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Aliases for TIAL1 Gene

Aliases for TIAL1 Gene

  • TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 2 3 5
  • TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 1 2
  • Aging-Associated Gene 7 Protein 3
  • T-Cluster Binding Protein 3
  • TIA-1-Related Nucleolysin 3
  • TIA-1-Related Protein 4
  • TCBP 3
  • TIAR 3

External Ids for TIAL1 Gene

Previous GeneCards Identifiers for TIAL1 Gene

  • GC10M120253
  • GC10M120578
  • GC10M121466
  • GC10M120999
  • GC10M121324
  • GC10M114963

Summaries for TIAL1 Gene

Entrez Gene Summary for TIAL1 Gene

  • The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIAL1 Gene

TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM39.

UniProtKB/Swiss-Prot for TIAL1 Gene

  • RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Gene Wiki entry for TIAL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAL1 Gene

Genomics for TIAL1 Gene

Regulatory Elements for TIAL1 Gene

Promoters for TIAL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIAL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIAL1 Gene

Chromosome:
10
Start:
119,571,802 bp from pter
End:
119,597,029 bp from pter
Size:
25,228 bases
Orientation:
Minus strand

Genomic View for TIAL1 Gene

Genes around TIAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAL1 Gene

Proteins for TIAL1 Gene

  • Protein details for TIAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01085-TIAR_HUMAN
    Recommended name:
    Nucleolysin TIAR
    Protein Accession:
    Q01085
    Secondary Accessions:
    • A8K3T0
    • A8K4L9

    Protein attributes for TIAL1 Gene

    Size:
    375 amino acids
    Molecular mass:
    41591 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TIAL1 Gene

    Alternative splice isoforms for TIAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAL1 Gene

Proteomics data for TIAL1 Gene at MOPED

Post-translational modifications for TIAL1 Gene

  • Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
  • Ubiquitination at Lys 122 and Lys 203
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TIAL1 (TIAL1)

No data available for DME Specific Peptides for TIAL1 Gene

Domains & Families for TIAL1 Gene

Gene Families for TIAL1 Gene

Protein Domains for TIAL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q01085

UniProtKB/Swiss-Prot:

TIAR_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with TIAL1: view

Function for TIAL1 Gene

Molecular function for TIAL1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Gene Ontology (GO) - Molecular Function for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TIAL1: view
genes like me logo Genes that share phenotypes with TIAL1: view

Animal Models for TIAL1 Gene

MGI Knock Outs for TIAL1:

Animal Model Products

CRISPR Products

miRNA for TIAL1 Gene

miRTarBase miRNAs that target TIAL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAL1 Gene

Localization for TIAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAL1 Gene

Cytoplasm. Nucleus. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIAL1 Gene COMPARTMENTS Subcellular localization image for TIAL1 gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 4
vacuole 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TIAL1: view

Pathways & Interactions for TIAL1 Gene

genes like me logo Genes that share pathways with TIAL1: view

Pathways by source for TIAL1 Gene

Gene Ontology (GO) - Biological Process for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0017145 stem cell division IEA --
genes like me logo Genes that share ontologies with TIAL1: view

No data available for SIGNOR curated interactions for TIAL1 Gene

Drugs & Compounds for TIAL1 Gene

(3) Drugs for TIAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TIAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIAL1: view

Transcripts for TIAL1 Gene

Unigene Clusters for TIAL1 Gene

TIA1 cytotoxic granule-associated RNA binding protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 16a · 16b · 16c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TIAL1 Gene

GeneLoc Exon Structure for
TIAL1
ECgene alternative splicing isoforms for
TIAL1

Expression for TIAL1 Gene

mRNA expression in normal human tissues for TIAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIAL1 Gene

This gene is overexpressed in Bone (10.5) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIAL1 Gene



SOURCE GeneReport for Unigene cluster for TIAL1 Gene Hs.501203

genes like me logo Genes that share expression patterns with TIAL1: view

Protein tissue co-expression partners for TIAL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIAL1 Gene

Orthologs for TIAL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIAL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIAL1 35
  • 95.56 (n)
  • 100 (a)
TIAL1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIAL1 35
  • 97.28 (n)
  • 100 (a)
TIAL1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tial1 35
  • 94.81 (n)
  • 99.23 (a)
Tial1 16
Tial1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIAL1 35
  • 99.74 (n)
  • 100 (a)
TIAL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tial1 35
  • 94.98 (n)
  • 99.23 (a)
oppossum
(Monodelphis domestica)
Mammalia TIAL1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIAL1 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIA1 35
  • 87.89 (n)
  • 95.1 (a)
TIAR 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIAL1 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tial1-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii tial1 35
  • 76.4 (n)
  • 85.14 (a)
zgc66130 35
tial1 36
  • 85 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4787 37
  • 62 (a)
Rox8 35
  • 55.84 (n)
  • 55.47 (a)
CG34354 36
  • 30 (a)
ManyToMany
CG34362 36
  • 20 (a)
ManyToMany
Rox8 36
  • 38 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002335 35
  • 54.47 (n)
  • 56.16 (a)
worm
(Caenorhabditis elegans)
Secernentea C07A4.1 37
  • 46 (a)
C18A3.5a 37
  • 51 (a)
C18A3.5b 37
  • 44 (a)
Y46G5A.13 37
  • 44 (a)
tiar-1 36
  • 39 (a)
ManyToMany
tiar-2 36
  • 34 (a)
ManyToMany
tiar-3 36
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUB1 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP1B 35
  • 52.01 (n)
  • 43.61 (a)
rice
(Oryza sativa)
Liliopsida Os11g0620100 35
  • 53.14 (n)
  • 45.76 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5046 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
CSA.8430 36
  • 48 (a)
ManyToMany
Species with no ortholog for TIAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TIAL1 Gene

ENSEMBL:
Gene Tree for TIAL1 (if available)
TreeFam:
Gene Tree for TIAL1 (if available)

Paralogs for TIAL1 Gene

Paralogs for TIAL1 Gene

Pseudogenes.org Pseudogenes for TIAL1 Gene

genes like me logo Genes that share paralogs with TIAL1: view

Variants for TIAL1 Gene

Sequence variations from dbSNP and Humsavar for TIAL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1060033 -- 119,576,880(-) TTAGA(C/T)AATGA intron-variant, nc-transcript-variant
rs1060034 -- 119,576,879(-) TAGAC(A/G)ATGAT intron-variant, nc-transcript-variant
rs2069142 -- 119,582,875(-) GATCT(G/T)AGTTT intron-variant
rs3009878 -- 119,573,776(+) TAAGG(A/G)TATAT nc-transcript-variant, utr-variant-3-prime
rs3009879 -- 119,578,995(+) GAAAA(C/T)GATTT intron-variant

Variation tolerance for TIAL1 Gene

Residual Variation Intolerance Score: 27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIAL1 Gene

HapMap Linkage Disequilibrium report
TIAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIAL1 Gene

Disorders for TIAL1 Gene

Relevant External Links for TIAL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIAL1

No disorders were found for TIAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIAL1 Gene

Publications for TIAL1 Gene

  1. Identification and functional characterization of a TIA-1-related nucleolysin. (PMID: 1326761) Kawakami A. … Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23 67
  2. A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. (PMID: 18456862) Aznarez I. … Blencowe B.J. (Genome Res. 2008) 3 23
  3. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. (PMID: 17486099) Liao B. … Brewer G. (Nat. Struct. Mol. Biol. 2007) 3 23
  4. Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein. (PMID: 17488725) Izquierdo J.M. … ValcA!rcel J. (J. Biol. Chem. 2007) 3 23
  5. Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. (PMID: 17682065) Kim H.S. … Wilce J.A. (Mol. Cell. Biol. 2007) 3 23

Products for TIAL1 Gene

Sources for TIAL1 Gene

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