Gene

  • Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Gene Wiki entry for TRAF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF5 Gene

Genomics for TRAF5 Gene

Regulatory Elements for TRAF5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAF5 Gene

Chromosome:
1
Start:
211,326,579 bp from pter
End:
211,374,946 bp from pter
Size:
48,368 bases
Orientation:
Plus strand

Genomic View for TRAF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF5 Gene

Proteins for TRAF5 Gene

  • Protein details for TRAF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00463-TRAF5_HUMAN
    Recommended name:
    TNF receptor-associated factor 5
    Protein Accession:
    O00463
    Secondary Accessions:
    • B4DIS9
    • B4E0A2
    • Q6FHY1

    Protein attributes for TRAF5 Gene

    Size:
    557 amino acids
    Molecular mass:
    64406 Da
    Quaternary structure:
    • Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain).

    Alternative splice isoforms for TRAF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF5 Gene

Proteomics data for TRAF5 Gene at MOPED

Post-translational modifications for TRAF5 Gene

  • Ubiquitination at Lys 534
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAF5 Gene

Antibody Products

No data available for DME Specific Peptides for TRAF5 Gene

Domains & Families for TRAF5 Gene

Suggested Antigen Peptide Sequences for TRAF5 Gene

Graphical View of Domain Structure for InterPro Entry

O00463

UniProtKB/Swiss-Prot:

TRAF5_HUMAN :
  • The MATH/TRAF domain binds to receptor cytoplasmic domains
  • Belongs to the TNF receptor-associated factor family. A subfamily.
  • Contains 1 RING-type zinc finger.
Domain:
  • The MATH/TRAF domain binds to receptor cytoplasmic domains
  • Contains 1 MATH domain.
Family:
  • Belongs to the TNF receptor-associated factor family. A subfamily.
Similarity:
  • Contains 1 RING-type zinc finger.
  • Contains 2 TRAF-type zinc fingers.
genes like me logo Genes that share domains with TRAF5: view

Function for TRAF5 Gene

Molecular function for TRAF5 Gene

GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor-associated factor 5,expressed in all visceral organs,interacting with the lymphotoxin beta receptor,activating NFKB through the cytoplasmic domain of CD40 (TNFRSF5) and modulating of its activity
UniProtKB/Swiss-Prot Function:
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Gene Ontology (GO) - Molecular Function for TRAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 9153189
GO:0008270 zinc ion binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11279055
genes like me logo Genes that share ontologies with TRAF5: view
genes like me logo Genes that share phenotypes with TRAF5: view

Animal Models for TRAF5 Gene

MGI Knock Outs for TRAF5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TRAF5 Gene

Localization for TRAF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF5 Gene

Cytoplasm. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAF5 Gene COMPARTMENTS Subcellular localization image for TRAF5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TRAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol IDA 15121867
GO:0009898 cytoplasmic side of plasma membrane ISS --
GO:0035631 CD40 receptor complex ISS --
genes like me logo Genes that share ontologies with TRAF5: view

Pathways & Interactions for TRAF5 Gene

genes like me logo Genes that share pathways with TRAF5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for TRAF5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0016567 protein ubiquitination IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with TRAF5: view

Drugs & Compounds for TRAF5 Gene

(1) Drugs for TRAF5 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
genes like me logo Genes that share compounds with TRAF5: view

Transcripts for TRAF5 Gene

Unigene Clusters for TRAF5 Gene

TNF receptor-associated factor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for TRAF5 Gene

GeneLoc Exon Structure for
TRAF5
ECgene alternative splicing isoforms for
TRAF5

Expression for TRAF5 Gene

mRNA expression in normal human tissues for TRAF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF5 Gene

This gene is overexpressed in Uterus (59.5) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF5 Gene



SOURCE GeneReport for Unigene cluster for TRAF5 Gene Hs.523930

mRNA Expression by UniProt/SwissProt for TRAF5 Gene

O00463-TRAF5_HUMAN
Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood
genes like me logo Genes that share expression patterns with TRAF5: view

Protein tissue co-expression partners for TRAF5 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRAF5 Gene

Orthologs for TRAF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAF5 35
  • 88.69 (n)
  • 87.97 (a)
TRAF5 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAF5 35
  • 88.63 (n)
  • 88.49 (a)
TRAF5 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traf5 35
  • 81.93 (n)
  • 79.89 (a)
Traf5 16
Traf5 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAF5 35
  • 99.34 (n)
  • 98.92 (a)
TRAF5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC684173 35
  • 81.26 (n)
  • 79.73 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAF5 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF5 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAF5 35
  • 73.18 (n)
  • 71.61 (a)
TRAF-5 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF5 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491604 35
  • 64.22 (n)
  • 59.37 (a)
zebrafish
(Danio rerio)
Actinopterygii traf5 35
  • 51.07 (n)
  • 42.57 (a)
traf5 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Traf-like 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trf-1 35
  • 44.57 (n)
  • 35.91 (a)
Y110A7A.2 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
ManyToMany
Species with no ortholog for TRAF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF5 Gene

ENSEMBL:
Gene Tree for TRAF5 (if available)
TreeFam:
Gene Tree for TRAF5 (if available)

Paralogs for TRAF5 Gene

Paralogs for TRAF5 Gene

(4) SIMAP similar genes for TRAF5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRAF5: view

Variants for TRAF5 Gene

Sequence variations from dbSNP and Humsavar for TRAF5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs784374 -- 211,367,590(+) AAGAG(A/G)CCTTC intron-variant
rs784375 -- 211,368,948(+) TTTTG(A/C)TACTG intron-variant
rs784376 -- 211,375,144(+) GATTA(C/T)AGTGG downstream-variant-500B
rs1046690 -- 211,373,159(+) TTAAG(A/T)AGTGG utr-variant-3-prime, downstream-variant-500B
rs2175633 -- 211,332,403(+) AGGCG(G/T)ATGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF5 Gene

Variant ID Type Subtype PubMed ID
nsv508059 CNV Loss 20534489

Variation tolerance for TRAF5 Gene

Residual Variation Intolerance Score: 70.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF5 Gene

HapMap Linkage Disequilibrium report
TRAF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF5 Gene

Disorders for TRAF5 Gene

Relevant External Links for TRAF5

Genetic Association Database (GAD)
TRAF5
Human Genome Epidemiology (HuGE) Navigator
TRAF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAF5
genes like me logo Genes that share disorders with TRAF5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAF5 Gene

Publications for TRAF5 Gene

  1. TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation. (PMID: 19918265) Sondarva G. … Rana A. (Cell Res. 2010) 23 67
  2. TRAF1 is involved in the classical NF-kappaB activation and CD30-induced alternative activity in Hodgkin's lymphoma cells. (PMID: 19540595) Guo F. … Chen Z. (Mol. Immunol. 2009) 23 67
  3. TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells. (PMID: 19409903) Zhang L. … Habelhah H. (J. Mol. Biol. 2009) 23 67
  4. Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. (PMID: 18292232) Zarnegar B. … Cheng G. (Proc. Natl. Acad. Sci. U.S.A. 2008) 23 67
  5. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PMID: 18990758) Cerhan J.R. … Slager S.L. (Cancer Epidemiol. Biomarkers Prev. 2008) 23 67

Products for TRAF5 Gene

Sources for TRAF5 Gene

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