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Aliases for TSPAN4 Gene

Aliases for TSPAN4 Gene

  • Tetraspanin 4 2 3
  • Transmembrane 4 Superfamily Member 7 2 3 4
  • TM4SF7 3 4 6
  • NAG2 3 4 6
  • Novel Antigen 2 3 4
  • TSPAN-4 3 4
  • NAG-2 3 4
  • Tetraspan TM4SF 3
  • Tetraspanin-4 3
  • Tetraspan 3

External Ids for TSPAN4 Gene

Previous Symbols for TSPAN4 Gene

  • TM4SF7

Summaries for TSPAN4 Gene

Entrez Gene Summary for TSPAN4 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN4 Gene

TSPAN4 (Tetraspanin 4) is a Protein Coding gene. Diseases associated with TSPAN4 include congenital hypomyelination neuropathy. An important paralog of this gene is TSPAN9.

Gene Wiki entry for TSPAN4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN4 Gene

Genomics for TSPAN4 Gene

Genomic Location for TSPAN4 Gene

Start:
842,808 bp from pter
End:
867,116 bp from pter
Size:
24,309 bases
Orientation:
Plus strand

Genomic View for TSPAN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN4 Gene

Regulatory Elements for TSPAN4 Gene

Transcription factor binding sites by QIAGEN in the TSPAN4 gene promoter:

Proteins for TSPAN4 Gene

  • Protein details for TSPAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14817-TSN4_HUMAN
    Recommended name:
    Tetraspanin-4
    Protein Accession:
    O14817
    Secondary Accessions:
    • Q6IAP6

    Protein attributes for TSPAN4 Gene

    Size:
    238 amino acids
    Molecular mass:
    26118 Da
    Quaternary structure:
    • Forms a complex with integrins

neXtProt entry for TSPAN4 Gene

Proteomics data for TSPAN4 Gene at MOPED

Post-translational modifications for TSPAN4 Gene

  • Glycosylation at Asn152 and Asn161

No data available for DME Specific Peptides for TSPAN4 Gene

Domains for TSPAN4 Gene

Gene Families for TSPAN4 Gene

HGNC:

UniProtKB/Swiss-Prot:

TSN4_HUMAN
Family:
  • Belongs to the tetraspanin (TM4SF) family.:
    • O14817
genes like me logo Genes that share domains with TSPAN4: view

Function for TSPAN4 Gene

Gene Ontology (GO) - Molecular Function for TSPAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IDA 9360996
GO:0005178 integrin binding IPI 9360996
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TSPAN4: view

Phenotypes for TSPAN4 Gene

GenomeRNAi human phenotypes for TSPAN4:
genes like me logo Genes that share phenotypes with TSPAN4: view

miRNA for TSPAN4 Gene

miRTarBase miRNAs that target TSPAN4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSPAN4 Gene

Localization for TSPAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN4 Gene COMPARTMENTS Subcellular localization image for TSPAN4 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TSPAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 9360996
GO:0005925 focal adhesion IDA 21423176
GO:0016021 integral component of membrane IEA --
GO:0031982 vesicle IDA 9360996
genes like me logo Genes that share ontologies with TSPAN4: view

Pathways for TSPAN4 Gene

SuperPathways for TSPAN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly IDA 9360996
genes like me logo Genes that share ontologies with TSPAN4: view

No data available for Pathways by source for TSPAN4 Gene

Transcripts for TSPAN4 Gene

Unigene Clusters for TSPAN4 Gene

Tetraspanin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN4 Gene

No ASD Table

Relevant External Links for TSPAN4 Gene

GeneLoc Exon Structure for
TSPAN4
ECgene alternative splicing isoforms for
TSPAN4

Expression for TSPAN4 Gene

mRNA expression in normal human tissues for TSPAN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN4 Gene

SOURCE GeneReport for Unigene cluster for TSPAN4 Gene Hs.654836

mRNA Expression by UniProt/SwissProt for TSPAN4 Gene

O14817-TSN4_HUMAN
Tissue specificity: Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets
genes like me logo Genes that share expressions with TSPAN4: view

Orthologs for TSPAN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN4 36
  • 99.58 (n)
  • 99.58 (a)
TSPAN4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN4 36
  • 90.2 (n)
  • 93.28 (a)
TSPAN4 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN4 36
  • 86.97 (n)
  • 93.1 (a)
TSPAN4 37
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan4 36
  • 87.25 (n)
  • 93.7 (a)
Tspan4 16
Tspan4 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSPAN4 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan4 36
  • 86.69 (n)
  • 93.28 (a)
chicken
(Gallus gallus)
Aves TSPAN4 36
  • 78.43 (n)
  • 86.55 (a)
TSPAN4 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN4 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23670 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492951 36
  • 76.33 (n)
  • 82.77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9843 36
zebrafish
(Danio rerio)
Actinopterygii tspan4a 36
  • 73.95 (n)
  • 71.43 (a)
tspan4a 37
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tsp5D 37
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-8 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for TSPAN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN4 Gene

ENSEMBL:
Gene Tree for TSPAN4 (if available)
TreeFam:
Gene Tree for TSPAN4 (if available)

Paralogs for TSPAN4 Gene

Paralogs for TSPAN4 Gene

genes like me logo Genes that share paralogs with TSPAN4: view

Variants for TSPAN4 Gene

Sequence variations from dbSNP and Humsavar for TSPAN4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7091 -- 866,794(+) GCCCT(A/G)GCTCA utr-variant-3-prime
rs10492 -- 866,920(+) AGCAG(G/T)GTTCA utr-variant-3-prime
rs1128960 -- 862,690(+) ATCGG(C/T)TTCGT reference, synonymous-codon, intron-variant
rs1802044 -- 866,878(+) GGGAG(C/G)GGCCT utr-variant-3-prime
rs3923831 -- 858,820(+) CCCCC(A/G)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN4 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
dgv946n71 CNV Loss 21882294
essv11734 CNV CNV 17122850
dgv947n71 CNV Loss 21882294
nsv896599 CNV Loss 21882294
nsv832044 CNV Loss 17160897
nsv896608 CNV Loss 21882294
dgv954n71 CNV Gain 21882294
nsv896619 CNV Gain 21882294
nsv896633 CNV Loss 21882294
dgv956n71 CNV Loss 21882294
nsv8760 CNV Loss 18304495
nsv896636 CNV Loss 21882294
nsv896638 CNV Gain 21882294
esv29561 CNV Loss 19812545
esv2743874 CNV Deletion 23290073
esv2743876 CNV Deletion 23290073
esv2743877 CNV Deletion 23290073
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226

Relevant External Links for TSPAN4 Gene

HapMap Linkage Disequilibrium report
TSPAN4

Disorders for TSPAN4 Gene

Relevant External Links for TSPAN4

Human Genome Epidemiology (HuGE) Navigator
TSPAN4
genes like me logo Genes that share disorders with TSPAN4: view

No data available for UniProtKB/Swiss-Prot for TSPAN4 Gene

Publications for TSPAN4 Gene

  1. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. (PMID: 9360996) Tachibana I. … Hemler M.E. (J. Biol. Chem. 1997) 2 3 4 23
  2. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd S.C. … Levy S. (Biochim. Biophys. Acta 1998) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for TSPAN4 Gene

  • antibodies-online peptides for TSPAN4
  • antibodies-online antibodies for TSPAN4
  • antibodies-online kits for TSPAN4

Sources for TSPAN4 Gene

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