Aliases for TPI1 Gene
External Ids for TPI1 Gene
Previous GeneCards Identifiers for TPI1 Gene
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
GeneCards Summary for TPI1 Gene
TPI1 (Triosephosphate Isomerase 1) is a Protein Coding gene. Diseases associated with TPI1 include Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency and Congenital Hemolytic Anemia. Among its related pathways are Glycosaminoglycan metabolism and Carbon metabolism. GO annotations related to this gene include ubiquitin protein ligase binding and triose-phosphate isomerase activity.