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Aliases for TPM4 Gene

Aliases for TPM4 Gene

  • Tropomyosin 4 2 3 5
  • TM30p1 3 4
  • Epididymis Secretory Protein Li 108 3
  • Tropomyosin Alpha-4 Chain 3
  • Tropomyosin-4 4
  • HEL-S-108 3

External Ids for TPM4 Gene

Previous GeneCards Identifiers for TPM4 Gene

  • GC19P016682
  • GC19P016571
  • GC19P016023
  • GC19P016048
  • GC19P016039
  • GC19P016178
  • GC19P015749
  • GC19P017060
  • GC19P017322
  • GC19P017852
  • GC19P016069
  • GC19P016765
  • GC19P017020
  • GC19P018205
  • GC19P018599
  • GC19P018916
  • GC19P019244

Summaries for TPM4 Gene

Entrez Gene Summary for TPM4 Gene

  • This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for TPM4 Gene

TPM4 (Tropomyosin 4) is a Protein Coding gene. Diseases associated with TPM4 include Autosomal Dominant Macrothrombocytopenia and Inflammatory Myofibroblastic Tumor. Among its related pathways are Cardiac conduction and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is TPM2.

UniProtKB/Swiss-Prot for TPM4 Gene

  • Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432).

Gene Wiki entry for TPM4 Gene

Additional gene information for TPM4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPM4 Gene

Genomics for TPM4 Gene

GeneHancer (GH) Regulatory Elements for TPM4 Gene

Promoters and enhancers for TPM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I016063 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 585 +5.9 5892 18.7 CLOCK FEZF1 DMAP1 IRF4 E2F8 ZNF143 ZNF263 MCM3 SP3 MEF2D TPM4 AKAP8 CHERP ENSG00000269578 C19orf44 BRD4 ENSG00000267904 ENSG00000268087 SMIM7 MED26
GH19I015123 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.2 -941.8 -941769 3.7 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ILVBL ENSG00000268564 AKAP8 BRD4 ZNF333 TPM4 AKAP8L DDX39A OR1I1 ADGRL1
GH19I015376 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.4 -687.7 -687720 5.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B ZNF766 AKAP8 ENSG00000268189 ZNF333 BRD4 TPM4 DDX39A AKAP8L GC19M015202
GH19I016110 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 +49.2 49154 11 MLX DMAP1 YBX1 IRF4 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC RAB8A CHERP AKAP8 BRD4 ENSG00000268743 ENSG00000269578 HAUS8 C19orf44 ENSG00000267904 ENSG00000268087
GH19I015416 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 -648.6 -648610 3.4 HDGF PKNOX1 SMAD1 FOXA2 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 AKAP8L AKAP8 BRD4 DDX39A NOTCH3 SYDE1 SNRPGP15 TPM4 ENSG00000279716 WIZ
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPM4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPM4 gene promoter:

Genomic Locations for TPM4 Gene

Genomic Locations for TPM4 Gene
chr19:16,067,021-16,103,005
(GRCh38/hg38)
Size:
35,985 bases
Orientation:
Plus strand
chr19:16,177,831-16,213,813
(GRCh37/hg19)

Genomic View for TPM4 Gene

Genes around TPM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPM4 Gene

Proteins for TPM4 Gene

  • Protein details for TPM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67936-TPM4_HUMAN
    Recommended name:
    Tropomyosin alpha-4 chain
    Protein Accession:
    P67936
    Secondary Accessions:
    • P07226
    • Q15659
    • Q5U0D9
    • Q9BU85
    • Q9H8Q3
    • Q9UCS1
    • Q9UCS2
    • Q9UCS3
    • Q9UCS4

    Protein attributes for TPM4 Gene

    Size:
    248 amino acids
    Molecular mass:
    28522 Da
    Quaternary structure:
    • Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.

    Alternative splice isoforms for TPM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPM4 Gene

Post-translational modifications for TPM4 Gene

  • Ubiquitination at isoforms=13, posLast=190190, and posLast=228228

No data available for DME Specific Peptides for TPM4 Gene

Domains & Families for TPM4 Gene

Gene Families for TPM4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TPM4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P67936

UniProtKB/Swiss-Prot:

TPM4_HUMAN :
  • The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • Belongs to the tropomyosin family.
Domain:
  • The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Family:
  • Belongs to the tropomyosin family.
genes like me logo Genes that share domains with TPM4: view

Function for TPM4 Gene

Molecular function for TPM4 Gene

GENATLAS Biochemistry:
tropomyosin 4,alpha,skeletal muscle and non muscle isoforms,dimerizing to form a helical coiled coil binding to actin in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and muscle contraction
UniProtKB/Swiss-Prot Function:
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432).

Phenotypes From GWAS Catalog for TPM4 Gene

Gene Ontology (GO) - Molecular Function for TPM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005509 calcium ion binding NAS 1836432
GO:0005515 protein binding IPI 24407287
GO:0008307 structural constituent of muscle TAS 8641132
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with TPM4: view
genes like me logo Genes that share phenotypes with TPM4: view

Animal Model Products

miRNA for TPM4 Gene

miRTarBase miRNAs that target TPM4

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPM4 Gene

Localization for TPM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPM4 Gene

Cytoplasm, cytoskeleton. Note=Associates with F-actin stress fibers. {ECO:0000250 UniProtKB:P09495}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPM4 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TPM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16236705
GO:0002102 podosome IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton TAS 16130169
genes like me logo Genes that share ontologies with TPM4: view

Pathways & Interactions for TPM4 Gene

genes like me logo Genes that share pathways with TPM4: view

Gene Ontology (GO) - Biological Process for TPM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation HDA 16210410
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0006936 muscle contraction TAS,IBA --
GO:0007015 actin filament organization IBA --
GO:0030049 muscle filament sliding TAS --
genes like me logo Genes that share ontologies with TPM4: view

No data available for SIGNOR curated interactions for TPM4 Gene

Drugs & Compounds for TPM4 Gene

(2) Drugs for TPM4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Phenethyl isothiocyanate Investigational Pharma Target 12
genes like me logo Genes that share compounds with TPM4: view

Transcripts for TPM4 Gene

Unigene Clusters for TPM4 Gene

Tropomyosin 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPM4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - - -
SP7: -

Relevant External Links for TPM4 Gene

GeneLoc Exon Structure for
TPM4
ECgene alternative splicing isoforms for
TPM4

Expression for TPM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPM4 Gene

Protein differential expression in normal tissues from HIPED for TPM4 Gene

This gene is overexpressed in Platelet (9.0) and Bone marrow stromal cell (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPM4 Gene



Protein tissue co-expression partners for TPM4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TPM4 Gene:

TPM4

SOURCE GeneReport for Unigene cluster for TPM4 Gene:

Hs.631618

mRNA Expression by UniProt/SwissProt for TPM4 Gene:

P67936-TPM4_HUMAN
Tissue specificity: Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).

Evidence on tissue expression from TISSUES for TPM4 Gene

  • Nervous system(4.7)
  • Skin(4.4)
  • Blood(4.3)
  • Liver(4.3)
  • Eye(4.2)
  • Heart(2.8)
  • Spleen(2.7)
  • Muscle(2.6)
  • Lung(2.5)
  • Intestine(2.4)
  • Gall bladder(2.3)
  • Kidney(2.1)
  • Stomach(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with TPM4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPM4 Gene

Orthologs for TPM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPM4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPM4 33 34
  • 93.78 (n)
dog
(Canis familiaris)
Mammalia TPM4 33 34
  • 92.72 (n)
oppossum
(Monodelphis domestica)
Mammalia TPM4 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPM4 34
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TPM4 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpm4 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPM4 34
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPM4 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.568 33
zebrafish
(Danio rerio)
Actinopterygii tpm4b 34
  • 78 (a)
ManyToMany
tpm4a 33
  • 76.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tm2 34
  • 46 (a)
ManyToMany
Tm1 34
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lev-11 34
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11015 34
  • 69 (a)
ManyToMany
CSA.10371 34
  • 63 (a)
ManyToMany
Species where no ortholog for TPM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPM4 Gene

ENSEMBL:
Gene Tree for TPM4 (if available)
TreeFam:
Gene Tree for TPM4 (if available)

Paralogs for TPM4 Gene

Paralogs for TPM4 Gene

genes like me logo Genes that share paralogs with TPM4: view

Variants for TPM4 Gene

Sequence variations from dbSNP and Humsavar for TPM4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_036535 A breast cancer sample p.Glu204Gln
rs1000012430 -- 16,074,986(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000112794 -- 16,092,274(+) G/A intron_variant
rs1000162675 -- 16,095,250(+) C/G intron_variant
rs1000308941 -- 16,070,541(+) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPM4 Gene

Variant ID Type Subtype PubMed ID
esv2718258 CNV deletion 23290073
nsv1142254 CNV tandem duplication 24896259
nsv137994 CNV deletion 16902084
nsv479686 CNV novel sequence insertion 20440878
nsv960804 CNV duplication 23825009

Variation tolerance for TPM4 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPM4 Gene

Human Gene Mutation Database (HGMD)
TPM4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPM4 Gene

Disorders for TPM4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TPM4 Gene - From: HGMD, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
autosomal dominant macrothrombocytopenia
inflammatory myofibroblastic tumor
  • inflammatory fibrosarcoma
cerebral atherosclerosis
  • intracranial arteriosclerosis
mesenchymal cell neoplasm
  • benign miscellaneous mesenchymal tumor
- elite association - COSMIC cancer census association via MalaCards
Search TPM4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TPM4

genes like me logo Genes that share disorders with TPM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPM4 Gene

Publications for TPM4 Gene

  1. A systematic nomenclature for mammalian tropomyosin isoforms. (PMID: 25369766) Geeves MA … Gunning PW (Journal of muscle research and cell motility 2015) 2 3 58
  2. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PMID: 22423221) Qayyum R … Reiner AP (PLoS genetics 2012) 3 44 58
  3. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TPM4 Gene

Sources for TPM4 Gene

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