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Aliases for TSPAN7 Gene

Aliases for TSPAN7 Gene

  • Tetraspanin 7 2 3
  • Transmembrane 4 Superfamily Member 2 2 3 4
  • TM4SF2 3 4 6
  • MXS1 3 4 6
  • A15 3 4 6
  • T-Cell Acute Lymphoblastic Leukemia-Associated Antigen 1 3 4
  • Membrane Component Chromosome X Surface Marker 1 3 4
  • Cell Surface Glycoprotein A15 3 4
  • CD231 Antigen 3 4
  • DXS1692E 3 4
  • Tspan-7 3 4
  • TALLA-1 3 4
  • MRX58 3 6
  • T-Cell Acute Lymphoblastic Leukemia Associated Antigen 1 3
  • Membrane Component, X Chromosome, Surface Marker 1 3
  • Mental Retardation, X-Linked 58 2
  • Transmembrane 4 Superfamily 2b 3
  • Transmembrane Protein A15 3
  • Tetraspanin Protein 3
  • Tetraspanin-7 3
  • TM4SF2b 3
  • CCG-B7 3
  • CD231 3

External Ids for TSPAN7 Gene

Previous HGNC Symbols for TSPAN7 Gene

  • MXS1
  • TM4SF2
  • MRX58

Previous GeneCards Identifiers for TSPAN7 Gene

  • GC00U921555
  • GC0XP038177
  • GC0XP038305
  • GC0XP037208
  • GC0XP038420
  • GC0XP036165

Summaries for TSPAN7 Gene

Entrez Gene Summary for TSPAN7 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN7 Gene

TSPAN7 (Tetraspanin 7) is a Protein Coding gene. Diseases associated with TSPAN7 include lymphoblastic leukemia and miliaria rubra. Among its related pathways are Transcriptional misregulation in cancer. An important paralog of this gene is ENSG00000250349.

UniProtKB/Swiss-Prot for TSPAN7 Gene

  • May be involved in cell proliferation and cell motility

Gene Wiki entry for TSPAN7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN7 Gene

Genomics for TSPAN7 Gene

Regulatory Elements for TSPAN7 Gene

Transcription factor binding sites by QIAGEN in the TSPAN7 gene promoter:

Genomic Location for TSPAN7 Gene

Start:
38,561,370 bp from pter
End:
38,688,920 bp from pter
Size:
127,551 bases
Orientation:
Plus strand

Genomic View for TSPAN7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN7 Gene

Proteins for TSPAN7 Gene

  • Protein details for TSPAN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41732-TSN7_HUMAN
    Recommended name:
    Tetraspanin-7
    Protein Accession:
    P41732
    Secondary Accessions:
    • B2R5W7
    • D3DWB1
    • Q8WVG5
    • Q9UEY9

    Protein attributes for TSPAN7 Gene

    Size:
    249 amino acids
    Molecular mass:
    27574 Da
    Quaternary structure:
    • Interacts with herpes simplex virus 1 (HHV-1) UL35.
    SequenceCaution:
    • Sequence=BAA01501.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA06191.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSPAN7 Gene

Proteomics data for TSPAN7 Gene at MOPED

Post-translational modifications for TSPAN7 Gene

  • Glycosylation at Asn54, Asn155, Asn158, Asn177, and Asn188
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN7 Gene

No data available for DME Specific Peptides for TSPAN7 Gene

Domains for TSPAN7 Gene

Gene Families for TSPAN7 Gene

HGNC:
  • CD :CD molecules
  • TSPAN :Tetraspanins

Graphical View of Domain Structure for InterPro Entry

P41732

UniProtKB/Swiss-Prot:

TSN7_HUMAN :
  • P41732
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN7: view

Function for TSPAN7 Gene

Molecular function for TSPAN7 Gene

UniProtKB/Swiss-Prot Function: May be involved in cell proliferation and cell motility

miRNA for TSPAN7 Gene

miRTarBase miRNAs that target TSPAN7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSPAN7 Gene

Localization for TSPAN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN7 Gene COMPARTMENTS Subcellular localization image for TSPAN7 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TSPAN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8420826
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TSPAN7: view

Pathways for TSPAN7 Gene

genes like me logo Genes that share pathways with TSPAN7: view

Pathways by source for TSPAN7 Gene

1 KEGG pathway for TSPAN7 Gene

Gene Ontology (GO) - Biological Process for TSPAN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TSPAN7: view

Compounds for TSPAN7 Gene

(4) Novoseek inferred chemical compound relationships for TSPAN7 Gene

Compound -log(P) Hits PubMed IDs
matrigel 26.8 1
phosphoinositide 19.8 1
lipid 10.7 3
cholesterol 6.91 1
genes like me logo Genes that share compounds with TSPAN7: view

Transcripts for TSPAN7 Gene

Unigene Clusters for TSPAN7 Gene

Tetraspanin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN7 Gene

No ASD Table

Relevant External Links for TSPAN7 Gene

GeneLoc Exon Structure for
TSPAN7
ECgene alternative splicing isoforms for
TSPAN7

Expression for TSPAN7 Gene

mRNA expression in normal human tissues for TSPAN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.1), Brain - Putamen (basal ganglia) (4.9), Brain - Frontal Cortex (BA9) (4.8), Brain - Caudate (basal ganglia) (4.6), and Brain - Anterior cingulate cortex (BA24) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TSPAN7 Gene

SOURCE GeneReport for Unigene cluster for TSPAN7 Gene Hs.441664

mRNA Expression by UniProt/SwissProt for TSPAN7 Gene

P41732-TSN7_HUMAN
Tissue specificity: Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients
genes like me logo Genes that share expressions with TSPAN7: view

Orthologs for TSPAN7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN7 35
  • 100 (n)
  • 100 (a)
TSPAN7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN7 35
  • 93.44 (n)
  • 97.59 (a)
TSPAN7 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 85 (a)
OneToMany
TSPAN7 35
  • 94.11 (n)
  • 99.6 (a)
mouse
(Mus musculus)
Mammalia Gm5334 36
  • 64 (a)
ManyToMany
Tspan7 35
  • 93.44 (n)
  • 98.39 (a)
Tspan7 16
Tspan7 36
  • 98 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tspan7 35
  • 93.51 (n)
  • 97.74 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 83 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia tm4sf2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76243 35
tspan7 35
  • 79.52 (n)
  • 89.56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.702 35
zebrafish
(Danio rerio)
Actinopterygii tspan7b 35
  • 77.24 (n)
  • 83.94 (a)
tspan7b 36
  • 84 (a)
OneToMany
wufb53h11 35
worm
(Caenorhabditis elegans)
Secernentea tsp-14 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7928 36
  • 38 (a)
OneToMany
Species with no ortholog for TSPAN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN7 Gene

ENSEMBL:
Gene Tree for TSPAN7 (if available)
TreeFam:
Gene Tree for TSPAN7 (if available)

Paralogs for TSPAN7 Gene

genes like me logo Genes that share paralogs with TSPAN7: view

Variants for TSPAN7 Gene

Sequence variations from dbSNP and Humsavar for TSPAN7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3269 -- 38,688,829(+) CAAAA(A/C/G)TAATG utr-variant-3-prime
rs10333 -- 38,688,608(+) CTCTC(A/G)GTTGA utr-variant-3-prime
rs15765 -- 38,688,054(+) CCTCT(A/C)CCCCT utr-variant-3-prime
rs754341 -- 38,600,898(+) AGTGG(C/T)GTTTT intron-variant
rs963481 -- 38,625,725(+) ATTAG(A/T)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN7 Gene

Variant ID Type Subtype PubMed ID
nsv520210 CNV Gain 19592680

Relevant External Links for TSPAN7 Gene

HapMap Linkage Disequilibrium report
TSPAN7
Human Gene Mutation Database (HGMD)
TSPAN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN7 Gene

Disorders for TSPAN7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (7) Diseases for TSPAN7 Gene including...

Search for TSPAN7 Gene in MalaCards »

(1) OMIM Diseases for TSPAN7 Gene (300096)

UniProtKB/Swiss-Prot

TSN7_HUMAN
  • Mental retardation, X-linked 58 (MRX58) [MIM:300210]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:10655063}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for TSPAN7 Gene

(4) Novoseek inferred disease relationships for TSPAN7 Gene

Disease -log(P) Hits PubMed IDs
metastasis 24.7 3
tumors 13.5 3
prostate cancer 0 1
cancer 0 1

Relevant External Links for TSPAN7

Genetic Association Database (GAD)
TSPAN7
Human Genome Epidemiology (HuGE) Navigator
TSPAN7
genes like me logo Genes that share disorders with TSPAN7: view

Publications for TSPAN7 Gene

  1. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. (PMID: 10655063) Zemni R. … Chelly J. (Nat. Genet. 2000) 3 4 23
  2. Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins. (PMID: 17989173) Sato K. … Koyanagi Y. (J. Virol. 2008) 3 23
  3. Novel partners of SPAG11B isoform D in the human male reproductive tract. (PMID: 19535787) Radhakrishnan Y. … French F.S. (Biol. Reprod. 2009) 3 23
  4. Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins. (PMID: 8168850) Virtaneva K.I. … SchrAPder J.P. (Immunogenetics 1994) 3 23
  5. Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily. (PMID: 7768645) Takagi S. … Yoshie O. (Int. J. Cancer 1995) 3 4

Products for TSPAN7 Gene

Sources for TSPAN7 Gene

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