Aliases for TIAL1 Gene
Aliases for TIAL1 Gene
External Ids for TIAL1 Gene
- HGNC: 11804
- Entrez Gene: 7073
- Ensembl: ENSG00000151923
- OMIM: 603413
- UniProtKB: Q01085
Previous GeneCards Identifiers for TIAL1 Gene
- GC10M120253
- GC10M120578
- GC10M121466
- GC10M120999
- GC10M121324
- GC10M114963
Summaries for TIAL1 Gene
-
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIAL1 Gene
TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TIA1.
UniProtKB/Swiss-Prot for TIAL1 Gene
-
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAL1 Gene
Genomics for TIAL1 Gene
GeneHancer (GH) Regulatory Elements for TIAL1 Gene
Promoters and enhancers for TIAL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TIAL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TIAL1 gene promoter:
Regulatory Element Products
Genomic Locations for TIAL1 Gene
Genomic Locations for TIAL1 Gene
- chr10:119,571,802-119,597,029
- (GRCh38/hg38)
- Size:
- 25,228 bases
- Orientation:
- Minus strand
- chr10:121,332,977-121,356,541
- (GRCh37/hg19)
Genomic View for TIAL1 Gene
Genes around TIAL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.11 by Ensembl
- 10q26.11 by Entrez Gene
- 10q26.11 by HGNC
TIAL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TIAL1 Gene
Proteins for TIAL1 Gene
-
Protein details for TIAL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01085-TIAR_HUMAN
- Recommended name:
- Nucleolysin TIAR
- Protein Accession:
- Q01085
- A8K3T0
- A8K4L9
Protein attributes for TIAL1 Gene
- Size:
- 375 amino acids
- Molecular mass:
- 41591 Da
- Quaternary structure:
- No Data Available
Protein Expression for TIAL1 Gene
Post-translational modifications for TIAL1 Gene
- Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
- Ubiquitination at posLast=122122 and posLast=203203
Other Protein References for TIAL1 Gene
Antibody Products
- Cell Signaling Technology (CST) Antibodies for TIAL1 (TIAL1)
- Novus Biologicals Antibodies for TIAL1
-
Abcam antibodies for TIAL1
- Invitrogen Antibodies for TIAL1
- GeneTex TIAL1 antibody for TIAL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TIAL1
Protein Products
-
OriGene Purified Proteins for TIAL1
- Search Origene for MassSpec and Protein Over-expression Lysates for TIAL1
- Origene Custom Protein Services for TIAL1
- ProSpec Recombinant Proteins for TIAL1
- antibodies-online: Search results for 6 available TIAL1 Proteins ranked by validation data
- Compare Top TIAL1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for TIAL1
-
Abcam proteins for TIAL1
Assay Products
No data available for DME Specific Peptides for TIAL1 Gene
Domains & Families for TIAL1 Gene
Gene Families for TIAL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TIAL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TIAL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TIAL1 Gene
Function for TIAL1 Gene
Molecular function for TIAL1 Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Phenotypes From GWAS Catalog for TIAL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | HDA,IEA | 22658674 |
| GO:0017091 | AU-rich element binding | IEA | -- |
Phenotypes for TIAL1 Gene
- MGI mutant phenotypes for TIAL1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TIAL1:
Animal Models for TIAL1 Gene
- MGI Knock Outs for TIAL1:
-
- Tial1 tm1Mst
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TIAL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIAL1 gene
- Search ViGene Biosciences for TIAL1
CRISPR Products
-
OriGene CRISPR knockouts for TIAL1
- genomics-online: gRNA clones - Search results for available TIAL1 gene related products
- Applied Biological Materials CRISPR for TIAL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIAL1
- GenScript: Design CRISPR guide RNA sequences for TIAL1
miRNA for TIAL1 Gene
- miRTarBase miRNAs that target TIAL1
-
- hsa-mir-181a-5p (MIRT025099)
- hsa-mir-30a-5p (MIRT028531)
- hsa-mir-27a-3p (MIRT028690)
- hsa-mir-181c-5p (MIRT047221)
- hsa-mir-504-3p (MIRT230299)
- hsa-mir-1250-3p (MIRT261621)
- hsa-mir-1273e (MIRT505399)
- hsa-mir-25-5p (MIRT505400)
- hsa-mir-658 (MIRT505401)
- hsa-mir-4722-5p (MIRT505402)
- hsa-mir-6087 (MIRT505403)
- hsa-mir-6840-3p (MIRT505404)
- hsa-mir-665 (MIRT505405)
- hsa-mir-4459 (MIRT505406)
- hsa-mir-4768-3p (MIRT505407)
- hsa-mir-4695-5p (MIRT505408)
- hsa-mir-4538 (MIRT505409)
- hsa-mir-4453 (MIRT505410)
- hsa-mir-5698 (MIRT619239)
- hsa-mir-30e-3p (MIRT619240)
- hsa-mir-30d-3p (MIRT619241)
- hsa-mir-30a-3p (MIRT619242)
- hsa-mir-143-5p (MIRT619243)
- hsa-mir-4430 (MIRT619244)
- hsa-mir-3652 (MIRT619245)
- hsa-mir-6722-5p (MIRT619246)
- hsa-mir-122-5p (MIRT619247)
- hsa-mir-3135b (MIRT619248)
- hsa-mir-6499-3p (MIRT619249)
- hsa-mir-5693 (MIRT619250)
- hsa-mir-6736-3p (MIRT619251)
- hsa-mir-653-3p (MIRT619252)
- hsa-mir-365b-5p (MIRT619253)
- hsa-mir-365a-5p (MIRT619254)
- hsa-mir-8052 (MIRT619255)
- hsa-mir-3199 (MIRT619256)
- hsa-mir-6778-3p (MIRT619257)
- hsa-mir-150-5p (MIRT619258)
- hsa-mir-6814-5p (MIRT619259)
- hsa-mir-3691-3p (MIRT619260)
- hsa-mir-224-5p (MIRT619261)
- hsa-mir-6855-5p (MIRT634237)
- hsa-mir-3170 (MIRT634238)
- hsa-mir-3620-5p (MIRT634239)
- hsa-mir-6842-3p (MIRT634240)
- hsa-mir-1587 (MIRT634241)
- hsa-mir-647 (MIRT634242)
- hsa-mir-197-3p (MIRT634243)
- hsa-mir-193b-5p (MIRT634244)
- hsa-mir-4741 (MIRT634245)
- hsa-mir-4675 (MIRT634246)
- hsa-mir-762 (MIRT634247)
- hsa-mir-5001-5p (MIRT634248)
- hsa-mir-4498 (MIRT634249)
- hsa-mir-4492 (MIRT634250)
- hsa-mir-6829-5p (MIRT634251)
- hsa-mir-4656 (MIRT634252)
- hsa-mir-5787 (MIRT634253)
- hsa-mir-4505 (MIRT634254)
- hsa-mir-378g (MIRT634255)
- hsa-mir-4716-5p (MIRT634256)
- hsa-mir-4781-3p (MIRT634257)
- hsa-mir-6890-5p (MIRT634258)
- hsa-mir-887-5p (MIRT634259)
- hsa-mir-6780a-5p (MIRT634260)
- hsa-mir-6779-5p (MIRT634261)
- hsa-mir-3689c (MIRT634262)
- hsa-mir-3689b-3p (MIRT634263)
- hsa-mir-3689a-3p (MIRT634264)
- hsa-mir-30b-3p (MIRT634265)
- hsa-mir-1273h-5p (MIRT634266)
- hsa-mir-6788-5p (MIRT634267)
- hsa-mir-30c-2-3p (MIRT634268)
- hsa-mir-30c-1-3p (MIRT634269)
- hsa-mir-7977 (MIRT634270)
- hsa-mir-6799-5p (MIRT634271)
- hsa-mir-6883-5p (MIRT634272)
- hsa-mir-6785-5p (MIRT634273)
- hsa-mir-4728-5p (MIRT634274)
- hsa-mir-149-3p (MIRT634275)
- hsa-mir-7106-5p (MIRT634276)
- hsa-mir-24-3p (MIRT634277)
- hsa-mir-4284 (MIRT634278)
- hsa-mir-3189-3p (MIRT634279)
- hsa-mir-3065-3p (MIRT634280)
- hsa-mir-6813-3p (MIRT634281)
- hsa-mir-4314 (MIRT665835)
- hsa-mir-7160-5p (MIRT665836)
- hsa-mir-6884-5p (MIRT665837)
- hsa-mir-485-5p (MIRT665838)
- hsa-mir-1827 (MIRT665839)
- hsa-mir-6506-5p (MIRT665840)
- hsa-mir-619-5p (MIRT665841)
- hsa-mir-3192-5p (MIRT665842)
- hsa-mir-4646-5p (MIRT665843)
- hsa-mir-204-3p (MIRT665844)
- hsa-mir-4649-3p (MIRT665845)
- hsa-mir-3664-3p (MIRT665846)
- hsa-mir-4433a-3p (MIRT665847)
- hsa-mir-1298-3p (MIRT665848)
- hsa-mir-4478 (MIRT665849)
- hsa-mir-4419b (MIRT665850)
- hsa-mir-3929 (MIRT665851)
- hsa-mir-940 (MIRT665852)
- hsa-mir-6893-5p (MIRT665853)
- hsa-mir-6808-5p (MIRT665854)
- hsa-mir-510-5p (MIRT665855)
- hsa-mir-512-5p (MIRT665856)
- hsa-mir-6812-3p (MIRT671757)
- hsa-mir-6818-3p (MIRT698478)
- hsa-mir-4684-5p (MIRT698479)
- hsa-mir-593-3p (MIRT698480)
- hsa-mir-6895-3p (MIRT698481)
- hsa-mir-4305 (MIRT698482)
- hsa-mir-5699-3p (MIRT698483)
- hsa-mir-4421 (MIRT698484)
- hsa-mir-339-5p (MIRT698485)
- hsa-mir-4699-3p (MIRT698486)
- hsa-mir-28-3p (MIRT698487)
- hsa-mir-4282 (MIRT698488)
- hsa-mir-548c-3p (MIRT698489)
miRNA Products
- Search ViGene Biosciences for TIAL1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TIAL1
- Browse OriGene Inhibitory RNA Products For TIAL1
- genomics-online: shRNA clones - Search results for available TIAL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TIAL1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available TIAL1 gene related products
- orf clones - Search results for available TIAL1 gene related products
- Applied Biological Materials Clones for TIAL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TIAL1
-
ViGene Biosciences adenoviral particle packaged cDNA for TIAL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TIAL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIAL1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAL1 Gene
Localization for TIAL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TIAL1 Gene
- Cytoplasm. Nucleus. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| lysosome | 4 |
| cytosol | 3 |
- Nucleus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005764 | lysosome | TAS | 1326761 |
| GO:0010494 | cytoplasmic stress granule | ISS | -- |
Pathways & Interactions for TIAL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by FGFR2 | ||
| 2 | Apoptosis and Autophagy | ||
| 3 | Chromatin Regulation / Acetylation | ||
| 4 | Translational Control | ||
| 5 | mRNA Capping | ||
Pathways by source for TIAL1 Gene
3 Cell Signaling Technology pathways for TIAL1 Gene
4 Reactome pathways for TIAL1 Gene
Interacting Proteins for TIAL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 9207209 |
| GO:0006915 | apoptotic process | IEA,TAS | -- |
| GO:0006952 | defense response | TAS | 1326761 |
| GO:0007281 | germ cell development | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
No data available for SIGNOR curated interactions for TIAL1 Gene
Transcripts for TIAL1 Gene
mRNA/cDNA for TIAL1 Gene
- (10) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (378) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TIAL1 Gene
- TIA1 cytotoxic granule-associated RNA binding protein-like 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TIAL1
- genomics-online: gRNA clones - Search results for available TIAL1 gene related products
- Applied Biological Materials CRISPR for TIAL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIAL1
- GenScript: Design CRISPR guide RNA sequences for TIAL1
miRNA Products
- Search ViGene Biosciences for TIAL1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TIAL1
- Browse OriGene Inhibitory RNA Products For TIAL1
- genomics-online: shRNA clones - Search results for available TIAL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TIAL1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available TIAL1 gene related products
- orf clones - Search results for available TIAL1 gene related products
- Applied Biological Materials Clones for TIAL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 16a | · | 16b | · | 16c |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: |
Expression for TIAL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
This gene is overexpressed in Bone (10.5) and Peripheral blood mononuclear cells (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIAL1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TIAL1 Gene:
TIAL1SOURCE GeneReport for Unigene cluster for TIAL1 Gene:
Hs.501203Evidence on tissue expression from TISSUES for TIAL1 Gene
- Lung(4.4)
- Nervous system(3.3)
- Blood(2.1)
- Kidney(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for TIAL1
-
OriGene qPCR primer pairs and template standards for TIAL1
- genomics-online: primer clones - Search results for available TIAL1 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIAL1 Gene
Orthologs for TIAL1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TIAL1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TIAL1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TIAL1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TIAL1 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TIAL1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Tial1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tial1 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | TIAR 34 |
|
OneToOne | |
| TIA1 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | TIAL1 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | tial1-A-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tial1 33 34 |
|
||
| zgc66130 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG4787 35 |
|
|
|
| Rox8 33 34 |
|
||||
| CG34354 34 |
|
ManyToMany | |||
| CG34362 34 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002335 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C18A3.5a 35 |
|
|
|
| C07A4.1 35 |
|
|
|||
| C18A3.5b 35 |
|
|
|||
| Y46G5A.13 35 |
|
|
|||
| tiar-1 34 |
|
ManyToMany | |||
| tiar-2 34 |
|
ManyToMany | |||
| tiar-3 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PUB1 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | UBP1B 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os11g0620100 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8430 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5046 33 |
|
- Species where no ortholog for TIAL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for TIAL1 Gene
(22) SIMAP similar genes for TIAL1 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for TIAL1 Gene
Variants for TIAL1 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000047430 | -- | 119,583,780(-) | C/G | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant | |
| rs1000166312 | -- | 119,575,261(-) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1000431168 | -- | 119,590,798(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000500974 | -- | 119,573,585(-) | G/C | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1000651334 | -- | 119,582,083(-) | G/A | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1044497 | CNV | gain | 25217958 |
| nsv552215 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.14;
3.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TIAL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TIAL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAL1 Gene
Disorders for TIAL1 Gene
Additional Disease Information for TIAL1
No disorders were found for TIAL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIAL1 Gene
Publications for TIAL1 Gene
- Identification and functional characterization of a TIA-1-related nucleolysin. (PMID: 1326761) Kawakami A … Anderson P (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 22 58
- DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PMID: 20932473) Reinhardt HC … Yaffe MB (Molecular cell 2010) 3 4 58
- A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. (PMID: 18456862) Aznarez I … Blencowe BJ (Genome research 2008) 3 22 58
- Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. (PMID: 17486099) Liao B … Brewer G (Nature structural & molecular biology 2007) 3 22 58
- Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein. (PMID: 17488725) Izquierdo JM … Valcárcel J (The Journal of biological chemistry 2007) 3 22 58
Products for TIAL1 Gene
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TIAL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for 26 available TIAL1 Antibodies ranked by validation data
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- antibodies-online: Search results for available TIAL1 related products ranked by validation data
- antibodies-online: Search results for 6 available TIAL1 Proteins ranked by validation data
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- Quality Products:
- GeneTex TIAL1 antibody for TIAL1
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- ViGene Biosciences adenoviral particle packaged cDNA for TIAL1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for TIAL1
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- Horizon Cell Lines for TIAL1
- genomics-online: cdna clones - Search results for available TIAL1 gene related products
- orf clones - Search results for available TIAL1 gene related products
- genomics-online: gRNA clones - Search results for available TIAL1 gene related products
- genomics-online: primer clones - Search results for available TIAL1 gene related products
- genomics-online: shRNA clones - Search results for available TIAL1 gene related products
Sources for TIAL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (88) MaxQB
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- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (135) Horizon
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- (139) VectorBuilder
- (140) SNPedia
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew