Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLE1 Gene

Aliases for TLE1 Gene

  • Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila) 2 3
  • ESG1 3 4 6
  • Enhancer Of Split Groucho-Like Protein 1 3 4
  • Transducin-Like Enhancer Of Split 1, Homolog Of Drosophila E(Sp1) 2
  • Transducin-Like Enhancer Protein 1 3
  • Enhancer Of Split Groucho 1 2
  • E(Sp1) Homolog 4
  • GRG1 3
  • ESG 3

External Ids for TLE1 Gene

Previous GeneCards Identifiers for TLE1 Gene

  • GC09M075257
  • GC09M076067
  • GC09M077768
  • GC09M079655
  • GC09M081428
  • GC09M083388
  • GC09M084198
  • GC09M054030

Summaries for TLE1 Gene

GeneCards Summary for TLE1 Gene

TLE1 (Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and RNA polymerase II transcription corepressor activity. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot for TLE1 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Gene Wiki entry for TLE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE1 Gene

Genomics for TLE1 Gene

Regulatory Elements for TLE1 Gene

Genomic Location for TLE1 Gene

Start:
81,583,683 bp from pter
End:
81,689,344 bp from pter
Size:
105,662 bases
Orientation:
Minus strand

Genomic View for TLE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE1 Gene

Proteins for TLE1 Gene

  • Protein details for TLE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04724-TLE1_HUMAN
    Recommended name:
    Transducin-like enhancer protein 1
    Protein Accession:
    Q04724
    Secondary Accessions:
    • A8K495
    • Q5T3G4
    • Q969V9

    Protein attributes for TLE1 Gene

    Size:
    770 amino acids
    Molecular mass:
    83201 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif). Interacts with SIX3. Interacts with EFNB1.

    Three dimensional structures from OCA and Proteopedia for TLE1 Gene

neXtProt entry for TLE1 Gene

Proteomics data for TLE1 Gene at MOPED

Post-translational modifications for TLE1 Gene

  • Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1
  • Ubiquitinated by XIAP/BIRC4.
  • Ubiquitination at Lys30 and Lys718
  • Modification sites at PhosphoSitePlus

Other Protein References for TLE1 Gene

No data available for DME Specific Peptides for TLE1 Gene

Domains for TLE1 Gene

Gene Families for TLE1 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for TLE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q04724

UniProtKB/Swiss-Prot:

TLE1_HUMAN :
  • Q04724
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with TLE1: view

Function for TLE1 Gene

Molecular function for TLE1 Gene

GENATLAS Biochemistry: transducin-like enhancer of split related,with homology to Drosophila split Groucho (Notch signaling pathway),negative regulator of CBFA2 (AML1)
UniProtKB/Swiss-Prot Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Gene Ontology (GO) - Molecular Function for TLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IDA 10748198
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity --
GO:0005515 protein binding IPI 10748198
GO:0008134 transcription factor binding IPI 8687460
genes like me logo Genes that share ontologies with TLE1: view
genes like me logo Genes that share phenotypes with TLE1: view

miRNA for TLE1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TLE1 Gene

Localization for TLE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE1 Gene

Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLE1 Gene COMPARTMENTS Subcellular localization image for TLE1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for TLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 22952044
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TLE1: view

Pathways for TLE1 Gene

genes like me logo Genes that share pathways with TLE1: view

Gene Ontology (GO) - Biological Process for TLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0007165 signal transduction TAS 8808280
genes like me logo Genes that share ontologies with TLE1: view

Transcripts for TLE1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TLE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for TLE1 Gene

GeneLoc Exon Structure for
TLE1
ECgene alternative splicing isoforms for
TLE1

Expression for TLE1 Gene

mRNA expression in normal human tissues for TLE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLE1 Gene

SOURCE GeneReport for Unigene cluster for TLE1 Gene Hs.197320

mRNA Expression by UniProt/SwissProt for TLE1 Gene

Q04724-TLE1_HUMAN
Tissue specificity: In all tissues examined, mostly in brain, liver and muscle
genes like me logo Genes that share expressions with TLE1: view

No data available for mRNA differential expression in normal tissues for TLE1 Gene

Orthologs for TLE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC464546 35
  • 99.48 (n)
  • 99.61 (a)
TLE1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLE1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLE1 35
  • 92.21 (n)
  • 98.96 (a)
TLE1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tle1 35
  • 90.32 (n)
  • 97.66 (a)
Tle1 16
Tle1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLE1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tle1 35
  • 90.41 (n)
  • 97.53 (a)
chicken
(Gallus gallus)
Aves TLE1 35
  • 85.15 (n)
  • 98.05 (a)
TLE1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLE1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5824 35
tle1 35
  • 82.23 (n)
  • 95.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta gro 36
  • 66 (a)
OneToMany
gro 37
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-37 37
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10712 36
  • 52 (a)
ManyToMany
CSA.8664 36
  • 56 (a)
ManyToMany
Species with no ortholog for TLE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TLE1 Gene

ENSEMBL:
Gene Tree for TLE1 (if available)
TreeFam:
Gene Tree for TLE1 (if available)

Paralogs for TLE1 Gene

Paralogs for TLE1 Gene

Selected SIMAP similar genes for TLE1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TLE1: view

Variants for TLE1 Gene

Sequence variations from dbSNP and Humsavar for TLE1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1253 -- 81,664,878(+) TATTC(A/G)TTTCT intron-variant
rs2591 -- 81,673,438(+) CAAAA(C/T)GGAAG intron-variant
rs8782 -- 81,590,945(-) CCAAC(C/T)CCGCG reference, synonymous-codon
rs10420 -- 81,584,003(-) TAGAC(A/C)AAATG utr-variant-3-prime
rs747151 -- 81,655,757(-) TTTGT(C/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLE1 Gene

Variant ID Type Subtype PubMed ID
nsv821665 CNV Loss 15273396
nsv831638 CNV Loss 17160897
nsv8532 CNV Loss 18304495
nsv521784 CNV Gain 19592680
esv2456414 CNV Deletion 19546169

Relevant External Links for TLE1 Gene

HapMap Linkage Disequilibrium report
TLE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE1 Gene

Disorders for TLE1 Gene

(1) University of Copenhagen DISEASES for TLE1 Gene

(2) Novoseek inferred disease relationships for TLE1 Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 6.12 1
tumors 0 5

Relevant External Links for TLE1

Genetic Association Database (GAD)
TLE1
Human Genome Epidemiology (HuGE) Navigator
TLE1
genes like me logo Genes that share disorders with TLE1: view

No data available for UniProtKB/Swiss-Prot for TLE1 Gene

Publications for TLE1 Gene

  1. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PMID: 8365415) Miyasaka H. … Li S.S.-L. (Eur. J. Biochem. 1993) 2 3 23
  2. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PMID: 9874198) Grbavec D. … Stifani S. (Eur. J. Biochem. 1998) 3 4 23
  3. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PMID: 10748198) Wang J.-C. … Granner D.K. (J. Biol. Chem. 2000) 3 4 23
  4. Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. (PMID: 11731482) Dasen J.S. … Rosenfeld M.G. (Genes Dev. 2001) 3 4 23
  5. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PMID: 14651967) Hentschke M. … Borgmeyer U. (Biochem. Biophys. Res. Commun. 2003) 3 4 23

Products for TLE1 Gene

Sources for TLE1 Gene

Back to Top

Content