Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TP53BP2 Gene

Aliases for TP53BP2 Gene

  • Tumor Protein P53 Binding Protein 2 2 3 5
  • Tumor Suppressor P53-Binding Protein 2 3 4
  • Renal Carcinoma Antigen NY-REN-51 3 4
  • P53BP2 3 4
  • 53BP2 3 4
  • ASPP2 3 4
  • BBP 3 4
  • Apoptosis-Stimulating Protein Of P53, 2 3
  • Tumor Protein P53-Binding Protein, 2 2
  • Tumor Protein P53 Binding Protein, 2 3
  • P53-Binding Protein 2 4
  • BCL2-Binding Protein 3
  • Bcl2-Binding Protein 4
  • PPP1R13A 3

External Ids for TP53BP2 Gene

Previous GeneCards Identifiers for TP53BP2 Gene

  • GC01P222570
  • GC01P219863
  • GC01M220469
  • GC01M220942
  • GC01M220274
  • GC01M222034
  • GC01M223967
  • GC01M194580

Summaries for TP53BP2 Gene

Entrez Gene Summary for TP53BP2 Gene

  • This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TP53BP2 Gene

TP53BP2 (Tumor Protein P53 Binding Protein 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include identical protein binding and p53 binding. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for TP53BP2 Gene

  • Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

Gene Wiki entry for TP53BP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53BP2 Gene

Genomics for TP53BP2 Gene

Regulatory Elements for TP53BP2 Gene

Promoters for TP53BP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TP53BP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TP53BP2 Gene

Chromosome:
1
Start:
223,779,893 bp from pter
End:
223,845,981 bp from pter
Size:
66,089 bases
Orientation:
Minus strand

Genomic View for TP53BP2 Gene

Genes around TP53BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53BP2 Gene

Proteins for TP53BP2 Gene

  • Protein details for TP53BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13625-ASPP2_HUMAN
    Recommended name:
    Apoptosis-stimulating of p53 protein 2
    Protein Accession:
    Q13625
    Secondary Accessions:
    • B4DG66
    • Q12892
    • Q86X75
    • Q96KQ3

    Protein attributes for TP53BP2 Gene

    Size:
    1128 amino acids
    Molecular mass:
    125616 Da
    Quaternary structure:
    • Binds to the central domain of TP53 as well as to BCL2. Interacts with protein phosphatase 1. Interacts with RELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing its interaction with TP53. Interacts with APC2 and APPBP1. Interacts with DDX42 (via the C-terminus); the interaction is not inhibited by TP53BP2 ubiquitination and is independent of p53/TP53.
    SequenceCaution:
    • Sequence=AAH46150.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH46150.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58918.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TP53BP2 Gene

    Alternative splice isoforms for TP53BP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53BP2 Gene

Proteomics data for TP53BP2 Gene at MOPED

Post-translational modifications for TP53BP2 Gene

  • Ubiquitination at Lys 152, Lys 224, and Lys 234
  • Modification sites at PhosphoSitePlus

Other Protein References for TP53BP2 Gene

Antibody Products

No data available for DME Specific Peptides for TP53BP2 Gene

Domains & Families for TP53BP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13625

UniProtKB/Swiss-Prot:

ASPP2_HUMAN :
  • The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53.
  • Belongs to the ASPP family.
  • Contains 4 ANK repeats.
Domain:
  • The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the ASPP family.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with TP53BP2: view

Function for TP53BP2 Gene

Molecular function for TP53BP2 Gene

GENATLAS Biochemistry:
TP53 binding protein 2,cytoplasmic not binding mutant TP53
UniProtKB/Swiss-Prot Function:
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
UniProtKB/Swiss-Prot Induction:
Following DNA damage induced by UV irradiation. Down-regulated by wild-type, but not mutant, p53/TP53.

Gene Ontology (GO) - Molecular Function for TP53BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8668206
genes like me logo Genes that share ontologies with TP53BP2: view
genes like me logo Genes that share phenotypes with TP53BP2: view

Animal Models for TP53BP2 Gene

MGI Knock Outs for TP53BP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TP53BP2

CRISPR Products

miRNA for TP53BP2 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TP53BP2 Gene

Localization for TP53BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53BP2 Gene

Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TP53BP2 Gene COMPARTMENTS Subcellular localization image for TP53BP2 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TP53BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,TAS 15782125
genes like me logo Genes that share ontologies with TP53BP2: view

Pathways & Interactions for TP53BP2 Gene

genes like me logo Genes that share pathways with TP53BP2: view

SIGNOR curated interactions for TP53BP2 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for TP53BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9748285
GO:0009967 positive regulation of signal transduction TAS --
GO:0042981 regulation of apoptotic process TAS --
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IDA 11684014
GO:1900119 positive regulation of execution phase of apoptosis IMP 14985081
genes like me logo Genes that share ontologies with TP53BP2: view

Drugs & Compounds for TP53BP2 Gene

(8) Drugs for TP53BP2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NSC 319726 Pharma Reactivator of mutant p53 0
Pifithrin-α (PFTα) Pharma p53 inhibitor 0
PRIMA-1 Pharma BAX inhibitor 0
PRIMA-1MET Pharma Restore mutant p53 activity, induce BAX and PUMA 0
RG7388 Pharma MDM2 antagonist, oral, selective 0

(1) Additional Compounds for TP53BP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TP53BP2: view

Transcripts for TP53BP2 Gene

Unigene Clusters for TP53BP2 Gene

Tumor protein p53 binding protein, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TP53BP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5: -

Relevant External Links for TP53BP2 Gene

GeneLoc Exon Structure for
TP53BP2
ECgene alternative splicing isoforms for
TP53BP2

Expression for TP53BP2 Gene

mRNA expression in normal human tissues for TP53BP2 Gene

Protein differential expression in normal tissues from HIPED for TP53BP2 Gene

This gene is overexpressed in Spinal cord (39.0) and Testis (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TP53BP2 Gene



SOURCE GeneReport for Unigene cluster for TP53BP2 Gene Hs.523968

mRNA Expression by UniProt/SwissProt for TP53BP2 Gene

Q13625-ASPP2_HUMAN
Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.
genes like me logo Genes that share expression patterns with TP53BP2: view

Protein tissue co-expression partners for TP53BP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TP53BP2 Gene

Orthologs for TP53BP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53BP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TP53BP2 35
  • 87.44 (n)
  • 91.73 (a)
TP53BP2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TP53BP2 35
  • 83.84 (n)
  • 88.52 (a)
TP53BP2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trp53bp2 35
  • 86.73 (n)
  • 91.17 (a)
Trp53bp2 16
Trp53bp2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TP53BP2 35
  • 99.06 (n)
  • 98.87 (a)
TP53BP2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53bp2 35
  • 86.28 (n)
  • 89.97 (a)
oppossum
(Monodelphis domestica)
Mammalia TP53BP2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TP53BP2 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TP53BP2 35
  • 75.02 (n)
  • 81.67 (a)
TP53BP2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TP53BP2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15314 35
tp53bp2 35
  • 67.77 (n)
  • 72.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21747 35
zebrafish
(Danio rerio)
Actinopterygii tp53bp2 35
  • 61.51 (n)
  • 65.15 (a)
wufc90h02 35
tp53bp2 36
  • 64 (a)
OneToMany
TP53BP2 (2 of 2) 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18375 37
  • 57 (a)
ASPP 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ape-1 36
  • 27 (a)
ManyToMany
mel-11 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8965 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TP53BP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TP53BP2 Gene

ENSEMBL:
Gene Tree for TP53BP2 (if available)
TreeFam:
Gene Tree for TP53BP2 (if available)

Paralogs for TP53BP2 Gene

(7) SIMAP similar genes for TP53BP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TP53BP2: view

Variants for TP53BP2 Gene

Sequence variations from dbSNP and Humsavar for TP53BP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17739 -- 223,780,251(+) GGTAC(C/T)GTAGC utr-variant-3-prime
rs720757 -- 223,835,404(+) ACATT(C/T)AGTTA intron-variant
rs898878 -- 223,820,097(+) TAACA(A/T)TTTAG intron-variant
rs1003061 -- 223,840,297(+) AACTA(C/T)ACATT intron-variant
rs1124943 -- 223,805,922(+) AAATA(G/T)TTACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TP53BP2 Gene

Variant ID Type Subtype PubMed ID
nsv832681 CNV Gain 17160897
esv34082 CNV Loss 18971310
essv335 CNV CNV 17122850
dgv182e1 CNV Complex 17122850
nsv4698 CNV Insertion 18451855
esv2663989 CNV Deletion 23128226

Variation tolerance for TP53BP2 Gene

Residual Variation Intolerance Score: 5.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TP53BP2 Gene

HapMap Linkage Disequilibrium report
TP53BP2
Human Gene Mutation Database (HGMD)
TP53BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53BP2 Gene

Disorders for TP53BP2 Gene

Relevant External Links for TP53BP2

Genetic Association Database (GAD)
TP53BP2
Human Genome Epidemiology (HuGE) Navigator
TP53BP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TP53BP2

No disorders were found for TP53BP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP53BP2 Gene

Publications for TP53BP2 Gene

  1. Two cellular proteins that bind to wild-type but not mutant p53. (PMID: 8016121) Iwabuchi K. … Fields S. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23 67
  2. Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma. (PMID: 20034025) Zhao J. … Guo Y. (Hepatology 2010) 3 23
  3. 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling. (PMID: 17965023) Hakuno F. … Takahashi S. (J. Biol. Chem. 2007) 3 23
  4. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. (PMID: 15706352) Hershko T. … Ginsberg D. (Cell Death Differ. 2005) 3 23
  5. ASPP1 and ASPP2 are new transcriptional targets of E2F. (PMID: 15731768) Fogal V. … Lu X. (Cell Death Differ. 2005) 3 23

Products for TP53BP2 Gene

Sources for TP53BP2 Gene

Back to Top

Content