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Aliases for TLR2 Gene

Aliases for TLR2 Gene

  • Toll Like Receptor 2 2 3
  • Toll/Interleukin-1 Receptor-Like Protein 4 3 4
  • Toll-Like Receptor 2 2 5
  • TIL4 3 4
  • CD282 Antigen 4
  • CD282 3

External Ids for TLR2 Gene

Previous GeneCards Identifiers for TLR2 Gene

  • GC04P155458
  • GC04P154997
  • GC04P155183
  • GC04P155186
  • GC04P154966
  • GC04P154824
  • GC04P154606
  • GC04P150336
  • GC04P154612

Summaries for TLR2 Gene

Entrez Gene Summary for TLR2 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for TLR2 Gene

TLR2 (Toll Like Receptor 2) is a Protein Coding gene. Diseases associated with TLR2 include leprosy and colorectal cancer. Among its related pathways are Amoebiasis and Toll-like receptor signaling pathway. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR2 Gene

  • Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36).The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211).

Tocris Summary for TLR2 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

Gene Wiki entry for TLR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR2 Gene

Genomics for TLR2 Gene

Regulatory Elements for TLR2 Gene

Enhancers for TLR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TLR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLR2 Gene

Chromosome:
4
Start:
153,684,256 bp from pter
End:
153,706,091 bp from pter
Size:
21,836 bases
Orientation:
Plus strand

Genomic View for TLR2 Gene

Genes around TLR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR2 Gene

Proteins for TLR2 Gene

  • Protein details for TLR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60603-TLR2_HUMAN
    Recommended name:
    Toll-like receptor 2
    Protein Accession:
    O60603
    Secondary Accessions:
    • B3Y612
    • D1CS45
    • D1CS48
    • D1CS49
    • O15454
    • Q8NI00

    Protein attributes for TLR2 Gene

    Size:
    784 amino acids
    Molecular mass:
    89838 Da
    Quaternary structure:
    • Interacts with LY96, TLR1 and TLR6 (via extracellular domain) (PubMed:17889651). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211). Binds MYD88 (via TIR domain). Interacts with TICAM1 (PubMed:12471095). Interacts with CNPY3 (By similarity). Interacts with ATG16L1 (PubMed:23376921).

    Three dimensional structures from OCA and Proteopedia for TLR2 Gene

neXtProt entry for TLR2 Gene

Proteomics data for TLR2 Gene at MOPED

Post-translational modifications for TLR2 Gene

  • Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • Glycosylation at Asn 114, Asn 199, Asn 414, and Asn 442
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR2 Gene

Antibody Products

No data available for DME Specific Peptides for TLR2 Gene

Domains & Families for TLR2 Gene

Gene Families for TLR2 Gene

Graphical View of Domain Structure for InterPro Entry

O60603

UniProtKB/Swiss-Prot:

TLR2_HUMAN :
  • Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
  • Belongs to the Toll-like receptor family.
  • Contains 19 LRR (leucine-rich) repeats.
Domain:
  • Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
  • The ATG16L1-binding motif mediates interaction with ATG16L1.
  • Contains 1 LRRCT domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 19 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR2: view

Function for TLR2 Gene

Molecular function for TLR2 Gene

GENATLAS Biochemistry:
Drosophila transmembrane receptor Toll homolog 2,with two alternatively spliced isoforms,one expressed in lung,the other in heart,brain,muscle,mediator of liposaccharide (LPS) considered as a receptor,induced cellular signaling,involved in innate immunity through the recruitment of MYD88,against Gram positive bacteria
UniProtKB/Swiss-Prot Function:
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36).The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211).

Gene Ontology (GO) - Molecular Function for TLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042834 peptidoglycan binding IDA 11986301
genes like me logo Genes that share ontologies with TLR2: view
genes like me logo Genes that share phenotypes with TLR2: view

Animal Models for TLR2 Gene

MGI Knock Outs for TLR2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR2 Gene

Localization for TLR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR2 Gene

Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. {ECO:0000269 PubMed:16880211}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR2 Gene COMPARTMENTS Subcellular localization image for TLR2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 3
extracellular 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
mitochondrion 2
vacuole 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 12443841
genes like me logo Genes that share ontologies with TLR2: view

Pathways & Interactions for TLR2 Gene

genes like me logo Genes that share pathways with TLR2: view

Gene Ontology (GO) - Biological Process for TLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway IEA --
GO:0002374 cytokine secretion involved in immune response IMP 20441518
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006915 apoptotic process TAS 10426996
GO:0006955 immune response IEA,TAS 10426995
genes like me logo Genes that share ontologies with TLR2: view

No data available for SIGNOR curated interactions for TLR2 Gene

Drugs & Compounds for TLR2 Gene

(66) Drugs for TLR2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
OspA lipoprotein Approved, Withdrawn Pharma Target, other/unknown 0
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2701
Cyproterone Acetate Approved, Investigational Pharma Androgen receptor antagonist 39
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1649
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1649

(51) Additional Compounds for TLR2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Pam3CSK4
112208-00-1
Poly(I:C)
24939-03-5
RWJ 21757
121288-39-9

(5) Tocris Compounds for TLR2 Gene

Compound Action Cas Number
Imiquimod Toll-like receptor 7 (TLR7) agonist 99011-02-6
Pam3CSK4 TLR1/2 agonist; induces cytokine production 112208-00-1
Poly(I:C) TLR3 agonist 24939-03-5
Resiquimod Toll-like receptor 7 (TLR7) agonist 144875-48-9
RWJ 21757 Toll-like receptor 7 (TLR7) agonist 121288-39-9
genes like me logo Genes that share compounds with TLR2: view

Transcripts for TLR2 Gene

Unigene Clusters for TLR2 Gene

Toll-like receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLR2 Gene

No ASD Table

Relevant External Links for TLR2 Gene

GeneLoc Exon Structure for
TLR2
ECgene alternative splicing isoforms for
TLR2

Expression for TLR2 Gene

mRNA expression in normal human tissues for TLR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR2 Gene

This gene is overexpressed in Whole Blood (x30.2).

Protein differential expression in normal tissues from HIPED for TLR2 Gene

This gene is overexpressed in Monocytes (39.9), Peripheral blood mononuclear cells (16.1), and Milk (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLR2 Gene



SOURCE GeneReport for Unigene cluster for TLR2 Gene Hs.519033

mRNA Expression by UniProt/SwissProt for TLR2 Gene

O60603-TLR2_HUMAN
Tissue specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
genes like me logo Genes that share expression patterns with TLR2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for TLR2 Gene

Orthologs for TLR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLR2 35
  • 83.4 (n)
  • 77.78 (a)
TLR2 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLR2 35
  • 82.65 (n)
  • 76.79 (a)
TLR2 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlr2 35
  • 75.64 (n)
  • 70.92 (a)
Tlr2 16
Tlr2 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLR2 35
  • 99.62 (n)
  • 99.62 (a)
TLR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr2 35
  • 76.19 (n)
  • 71.68 (a)
oppossum
(Monodelphis domestica)
Mammalia TLR2 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLR2 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLR2-2 35
  • 60.08 (n)
  • 53.71 (a)
-- 36
  • 52 (a)
OneToMany
TLR15 36
  • 22 (a)
OneToMany
TLR2-2 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485771 35
  • 55.84 (n)
  • 50.4 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr2 35
  • 50.99 (n)
  • 43.68 (a)
tlr2 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Toll-9 36
  • 17 (a)
OneToMany
Species with no ortholog for TLR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR2 Gene

ENSEMBL:
Gene Tree for TLR2 (if available)
TreeFam:
Gene Tree for TLR2 (if available)

Paralogs for TLR2 Gene

Paralogs for TLR2 Gene

(4) SIMAP similar genes for TLR2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for TLR2 Gene

genes like me logo Genes that share paralogs with TLR2: view

Variants for TLR2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TLR2 Gene

O60603-TLR2_HUMAN
Genetic variations in TLR2 are associated with susceptibility to leprosy [MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy.

Sequence variations from dbSNP and Humsavar for TLR2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs977544 -- 153,700,432(+) aagac(C/T)taaat intron-variant, upstream-variant-2KB
rs977545 -- 153,700,737(+) ATCAC(C/T)TAGAT intron-variant, upstream-variant-2KB
rs893629 -- 153,683,816(+) ATGGA(A/G)AAGCA upstream-variant-2KB
rs893630 -- 153,683,833(+) GTGGA(A/G)TTTAA upstream-variant-2KB
rs970233 -- 153,684,893(+) GTCGC(C/T)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLR2 Gene

Variant ID Type Subtype PubMed ID
nsv482972 CNV Gain 15286789

Variation tolerance for TLR2 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLR2 Gene

HapMap Linkage Disequilibrium report
TLR2
Human Gene Mutation Database (HGMD)
TLR2

Disorders for TLR2 Gene

MalaCards: The human disease database

(89) MalaCards diseases for TLR2 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leprosy
  • leprosy, susceptibility to
colorectal cancer
  • colorectal cancer, somatic
lepromatous leprosy
  • lepromatous leprosy [type l]
tuberculosis
  • tuberculosis of mother, with delivery
rosacea
  • acne rosacea
- elite association - COSMIC cancer census association via MalaCards
Search TLR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLR2

Genetic Association Database (GAD)
TLR2
Human Genome Epidemiology (HuGE) Navigator
TLR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLR2
genes like me logo Genes that share disorders with TLR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR2 Gene

Publications for TLR2 Gene

  1. A family of human receptors structurally related to Drosophila Toll. (PMID: 9435236) Rock F.L. … Bazan J.F. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. TLR2 plays a role in the activation of human resident renal stem/progenitor cells. (PMID: 19843711) Sallustio F. … Schena F.P. (FASEB J. 2010) 3 23
  3. Treponema denticola suppresses expression of human {beta}-defensin-3 in gingival epithelial cells through inhibition of the toll-like receptor 2 axis. (PMID: 19995893) Shin J.E. … Choi Y. (Infect. Immun. 2010) 3 23
  4. A network of hydrogen bonds on the surface of TLR2 controls ligand positioning and cell signaling. (PMID: 20007698) Kajava A.V. … Vasselon T. (J. Biol. Chem. 2010) 3 23
  5. Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. (PMID: 20067962) Dasu M.R. … Jialal I. (Diabetes Care 2010) 3 23

Products for TLR2 Gene

Sources for TLR2 Gene

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