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Aliases for TRAF5 Gene

Aliases for TRAF5 Gene

  • TNF Receptor Associated Factor 5 2 3 5
  • RING Finger Protein 84 3 4
  • RNF84 3 4
  • TNF Receptor-Associated Factor 5 3
  • MGC:39780 3

External Ids for TRAF5 Gene

Previous GeneCards Identifiers for TRAF5 Gene

  • GC01P210231
  • GC01P207335
  • GC01P208139
  • GC01P208579
  • GC01P207888
  • GC01P209566
  • GC01P211499
  • GC01P182176

Summaries for TRAF5 Gene

Entrez Gene Summary for TRAF5 Gene

  • The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for TRAF5 Gene

TRAF5 (TNF Receptor Associated Factor 5) is a Protein Coding gene. Among its related pathways are 4-1BB Pathway and RANK Signaling in Osteoclasts. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin protein ligase binding. An important paralog of this gene is TRAF3.

UniProtKB/Swiss-Prot for TRAF5 Gene

  • Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Gene Wiki entry for TRAF5 Gene

Additional gene information for TRAF5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF5 Gene

Genomics for TRAF5 Gene

Regulatory Elements for TRAF5 Gene

Enhancers for TRAF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H211513 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +189.4 189382 4 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 SLC30A1 TRAF5 LINC00467 RD3 GC01M211578
GH01H211381 1.4 ENCODE dbSUPER 12.6 +56.3 56325 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 TRAF5 LINC00467 SNX25P1
GH01H211351 1.3 Ensembl ENCODE dbSUPER 12.9 +26.6 26568 2 SOX13 CTCF FOXA2 ZNF644 ZNF2 RAD21 CHAMP1 TEAD3 ZNF316 CBX5 TRAF5 RCOR3 LINC00467
GH01H211914 1.5 Ensembl ENCODE dbSUPER 11.1 +591.7 591702 6 PKNOX1 FOXA2 ZFP64 ARID4B YY1 TCF12 FOS ATF7 MCM3 NFIL3 LPGAT1 LOC102723727 SNORA16B TRAF5 ENSG00000212187 ENSG00000229832 INTS7 ENSG00000233626 PIR53279
GH01H211326 1.6 FANTOM5 ENCODE dbSUPER 8.1 +1.9 1854 4 ARNT SIN3A ZNF121 ZNF766 GLIS2 RUNX3 ZNF592 SNIP1 SMARCA4 NBN RCOR3 LINC00467 SNX25P1 TRAF5 PPP2R5A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAF5 on UCSC Golden Path with GeneCards custom track

Promoters for TRAF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019543 721 1401 ARNT SIN3A ZNF121 ZNF766 GLIS2 GATA2 ZNF592 SMARCA4 NR2C1 KLF1

Genomic Location for TRAF5 Gene

Chromosome:
1
Start:
211,326,579 bp from pter
End:
211,374,946 bp from pter
Size:
48,368 bases
Orientation:
Plus strand

Genomic View for TRAF5 Gene

Genes around TRAF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF5 Gene

Proteins for TRAF5 Gene

  • Protein details for TRAF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00463-TRAF5_HUMAN
    Recommended name:
    TNF receptor-associated factor 5
    Protein Accession:
    O00463
    Secondary Accessions:
    • B4DIS9
    • B4E0A2
    • Q6FHY1

    Protein attributes for TRAF5 Gene

    Size:
    557 amino acids
    Molecular mass:
    64406 Da
    Quaternary structure:
    • Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain).

    Alternative splice isoforms for TRAF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF5 Gene

Post-translational modifications for TRAF5 Gene

  • Ubiquitination at Lys534
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRAF5 (TRAF5)

No data available for DME Specific Peptides for TRAF5 Gene

Domains & Families for TRAF5 Gene

Gene Families for TRAF5 Gene

Suggested Antigen Peptide Sequences for TRAF5 Gene

Graphical View of Domain Structure for InterPro Entry

O00463

UniProtKB/Swiss-Prot:

TRAF5_HUMAN :
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
  • Belongs to the TNF receptor-associated factor family. A subfamily.
Domain:
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
Family:
  • Belongs to the TNF receptor-associated factor family. A subfamily.
genes like me logo Genes that share domains with TRAF5: view

Function for TRAF5 Gene

Molecular function for TRAF5 Gene

GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor-associated factor 5,expressed in all visceral organs,interacting with the lymphotoxin beta receptor,activating NFKB through the cytoplasmic domain of CD40 (TNFRSF5) and modulating of its activity
UniProtKB/Swiss-Prot Function:
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Phenotypes From GWAS Catalog for TRAF5 Gene

Gene Ontology (GO) - Molecular Function for TRAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9153189
GO:0008270 zinc ion binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11279055
GO:0031996 thioesterase binding IPI 11279055
GO:0042802 identical protein binding IPI 22493164
genes like me logo Genes that share ontologies with TRAF5: view
genes like me logo Genes that share phenotypes with TRAF5: view

Animal Models for TRAF5 Gene

MGI Knock Outs for TRAF5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRAF5
  • Applied Biological Materials Clones for TRAF5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF5 Gene

Localization for TRAF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF5 Gene

Cytoplasm. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 3
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol IDA,IEA 15121867
GO:0009898 cytoplasmic side of plasma membrane ISS --
GO:0035631 CD40 receptor complex ISS --
genes like me logo Genes that share ontologies with TRAF5: view

Pathways & Interactions for TRAF5 Gene

genes like me logo Genes that share pathways with TRAF5: view

SIGNOR curated interactions for TRAF5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS,IEA --
GO:0042981 regulation of apoptotic process IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP 12761501
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IMP 12296995
genes like me logo Genes that share ontologies with TRAF5: view

Drugs & Compounds for TRAF5 Gene

(1) Drugs for TRAF5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TRAF5: view

Transcripts for TRAF5 Gene

Unigene Clusters for TRAF5 Gene

TNF receptor-associated factor 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRAF5
  • Applied Biological Materials Clones for TRAF5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for TRAF5 Gene

GeneLoc Exon Structure for
TRAF5
ECgene alternative splicing isoforms for
TRAF5

Expression for TRAF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF5 Gene

This gene is overexpressed in Uterus (59.5) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAF5 Gene



Protein tissue co-expression partners for TRAF5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAF5 Gene:

TRAF5

SOURCE GeneReport for Unigene cluster for TRAF5 Gene:

Hs.523930

mRNA Expression by UniProt/SwissProt for TRAF5 Gene:

O00463-TRAF5_HUMAN
Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

Evidence on tissue expression from TISSUES for TRAF5 Gene

  • Nervous system(4.1)
  • Blood(2.5)
  • Lymph node(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with TRAF5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF5 Gene

Orthologs for TRAF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAF5 33 34
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia TRAF5 33 34
  • 88.69 (n)
dog
(Canis familiaris)
Mammalia TRAF5 33 34
  • 88.63 (n)
mouse
(Mus musculus)
Mammalia Traf5 33 16 34
  • 81.93 (n)
rat
(Rattus norvegicus)
Mammalia LOC684173 33
  • 81.26 (n)
oppossum
(Monodelphis domestica)
Mammalia TRAF5 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF5 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAF5 33
  • 73.18 (n)
TRAF-5 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF5 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491604 33
  • 64.22 (n)
zebrafish
(Danio rerio)
Actinopterygii traf5 33 34
  • 51.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Traf-like 34
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trf-1 33
  • 44.57 (n)
Y110A7A.2 34
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
ManyToMany
Species where no ortholog for TRAF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF5 Gene

ENSEMBL:
Gene Tree for TRAF5 (if available)
TreeFam:
Gene Tree for TRAF5 (if available)

Paralogs for TRAF5 Gene

Paralogs for TRAF5 Gene

(4) SIMAP similar genes for TRAF5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRAF5: view

Variants for TRAF5 Gene

Sequence variations from dbSNP and Humsavar for TRAF5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000128516 -- 211,345,365(+) CTCCC(A/C)CCCCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000156736 -- 211,354,079(+) TGGAA(C/T)AGGAC intron-variant
rs1000194738 -- 211,350,215(+) TTTTC(-/TTTCT)TTTTT intron-variant
rs1000282282 -- 211,374,230(+) AACAA(C/T)AACAA utr-variant-3-prime
rs1000344900 -- 211,330,769(+) TCCCC(A/G)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF5 Gene

Variant ID Type Subtype PubMed ID
esv2762141 CNV loss 21179565
esv3588730 CNV loss 21293372
nsv508059 OTHER sequence alteration 20534489

Variation tolerance for TRAF5 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF5 Gene

Disorders for TRAF5 Gene

Relevant External Links for TRAF5

Genetic Association Database (GAD)
TRAF5
Human Genome Epidemiology (HuGE) Navigator
TRAF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAF5

No disorders were found for TRAF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAF5 Gene

Publications for TRAF5 Gene

  1. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PMID: 18990758) Cerhan JR … Slager SL (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 22 45 60
  2. Investigation of association between the TRAF family genes and RA susceptibility. (PMID: 17277003) Potter C … Barton A (Annals of the rheumatic diseases 2007) 3 22 45 60
  3. TRAF family proteins link PKR with NF-kappa B activation. (PMID: 15121867) Gil J … Esteban M (Molecular and cellular biology 2004) 3 4 22 60
  4. Tumor necrosis factor receptor-associated factors (TRAFs). (PMID: 11607847) Bradley JR … Pober JS (Oncogene 2001) 3 4 22 60
  5. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. (PMID: 10908663) Shu HB … Johnson H (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 22 60

Products for TRAF5 Gene

  • Addgene plasmids for TRAF5

Sources for TRAF5 Gene

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