Aliases for TJP1 Gene
External Ids for TJP1 Gene
Previous GeneCards Identifiers for TJP1 Gene
This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for TJP1 Gene
TJP1 (Tight Junction Protein 1) is a Protein Coding gene. Diseases associated with TJP1 include sciatic neuropathy and congenital nephrotic syndrome finnish type. Among its related pathways are Signaling by GPCR and PAK Pathway. GO annotations related to this gene include protein domain specific binding and protein C-terminus binding. An important paralog of this gene is TJP2.
UniProtKB/Swiss-Prot for TJP1 Gene
The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.