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Aliases for NR2C2 Gene

Aliases for NR2C2 Gene

  • Nuclear Receptor Subfamily 2 Group C Member 2 2 3 5
  • Orphan Nuclear Receptor TAK1 3 4
  • Orphan Nuclear Receptor TR4 3 4
  • TAK1 3 4
  • TR4 3 4
  • Nuclear Receptor Subfamily 2, Group C, Member 2 2
  • Testicular Nuclear Receptor 4 3
  • Nuclear Hormone Receptor TR4 3
  • Testicular Receptor 4 4
  • Orphan Receptor TR4 3

External Ids for NR2C2 Gene

Previous HGNC Symbols for NR2C2 Gene

  • TR4

Previous GeneCards Identifiers for NR2C2 Gene

  • GC03P014918
  • GC03P014964
  • GC03P014989

Summaries for NR2C2 Gene

Entrez Gene Summary for NR2C2 Gene

  • This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

GeneCards Summary for NR2C2 Gene

NR2C2 (Nuclear Receptor Subfamily 2 Group C Member 2) is a Protein Coding gene. Among its related pathways are Non-Canonical Wnt Pathway and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is NR2C1.

UniProtKB/Swiss-Prot for NR2C2 Gene

  • Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5-AGGTCA-3 half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

Gene Wiki entry for NR2C2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2C2 Gene

Genomics for NR2C2 Gene

Regulatory Elements for NR2C2 Gene

Enhancers for NR2C2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G015305 1.5 Ensembl ENCODE dbSUPER 4.8 +358.4 358401 1.6 HDGF PKNOX1 ATF1 ARNT SIN3A E2F7 TCF12 ZNF766 ELK1 GATA2 RNU6-454P SH3BP5 NR2C2 GC03P015339 PIR49400
GH03G014450 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4 -494.3 -494286 5.0 FOXA2 ARNT ARID4B SIN3A FEZF1 GLI4 ZNF48 ZNF121 GLIS2 GATA2 SH3BP5-AS1 SLC6A6 CAPN7 ENSG00000228242 FGD5 TMEM43 CCDC174 NR2C2 XPC GC03P014432
GH03G015287 2.1 FANTOM5 Ensembl ENCODE dbSUPER 2.8 +344.9 344868 10.9 HNRNPUL1 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B YY1 CBX5 SH3BP5 CAPN7 EAF1 RPS24P10 SH3BP5-AS1 RNU6-454P COL6A4P1 RNU6-1024P EAF1-AS1 RPS3AP53
GH03G015243 0.8 FANTOM5 dbSUPER 4.4 +296.5 296499 0.2 PKNOX1 ZKSCAN1 CAPN7 COL6A4P1 NR2C2 RBSN SH3BP5 SH3BP5-AS1
GH03G015313 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.6 +368.3 368264 5.1 HDGF TBP PKNOX1 WRNIP1 BMI1 ZBTB40 ZNF121 ETV6 RELB IKZF2 SH3BP5 EAF1 SH3BP5-AS1 EAF1-AS1 COLQ CAPN7 NR2C2 ANKRD28 GC03P015339 PIR49400
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NR2C2 on UCSC Golden Path with GeneCards custom track

Promoters for NR2C2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000148998 116 2601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766

Genomic Location for NR2C2 Gene

Chromosome:
3
Start:
14,947,584 bp from pter
End:
15,053,600 bp from pter
Size:
106,017 bases
Orientation:
Plus strand

Genomic View for NR2C2 Gene

Genes around NR2C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR2C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR2C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2C2 Gene

Proteins for NR2C2 Gene

  • Protein details for NR2C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49116-NR2C2_HUMAN
    Recommended name:
    Nuclear receptor subfamily 2 group C member 2
    Protein Accession:
    P49116
    Secondary Accessions:
    • A8K3H5
    • B6ZGT8
    • P55092

    Protein attributes for NR2C2 Gene

    Size:
    596 amino acids
    Molecular mass:
    65414 Da
    Quaternary structure:
    • Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with PCAF; the interaction preferentially occurs on the non-phosphorylated form and induces NR2C2-mediated transactivation activity and does not require the ligand-binding domain (By similarity). Interacts (MAPK-mediated phosphorylated form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity (PubMed:9556573). Interacts with NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity (PubMed:12486131). Interacts with NLRP10 (PubMed:22672233). Interacts (via ligand-binding region) with transcriptional corepressor JAZF1; the interaction promotes NR2C2-mediated transcriptional repression (PubMed:15302918).

    Three dimensional structures from OCA and Proteopedia for NR2C2 Gene

    Alternative splice isoforms for NR2C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2C2 Gene

Post-translational modifications for NR2C2 Gene

  • Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NR2C2 Gene

Domains & Families for NR2C2 Gene

Gene Families for NR2C2 Gene

Suggested Antigen Peptide Sequences for NR2C2 Gene

Graphical View of Domain Structure for InterPro Entry

P49116

UniProtKB/Swiss-Prot:

NR2C2_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with NR2C2: view

Function for NR2C2 Gene

Molecular function for NR2C2 Gene

GENATLAS Biochemistry:
nuclear receptor subfamily 2,group C,member 2,with two isoforms short TR4ORA2,long TR4ORA1,predominantly expressed in granule cell of the hippocampus and cerebellum,steroid/thyroid hormone receptor superfamily
UniProtKB/Swiss-Prot Function:
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5-AGGTCA-3 half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
UniProtKB/Swiss-Prot Induction:
Induced by oxidative stress via FOXO3 activation.

Gene Ontology (GO) - Molecular Function for NR2C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 9556573
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10644740
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10644740
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 9556573
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NR2C2: view
genes like me logo Genes that share phenotypes with NR2C2: view

Animal Models for NR2C2 Gene

MGI Knock Outs for NR2C2:

Animal Model Products

CRISPR Products

miRNA for NR2C2 Gene

miRTarBase miRNAs that target NR2C2
Targeted motifs for NR2C2 Gene
HOMER Transcription Factor Regulatory Elements motif NR2C2
  • Consensus sequence: GAGGTCAAAGGTCA Submotif: DR1 Cell Type: Hela GEO ID: GSE24685

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NR2C2 Gene

Localization for NR2C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2C2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR2C2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NR2C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with NR2C2: view

Pathways & Interactions for NR2C2 Gene

genes like me logo Genes that share pathways with NR2C2: view

SIGNOR curated interactions for NR2C2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NR2C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 9006963
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007283 spermatogenesis IEA --
GO:0007399 nervous system development TAS 9006963
genes like me logo Genes that share ontologies with NR2C2: view

Drugs & Compounds for NR2C2 Gene

(5) Drugs for NR2C2 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra binder 228
retinol Nutra Full agonist, Agonist 492

(4) Additional Compounds for NR2C2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
all-trans-retinoic acid
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • Acide retinoique (French)
Full agonist, Agonist 302-79-4
genes like me logo Genes that share compounds with NR2C2: view

Transcripts for NR2C2 Gene

Unigene Clusters for NR2C2 Gene

Nuclear receptor subfamily 2, group C, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for NR2C2 Gene

GeneLoc Exon Structure for
NR2C2
ECgene alternative splicing isoforms for
NR2C2

Expression for NR2C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR2C2 Gene

Protein differential expression in normal tissues from HIPED for NR2C2 Gene

This gene is overexpressed in Tlymphocyte (12.1), Peripheral blood mononuclear cells (11.7), CD8 Tcells (9.2), and Plasma (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NR2C2 Gene



Protein tissue co-expression partners for NR2C2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NR2C2 Gene:

NR2C2

SOURCE GeneReport for Unigene cluster for NR2C2 Gene:

Hs.555973

Evidence on tissue expression from TISSUES for NR2C2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with NR2C2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2C2 Gene

Orthologs for NR2C2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2C2 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia NR2C2 34 35
  • 94.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NR2C2 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr2c2 34 16 35
  • 92.56 (n)
rat
(Rattus norvegicus)
Mammalia Nr2c2 34
  • 91.89 (n)
cow
(Bos Taurus)
Mammalia NR2C2 34 35
  • 90.64 (n)
oppossum
(Monodelphis domestica)
Mammalia NR2C2 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR2C2 34 35
  • 81.18 (n)
lizard
(Anolis carolinensis)
Reptilia NR2C2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr2c2 34
  • 78.26 (n)
zebrafish
(Danio rerio)
Actinopterygii nr2c2 34 35
  • 72.81 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5700 34
fruit fly
(Drosophila melanogaster)
Insecta Hr78 36 35
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea nhr-41 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9698 35
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4782 34
Species where no ortholog for NR2C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR2C2 Gene

ENSEMBL:
Gene Tree for NR2C2 (if available)
TreeFam:
Gene Tree for NR2C2 (if available)

Paralogs for NR2C2 Gene

Variants for NR2C2 Gene

Sequence variations from dbSNP and Humsavar for NR2C2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000017575 -- 15,042,951(+) CCCTA(C/T)ATCCT nc-transcript-variant, reference, synonymous-codon
rs1000043493 -- 14,973,426(+) ACAGG(A/G)TCTTG intron-variant
rs1000047549 -- 15,006,820(+) GCCCA(A/G)GCTGG intron-variant
rs1000056973 -- 14,958,968(+) AGACT(C/T)CGTCT intron-variant, upstream-variant-2KB
rs1000103870 -- 14,971,723(+) TTGCA(C/T)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NR2C2 Gene

Variant ID Type Subtype PubMed ID
esv2663121 CNV deletion 23128226
esv2759130 CNV gain 17122850
esv3595377 CNV gain 21293372
esv3595378 CNV loss 21293372
nsv1074573 CNV deletion 25765185
nsv834620 CNV gain 17160897
nsv955319 CNV duplication 24416366

Variation tolerance for NR2C2 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NR2C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR2C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2C2 Gene

Disorders for NR2C2 Gene

Relevant External Links for NR2C2

Genetic Association Database (GAD)
NR2C2
Human Genome Epidemiology (HuGE) Navigator
NR2C2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NR2C2

No disorders were found for NR2C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NR2C2 Gene

Publications for NR2C2 Gene

  1. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. (PMID: 17974920) Tanabe O. … Engel J.D. (Genes Dev. 2007) 3 4 22 64
  2. Identification of a novel testicular orphan receptor-4 (TR4)- associated protein as repressor for the selective suppression of TR4- mediated transactivation. (PMID: 12486131) Yang Y. … Chang C. (J. Biol. Chem. 2003) 3 4 22 64
  3. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PMID: 10644740) Zhang Y. … Dufau M.L. (J. Biol. Chem. 2000) 3 4 22 64
  4. New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene. (PMID: 8661150) Yoshikawa T. … Detera-Wadleigh S.D. (Genomics 1996) 2 3 22 64
  5. TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. (PMID: 7708055) Hirose T. … Jetten A.M. (Mol. Endocrinol. 1994) 3 4 22 64

Products for NR2C2 Gene

Sources for NR2C2 Gene

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