Aliases for TLE1 Gene
External Ids for TLE1 Gene
Previous GeneCards Identifiers for TLE1 Gene
GeneCards Summary for TLE1 Gene
TLE1 (Transducin Like Enhancer Of Split 1) is a Protein Coding gene. Diseases associated with TLE1 include Synovium Cancer and Core Binding Factor Acute Myeloid Leukemia. Among its related pathways are Signaling by NOTCH1 and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is TLE4.
UniProtKB/Swiss-Prot for TLE1 Gene
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.