Aliases for TIAL1 Gene
Aliases for TIAL1 Gene
External Ids for TIAL1 Gene
- HGNC: 11804
- Entrez Gene: 7073
- Ensembl: ENSG00000151923
- OMIM: 603413
- UniProtKB: Q01085
Previous GeneCards Identifiers for TIAL1 Gene
- GC10M120253
- GC10M120578
- GC10M121466
- GC10M120999
- GC10M121324
- GC10M114963
Summaries for TIAL1 Gene
-
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIAL1 Gene
TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and Signaling by FGFR2. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TIA1.
UniProtKB/Swiss-Prot for TIAL1 Gene
-
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAL1 Gene
Genomics for TIAL1 Gene
Regulatory Elements for TIAL1 Gene
Enhancers for TIAL1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH10G119650 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 11.5 | -58.6 | -58603 | 10.1 | HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 | SEC23IP BAG3 INPP5F TIAL1 MCMBP PHACTR2P1 GRK5 TXNP1 |
| GH10G119515 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 11.3 | +79.1 | 79068 | 5.4 | HDGF TCF12 ZNF263 CAVIN1 JUNB TBX21 ZNF592 SMARCA4 NBN SP7 | RGS10 TIAL1 EIF3A GC10P119418 |
| GH10G119498 | 1.5 | Ensembl ENCODE dbSUPER | 11.3 | +95.9 | 95877 | 5.6 | PKNOX1 FOXA2 MLX ARID4B FEZF1 FOS ZNF263 MIER2 PPARG TBX21 | RGS10 TIAL1 GC10P119418 |
| GH10G119521 | 1.4 | Ensembl ENCODE dbSUPER | 11.3 | +74.4 | 74436 | 2.4 | ELF3 INSM2 SIN3A THRB RARA ZNF366 FOS CEBPB ZNF592 ZNF579 | TIAL1 RGS10 GC10P119418 |
| GH10G119494 | 1.4 | Ensembl ENCODE dbSUPER | 11.3 | +101.7 | 101718 | 2.9 | HDAC1 PKNOX1 FOXA2 TBL1XR1 FEZF1 TCF12 ZNF121 ZSCAN5C FOS RELB | RGS10 TIAL1 GC10P119418 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TIAL1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TIAL1 gene promoter:
Regulatory Element Products
Genomic Location for TIAL1 Gene
- Chromosome:
- 10
- Start:
- 119,571,802 bp from pter
- End:
- 119,597,029 bp from pter
- Size:
- 25,228 bases
- Orientation:
- Minus strand
Genomic View for TIAL1 Gene
Genes around TIAL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.11 by Ensembl
- 10q26.11 by Entrez Gene
- 10q26.11 by HGNC
TIAL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TIAL1 Gene
Proteins for TIAL1 Gene
-
Protein details for TIAL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01085-TIAR_HUMAN
- Recommended name:
- Nucleolysin TIAR
- Protein Accession:
- Q01085
- A8K3T0
- A8K4L9
Protein attributes for TIAL1 Gene
- Size:
- 375 amino acids
- Molecular mass:
- 41591 Da
- Quaternary structure:
- No Data Available
Protein Expression for TIAL1 Gene
Post-translational modifications for TIAL1 Gene
- Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
- Ubiquitination at posLast=122122 and Lys203
- Modification sites at PhosphoSitePlus
Other Protein References for TIAL1 Gene
Antibody Products
- Cell Signaling Technology (CST) Antibodies for TIAL1 (TIAL1)
- Novus Biologicals Antibodies for TIAL1
-
Abcam antibodies for TIAL1
- Invitrogen Antibodies for TIAL1
- antibodies-online Antibodies for TIAL1: See all 21
- GeneTex TIAL1 antibody for TIAL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TIAL1
Protein Products
-
OriGene Purified Proteins for TIAL1
- Search Origene for MassSpec and Protein Over-expression Lysates for TIAL1
- Origene Custom Protein Services for TIAL1
- ProSpec Recombinant Proteins for TIAL1
- antibodies-online Proteins for TIAL1: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TIAL1
No data available for DME Specific Peptides for TIAL1 Gene
Domains & Families for TIAL1 Gene
Gene Families for TIAL1 Gene
Protein Domains for TIAL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TIAL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TIAL1 Gene
Function for TIAL1 Gene
Molecular function for TIAL1 Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | TAS,IDA | 22658674 |
| GO:0017091 | AU-rich element binding | IEA | -- |
Phenotypes for TIAL1 Gene
- MGI mutant phenotypes for TIAL1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TIAL1:
Animal Models for TIAL1 Gene
- MGI Knock Outs for TIAL1:
-
- Tial1 tm1Mst
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TIAL1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TIAL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIAL1 gene
- Search ViGene Biosciences for TIAL1
CRISPR Products
-
OriGene CRISPR knockouts for TIAL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIAL1
- GenScript: Design CRISPR guide RNA sequences for TIAL1
miRNA for TIAL1 Gene
- miRTarBase miRNAs that target TIAL1
-
- hsa-mir-181a-5p (MIRT025099)
- hsa-mir-30a-5p (MIRT028531)
- hsa-mir-27a-3p (MIRT028690)
- hsa-mir-181c-5p (MIRT047221)
- hsa-mir-504-3p (MIRT230299)
- hsa-mir-1250-3p (MIRT261621)
- ebv-mir-bart13-3p (MIRT439457)
- hsa-mir-1273e (MIRT505399)
- hsa-mir-25-5p (MIRT505400)
- hsa-mir-658 (MIRT505401)
- hsa-mir-4722-5p (MIRT505402)
- hsa-mir-6087 (MIRT505403)
- hsa-mir-6840-3p (MIRT505404)
- hsa-mir-665 (MIRT505405)
- hsa-mir-4459 (MIRT505406)
- hsa-mir-4768-3p (MIRT505407)
- hsa-mir-4695-5p (MIRT505408)
- hsa-mir-4538 (MIRT505409)
- hsa-mir-4453 (MIRT505410)
- hsa-mir-5698 (MIRT619239)
- hsa-mir-30e-3p (MIRT619240)
- hsa-mir-30d-3p (MIRT619241)
- hsa-mir-30a-3p (MIRT619242)
- hsa-mir-143-5p (MIRT619243)
- hsa-mir-4430 (MIRT619244)
- hsa-mir-3652 (MIRT619245)
- hsa-mir-6722-5p (MIRT619246)
- hsa-mir-122-5p (MIRT619247)
- hsa-mir-3135b (MIRT619248)
- hsa-mir-6499-3p (MIRT619249)
- hsa-mir-5693 (MIRT619250)
- hsa-mir-6736-3p (MIRT619251)
- hsa-mir-653-3p (MIRT619252)
- hsa-mir-365b-5p (MIRT619253)
- hsa-mir-365a-5p (MIRT619254)
- hsa-mir-8052 (MIRT619255)
- hsa-mir-3199 (MIRT619256)
- hsa-mir-6778-3p (MIRT619257)
- hsa-mir-150-5p (MIRT619258)
- hsa-mir-6814-5p (MIRT619259)
- hsa-mir-3691-3p (MIRT619260)
- hsa-mir-224-5p (MIRT619261)
- hsa-mir-6855-5p (MIRT634237)
- hsa-mir-3170 (MIRT634238)
- hsa-mir-3620-5p (MIRT634239)
- hsa-mir-6842-3p (MIRT634240)
- hsa-mir-1587 (MIRT634241)
- hsa-mir-647 (MIRT634242)
- hsa-mir-197-3p (MIRT634243)
- hsa-mir-193b-5p (MIRT634244)
- hsa-mir-4741 (MIRT634245)
- hsa-mir-4675 (MIRT634246)
- hsa-mir-762 (MIRT634247)
- hsa-mir-5001-5p (MIRT634248)
- hsa-mir-4498 (MIRT634249)
- hsa-mir-4492 (MIRT634250)
- hsa-mir-6829-5p (MIRT634251)
- hsa-mir-4656 (MIRT634252)
- hsa-mir-5787 (MIRT634253)
- hsa-mir-4505 (MIRT634254)
- hsa-mir-378g (MIRT634255)
- hsa-mir-4716-5p (MIRT634256)
- hsa-mir-4781-3p (MIRT634257)
- hsa-mir-6890-5p (MIRT634258)
- hsa-mir-887-5p (MIRT634259)
- hsa-mir-6780a-5p (MIRT634260)
- hsa-mir-6779-5p (MIRT634261)
- hsa-mir-3689c (MIRT634262)
- hsa-mir-3689b-3p (MIRT634263)
- hsa-mir-3689a-3p (MIRT634264)
- hsa-mir-30b-3p (MIRT634265)
- hsa-mir-1273h-5p (MIRT634266)
- hsa-mir-6788-5p (MIRT634267)
- hsa-mir-30c-2-3p (MIRT634268)
- hsa-mir-30c-1-3p (MIRT634269)
- hsa-mir-7977 (MIRT634270)
- hsa-mir-6799-5p (MIRT634271)
- hsa-mir-6883-5p (MIRT634272)
- hsa-mir-6785-5p (MIRT634273)
- hsa-mir-4728-5p (MIRT634274)
- hsa-mir-149-3p (MIRT634275)
- hsa-mir-7106-5p (MIRT634276)
- hsa-mir-24-3p (MIRT634277)
- hsa-mir-4284 (MIRT634278)
- hsa-mir-3189-3p (MIRT634279)
- hsa-mir-3065-3p (MIRT634280)
- hsa-mir-6813-3p (MIRT634281)
- hsa-mir-4314 (MIRT665835)
- hsa-mir-7160-5p (MIRT665836)
- hsa-mir-6884-5p (MIRT665837)
- hsa-mir-485-5p (MIRT665838)
- hsa-mir-1827 (MIRT665839)
- hsa-mir-6506-5p (MIRT665840)
- hsa-mir-619-5p (MIRT665841)
- hsa-mir-3192-5p (MIRT665842)
- hsa-mir-4646-5p (MIRT665843)
- hsa-mir-204-3p (MIRT665844)
- hsa-mir-4649-3p (MIRT665845)
- hsa-mir-3664-3p (MIRT665846)
- hsa-mir-4433a-3p (MIRT665847)
- hsa-mir-1298-3p (MIRT665848)
- hsa-mir-4478 (MIRT665849)
- hsa-mir-4419b (MIRT665850)
- hsa-mir-3929 (MIRT665851)
- hsa-mir-940 (MIRT665852)
- hsa-mir-6893-5p (MIRT665853)
- hsa-mir-6808-5p (MIRT665854)
- hsa-mir-510-5p (MIRT665855)
- hsa-mir-512-5p (MIRT665856)
- hsa-mir-6812-3p (MIRT671757)
- hsa-mir-6818-3p (MIRT698478)
- hsa-mir-4684-5p (MIRT698479)
- hsa-mir-593-3p (MIRT698480)
- hsa-mir-6895-3p (MIRT698481)
- hsa-mir-4305 (MIRT698482)
- hsa-mir-5699-3p (MIRT698483)
- hsa-mir-4421 (MIRT698484)
- hsa-mir-339-5p (MIRT698485)
- hsa-mir-4699-3p (MIRT698486)
- hsa-mir-28-3p (MIRT698487)
- hsa-mir-4282 (MIRT698488)
- hsa-mir-548c-3p (MIRT698489)
miRNA Products
- Search ViGene Biosciences for TIAL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TIAL1
- Browse OriGene Inhibitory RNA Products For TIAL1
-
ViGene Biosciences ready-to-package AAV shRNAs for TIAL1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TIAL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIAL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TIAL1
-
ViGene Biosciences adenoviral particle packaged cDNA for TIAL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TIAL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIAL1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAL1 Gene
Localization for TIAL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TIAL1 Gene
- Cytoplasm. Nucleus. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| lysosome | 4 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005764 | lysosome | TAS | 1326761 |
| GO:0010494 | cytoplasmic stress granule | ISS | -- |
Pathways & Interactions for TIAL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by FGFR2 | ||
| 2 | Apoptosis and Autophagy | ||
| 3 | Chromatin Regulation / Acetylation | ||
| 4 | Translational Control | ||
| 5 | mRNA Capping | ||
Pathways by source for TIAL1 Gene
3 Cell Signaling Technology pathways for TIAL1 Gene
4 Reactome pathways for TIAL1 Gene
Interacting Proteins for TIAL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | TAS | 9207209 |
| GO:0006915 | apoptotic process | TAS,IEA | -- |
| GO:0006952 | defense response | TAS | 1326761 |
| GO:0007281 | germ cell development | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
No data available for SIGNOR curated interactions for TIAL1 Gene
Transcripts for TIAL1 Gene
mRNA/cDNA for TIAL1 Gene
- (10) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (378) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TIAL1 Gene
- TIA1 cytotoxic granule-associated RNA binding protein-like 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TIAL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIAL1
- GenScript: Design CRISPR guide RNA sequences for TIAL1
miRNA Products
- Search ViGene Biosciences for TIAL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TIAL1
- Browse OriGene Inhibitory RNA Products For TIAL1
-
ViGene Biosciences ready-to-package AAV shRNAs for TIAL1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TIAL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIAL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 16a | · | 16b | · | 16c |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: |
Expression for TIAL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
This gene is overexpressed in Bone (10.5) and Peripheral blood mononuclear cells (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIAL1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TIAL1 Gene:
TIAL1SOURCE GeneReport for Unigene cluster for TIAL1 Gene:
Hs.501203Evidence on tissue expression from TISSUES for TIAL1 Gene
- Lung(4.4)
- Nervous system(3.3)
- Blood(2.1)
- Kidney(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for TIAL1
-
OriGene qPCR primer pairs and template standards for TIAL1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIAL1 Gene
Orthologs for TIAL1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TIAL1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TIAL1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TIAL1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TIAL1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TIAL1 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Tial1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tial1 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | TIAR 35 |
|
OneToOne | |
| TIA1 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | TIAL1 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | tial1-A-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tial1 34 35 |
|
||
| zgc66130 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG4787 36 |
|
|
|
| Rox8 34 35 |
|
||||
| CG34354 35 |
|
ManyToMany | |||
| CG34362 35 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002335 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C18A3.5a 36 |
|
|
|
| C07A4.1 36 |
|
|
|||
| C18A3.5b 36 |
|
|
|||
| Y46G5A.13 36 |
|
|
|||
| tiar-1 35 |
|
ManyToMany | |||
| tiar-2 35 |
|
ManyToMany | |||
| tiar-3 35 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PUB1 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | UBP1B 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os11g0620100 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8430 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5046 34 |
|
- Species where no ortholog for TIAL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for TIAL1 Gene
(22) SIMAP similar genes for TIAL1 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for TIAL1 Gene
Variants for TIAL1 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000047430 | -- | 119,583,780(+) | ACTGA(C/G)AACAA | intron-variant | |
| rs1000166312 | -- | 119,575,261(+) | TATAT(A/G)TGATT | nc-transcript-variant, utr-variant-3-prime | |
| rs1000431168 | -- | 119,590,798(+) | AAAGA(A/G)AGAAA | intron-variant | |
| rs1000500974 | -- | 119,573,585(+) | TGGCA(C/G)ACCAA | nc-transcript-variant, utr-variant-3-prime | |
| rs1000651334 | -- | 119,582,083(+) | TAGAG(A/G)AGGAA | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1044497 | CNV | gain | 25217958 |
| nsv552215 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.14;
3.27% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TIAL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TIAL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAL1 Gene
Disorders for TIAL1 Gene
Relevant External Links for TIAL1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TIAL1
No disorders were found for TIAL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIAL1 Gene
Publications for TIAL1 Gene
- Identification and functional characterization of a TIA-1-related nucleolysin. (PMID: 1326761) Kawakami A. … Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 22 64
- DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PMID: 20932473) Reinhardt H.C. … Yaffe M.B. (Mol. Cell 2010) 3 4 64
- A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. (PMID: 18456862) Aznarez I. … Blencowe B.J. (Genome Res. 2008) 3 22 64
- Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. (PMID: 17486099) Liao B. … Brewer G. (Nat. Struct. Mol. Biol. 2007) 3 22 64
- Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein. (PMID: 17488725) Izquierdo J.M. … ValcA!rcel J. (J. Biol. Chem. 2007) 3 22 64
Products for TIAL1 Gene
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- OriGene Purified Proteins for TIAL1
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TIAL1
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- OriGene qPCR primer pairs and template standards for TIAL1
- OriGene qPCR primer pairs for TIAL1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for TIAL1 in any vector
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- GenScript: Design CRISPR guide RNA sequences for TIAL1
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- ProSpec Recombinant Proteins for TIAL1
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- antibodies-online Antibodies for TIAL1: See all 21
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- antibodies-online Proteins for TIAL1: See all 6
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- GeneTex TIAL1 antibody for TIAL1
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- ViGene Biosciences adenoviral particle packaged cDNA for TIAL1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for TIAL1 gene
- Search ViGene Biosciences for TIAL1
- Santa Cruz Biotechnology (SCBT) Antibodies for TIAL1
- Search Santa Cruz Biotechnology (SCBT) for TIAL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TIAL1
- Horizon Cell Lines for TIAL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for TIAL1
- VectorBuilder custom plasmid, inducible vectors for TIAL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIAL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TIAL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
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- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
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- (55) HORDE
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- (68) Abcam
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- (71) Sino Biological
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
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- (100) COMPARTMENTS
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- (110) PathCards
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