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Aliases for TPBG Gene

Aliases for TPBG Gene

  • Trophoblast Glycoprotein 2 3
  • 5T4 Oncofetal Trophoblast Glycoprotein 3 4
  • Wnt-Activated Inhibitory Factor 1 3 4
  • 5T4 Oncotrophoblast Glycoprotein 3 4
  • 5T4 Oncofetal Antigen 3 4
  • WAIF1 3 4
  • M6P1 3 4
  • 5T4 3 4
  • 5T4AG 3

External Ids for TPBG Gene

Previous GeneCards Identifiers for TPBG Gene

  • GC06P083027
  • GC06P083069
  • GC06P083130
  • GC06P080300
  • GC06P083072

Summaries for TPBG Gene

Entrez Gene Summary for TPBG Gene

  • This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

GeneCards Summary for TPBG Gene

TPBG (Trophoblast Glycoprotein) is a Protein Coding gene. Diseases associated with TPBG include vaccinia and malignant pleural mesothelioma. An important paralog of this gene is TPBGL.

UniProtKB/Swiss-Prot for TPBG Gene

  • May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.

Gene Wiki entry for TPBG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPBG Gene

Genomics for TPBG Gene

Regulatory Elements for TPBG Gene

Genomic Location for TPBG Gene

Start:
82,363,206 bp from pter
End:
82,370,828 bp from pter
Size:
7,623 bases
Orientation:
Plus strand

Genomic View for TPBG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPBG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPBG Gene

Proteins for TPBG Gene

  • Protein details for TPBG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13641-TPBG_HUMAN
    Recommended name:
    Trophoblast glycoprotein
    Protein Accession:
    Q13641
    Secondary Accessions:
    • A8K555

    Protein attributes for TPBG Gene

    Size:
    420 amino acids
    Molecular mass:
    46032 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy
    • Reduction of TPBG levels by siRNA significantly enhanced the beta-catenin/TCF transcription-based reporter pBAR activation in response to Wnt stimulation

    Three dimensional structures from OCA and Proteopedia for TPBG Gene

neXtProt entry for TPBG Gene

Proteomics data for TPBG Gene at MOPED

Post-translational modifications for TPBG Gene

Other Protein References for TPBG Gene

No data available for DME Specific Peptides for TPBG Gene

Domains for TPBG Gene

Suggested Antigen Peptide Sequences for TPBG Gene

Graphical View of Domain Structure for InterPro Entry

Q13641

UniProtKB/Swiss-Prot:

TPBG_HUMAN :
  • Q13641
Domain:
  • The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TPBG: view

No data available for Gene Families for TPBG Gene

Function for TPBG Gene

Molecular function for TPBG Gene

GENATLAS Biochemistry: trophoblast glycoprotein
UniProtKB/Swiss-Prot Function: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.

Gene Ontology (GO) - Molecular Function for TPBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TPBG: view

Phenotypes for TPBG Gene

genes like me logo Genes that share phenotypes with TPBG: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TPBG Gene

Localization for TPBG Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPBG Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPBG Gene COMPARTMENTS Subcellular localization image for TPBG gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
mitochondrion 2
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TPBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum IEA --
GO:0005887 integral component of plasma membrane TAS 10366710
GO:0009986 cell surface IDA 19581412
genes like me logo Genes that share ontologies with TPBG: view

Pathways for TPBG Gene

SuperPathways for TPBG Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS 10366710
genes like me logo Genes that share ontologies with TPBG: view

No data available for Pathways by source for TPBG Gene

Compounds for TPBG Gene

(1) Novoseek inferred chemical compound relationships for TPBG Gene

Compound -log(P) Hits PubMed IDs
trovax 98.2 4
genes like me logo Genes that share compounds with TPBG: view

Transcripts for TPBG Gene

Unigene Clusters for TPBG Gene

Trophoblast glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPBG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for TPBG Gene

GeneLoc Exon Structure for
TPBG
ECgene alternative splicing isoforms for
TPBG

Expression for TPBG Gene

mRNA expression in normal human tissues for TPBG Gene

mRNA differential expression in normal tissues according to GTEx for TPBG Gene

This gene is overexpressed in Esophagus - Muscularis (6.5) and Esophagus - Gastroesophageal Junction (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPBG Gene

SOURCE GeneReport for Unigene cluster for TPBG Gene Hs.82128

mRNA Expression by UniProt/SwissProt for TPBG Gene

Q13641-TPBG_HUMAN
Tissue specificity: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma
genes like me logo Genes that share expressions with TPBG: view

Orthologs for TPBG Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPBG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPBG 35
  • 99.68 (n)
  • 99.52 (a)
TPBG 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPBG 35
  • 87.22 (n)
  • 86.9 (a)
TPBG 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPBG 35
  • 87.14 (n)
  • 87.86 (a)
TPBG 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpbg 35
  • 82.86 (n)
  • 82.62 (a)
Tpbg 16
Tpbg 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPBG 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPBG 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpbg 35
  • 82.78 (n)
  • 81.67 (a)
chicken
(Gallus gallus)
Aves TPBG 35
  • 69.14 (n)
  • 68.38 (a)
TPBG 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPBG 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5548 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.220 35
tpbg 35
  • 55.87 (n)
  • 52.11 (a)
zebrafish
(Danio rerio)
Actinopterygii tpbgb 35
  • 52.7 (n)
  • 49.26 (a)
tpbgb 36
  • 43 (a)
OneToOne
Species with no ortholog for TPBG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPBG Gene

ENSEMBL:
Gene Tree for TPBG (if available)
TreeFam:
Gene Tree for TPBG (if available)

Paralogs for TPBG Gene

Paralogs for TPBG Gene

Pseudogenes.org Pseudogenes for TPBG Gene

genes like me logo Genes that share paralogs with TPBG: view

Variants for TPBG Gene

Sequence variations from dbSNP and Humsavar for TPBG Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs700494 -- 82,366,197(-) AGGTT(C/T)GTTAA synonymous-codon, reference
rs700495 -- 82,367,074(-) ATTTC(A/G)AAACG utr-variant-3-prime
rs770896 -- 82,362,671(-) TAAGA(C/T)CTGGT upstream-variant-2KB
rs770911 -- 82,364,648(-) TTGGC(A/G)CCCCT utr-variant-5-prime
rs770912 -- 82,364,214(-) CCACC(A/C)GGTCC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPBG Gene

Variant ID Type Subtype PubMed ID
nsv7937 CNV Loss 18304495

Relevant External Links for TPBG Gene

HapMap Linkage Disequilibrium report
TPBG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPBG Gene

Disorders for TPBG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for TPBG Gene including...

Search for TPBG Gene in MalaCards »

(15) Novoseek inferred disease relationships for TPBG Gene

Disease -log(P) Hits PubMed IDs
carcinoma 47.8 14
carcinoma renal cell 44.3 4
melanoma b16 41.8 1
colorectal cancer 40.8 7
metastasis 40.4 6

Relevant External Links for TPBG

Genetic Association Database (GAD)
TPBG
genes like me logo Genes that share disorders with TPBG: view

No data available for UniProtKB/Swiss-Prot for TPBG Gene

Publications for TPBG Gene

  1. Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats. (PMID: 8132670) Myers K.A. … Stern P.L. (J. Biol. Chem. 1994) 2 3 4 23
  2. Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors. (PMID: 12481437) Mulryan K. … Carroll M.W. (Mol. Cancer Ther. 2002) 3 4 23
  3. Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues. (PMID: 10366710) King K.W. … Myers K.A. (Biochim. Biophys. Acta 1999) 3 23
  4. Metastasis-associated 5T4 antigen disrupts cell-cell contacts and induces cellular motility in epithelial cells. (PMID: 8895545) Carsberg C.J. … Stern P.L. (Int. J. Cancer 1996) 3 23
  5. CD8 T-cell recognition of human 5T4 oncofetal antigen. (PMID: 16646078) Smyth L.J. … Stern P.L. (Int. J. Cancer 2006) 3 23

Products for TPBG Gene

Sources for TPBG Gene

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