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Aliases for TRAF3 Gene

Aliases for TRAF3 Gene

  • TNF Receptor-Associated Factor 3 2 3
  • CD40bp 3 4 6
  • CRAF1 3 4 6
  • CAP1 3 4 6
  • LAP1 3 4 6
  • LMP1-Associated Protein 1 3 4
  • IIAE5 3 6
  • CAP-1 3 4
  • CD40 Receptor Associated Factor 1 3
  • CD40 Receptor-Associated Factor 1 4
  • CD40 Associated Protein 1 3
  • CD40 Binding Protein 3
  • CD40-Binding Protein 4
  • EC 6.3.2.- 4

External Ids for TRAF3 Gene

Previous GeneCards Identifiers for TRAF3 Gene

  • GC14P100636
  • GC14P097059
  • GC14P101233
  • GC14P102313
  • GC14P103243
  • GC14P083420

Summaries for TRAF3 Gene

Entrez Gene Summary for TRAF3 Gene

  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]

GeneCards Summary for TRAF3 Gene

TRAF3 (TNF Receptor-Associated Factor 3) is a Protein Coding gene. Diseases associated with TRAF3 include herpes simplex encephalitis 3 and herpes simplex encephalitis. Among its related pathways are Pathways in cancer and L1CAM interactions. GO annotations related to this gene include protein kinase binding and signal transducer activity. An important paralog of this gene is TRAF5.

UniProtKB/Swiss-Prot for TRAF3 Gene

  • Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote Lys-63-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

Gene Wiki entry for TRAF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF3 Gene

Genomics for TRAF3 Gene

Regulatory Elements for TRAF3 Gene

Transcription factor binding sites by QIAGEN in the TRAF3 gene promoter:

Genomic Location for TRAF3 Gene

Start:
102,777,476 bp from pter
End:
102,911,500 bp from pter
Size:
134,025 bases
Orientation:
Plus strand

Genomic View for TRAF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF3 Gene

Proteins for TRAF3 Gene

  • Protein details for TRAF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13114-TRAF3_HUMAN
    Recommended name:
    TNF receptor-associated factor 3
    Protein Accession:
    Q13114
    Secondary Accessions:
    • B7Z8C4
    • Q12990
    • Q13076
    • Q13947
    • Q6AZX1
    • Q9UNL1

    Protein attributes for TRAF3 Gene

    Size:
    568 amino acids
    Molecular mass:
    64490 Da
    Quaternary structure:
    • Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP, TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with RNF216, MAVS, OPTN and TBK1. Identified in a complex with TRAF2, MAP3K14 and BIRC3. Interacts with BIRC2 and BIRC3. Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4, TRAF3, TRAF6, IKBKG, MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N (By similarity). Interacts with Epstein-Barr virus protein LMP1. Interacts (via RING-type zinc finger domain) with SRC. Interacts with CARD14. Interacts (via MATH domain) with PTPN22; the interaction promotes TRAF3 polyubiquitination (PubMed:23871208).

    Three dimensional structures from OCA and Proteopedia for TRAF3 Gene

    Alternative splice isoforms for TRAF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF3 Gene

Proteomics data for TRAF3 Gene at MOPED

Post-translational modifications for TRAF3 Gene

  • Undergoes Lys-48-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. Lys-48-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes Lys-63-linked ubiquitination during early stages of virus infection, and Lys-48-linked ubiquitination during later stages. Undergoes both Lys-48-linked and Lys-63-linked ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated by OTUB1, OTUB2 and OTUD5.
  • Ubiquitination at Lys107, Lys156, and Lys369
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRAF3 (TRAF3)

No data available for DME Specific Peptides for TRAF3 Gene

Domains for TRAF3 Gene

Suggested Antigen Peptide Sequences for TRAF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13114

UniProtKB/Swiss-Prot:

TRAF3_HUMAN :
  • Q13114
Domain:
  • The MATH/TRAF domain binds to receptor cytoplasmic domains
  • The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic processing.
  • Contains 1 MATH domain.
Family:
  • Belongs to the TNF receptor-associated factor family. A subfamily.
Similarity:
  • Contains 1 RING-type zinc finger.
  • Contains 2 TRAF-type zinc fingers.
genes like me logo Genes that share domains with TRAF3: view

No data available for Gene Families for TRAF3 Gene

Function for TRAF3 Gene

Molecular function for TRAF3 Gene

GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor associated factor 3,expressed in B cells,interacting with the cytoplasmic tail of CD40 (TNFRSF5) and other TNF receptor family members,and activating NFKB
UniProtKB/Swiss-Prot Function:
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote Lys-63-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

Enzyme Numbers (IUBMB) for TRAF3 Gene

Gene Ontology (GO) - Molecular Function for TRAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0004871 signal transducer activity TAS 7530216
GO:0005164 tumor necrosis factor receptor binding IPI 11728344
GO:0005515 protein binding IPI 10791955
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRAF3: view
genes like me logo Genes that share phenotypes with TRAF3: view

Animal Models for TRAF3 Gene

MGI Knock Outs for TRAF3:

Animal Model Products

miRNA for TRAF3 Gene

miRTarBase miRNAs that target TRAF3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAF3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TRAF3 Gene

Localization for TRAF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF3 Gene

Cytoplasm. Endosome. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAF3 Gene COMPARTMENTS Subcellular localization image for TRAF3 gene
Compartment Confidence
mitochondrion 5
cytosol 4
nucleus 3
plasma membrane 3
endosome 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TRAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0009898 cytoplasmic side of plasma membrane ISS --
GO:0035631 CD40 receptor complex ISS --
genes like me logo Genes that share ontologies with TRAF3: view

Pathways for TRAF3 Gene

genes like me logo Genes that share pathways with TRAF3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for TRAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production ISS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 7530216
genes like me logo Genes that share ontologies with TRAF3: view

Compounds for TRAF3 Gene

(30) Novoseek inferred chemical compound relationships for TRAF3 Gene

Compound -log(P) Hits PubMed IDs
17-(allylamino)-17-demethoxygeldanamycin 60.6 1
threonine 56 15
bcma 49.5 2
serine 46.3 16
geldanamycin 45.6 2
genes like me logo Genes that share compounds with TRAF3: view

Transcripts for TRAF3 Gene

Unigene Clusters for TRAF3 Gene

TNF receptor-associated factor 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3: - -

Relevant External Links for TRAF3 Gene

GeneLoc Exon Structure for
TRAF3
ECgene alternative splicing isoforms for
TRAF3

Expression for TRAF3 Gene

mRNA expression in normal human tissues for TRAF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TRAF3 Gene

This gene is overexpressed in Retina (16.1), Heart (15.2), Fetal Brain (11.5), Adipocyte (9.1), Placenta (7.0), and Spinal cord (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF3 Gene

SOURCE GeneReport for Unigene cluster for TRAF3 Gene Hs.510528

genes like me logo Genes that share expressions with TRAF3: view

Expression partners for TRAF3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAF3 Gene

Orthologs for TRAF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAF3 35
  • 88.03 (n)
  • 94.72 (a)
TRAF3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAF3 35
  • 90.79 (n)
  • 96.13 (a)
TRAF3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traf3 35
  • 89.07 (n)
  • 96.3 (a)
Traf3 16
Traf3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAF3 35
  • 99.65 (n)
  • 99.82 (a)
TRAF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Traf3 35
  • 88.71 (n)
  • 95.24 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAF3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF3 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAF3 35
  • 79.6 (n)
  • 88.01 (a)
TRAF3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia traf3 35
  • 73.26 (n)
  • 79.32 (a)
zebrafish
(Danio rerio)
Actinopterygii traf3 35
  • 58.73 (n)
  • 56.44 (a)
traf3 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1068 35
fruit fly
(Drosophila melanogaster)
Insecta Traf-like 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trf-1 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7175 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for TRAF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF3 Gene

ENSEMBL:
Gene Tree for TRAF3 (if available)
TreeFam:
Gene Tree for TRAF3 (if available)

Paralogs for TRAF3 Gene

Paralogs for TRAF3 Gene

Selected SIMAP similar genes for TRAF3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRAF3: view

Variants for TRAF3 Gene

Sequence variations from dbSNP and Humsavar for TRAF3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs941589 -- 102,874,719(+) gatca(C/T)ggctc intron-variant
rs941726 -- 102,783,339(+) AGTTT(C/T)ATTTG intron-variant
rs1046299 -- 102,910,988(+) AGGGC(A/G)GTGTC utr-variant-3-prime
rs1051742 -- 102,905,430(-) TTATA(A/G)CCAAA reference, synonymous-codon
rs1051743 -- 102,903,404(-) CCCGC(A/G)CTCTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRAF3 Gene

Variant ID Type Subtype PubMed ID
nsv902258 CNV Gain 21882294
esv27166 CNV Loss 19812545
nsv483032 CNV Gain 15286789
esv1008810 CNV Deletion 20482838
esv2749151 CNV Deletion 23290073
nsv902259 CNV Loss 21882294
nsv902260 CNV Gain 21882294
esv2672373 CNV Deletion 23128226
nsv519641 CNV Loss 19592680
nsv509552 CNV Insertion 20534489
dgv1985n71 CNV Loss 21882294
nsv902263 CNV Loss 21882294
nsv9167 CNV Gain 18304495

Relevant External Links for TRAF3 Gene

HapMap Linkage Disequilibrium report
TRAF3
Human Gene Mutation Database (HGMD)
TRAF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF3 Gene

Disorders for TRAF3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TRAF3 Gene in MalaCards »

(4) Diseases for TRAF3 Gene including...

(1) OMIM Diseases for TRAF3 Gene (601896)

UniProtKB/Swiss-Prot

TRAF3_HUMAN
  • Herpes simplex encephalitis 3 (HSE3) [MIM:614849]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269 PubMed:20832341}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for TRAF3 Gene

(23) Novoseek inferred disease relationships for TRAF3 Gene

Disease -log(P) Hits PubMed IDs
necrosis 60 24
tumors 51.8 48
hodgkin disease 33 5
lymphoproliferative disorders 22.6 1
lymphoma 12.6 4

Relevant External Links for TRAF3

Genetic Association Database (GAD)
TRAF3
Human Genome Epidemiology (HuGE) Navigator
TRAF3
genes like me logo Genes that share disorders with TRAF3: view

No data available for Genatlas for TRAF3 Gene

Publications for TRAF3 Gene

  1. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. (PMID: 7859281) Mosialos G. … Kieff E. (Cell 1995) 2 3 4 23
  2. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5- mediated NF-kappaB activation. (PMID: 9488716) Kawamata S. … Uchiyama T. (J. Biol. Chem. 1998) 3 4 23
  3. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. (PMID: 9718306) Pullen S.S. … Kehry M.R. (Biochemistry 1998) 3 4 23
  4. A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation. (PMID: 10199393) van Eyndhoven W.G. … Lederman S. (Mol. Immunol. 1998) 3 4 23
  5. MIP-T3, a novel protein linking tumor necrosis factor receptor- associated factor 3 to the microtubule network. (PMID: 10791955) Ling L. … Goeddel D.V. (J. Biol. Chem. 2000) 3 4 23

Products for TRAF3 Gene

  • Addgene plasmids for TRAF3

Sources for TRAF3 Gene

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