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Aliases for C2 Gene

Aliases for C2 Gene

  • Complement C2 2 3 5
  • Complement Component 2 2 3
  • C3/C5 Convertase 3 4
  • EC 3.4.21.43 4 56
  • Complement Component C2 3
  • EC 3.4.21 56
  • ARMD14 3
  • CO2 3

External Ids for C2 Gene

Previous GeneCards Identifiers for C2 Gene

  • GC06P031957
  • GC06P031636
  • GC06P031999
  • GC06P032003
  • GC06P031865
  • GC06P031682

Summaries for C2 Gene

Entrez Gene Summary for C2 Gene

  • Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

GeneCards Summary for C2 Gene

C2 (Complement C2) is a Protein Coding gene. Diseases associated with C2 include Complement Component 2 Deficiency and Macular Degeneration, Age-Related, 14. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CFB.

UniProtKB/Swiss-Prot for C2 Gene

  • Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

Gene Wiki entry for C2 Gene

Additional gene information for C2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2 Gene

Genomics for C2 Gene

GeneHancer (GH) Regulatory Elements for C2 Gene

Promoters and enhancers for C2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031901 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +4.5 4486 2.9 HDGF ARNT SIN3A DMAP1 ZNF2 ZNF766 E2F8 ZNF207 ZNF143 KLF13 C2 ZBTB12 C4A STK19B SKIV2L DXO PSORS1C2 VWA7 HLA-C HLA-DQB2
GH06I031896 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 80 3.5 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 C2 EHMT2 BAG6 HLA-C MSH5 CCHCR1 CSNK2B SAPCD1 VWA7 SKIV2L
GH06I031927 Promoter/Enhancer 1.4 EPDnew Ensembl 550.3 +29.9 29872 1.1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 RXRA SP5 ZHX2 ENSG00000244255 C2 STK19B ZBTB12
GH06I031861 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 -33.7 -33669 4.5 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 NEU1 LY6G5B LSM2 DDX39B ATF6B GPANK1 MSH5 TCF19 CSNK2B MICA
GH06I031944 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 12.2 +49.8 49753 6.8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 E2F8 CFB SKIV2L ATF6B CSNK2B STK19 BAG6 CCHCR1 STK19B HLA-DRB1 LY6G5B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C2 gene promoter:

Genomic Locations for C2 Gene

Genomic Locations for C2 Gene
chr6:31,897,785-31,945,674
(GRCh38/hg38)
Size:
47,890 bases
Orientation:
Plus strand
chr6:31,865,562-31,913,449
(GRCh37/hg19)

Genomic View for C2 Gene

Genes around C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for C2 Gene

  • Protein details for C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06681-CO2_HUMAN
    Recommended name:
    Complement C2
    Protein Accession:
    P06681
    Secondary Accessions:
    • B4DPF3
    • B4DV20
    • E9PFN7
    • O19694
    • Q13904

    Protein attributes for C2 Gene

    Size:
    752 amino acids
    Molecular mass:
    83268 Da
    Quaternary structure:
    • C2a interacts with Schistosoma haematobium TOR (via N-terminal extracellular domain). This results in inhibition of the classical and lectin pathway of complement activation, probably due to interference with binding of C2a to C4b such that C3 convertase cannot be formed. This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection.
    Miscellaneous:
    • C2 is a major histocompatibility complex class-III protein.

    Three dimensional structures from OCA and Proteopedia for C2 Gene

    Alternative splice isoforms for C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C2 Gene

Selected DME Specific Peptides for C2 Gene

P06681:
  • KVKMSTHARPICLPCT
  • LGATNPTQ
  • MVDRIFSFEI
  • VLTAAHC
  • SFECEDGF
  • IILLTDGKSNMG
  • GSTCRDHE
  • LRGSPVR
  • PCKGESGGAVFL
  • RPICLPCT
  • QPWLRQHL
  • WDGETAVCDNGA
  • NYKDHENGTGTN
  • GVWSGTE
  • HCPNPGIS
  • VAIITFAS
  • RDFHINL
  • LGSKKDGERHAFIL
  • DYLDIYAIGVG
  • EFYGDDIALLKL
  • LWRVNVGDP
  • IQRSGHLNLYLLLD
  • GDKVRYRCSS
  • RFFQVGLVSWGL
  • CKPVRCPAPVSFENG
  • EVVTDQFLCSG
  • ICGVGNMSANAS
  • KALHQVF
  • WVLTAAHCFR
  • LTAAHCF
  • WVLTAAH
  • PAHFVALNG
  • ICRQPYSYDFPEDVAPALGTSFSH
  • FTLSHGWAPGSLL

Post-translational modifications for C2 Gene

  • Glycosylation at posLast=2929, Asn112, posLast=290290, Asn333, Asn467, Asn471, Asn621, and Asn651

Antibody Products

  • R&D Systems Antibodies for C2 (Complement Component C2)
  • R&D Systems Antibodies for C2 (Complement Component C2b)
  • Abcam antibodies for C2

Domains & Families for C2 Gene

Gene Families for C2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P06681

UniProtKB/Swiss-Prot:

CO2_HUMAN :
  • The MIDAS-like motif in the VWFA domain binds divalent metal cations.
  • Belongs to the peptidase S1 family.
Domain:
  • The MIDAS-like motif in the VWFA domain binds divalent metal cations.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with C2: view

Function for C2 Gene

Molecular function for C2 Gene

GENATLAS Biochemistry:
complement component 2,110kDa,activated by C1r to form C2a and C2b,combining with C4A and C4B to form C3/C5 convertase,classical pathway of C3 activation
UniProtKB/Swiss-Prot CatalyticActivity:
Selective cleavage of Arg- -Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg- -Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
UniProtKB/Swiss-Prot Function:
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

Enzyme Numbers (IUBMB) for C2 Gene

Phenotypes From GWAS Catalog for C2 Gene

Gene Ontology (GO) - Molecular Function for C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS,IEA --
GO:0005515 protein binding IPI 25910212
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with C2: view
genes like me logo Genes that share phenotypes with C2: view

Human Phenotype Ontology for C2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for C2

CRISPR Products

miRNA for C2 Gene

miRTarBase miRNAs that target C2

Inhibitory RNA Products

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for C2 Gene

Localization for C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 8621452
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with C2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C2 Gene

Pathways & Interactions for C2 Gene

genes like me logo Genes that share pathways with C2: view

Gene Ontology (GO) - Biological Process for C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006956 complement activation TAS,IMP --
GO:0006958 complement activation, classical pathway TAS,IEA --
GO:0007584 response to nutrient IEA --
GO:0030449 regulation of complement activation TAS --
genes like me logo Genes that share ontologies with C2: view

No data available for SIGNOR curated interactions for C2 Gene

Drugs & Compounds for C2 Gene

(1) Drugs for C2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with C2: view

Transcripts for C2 Gene

Unigene Clusters for C2 Gene

Complement component 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ·
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: -
SP7: - -
SP8: - - -
SP9: - - - - -
SP10:
SP11:
SP12: -

ExUns: 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for C2 Gene

GeneLoc Exon Structure for
C2
ECgene alternative splicing isoforms for
C2

Expression for C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C2 Gene

This gene is overexpressed in Liver (x28.4).

Protein differential expression in normal tissues from HIPED for C2 Gene

This gene is overexpressed in Synovial fluid (18.8), Serum (16.2), and Monocytes (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C2 Gene



Protein tissue co-expression partners for C2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C2 Gene:

C2

SOURCE GeneReport for Unigene cluster for C2 Gene:

Hs.408903

Evidence on tissue expression from TISSUES for C2 Gene

  • Liver(4.9)
  • Nervous system(4.5)
  • Intestine(4.4)
  • Kidney(4.3)
  • Bone marrow(4.1)
  • Lung(3.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for C2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cheek
  • ear
  • eye
  • face
  • head
  • lip
  • meninges
  • mouth
  • neck
  • scalp
  • thyroid
Thorax:
  • bronchus
  • esophagus
  • heart
  • lung
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • lymph node
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with C2: view

No data available for mRNA Expression by UniProt/SwissProt for C2 Gene

Orthologs for C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2 33 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia C2 33
  • 85.29 (n)
cow
(Bos Taurus)
Mammalia C2 33 34
  • 83.73 (n)
rat
(Rattus norvegicus)
Mammalia C2 33
  • 80.21 (n)
mouse
(Mus musculus)
Mammalia C2 33 16 34
  • 79.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C2 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2 33 34
  • 54.74 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia c2 33
  • 49.51 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC563828 33
  • 48.98 (n)
C2 34
  • 31 (a)
OneToOne
-- 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
ManyToMany
-- 34
  • 19 (a)
ManyToMany
-- 34
  • 18 (a)
ManyToMany
Species where no ortholog for C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2 Gene

ENSEMBL:
Gene Tree for C2 (if available)
TreeFam:
Gene Tree for C2 (if available)

Paralogs for C2 Gene

Variants for C2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for C2 Gene

CO2_HUMAN-P06681
The variant Asp-318 is associated with a reduced risk of age-related macular degeneration (ARMD) [MIM:603075]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world.

Sequence variations from dbSNP and Humsavar for C2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1042663 likely-benign, benign, Macular degeneration, Complement component 2 deficiency, not specified 31,937,353(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs117576077 likely-benign, Macular degeneration, Complement component 2 deficiency 31,939,220(+) C/T genic_downstream_transcript_variant, intron_variant
rs137902889 likely-benign, Complement component 2 deficiency, Macular degeneration 31,928,126(+) C/T coding_sequence_variant, intron_variant, missense_variant, stop_gained
rs140225293 likely-benign, Atypical hemolytic uremic syndrome, Macular degeneration 31,943,100(+) G/A genic_downstream_transcript_variant, splice_donor_variant
rs142243595 likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity, Atypical hemolytic uremic syndrome, Complement component 2 deficiency, Macular degeneration 31,943,278(+) G/A/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for C2 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10464n54 CNV loss 21841781
dgv10465n54 CNV loss 21841781
esv2422045 CNV deletion 20811451
esv2658525 CNV deletion 23128226
esv2663182 CNV deletion 23128226
esv2731824 CNV deletion 23290073
esv2759415 CNV gain+loss 17122850
esv3567540 CNV deletion 23714750
esv3570963 CNV loss 25503493
esv3608572 CNV loss 21293372
esv3608573 CNV loss 21293372
esv3890823 CNV loss 25118596
esv988690 CNV gain 20482838
nsv1073969 CNV deletion 25765185
nsv10822 CNV gain 18304495
nsv10823 CNV loss 18304495
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv428141 CNV gain+loss 18775914
nsv508399 CNV deletion 20534489
nsv509126 CNV insertion 20534489
nsv601960 CNV loss 21841781
nsv601965 CNV loss 21841781
nsv823505 CNV loss 20364138
nsv830628 CNV loss 17160897

Variation tolerance for C2 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2 Gene

Human Gene Mutation Database (HGMD)
C2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2

Disorders for C2 Gene

MalaCards: The human disease database

(11) MalaCards diseases for C2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
complement component 2 deficiency
  • c2d
macular degeneration, age-related, 14
  • armd14
immunodeficiency due to a classical component pathway complement deficiency
  • immunodeficiency due to c1, c4, or c2 component complement deficiency
tympanic membrane disease
  • disorder of tympanic membrane
complement deficiency
  • complement deficiency disease
- elite association - COSMIC cancer census association via MalaCards
Search C2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CO2_HUMAN
  • Complement component 2 deficiency (C2D) [MIM:217000]: A rare defect of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent invasive infections. {ECO:0000269 PubMed:8621452, ECO:0000269 PubMed:9670930}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for C2 Gene

Henoch-Schonlein purpura susceptibility,lupus systemic discoid syndrome,polymyositis susceptibility (C2 deficiency,type I)

Additional Disease Information for C2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with C2: view

Publications for C2 Gene

  1. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. (PMID: 16518403) Gold B … Allikmets R (Nature genetics 2006) 3 4 44 58
  2. A novel type II complement C2 deficiency allele in an African-American family. (PMID: 9670930) Zhu ZB … Volanakis JE (Journal of immunology (Baltimore, Md. : 1950) 1998) 3 4 22 58
  3. Structure of the human C2 gene. (PMID: 8326124) Ishii Y … Volanakis JE (Journal of immunology (Baltimore, Md. : 1950) 1993) 3 4 22 58
  4. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PMID: 20801516) Booij JC … Florijn RJ (Ophthalmology 2011) 3 44 58
  5. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. (PMID: 21665990) Yu Y … Seddon JM (Human molecular genetics 2011) 3 44 58

Products for C2 Gene

Sources for C2 Gene

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