Aliases for TIAM1 Gene
External Ids for TIAM1 Gene
Previous GeneCards Identifiers for TIAM1 Gene
GeneCards Summary for TIAM1 Gene
TIAM1 (T-Cell Lymphoma Invasion And Metastasis 1) is a Protein Coding gene. Diseases associated with TIAM1 include amyotrophic lateral sclerosis 1 and colorectal cancer. Among its related pathways are Signaling by GPCR and Ras signaling pathway. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.
UniProtKB/Swiss-Prot for TIAM1 Gene
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.