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Aliases for C3 Gene

Aliases for C3 Gene

  • Complement Component 3 2 3
  • C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 1 3 4
  • Complement Component C3a 2 3
  • Complement Component C3b 2 3
  • C3a Anaphylatoxin 2 3
  • Prepro-C3 2 3
  • CPAMD1 3 4
  • AHUS5 3 6
  • ARMD9 3 6
  • Epididymis Secretory Sperm Binding Protein Li 62p 3
  • Acylation-Stimulating Protein Cleavage Product 3
  • Complement Component C3 3
  • Complement C3 3
  • HEL-S-62p 3
  • ASP 3
  • C3a 3
  • C3b 3

External Ids for C3 Gene

Previous GeneCards Identifiers for C3 Gene

  • GC19M006772
  • GC19M006617
  • GC19M006628
  • GC19M006440

Summaries for C3 Gene

Entrez Gene Summary for C3 Gene

  • Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. A peptide (C3a) derived from the encoded protein has antimicrobial activity, so people with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Nov 2014]

GeneCards Summary for C3 Gene

C3 (Complement Component 3) is a Protein Coding gene. Diseases associated with C3 include hemolytic uremic syndrome, atypical 5 and macular degeneration, age-related, 9. Among its related pathways are Signaling by GPCR and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include receptor binding and C5L2 anaphylatoxin chemotactic receptor binding. An important paralog of this gene is CD109.

UniProtKB/Swiss-Prot for C3 Gene

  • C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates

  • Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

  • C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation.

  • Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750).

Tocris Summary for C3 Gene

  • The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis, triggering inflammation and immune clearance. There are three pathways that can activate the complement system; the classical complement pathway (in response to IgG- or IgM-antigen complexes), the alternative complement pathway (spontaneous activation) and the mannose-binding lectin pathway (in response to lectin residues on pathogen cell surface membranes). All three pathway generate variants of C3 convertase, which cleaves C3 into C3a and C3b. C3a and C3b activate a series of further cleavage events that activates the complement cascade. This leads to immune defence responses such as degranulation of mast cells, increasing vascular permeability and initiation of the membrane attack pathway. Deregulation of the complement system would be extremely damaging to the host, so it is tightly regulated by complement control proteins. These regulatory proteins are found in much higher concentrations that complement proteins themselves and prevent complement system activation in 'self' tissues. The complement system has been implicated in many autoimmune disorders, including systemic lupus erythematosus, multiple sclerosis and arthritis, and more recently has been suggested to have a pathophysiological role in Alzheimer's and other neurodegenerative disorders.

Gene Wiki entry for C3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3 Gene

Genomics for C3 Gene

Regulatory Elements for C3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C3 Gene

Start:
6,677,704 bp from pter
End:
6,730,562 bp from pter
Size:
52,859 bases
Orientation:
Minus strand

Genomic View for C3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3 Gene

Proteins for C3 Gene

  • Protein details for C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01024-CO3_HUMAN
    Recommended name:
    Complement C3
    Protein Accession:
    P01024
    Secondary Accessions:
    • A7E236

    Protein attributes for C3 Gene

    Size:
    1663 amino acids
    Molecular mass:
    187148 Da
    Quaternary structure:
    • C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with VSIG4. C3b interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 2 (HHV-2) envelope glycoprotein C; this interaction inhibits the activation of the complement system. Interacts with S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2. Interacts with S.aureus fib. Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.

    Three dimensional structures from OCA and Proteopedia for C3 Gene

neXtProt entry for C3 Gene

Proteomics data for C3 Gene at MOPED

Post-translational modifications for C3 Gene

  • C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha chain fragment 1 + alpha chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons
  • Phosphorylation sites are present in the extracellular medium
  • Glycosylation at Asn85, Asn939, and Asn1617
  • Modification sites at PhosphoSitePlus

Other Protein References for C3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C3 (Complement Component C3a)
  • R&D Systems Antibodies for C3 (Complement Component C3d)

Assay Products

  • Enzo Life Sciences assays for C3
  • antibodies-online kits for C3

No data available for DME Specific Peptides for C3 Gene

Domains for C3 Gene

Gene Families for C3 Gene

HGNC:

Suggested Antigen Peptide Sequences for C3 Gene

Graphical View of Domain Structure for InterPro Entry

P01024

UniProtKB/Swiss-Prot:

CO3_HUMAN :
  • P01024
Domain:
  • Contains 1 anaphylatoxin-like domain.
  • Contains 1 NTR domain.
genes like me logo Genes that share domains with C3: view

Function for C3 Gene

Molecular function for C3 Gene

GENATLAS Biochemistry: complement component 3,glycoprotein,180kDa,activated by classical or alternative pathway with two forms,C3a (anaphylatoxin),C3b (opsonin)
UniProtKB/Swiss-Prot Function: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates
UniProtKB/Swiss-Prot Function: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
UniProtKB/Swiss-Prot Function: C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation.
UniProtKB/Swiss-Prot Function: Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750).

Gene Ontology (GO) - Molecular Function for C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity IEA --
GO:0005102 receptor binding TAS 9164946
GO:0005515 protein binding IPI 11705926
GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding IDA 15833747
genes like me logo Genes that share ontologies with C3: view
genes like me logo Genes that share phenotypes with C3: view

Animal Models for C3 Gene

MGI Knock Outs for C3:
  • C3 tm1Hrc
  • C3 tm1Crr
  • C3 tm1Pkna

Animal Model Products

CRISPR Products

miRNA for C3 Gene

miRTarBase miRNAs that target C3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for C3 Gene

Localization for C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C3 Gene COMPARTMENTS Subcellular localization image for C3 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
nucleus 3
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 21362503
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with C3: view

Pathways for C3 Gene

genes like me logo Genes that share pathways with C3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001798 positive regulation of type IIa hypersensitivity IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 15833747
GO:0001970 positive regulation of activation of membrane attack complex IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with C3: view

Compounds for C3 Gene

(4) Tocris Compounds for C3 Gene

Compound Action Cas Number
Compstatin C3-binding protein, inhibits complement activation [206645-99-0]
Compstatin control peptide Control peptide for Compstatin (Cat. No. 2585) [301544-78-5]
NDT 9513727 Potent, selective human C5a receptor antagonist [439571-48-9]
PMX 205 Potent C5a receptor peptide antagonist [514814-49-4]

(2) Drugbank Compounds for C3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Intravenous Immunoglobulin
  • Ig alpha-2 chain C region
9007-83-4 target binder
S-Hydroxycysteine
target

(30) Novoseek inferred chemical compound relationships for C3 Gene

Compound -log(P) Hits PubMed IDs
anaphylatoxin 72.2 6
triacylglycerol 61.6 30
fatty acid 46.6 24
glucose 42.8 70
lipid 37 36
genes like me logo Genes that share compounds with C3: view

Transcripts for C3 Gene

mRNA/cDNA for C3 Gene

Unigene Clusters for C3 Gene

Complement component 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35a · 35b ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42a · 42b
SP1: - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for C3 Gene

GeneLoc Exon Structure for
C3
ECgene alternative splicing isoforms for
C3

Expression for C3 Gene

mRNA expression in normal human tissues for C3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C3 Gene

This gene is overexpressed in Liver (20.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C3 Gene

SOURCE GeneReport for Unigene cluster for C3 Gene Hs.529053

mRNA Expression by UniProt/SwissProt for C3 Gene

P01024-CO3_HUMAN
Tissue specificity: Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods.
genes like me logo Genes that share expressions with C3: view

In Situ Assay Products

Orthologs for C3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3 35
  • 98.77 (n)
  • 98.36 (a)
C3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3 35
  • 81.14 (n)
  • 77.17 (a)
C3 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C3 35
  • 80.09 (n)
  • 74.3 (a)
C3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C3 35
  • 79.06 (n)
  • 77.11 (a)
C3 16
C3 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C3 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C3 35
  • 79.8 (n)
  • 78.98 (a)
chicken
(Gallus gallus)
Aves C3 35
  • 63.12 (n)
  • 54.86 (a)
C3D 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c3 35
  • 58.83 (n)
  • 52.22 (a)
Str.2323 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
C3 (1 of 9) 36
  • 36 (a)
OneToMany
C3 (3 of 9) 36
  • 39 (a)
OneToMany
C3 (5 of 9) 36
  • 45 (a)
OneToMany
C3 (7 of 9) 36
  • 41 (a)
OneToMany
C3 (8 of 9) 36
  • 36 (a)
OneToMany
C3 (9 of 9) 36
  • 42 (a)
OneToMany
c3a 36
  • 43 (a)
OneToMany
c3b 36
  • 43 (a)
OneToMany
c3c 36
  • 43 (a)
OneToMany
LOC100331428 35
  • 53.68 (n)
  • 45.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
CSA.4097 36
  • 21 (a)
ManyToMany
Species with no ortholog for C3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3 Gene

ENSEMBL:
Gene Tree for C3 (if available)
TreeFam:
Gene Tree for C3 (if available)

Paralogs for C3 Gene

Paralogs for C3 Gene

Selected SIMAP similar genes for C3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for C3 Gene

genes like me logo Genes that share paralogs with C3: view

Variants for C3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for C3 Gene

P01024-CO3_HUMAN
There are two alleles: C3S (C3 slow), the most common allele in all races and C3F (C3 fast), relatively frequent in Caucasians, less common in Black Americans, extremely rare in Orientals

Sequence variations from dbSNP and Humsavar for C3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7951 -- 6,681,980(-) AAAGC(C/T)TTCTC reference, synonymous-codon
rs17030 -- 6,677,978(+) TCCTC(A/G)GGCCA reference, synonymous-codon
rs163913 -- 6,722,624(+) atgca(C/T)tggta upstream-variant-2KB
rs182940 -- 6,683,443(-) aatag(A/T)ataaa intron-variant
rs189367 -- 6,710,561(+) agaga(A/G)agagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3 Gene

Variant ID Type Subtype PubMed ID
nsv910925 CNV Loss 21882294
nsv910926 CNV Gain 21882294
dgv3701n71 CNV Gain 21882294
nsv910928 CNV Gain 21882294
dgv3702n71 CNV Gain 21882294
nsv910932 CNV Gain 21882294
esv33172 CNV Gain 17666407
esv2265092 CNV Deletion 18987734
esv2718067 CNV Deletion 23290073
esv2718068 CNV Deletion 23290073
nsv470120 CNV Loss 18288195
dgv3703n71 CNV Loss 21882294
esv2718069 CNV Deletion 23290073
dgv14e196 CNV Duplication 17116639
esv5110 CNV Deletion 18987735
esv2677585 CNV Deletion 23128226
esv2718070 CNV Deletion 23290073
dgv3704n71 CNV Loss 21882294
dgv3705n71 CNV Gain 21882294

Relevant External Links for C3 Gene

HapMap Linkage Disequilibrium report
C3
Human Gene Mutation Database (HGMD)
C3
Locus Specific Mutation Databases (LSDB)
C3

Disorders for C3 Gene

(3) OMIM Diseases for C3 Gene (120700)

UniProtKB/Swiss-Prot

CO3_HUMAN
  • Complement component 3 deficiency (C3D) [MIM:613779]: A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis. {ECO:0000269 PubMed:7961791, ECO:0000269 Ref.50}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Macular degeneration, age-related, 9 (ARMD9) [MIM:611378]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. {ECO:0000269 PubMed:17634448, ECO:0000269 PubMed:24036952}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. {ECO:0000269 PubMed:18796626, ECO:0000269 PubMed:20513133}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype.
  • Note=Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage.

(37) Novoseek inferred disease relationships for C3 Gene

Disease -log(P) Hits PubMed IDs
afibrinogenemia 65.7 1
complement deficiency 65.6 1
hyperlipidemia familial combined 55.9 3
lipodystrophy 51.2 1
glomerulonephritis membranoproliferative 48.8 1

Genatlas disease for C3 Gene

glomerulonephritis,pyogenic recurrent infections,lupus systemic syndrome

Relevant External Links for C3

Genetic Association Database (GAD)
C3
Human Genome Epidemiology (HuGE) Navigator
C3
genes like me logo Genes that share disorders with C3: view

Publications for C3 Gene

  1. Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (Asp549 to Asn) impairs C3 secretion. (PMID: 7961791) Singer L. … Wetsel R.A. (J. Biol. Chem. 1994) 3 4 23
  2. Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line. (PMID: 9059512) Tao Y. … Germinario R.J. (Biochim. Biophys. Acta 1997) 3 4 23
  3. Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity. (PMID: 10432298) Murray I. … Cianflone K. (Biochem. J. 1999) 3 4 23
  4. Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period. (PMID: 9555951) Saleh J. … Frayn K.N. (J. Lipid Res. 1998) 3 4 23
  5. [Analysis of heterozygosity levels at P1,TF, PGM1, ACP1, HP, GC, GLO, C3, and ESD loci in pulmonary tuberculosis patients with different treatment outcomes]. (PMID: 11785295) Sergeev A.S. … Perel'man M.I. (Genetika 2001) 3 23 48

Products for C3 Gene

  • Addgene plasmids for C3

Sources for C3 Gene

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