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Aliases for NR2E1 Gene

Aliases for NR2E1 Gene

  • Nuclear Receptor Subfamily 2, Group E, Member 1 2 3
  • TLX 3 4 6
  • Protein Tailless Homolog 3 4
  • Nuclear Receptor TLX 3 4
  • TLL 3 4
  • Nuclear Receptor Subfamily 2 Group E Member 1 3
  • Tailes-Related Receptor 3
  • Tailless Homolog 3
  • XTLL 3
  • HTll 4

External Ids for NR2E1 Gene

Previous Symbols for NR2E1 Gene

  • TLX

Summaries for NR2E1 Gene

GeneCards Summary for NR2E1 Gene

NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1) is a Protein Coding gene. Diseases associated with NR2E1 include lymphoid leukemia. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding and histone deacetylase binding. An important paralog of this gene is RXRG.

UniProtKB/Swiss-Prot for NR2E1 Gene

  • Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5-AAGGTCA-3 in which the 5 flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells.

Gene Wiki entry for NR2E1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2E1 Gene

Genomics for NR2E1 Gene

Genomic Location for NR2E1 Gene

Start:
108,166,058 bp from pter
End:
108,188,809 bp from pter
Size:
22,752 bases
Orientation:
Plus strand

Genomic View for NR2E1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR2E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2E1 Gene

Regulatory Elements for NR2E1 Gene

Proteins for NR2E1 Gene

  • Protein details for NR2E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y466-NR2E1_HUMAN
    Recommended name:
    Nuclear receptor subfamily 2 group E member 1
    Protein Accession:
    Q9Y466
    Secondary Accessions:
    • Q6ZMP8

    Protein attributes for NR2E1 Gene

    Size:
    385 amino acids
    Molecular mass:
    42589 Da
    Quaternary structure:
    • Monomer. Interacts with ATN1; the interaction represses the transcription.

    Three dimensional structures from OCA and Proteopedia for NR2E1 Gene

    Alternative splice isoforms for NR2E1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2E1 Gene

Proteomics data for NR2E1 Gene at MOPED

Post-translational modifications for NR2E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR2E1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NR2E1 Gene

Domains for NR2E1 Gene

Gene Families for NR2E1 Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

UniProtKB/Swiss-Prot:

NR2E1_HUMAN
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.:
    • Q9Y466
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.:
    • Q9Y466
genes like me logo Genes that share domains with NR2E1: view

Function for NR2E1 Gene

Molecular function for NR2E1 Gene

GENATLAS Biochemistry: nuclear receptor subfamily 2,group E,member 1,Drosophila tailless homolog,predominantly expressed in the developing fore/midbrain neuroepithelium,retina and nasal epithelium,brain,steroid nuclear receptor superfamily (see TSG6F)
UniProtKB/Swiss-Prot Function: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5-AAGGTCA-3 in which the 5 flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells.

Gene Ontology (GO) - Molecular Function for NR2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with NR2E1: view
genes like me logo Genes that share phenotypes with NR2E1: view

miRNA for NR2E1 Gene

miRTarBase miRNAs that target NR2E1
Targeting motifs for NR2E1 Gene
HOMER Transcription Factor Regulatory Elements motif NR2E1
  • Consensus sequence: CTGGCAGGCTGCCA Submotif: canonical Cell Type: NPC GeoId: GSE16256

No data available for Enzyme Numbers (IUBMB) , Animal Models and Transcription Factor Targeting for NR2E1 Gene

Localization for NR2E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2E1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR2E1 Gene COMPARTMENTS Subcellular localization image for NR2E1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for NR2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with NR2E1: view

Pathways for NR2E1 Gene

genes like me logo Genes that share pathways with NR2E1: view

Pathways by source for NR2E1 Gene

1 BioSystems pathway for NR2E1 Gene

Gene Ontology (GO) - Biological Process for NR2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001662 behavioral fear response IEA --
GO:0002118 aggressive behavior IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with NR2E1: view

Compounds for NR2E1 Gene

(1) Novoseek inferred chemical compound relationships for NR2E1 Gene

Compound -log(P) Hits PubMed IDs
steroid 18.7 3
genes like me logo Genes that share compounds with NR2E1: view

Transcripts for NR2E1 Gene

mRNA/cDNA for NR2E1 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NR2E1 Gene

Nuclear receptor subfamily 2, group E, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR2E1 Gene

No ASD Table

Relevant External Links for NR2E1 Gene

GeneLoc Exon Structure for
NR2E1
ECgene alternative splicing isoforms for
NR2E1

Expression for NR2E1 Gene

mRNA expression in normal human tissues for NR2E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR2E1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (8.0), Brain - Nucleus accumbens (basal ganglia) (7.7), Brain - Amygdala (7.4), Brain - Putamen (basal ganglia) (6.1), Brain - Cortex (5.0), Brain - Frontal Cortex (BA9) (4.8), Brain - Anterior cingulate cortex (BA24) (4.7), and Brain - Hippocampus (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NR2E1 Gene

SOURCE GeneReport for Unigene cluster for NR2E1 Gene Hs.157688

mRNA Expression by UniProt/SwissProt for NR2E1 Gene

Q9Y466-NR2E1_HUMAN
Tissue specificity: Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
genes like me logo Genes that share expressions with NR2E1: view

Orthologs for NR2E1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2E1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2E1 36
  • 99.74 (n)
  • 100 (a)
NR2E1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NR2E1 36
  • 94.55 (n)
  • 99.48 (a)
NR2E1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR2E1 36
  • 94.55 (n)
  • 99.74 (a)
NR2E1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr2e1 36
  • 91.86 (n)
  • 98.96 (a)
Nr2e1 16
Nr2e1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR2E1 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR2E1 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr2e1 36
  • 91 (n)
  • 98.18 (a)
chicken
(Gallus gallus)
Aves NR2E1 36
  • 87.1 (n)
  • 97.14 (a)
NR2E1 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR2E1 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nr2e1-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nr2e1 36
  • 80.09 (n)
  • 94.29 (a)
zebrafish
(Danio rerio)
Actinopterygii nr2e1 36
  • 76.8 (n)
  • 91.69 (a)
nr2e1 37
  • 89 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dsf 36
  • 57.4 (n)
  • 53.97 (a)
tll 37
  • 39 (a)
OneToOne
tll 38
  • 39 (a)
dsf 38
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea nhr-67 36
  • 50 (n)
  • 41.78 (a)
nhr-67 38
  • 30 (a)
Species with no ortholog for NR2E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR2E1 Gene

ENSEMBL:
Gene Tree for NR2E1 (if available)
TreeFam:
Gene Tree for NR2E1 (if available)

Paralogs for NR2E1 Gene

Paralogs for NR2E1 Gene

Pseudogenes.org Pseudogenes for NR2E1 Gene

genes like me logo Genes that share paralogs with NR2E1: view

Variants for NR2E1 Gene

Sequence variations from dbSNP and Humsavar for NR2E1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs127501 -- 108,166,673(+) AGGGC(A/G)GCTGG upstream-variant-2KB, utr-variant-5-prime
rs217520 -- 108,172,145(+) GAGGC(A/C)GTGCT intron-variant
rs217521 -- 108,172,324(+) CCATA(A/T)CCCTG intron-variant
rs217522 -- 108,174,540(+) GCGGG(A/G)TCTGC intron-variant
rs217524 -- 108,177,411(-) AGCTG(G/T)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NR2E1 Gene

Variant ID Type Subtype PubMed ID
nsv830766 CNV Loss 17160897

Relevant External Links for NR2E1 Gene

HapMap Linkage Disequilibrium report
NR2E1
Human Gene Mutation Database (HGMD)
NR2E1

Disorders for NR2E1 Gene

(1) MalaCards Diseases for NR2E1 Gene

Search for NR2E1 Gene in MalaCards »

Relevant External Links for NR2E1

Genetic Association Database (GAD)
NR2E1
Human Genome Epidemiology (HuGE) Navigator
NR2E1
genes like me logo Genes that share disorders with NR2E1: view

No data available for UniProtKB/Swiss-Prot for NR2E1 Gene

Publications for NR2E1 Gene

  1. The human homologue of the Drosophila tailless gene (TLX): characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21. (PMID: 9628820) Jackson A. … Foroni L. (Genomics 1998) 2 3 4 23
  2. Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx. (PMID: 8047143) Yu R.T. … Umesono K. (Nature 1994) 3 23
  3. Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX. (PMID: 19555662) Iwahara N. … Horio Y. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX. (PMID: 11073974) Kobayashi M. … Umesono K. (Mol. Cell. Biol. 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NR2E1 Gene

  • Addgene plasmids for NR2E1

Sources for NR2E1 Gene

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