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Aliases for TIMP2 Gene

Aliases for TIMP2 Gene

  • TIMP Metallopeptidase Inhibitor 2 2 3
  • Tissue Inhibitor Of Metalloproteinases 2 3 4
  • CSC-21K 3 4
  • Tissue Inhibitor Of Metalloproteinase 2 2
  • TIMP-2 4
  • DDC8 3

External Ids for TIMP2 Gene

Previous GeneCards Identifiers for TIMP2 Gene

  • GC17M076623
  • GC17M080115
  • GC17M077310
  • GC17M077446
  • GC17M074363
  • GC17M076850
  • GC17M072271

Summaries for TIMP2 Gene

Entrez Gene Summary for TIMP2 Gene

  • This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIMP2 Gene

TIMP2 (TIMP Metallopeptidase Inhibitor 2) is a Protein Coding gene. Diseases associated with TIMP2 include conjunctivochalasis and rheumatic congestive heart failure. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include integrin binding and enzyme activator activity. An important paralog of this gene is TIMP4.

UniProtKB/Swiss-Prot for TIMP2 Gene

  • Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Gene Wiki entry for TIMP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMP2 Gene

Genomics for TIMP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIMP2 Gene

Chromosome:
17
Start:
78,852,977 bp from pter
End:
78,925,390 bp from pter
Size:
72,414 bases
Orientation:
Minus strand

Genomic View for TIMP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMP2 Gene

Proteins for TIMP2 Gene

  • Protein details for TIMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16035-TIMP2_HUMAN
    Recommended name:
    Metalloproteinase inhibitor 2
    Protein Accession:
    P16035
    Secondary Accessions:
    • Q16121
    • Q93006
    • Q9UDF7

    Protein attributes for TIMP2 Gene

    Size:
    220 amino acids
    Molecular mass:
    24399 Da
    Quaternary structure:
    • Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

    Three dimensional structures from OCA and Proteopedia for TIMP2 Gene

neXtProt entry for TIMP2 Gene

Proteomics data for TIMP2 Gene at MOPED

Post-translational modifications for TIMP2 Gene

  • The activity of TIMP2 is dependent on the presence of disulfide bonds
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TIMP2 (TIMP2)

No data available for DME Specific Peptides for TIMP2 Gene

Domains & Families for TIMP2 Gene

Gene Families for TIMP2 Gene

Protein Domains for TIMP2 Gene

Suggested Antigen Peptide Sequences for TIMP2 Gene

Graphical View of Domain Structure for InterPro Entry

P16035

UniProtKB/Swiss-Prot:

TIMP2_HUMAN :
  • Contains 1 NTR domain.
  • Belongs to the protease inhibitor I35 (TIMP) family.
Domain:
  • Contains 1 NTR domain.
Family:
  • Belongs to the protease inhibitor I35 (TIMP) family.
genes like me logo Genes that share domains with TIMP2: view

Function for TIMP2 Gene

Molecular function for TIMP2 Gene

GENATLAS Biochemistry:
matrix metalloproteinase,tissue inhibitor 2,with two alternatively spliced forms may be associated with SYN4,involved in the invasive phenotype of acute myelogenous leukemia
UniProtKB/Swiss-Prot Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.

Gene Ontology (GO) - Molecular Function for TIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IBA --
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 24112707
GO:0008047 enzyme activator activity IEA --
GO:0008191 metalloendopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with TIMP2: view
genes like me logo Genes that share phenotypes with TIMP2: view

Animal Models for TIMP2 Gene

MGI Knock Outs for TIMP2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TIMP2 Gene

Localization for TIMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMP2 Gene COMPARTMENTS Subcellular localization image for TIMP2 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IBA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with TIMP2: view

Pathways & Interactions for TIMP2 Gene

genes like me logo Genes that share pathways with TIMP2: view

Pathways by source for TIMP2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for TIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development IEA --
GO:0007568 aging IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0009725 response to hormone IBA --
GO:0010951 negative regulation of endopeptidase activity TAS 8810321
genes like me logo Genes that share ontologies with TIMP2: view

No data available for SIGNOR curated interactions for TIMP2 Gene

Drugs & Compounds for TIMP2 Gene

(43) Drugs for TIMP2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alendronate Approved Pharma Inhibition, Inhibitor Bone resorption inhibitor, Osteoclast function modifiers (important in bone metastasis) 153
Aprotinin Approved, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 24
Azathioprine Approved Pharma 145
Estradiol Approved, Investigational Pharma Sex hormone 1057
Heparin Approved, Investigational Pharma Antagonist 672,226

(45) Additional Compounds for TIMP2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(4-Aminophenyl)mercuric acetate
12-O-Tetradecanoylphorbol 13-acetate
5-Aza-2deoxycytidine
5fluorouracil
Actinomycin D
genes like me logo Genes that share compounds with TIMP2: view

Transcripts for TIMP2 Gene

Unigene Clusters for TIMP2 Gene

TIMP metallopeptidase inhibitor 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: -
SP3:
SP4: -
SP5: - - -

Relevant External Links for TIMP2 Gene

GeneLoc Exon Structure for
TIMP2
ECgene alternative splicing isoforms for
TIMP2

Expression for TIMP2 Gene

mRNA expression in normal human tissues for TIMP2 Gene

mRNA differential expression in normal tissues according to GTEx for TIMP2 Gene

This gene is overexpressed in Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for TIMP2 Gene

This gene is overexpressed in Amniocyte (39.0) and Serum (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMP2 Gene



SOURCE GeneReport for Unigene cluster for TIMP2 Gene Hs.633514

genes like me logo Genes that share expression patterns with TIMP2: view

Protein tissue co-expression partners for TIMP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TIMP2 Gene

Orthologs for TIMP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIMP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIMP2 35
  • 91.67 (n)
  • 91.82 (a)
TIMP2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMP2 35
  • 92.27 (n)
  • 96.36 (a)
TIMP2 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timp2 35
  • 91.97 (n)
  • 98.18 (a)
Timp2 16
Timp2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIMP2 35
  • 99.24 (n)
  • 98.64 (a)
TIMP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timp2 35
  • 91.97 (n)
  • 98.18 (a)
oppossum
(Monodelphis domestica)
Mammalia TIMP2 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIMP2 35
  • 79.63 (n)
  • 81.82 (a)
TIMP2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIMP2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia timp2 35
  • 77.16 (n)
  • 84.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26350 35
zebrafish
(Danio rerio)
Actinopterygii timp2 35
timp2a 35
  • 75.8 (n)
  • 76.65 (a)
timp2a 36
  • 71 (a)
OneToMany
timp2b 36
  • 50 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4143 35
Species with no ortholog for TIMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMP2 Gene

ENSEMBL:
Gene Tree for TIMP2 (if available)
TreeFam:
Gene Tree for TIMP2 (if available)

Paralogs for TIMP2 Gene

Paralogs for TIMP2 Gene

(4) SIMAP similar genes for TIMP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TIMP2: view

Variants for TIMP2 Gene

Sequence variations from dbSNP and Humsavar for TIMP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14526 -- 78,853,099(+) AGCAC(C/G)GGAAG utr-variant-3-prime
rs764763 -- 78,856,706(+) TGGCA(A/C)AACCT intron-variant
rs869172 -- 78,854,001(+) ACCCT(C/T)CCAGT utr-variant-3-prime
rs931227 -- 78,862,457(-) GGTGA(A/G)GCTGT intron-variant
rs1062704 -- 78,853,696(-) TTTTT(A/T)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TIMP2 Gene

Variant ID Type Subtype PubMed ID
nsv908894 CNV Loss 21882294
dgv3282n71 CNV Loss 21882294
esv2031325 CNV Deletion 18987734
dgv3283n71 CNV Loss 21882294
nsv457917 CNV Gain 19166990
nsv908900 CNV Loss 21882294
dgv3284n71 CNV Loss 21882294
esv2667094 CNV Deletion 23128226

Variation tolerance for TIMP2 Gene

Residual Variation Intolerance Score: 56.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMP2 Gene

HapMap Linkage Disequilibrium report
TIMP2
Human Gene Mutation Database (HGMD)
TIMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMP2 Gene

Disorders for TIMP2 Gene

MalaCards: The human disease database

(34) MalaCards diseases for TIMP2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
conjunctivochalasis
rheumatic congestive heart failure
  • rheumatic heart failure
microcystic meningioma
gingival hypertrophy
  • hypertrophy of gingivae
moyamoya disease
  • moyamoya disease 3
- elite association
Search TIMP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TIMP2

Genetic Association Database (GAD)
TIMP2
Human Genome Epidemiology (HuGE) Navigator
TIMP2
Tumor Gene Database (TGDB):
TIMP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMP2
genes like me logo Genes that share disorders with TIMP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIMP2 Gene

Publications for TIMP2 Gene

  1. Effects of high glucose and thiamine on the balance between matrix metalloproteinases and their tissue inhibitors in vascular cells. (PMID: 19404565) Tarallo S. … Porta M. (Acta Diabetol 2010) 23 67
  2. Increase in tissue inhibitor of metalloproteinase-2 (TIMP-2) levels and inhibition of MMP-2 activity in a metastatic breast cancer cell line by an anti-invasive small molecule SR13179. (PMID: 19751965) Waleh N.S. … Zaveri N.T. (Cancer Lett. 2010) 23 67
  3. Inhibition of matrix metalloproteinase activity in the chick sclera and its effect on myopia development. (PMID: 20130273) Liu H.H. … McBrien N.A. (Invest. Ophthalmol. Vis. Sci. 2010) 23 67
  4. Exercise ameliorates serum MMP-9 and TIMP-2 levels in patients with type 2 diabetes. (PMID: 20149706) Kadoglou N.P. … Angelopoulou N. (Diabetes Metab. 2010) 23 67
  5. Involvement of MT1-MMP and TIMP-2 in human periodontal disease. (PMID: 20233321) OyarzA_n A. … Smith P.C. (Oral Dis 2010) 23 67

Products for TIMP2 Gene

Sources for TIMP2 Gene

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