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Aliases for TMSB4X Gene

Aliases for TMSB4X Gene

  • TMSB4 3 4 6
  • TB4X 3 4 6
  • Thymosin, Beta 4, X Chromosome 2 3
  • Thymosin Beta 4, X-Linked 2 3
  • T Beta-4 3 4
  • PTMB4 3 6
  • FX 3 4
  • Prothymosin Beta-4 3
  • Thymosin Beta-4 3
  • THYB4 4

External Ids for TMSB4X Gene

Previous HGNC Symbols for TMSB4X Gene

  • TMSB4

Previous GeneCards Identifiers for TMSB4X Gene

  • GC04M091917
  • GC04M092061
  • GC0XP012354
  • GC0XP012752
  • GC0XP012903
  • GC0XP010756

Summaries for TMSB4X Gene

Entrez Gene Summary for TMSB4X Gene

  • This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMSB4X Gene

TMSB4X is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot for TMSB4X Gene

  • Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.

  • Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.

Gene Wiki entry for TMSB4X Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB4X Gene

Genomics for TMSB4X Gene

Regulatory Elements for TMSB4X Gene

Genomic Location for TMSB4X Gene

Start:
12,975,107 bp from pter
End:
12,977,227 bp from pter
Size:
2,121 bases
Orientation:
Plus strand

Genomic View for TMSB4X Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMSB4X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB4X Gene

Proteins for TMSB4X Gene

  • Protein details for TMSB4X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62328-TYB4_HUMAN
    Recommended name:
    Thymosin beta-4
    Protein Accession:
    P62328
    Secondary Accessions:
    • P01253
    • P01254
    • Q546P5
    • Q63576
    • Q9UE55

    Protein attributes for TMSB4X Gene

    Size:
    44 amino acids
    Molecular mass:
    5053 Da
    Quaternary structure:
    • Interacts with SERPINB1 (By similarity). Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.

    Three dimensional structures from OCA and Proteopedia for TMSB4X Gene

neXtProt entry for TMSB4X Gene

Proteomics data for TMSB4X Gene at MOPED

Post-translational modifications for TMSB4X Gene

  • Ubiquitination at Lys4, Lys12, Lys26, Lys32, and Lys39
  • Modification sites at PhosphoSitePlus

Other Protein References for TMSB4X Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB4X Gene

Domains for TMSB4X Gene

Protein Domains for TMSB4X Gene

Graphical View of Domain Structure for InterPro Entry

P62328

UniProtKB/Swiss-Prot:

TYB4_HUMAN :
  • P62328
Family:
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB4X: view

No data available for Gene Families for TMSB4X Gene

Function for TMSB4X Gene

Molecular function for TMSB4X Gene

GENATLAS Biochemistry: thymosin beta 4,identical to the interferon inducible gene 6-26 (4/6-26)-like 7,potential actin sequestering protein,escaping inactivation,ubiquitous
UniProtKB/Swiss-Prot Function: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
UniProtKB/Swiss-Prot Function: Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.
UniProtKB/Swiss-Prot Induction: By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant interferon-lambda.

Gene Ontology (GO) - Molecular Function for TMSB4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0003785 actin monomer binding IEA --
GO:0005515 protein binding IPI 17967441
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TMSB4X: view
genes like me logo Genes that share phenotypes with TMSB4X: view

Animal Models for TMSB4X Gene

MGI Knock Outs for TMSB4X:

miRNA for TMSB4X Gene

miRTarBase miRNAs that target TMSB4X

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TMSB4X Gene

Localization for TMSB4X Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB4X Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMSB4X Gene COMPARTMENTS Subcellular localization image for TMSB4X gene
Compartment Confidence
cytoskeleton 5
extracellular 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TMSB4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TMSB4X: view

Pathways for TMSB4X Gene

genes like me logo Genes that share pathways with TMSB4X: view

Pathways by source for TMSB4X Gene

1 Qiagen pathway for TMSB4X Gene
1 BioSystems pathway for TMSB4X Gene

Gene Ontology (GO) - Biological Process for TMSB4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007010 cytoskeleton organization --
GO:0007015 actin filament organization IEA --
GO:0007596 blood coagulation TAS --
GO:0030036 actin cytoskeleton organization --
genes like me logo Genes that share ontologies with TMSB4X: view

Compounds for TMSB4X Gene

(17) Novoseek inferred chemical compound relationships for TMSB4X Gene

Compound -log(P) Hits PubMed IDs
tetrapeptide 66.6 3
matrigel 37.6 3
phalloidin 37 2
perchloric acid 23.8 1
lysine 18 1
genes like me logo Genes that share compounds with TMSB4X: view

Transcripts for TMSB4X Gene

mRNA/cDNA for TMSB4X Gene

Unigene Clusters for TMSB4X Gene

Thymosin beta 4, X-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB4X Gene

No ASD Table

Relevant External Links for TMSB4X Gene

GeneLoc Exon Structure for
TMSB4X
ECgene alternative splicing isoforms for
TMSB4X

Expression for TMSB4X Gene

mRNA expression in normal human tissues for TMSB4X Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMSB4X Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMSB4X Gene

SOURCE GeneReport for Unigene cluster for TMSB4X Gene Hs.437277

mRNA Expression by UniProt/SwissProt for TMSB4X Gene

P62328-TYB4_HUMAN
Tissue specificity: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.
genes like me logo Genes that share expressions with TMSB4X: view

Orthologs for TMSB4X Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB4X Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 64 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia TMSB4X 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMSB4X 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmsb15a 36
  • 64 (a)
ManyToMany
Tmsb4x 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii Dr.12559 35
si:ch211-11c15.3 36
  • 69 (a)
ManyToMany
tmsb 36
  • 69 (a)
ManyToMany
tmsb4x 36
  • 82 (a)
ManyToMany
Species with no ortholog for TMSB4X:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB4X Gene

ENSEMBL:
Gene Tree for TMSB4X (if available)
TreeFam:
Gene Tree for TMSB4X (if available)

Paralogs for TMSB4X Gene

Paralogs for TMSB4X Gene

Selected SIMAP similar genes for TMSB4X Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TMSB4X Gene

genes like me logo Genes that share paralogs with TMSB4X: view

Variants for TMSB4X Gene

Sequence variations from dbSNP and Humsavar for TMSB4X Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs936667 -- 12,973,903(-) ATGGC(A/G)CAGGC upstream-variant-2KB
rs936668 -- 12,973,888(-) GTCTC(G/T)CTGGG upstream-variant-2KB
rs955279 -- 12,976,131(+) AGGAG(A/G/T)GCGAG intron-variant
rs1056398 -- 12,977,044(+) AGGAA(A/G)AAGTG utr-variant-3-prime
rs1056589 -- 12,977,058(+) TGGAA(A/G)AAGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMSB4X Gene

Variant ID Type Subtype PubMed ID
esv1002384 CNV Gain 20482838

Relevant External Links for TMSB4X Gene

HapMap Linkage Disequilibrium report
TMSB4X

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMSB4X Gene

Disorders for TMSB4X Gene

(20) Novoseek inferred disease relationships for TMSB4X Gene

Disease -log(P) Hits PubMed IDs
b-all 36.5 1
colorectal carcinoma 28.8 1
fibrosarcoma 25.8 1
thymoma 22.3 1
scar 14.6 1

Relevant External Links for TMSB4X

Genetic Association Database (GAD)
TMSB4X
genes like me logo Genes that share disorders with TMSB4X: view

No data available for UniProtKB/Swiss-Prot for TMSB4X Gene

Publications for TMSB4X Gene

  1. Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. (PMID: 1999398) Safer D. … Nachmias V.T. (J. Biol. Chem. 1991) 3 4 23
  2. Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity. (PMID: 10848969) Simenel C. … Delepierre M. (Eur. J. Biochem. 2000) 3 4 23
  3. The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cells. (PMID: 1330091) Goldschmidt-Clermont P.J. … Pollard T.D. (Mol. Biol. Cell 1992) 3 23
  4. Reduction of thymosin beta4 and actin in HL60 cells during apoptosis is preceded by a decrease of their mRNAs. (PMID: 12962156) MA1ller C.S. … Hannappel E. (Mol. Cell. Biochem. 2003) 3 23
  5. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. (PMID: 12970751) Ji P. … MA1ller-Tidow C. (Oncogene 2003) 23 48

Products for TMSB4X Gene

Sources for TMSB4X Gene

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