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Aliases for TP53BP2 Gene

Aliases for TP53BP2 Gene

  • Tumor Protein P53 Binding Protein 2 2 3
  • ASPP2 3 4 6
  • Tumor Suppressor P53-Binding Protein 2 3 4
  • Renal Carcinoma Antigen NY-REN-51 3 4
  • P53BP2 3 4
  • 53BP2 3 4
  • BBP 3 4
  • Apoptosis-Stimulating Protein Of P53, 2 3
  • Apoptosis-Stimulating Of P53 Protein 2 3
  • Tumor Protein P53-Binding Protein, 2 2
  • Tumor Protein P53 Binding Protein, 2 3
  • P53-Binding Protein 2 4
  • BCL2-Binding Protein 3
  • Bcl2-Binding Protein 4
  • PPP1R13A 3

External Ids for TP53BP2 Gene

Previous GeneCards Identifiers for TP53BP2 Gene

  • GC01P222570
  • GC01P219863
  • GC01M220469
  • GC01M220942
  • GC01M220274
  • GC01M222034
  • GC01M223967
  • GC01M194580

Summaries for TP53BP2 Gene

Entrez Gene Summary for TP53BP2 Gene

  • This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TP53BP2 Gene

TP53BP2 (Tumor Protein P53 Binding Protein 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for TP53BP2 Gene

  • Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

Gene Wiki entry for TP53BP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53BP2 Gene

Genomics for TP53BP2 Gene

Regulatory Elements for TP53BP2 Gene

Genomic Location for TP53BP2 Gene

Start:
223,779,893 bp from pter
End:
223,845,972 bp from pter
Size:
66,080 bases
Orientation:
Minus strand

Genomic View for TP53BP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TP53BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53BP2 Gene

Proteins for TP53BP2 Gene

  • Protein details for TP53BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13625-ASPP2_HUMAN
    Recommended name:
    Apoptosis-stimulating of p53 protein 2
    Protein Accession:
    Q13625
    Secondary Accessions:
    • B4DG66
    • Q12892
    • Q86X75
    • Q96KQ3

    Protein attributes for TP53BP2 Gene

    Size:
    1128 amino acids
    Molecular mass:
    125616 Da
    Quaternary structure:
    • Binds to the central domain of TP53 as well as to BCL2. Interacts with protein phosphatase 1. Interacts with RELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing its interaction with TP53. Interacts with APC2 and APPBP1. Interacts with DDX42 (via the C-terminus); the interaction is not inhibited by TP53BP2 ubiquitination and is independent of p53/TP53.
    SequenceCaution:
    • Sequence=AAH46150.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH46150.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58918.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TP53BP2 Gene

    Alternative splice isoforms for TP53BP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53BP2 Gene

Proteomics data for TP53BP2 Gene at MOPED

Post-translational modifications for TP53BP2 Gene

  • Ubiquitination at Lys152, Lys224, and Lys234
  • Modification sites at PhosphoSitePlus

Other Protein References for TP53BP2 Gene

Antibody Products

No data available for DME Specific Peptides for TP53BP2 Gene

Domains for TP53BP2 Gene

Gene Families for TP53BP2 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Graphical View of Domain Structure for InterPro Entry

Q13625

UniProtKB/Swiss-Prot:

ASPP2_HUMAN :
  • Q13625
Domain:
  • The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53
  • Contains 1 SH3 domain.
Family:
  • Belongs to the ASPP family.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with TP53BP2: view

Function for TP53BP2 Gene

Molecular function for TP53BP2 Gene

GENATLAS Biochemistry: TP53 binding protein 2,cytoplasmic not binding mutant TP53
UniProtKB/Swiss-Prot Function: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
UniProtKB/Swiss-Prot Induction: Following DNA damage induced by UV irradiation. Down-regulated by wild-type, but not mutant, p53/TP53.

Gene Ontology (GO) - Molecular Function for TP53BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 14985081
GO:0005070 SH3/SH2 adaptor activity TAS 8668206
GO:0005515 protein binding IPI 10498867
GO:0017124 SH3 domain binding IEA --
GO:0042802 identical protein binding IPI 18448430
genes like me logo Genes that share ontologies with TP53BP2: view
genes like me logo Genes that share phenotypes with TP53BP2: view

Animal Models for TP53BP2 Gene

MGI Knock Outs for TP53BP2:

Animal Model Products

CRISPR Products

miRNA for TP53BP2 Gene

miRTarBase miRNAs that target TP53BP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TP53BP2 Gene

Localization for TP53BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53BP2 Gene

Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53BP2 Gene COMPARTMENTS Subcellular localization image for TP53BP2 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TP53BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19377511
GO:0005737 cytoplasm TAS 15782125
GO:0048471 colocalizes_with perinuclear region of cytoplasm IDA 10646860
genes like me logo Genes that share ontologies with TP53BP2: view

Pathways for TP53BP2 Gene

genes like me logo Genes that share pathways with TP53BP2: view

Pathways by source for TP53BP2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for TP53BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction TAS 9748285
GO:0007417 central nervous system development IEA --
GO:0007507 heart development IEA --
GO:0009792 embryo development ending in birth or egg hatching IEA --
genes like me logo Genes that share ontologies with TP53BP2: view

Compounds for TP53BP2 Gene

(15) ApexBio Compounds for TP53BP2 Gene

Compound Action Cas Number
AMG232 potent and selective piperidinone inhibitor of the MDM2-p53 interaction.
CP 31398 dihydrochloride p53 stabilizing agent. [1217195-61-3]
JNJ-26854165 (Serdemetan) p53 activator, blocking Mdm2-p53 interaction [881202-45-5]
Nutlin-3 inhibitor of the MDM2/p53 interaction [890090-75-2]
Nutlin-3a chiral inhibits the MDM2-p53 interaction and activates p53. [675576-98-4]
p53 and MDM2 proteins-interaction-inhibitor chiral inhibitor of the interaction between p53 and MDM2 proteins. [939981-37-0]
Pifithrin-miu Inhibits p53 binding to mitochondria. [64984-31-2]
PRIMA-1 Cell-permeable BAX inhibitor, restore p53 activity [5608-24-2]
PRIMA-1MET Cell-permeable BAX inhibitor, restore p53 activity [5291-32-7]
RG7112 Restoration of p53 activity by inhibiting the p53-MDM2 interaction. [939981-39-2]
RG7388 Blocking the MDM2-p53 interaction stabilizes p53. [1229705-06-9]
RITA (NSC 652287) Cell-permeable antitumor agent, blocking Mdm2-p53 interaction and p53 ubiquitination [213261-59-7]
SJ 172550 Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells. [431979-47-4]
Tenovin-1 Cell-permeable, reversible SIRT2 inhibitor, activates p53 [380315-80-0]
Tenovin-3 Tenovin-3 [1011301-27-1]

(2) Novoseek inferred chemical compound relationships for TP53BP2 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 6.55 1
alanine 3.44 1
genes like me logo Genes that share compounds with TP53BP2: view

Transcripts for TP53BP2 Gene

Unigene Clusters for TP53BP2 Gene

Tumor protein p53 binding protein, 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TP53BP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53BP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5: -

Relevant External Links for TP53BP2 Gene

GeneLoc Exon Structure for
TP53BP2
ECgene alternative splicing isoforms for
TP53BP2

Expression for TP53BP2 Gene

mRNA expression in normal human tissues for TP53BP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TP53BP2 Gene

SOURCE GeneReport for Unigene cluster for TP53BP2 Gene Hs.523968

mRNA Expression by UniProt/SwissProt for TP53BP2 Gene

Q13625-ASPP2_HUMAN
Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.
genes like me logo Genes that share expressions with TP53BP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TP53BP2 Gene

Orthologs for TP53BP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53BP2 35
  • 99.06 (n)
  • 98.87 (a)
TP53BP2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TP53BP2 35
  • 87.44 (n)
  • 91.73 (a)
TP53BP2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TP53BP2 35
  • 83.84 (n)
  • 88.52 (a)
TP53BP2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trp53bp2 35
  • 86.73 (n)
  • 91.17 (a)
Trp53bp2 16
Trp53bp2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TP53BP2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TP53BP2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53bp2 35
  • 86.28 (n)
  • 89.97 (a)
chicken
(Gallus gallus)
Aves TP53BP2 35
  • 75.02 (n)
  • 81.67 (a)
TP53BP2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TP53BP2 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21747 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15314 35
tp53bp2 35
  • 67.77 (n)
  • 72.21 (a)
zebrafish
(Danio rerio)
Actinopterygii tp53bp2 35
  • 61.51 (n)
  • 65.15 (a)
tp53bp2 36
  • 64 (a)
OneToMany
TP53BP2 (2 of 2) 36
  • 62 (a)
OneToMany
wufc90h02 35
fruit fly
(Drosophila melanogaster)
Insecta ASPP 36
  • 31 (a)
OneToMany
CG18375 37
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea ape-1 36
  • 27 (a)
ManyToMany
mel-11 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8965 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TP53BP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TP53BP2 Gene

ENSEMBL:
Gene Tree for TP53BP2 (if available)
TreeFam:
Gene Tree for TP53BP2 (if available)

Paralogs for TP53BP2 Gene

Selected SIMAP similar genes for TP53BP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TP53BP2: view

Variants for TP53BP2 Gene

Sequence variations from dbSNP and Humsavar for TP53BP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs17739 -- 223,780,251(+) GGTAC(C/T)GTAGC utr-variant-3-prime
rs720757 -- 223,835,404(+) ACATT(C/T)AGTTA intron-variant
rs898878 -- 223,820,097(+) TAACA(A/T)TTTAG intron-variant
rs1003061 -- 223,840,297(+) AACTA(C/T)ACATT intron-variant
rs1124943 -- 223,805,922(+) AAATA(G/T)TTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TP53BP2 Gene

Variant ID Type Subtype PubMed ID
nsv832681 CNV Gain 17160897
esv34082 CNV Loss 18971310
essv335 CNV CNV 17122850
dgv182e1 CNV Complex 17122850
nsv4698 CNV Insertion 18451855
esv2663989 CNV Deletion 23128226

Relevant External Links for TP53BP2 Gene

HapMap Linkage Disequilibrium report
TP53BP2
Human Gene Mutation Database (HGMD)
TP53BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53BP2 Gene

Disorders for TP53BP2 Gene

(3) Novoseek inferred disease relationships for TP53BP2 Gene

Disease -log(P) Hits PubMed IDs
osteosarcoma 34.6 1
tumors 30 14
cancer 0 3

Relevant External Links for TP53BP2

Genetic Association Database (GAD)
TP53BP2
Human Genome Epidemiology (HuGE) Navigator
TP53BP2
genes like me logo Genes that share disorders with TP53BP2: view

No data available for UniProtKB/Swiss-Prot for TP53BP2 Gene

Publications for TP53BP2 Gene

  1. Two cellular proteins that bind to wild-type but not mutant p53. (PMID: 8016121) Iwabuchi K. … Fields S. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. (PMID: 8875926) Gorina S. … Pavletich N.P. (Science 1996) 3 4 23
  3. Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines. (PMID: 10631318) Mori T. … Okamoto T. (FEBS Lett. 2000) 3 4 23
  4. APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. (PMID: 10646860) Nakagawa H. … Nakamura Y. (Cancer Res. 2000) 3 4 23
  5. Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53. (PMID: 11027272) Lopez C.D. … Naumovski L. (Mol. Cell. Biol. 2000) 3 4 23

Products for TP53BP2 Gene

Sources for TP53BP2 Gene

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