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Aliases for TLR2 Gene

Aliases for TLR2 Gene

  • Toll-Like Receptor 2 2 3
  • TIL4 3 4 6
  • Toll/Interleukin-1 Receptor-Like Protein 4 3 4
  • Toll/Interleukin 1 Receptor-Like 4 3
  • CD282 Antigen 4
  • CD282 3

External Ids for TLR2 Gene

Summaries for TLR2 Gene

Entrez Gene Summary for TLR2 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR2 Gene

TLR2 (Toll-Like Receptor 2) is a Protein Coding gene. Diseases associated with TLR2 include enthesitis-related arthritis and leprosy. Among its related pathways are PI3K-Akt signaling pathway and Proteoglycans in cancer. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR2 Gene

  • Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6

Tocris Summary for TLR2 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like receptors are activated by molecules associated with biological threat and are highly specific towards evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR2 Gene

Genomics for TLR2 Gene

Genomic Location for TLR2 Gene

Start:
153,684,252 bp from pter
End:
153,706,091 bp from pter
Size:
21,840 bases
Orientation:
Plus strand

Genomic View for TLR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR2 Gene

Regulatory Elements for TLR2 Gene

Proteins for TLR2 Gene

  • Protein details for TLR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60603-TLR2_HUMAN
    Recommended name:
    Toll-like receptor 2
    Protein Accession:
    O60603
    Secondary Accessions:
    • B3Y612
    • D1CS45
    • D1CS48
    • D1CS49
    • O15454
    • Q8NI00

    Protein attributes for TLR2 Gene

    Size:
    784 amino acids
    Molecular mass:
    89838 Da
    Quaternary structure:
    • Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3 (By similarity). Interacts with ATG16L1.

    Three dimensional structures from OCA and Proteopedia for TLR2 Gene

neXtProt entry for TLR2 Gene

Proteomics data for TLR2 Gene at MOPED

Post-translational modifications for TLR2 Gene

  • Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn114, Asn199, Asn414, and Asn442

Other Protein References for TLR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TLR2 Gene

Domains for TLR2 Gene

Gene Families for TLR2 Gene

HGNC:
  • CD :CD molecules
IUPHAR :

UniProtKB/Swiss-Prot:

TLR2_HUMAN
Domain:
  • Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.:
    • O60603
  • The ATG16L1-binding motif mediates interaction with ATG16L1.:
    • O60603
  • Contains 1 LRRCT domain.:
    • O60603
  • Contains 1 TIR domain.:
    • O60603
Family:
  • Belongs to the Toll-like receptor family.:
    • O60603
Similarity:
  • Contains 19 LRR (leucine-rich) repeats.:
    • O60603
genes like me logo Genes that share domains with TLR2: view

Function for TLR2 Gene

Molecular function for TLR2 Gene

GENATLAS Biochemistry: Drosophila transmembrane receptor Toll homolog 2,with two alternatively spliced isoforms,one expressed in lung,the other in heart,brain,muscle,mediator of liposaccharide (LPS) considered as a receptor,induced cellular signaling,involved in innate immunity through the recruitment of MYD88,against Gram positive bacteria
UniProtKB/Swiss-Prot Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6

Gene Ontology (GO) - Molecular Function for TLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001875 lipopolysaccharide receptor activity TAS 11518816
GO:0004872 receptor activity IDA 11672593
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 10854325
GO:0008329 signaling pattern recognition receptor activity IDA 10384090
genes like me logo Genes that share ontologies with TLR2: view
genes like me logo Genes that share phenotypes with TLR2: view

Animal Models for TLR2 Gene

MGI Knock Outs for TLR2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TLR2 Gene

Localization for TLR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR2 Gene COMPARTMENTS Subcellular localization image for TLR2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 3
vacuole 2
cytoskeleton 1
cytosol 1
endosome 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19740627
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9435236
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 12443841
genes like me logo Genes that share ontologies with TLR2: view

Pathways for TLR2 Gene

genes like me logo Genes that share pathways with TLR2: view

Gene Ontology (GO) - Biological Process for TLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001774 microglial cell activation IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002238 response to molecule of fungal origin IEA --
GO:0002374 cytokine secretion involved in immune response IMP 20441518
genes like me logo Genes that share ontologies with TLR2: view

Compounds for TLR2 Gene

(5) Tocris Compounds for TLR2 Gene

Compound Action Cas Number
Imiquimod Toll-like receptor 7 (TLR7) agonist [99011-02-6]
Pam2CSK4 TLR2/6 agonist; induces TNF-alpha production [868247-72-7]
Pam3CSK4 TLR1/2 agonist; induces cytokine production [112208-00-1]
Poly(I:C) TLR3 agonist [42424-50-0]
Resiquimod Toll-like receptor 7 (TLR7) agonist [144875-48-9]

(2) Drugbank Compounds for TLR2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
OspA lipoprotein
target other/unknown
S-(Dimethylarsenic)Cysteine
target

(1) IUPHAR Ligand for TLR2 Gene

Ligand Type Action Affinity Pubmed IDs
peptidoglycan Agonist Agonist

(88) Novoseek inferred chemical compound relationships for TLR2 Gene

Compound -log(P) Hits PubMed IDs
lipoteichoic acid 90.7 113
peptidoglycan 87.1 133
loxoribine 75.5 4
hbd2 74.1 9
flagellin 73.8 28
genes like me logo Genes that share compounds with TLR2: view

Transcripts for TLR2 Gene

Unigene Clusters for TLR2 Gene

Toll-like receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLR2 Gene

No ASD Table

Relevant External Links for TLR2 Gene

GeneLoc Exon Structure for
TLR2
ECgene alternative splicing isoforms for
TLR2

Expression for TLR2 Gene

mRNA expression in normal human tissues for TLR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR2 Gene

This gene is overexpressed in Whole Blood (30.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TLR2 Gene

SOURCE GeneReport for Unigene cluster for TLR2 Gene Hs.519033

mRNA Expression by UniProt/SwissProt for TLR2 Gene

O60603-TLR2_HUMAN
Tissue specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues
genes like me logo Genes that share expressions with TLR2: view

Orthologs for TLR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR2 36
  • 99.62 (n)
  • 99.62 (a)
TLR2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLR2 36
  • 83.4 (n)
  • 77.78 (a)
TLR2 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLR2 36
  • 82.65 (n)
  • 76.79 (a)
TLR2 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlr2 36
  • 75.64 (n)
  • 70.92 (a)
Tlr2 16
Tlr2 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLR2 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLR2 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr2 36
  • 76.19 (n)
  • 71.68 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 52 (a)
OneToMany
TLR15 37
  • 22 (a)
OneToMany
TLR2-2 36
  • 60.08 (n)
  • 53.71 (a)
TLR2-2 37
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 36 (a)
OneToMany
-- 37
  • 50 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
-- 37
  • 27 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485771 36
  • 55.84 (n)
  • 50.4 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr2 36
  • 50.99 (n)
  • 43.68 (a)
tlr2 37
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Toll-9 37
  • 17 (a)
OneToMany
Species with no ortholog for TLR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR2 Gene

ENSEMBL:
Gene Tree for TLR2 (if available)
TreeFam:
Gene Tree for TLR2 (if available)

Paralogs for TLR2 Gene

Paralogs for TLR2 Gene

Selected SIMAP similar genes for TLR2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for TLR2 Gene

genes like me logo Genes that share paralogs with TLR2: view

Variants for TLR2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TLR2 Gene

O60603-TLR2_HUMAN
Genetic variations in TLR2 are associated with susceptibility to leprosy [MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy

Sequence variations from dbSNP and Humsavar for TLR2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs893629 -- 153,683,816(+) ATGGA(A/G)AAGCA upstream-variant-2KB
rs893630 -- 153,683,833(+) GTGGA(A/G)TTTAA upstream-variant-2KB
rs970233 -- 153,684,893(+) GTCGC(C/T)CTCCC intron-variant
rs977544 -- 153,700,432(+) aagac(C/T)taaat intron-variant, upstream-variant-2KB
rs977545 -- 153,700,737(+) ATCAC(C/T)TAGAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TLR2 Gene

Variant ID Type Subtype PubMed ID
nsv482972 CNV Gain 15286789

Relevant External Links for TLR2 Gene

HapMap Linkage Disequilibrium report
TLR2
Human Gene Mutation Database (HGMD)
TLR2

Disorders for TLR2 Gene

(3) OMIM Diseases for TLR2 Gene (603028)

(96) Novoseek inferred disease relationships for TLR2 Gene

Disease -log(P) Hits PubMed IDs
inflammation 70.6 81
necrosis 67.2 90
gram-positive bacterial infections 59.5 2
bacterial infections 58.9 19
tuberculosis 56.2 79

Relevant External Links for TLR2

Genetic Association Database (GAD)
TLR2
Human Genome Epidemiology (HuGE) Navigator
TLR2
genes like me logo Genes that share disorders with TLR2: view

No data available for UniProtKB/Swiss-Prot for TLR2 Gene

Publications for TLR2 Gene

  1. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. (PMID: 11035751) Lorenz E. … Schwartz D.A. (Infect. Immun. 2000) 3 23 49
  2. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. (PMID: 11476982) Kang T.-J. … Chae G.-T. (FEMS Immunol. Med. Microbiol. 2001) 3 4 23
  3. A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy. (PMID: 12445799) Kang T.J. … Chae G.T. (Cytokine 2002) 3 23 49
  4. A Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. (PMID: 12646604) Bochud P.-Y. … Aderem A. (J. Immunol. 2003) 3 4 23
  5. Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis. (PMID: 14551607) Hise A.G. … Kazura J.W. (Genes Immun. 2003) 3 23 49

Products for TLR2 Gene

  • Addgene plasmids for TLR2

Sources for TLR2 Gene

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