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Aliases for THY1 Gene

Aliases for THY1 Gene

  • Thy-1 Cell Surface Antigen 2 3 5
  • Thy-1 Antigen 3 4
  • CDw90 3 4
  • Thy-1 T-Cell Antigen 3
  • CD90 Antigen 4
  • CD90 3

External Ids for THY1 Gene

Previous GeneCards Identifiers for THY1 Gene

  • GC11M121288
  • GC11M120800
  • GC11M119322
  • GC11M118826
  • GC11M118795
  • GC11M119288
  • GC11M115230

Summaries for THY1 Gene

Entrez Gene Summary for THY1 Gene

  • This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for THY1 Gene

THY1 (Thy-1 Cell Surface Antigen) is a Protein Coding gene. Diseases associated with THY1 include Thymoma and Nasopharyngeal Carcinoma. Among its related pathways are IL4-mediated signaling events and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include protein kinase binding and GTPase activator activity.

UniProtKB/Swiss-Prot for THY1 Gene

  • May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

Gene Wiki entry for THY1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THY1 Gene

Genomics for THY1 Gene

Regulatory Elements for THY1 Gene

Enhancers for THY1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THY1 on UCSC Golden Path with GeneCards custom track

Genomic Location for THY1 Gene

Chromosome:
11
Start:
119,417,378 bp from pter
End:
119,424,985 bp from pter
Size:
7,608 bases
Orientation:
Minus strand

Genomic View for THY1 Gene

Genes around THY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THY1 Gene

Proteins for THY1 Gene

  • Protein details for THY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04216-THY1_HUMAN
    Recommended name:
    Thy-1 membrane glycoprotein
    Protein Accession:
    P04216
    Secondary Accessions:
    • Q16008
    • Q9NSP1

    Protein attributes for THY1 Gene

    Size:
    161 amino acids
    Molecular mass:
    17935 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THY1 Gene

Proteomics data for THY1 Gene at MOPED

Post-translational modifications for THY1 Gene

  • Glycosylation at Asn 42, Asn 79, Asn 119, and Asn 139
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for THY1 (THY1)

No data available for DME Specific Peptides for THY1 Gene

Domains & Families for THY1 Gene

Protein Domains for THY1 Gene

Graphical View of Domain Structure for InterPro Entry

P04216

UniProtKB/Swiss-Prot:

THY1_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with THY1: view

Function for THY1 Gene

Molecular function for THY1 Gene

GENATLAS Biochemistry:
Thy-1 cell surface antigen
UniProtKB/Swiss-Prot Function:
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
genes like me logo Genes that share phenotypes with THY1: view

Animal Models for THY1 Gene

MGI Knock Outs for THY1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THY1 Gene

Localization for THY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THY1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THY1 Gene COMPARTMENTS Subcellular localization image for THY1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0009897 external side of plasma membrane ISS --
GO:0030425 dendrite IEA,IBA --
genes like me logo Genes that share ontologies with THY1: view

Pathways & Interactions for THY1 Gene

genes like me logo Genes that share pathways with THY1: view

Gene Ontology (GO) - Biological Process for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity ISS --
GO:0007010 cytoskeleton organization ISS --
GO:0030336 negative regulation of cell migration ISS --
GO:0046777 protein autophosphorylation IEA --
GO:0050852 T cell receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with THY1: view

No data available for SIGNOR curated interactions for THY1 Gene

Drugs & Compounds for THY1 Gene

(1) Drugs for THY1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for THY1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THY1: view

Transcripts for THY1 Gene

Unigene Clusters for THY1 Gene

Thy-1 cell surface antigen:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THY1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - -
SP12: - -

Relevant External Links for THY1 Gene

GeneLoc Exon Structure for
THY1
ECgene alternative splicing isoforms for
THY1

Expression for THY1 Gene

mRNA expression in normal human tissues for THY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THY1 Gene

This gene is overexpressed in Brain - Cortex (x5.3), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for THY1 Gene

This gene is overexpressed in Frontal cortex (17.5), Brain (11.3), and Cerebrospinal fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THY1 Gene



SOURCE GeneReport for Unigene cluster for THY1 Gene Hs.644697

genes like me logo Genes that share expression patterns with THY1: view

Protein tissue co-expression partners for THY1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for THY1 Gene

Orthologs for THY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THY1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THY1 35
  • 80.12 (n)
  • 73.91 (a)
THY1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THY1 35
  • 85.71 (n)
  • 82.61 (a)
THY1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thy1 35
  • 76.81 (n)
  • 70.19 (a)
Thy1 16
Thy1 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THY1 35
  • 99.59 (n)
  • 100 (a)
THY1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thy1 35
  • 77.85 (n)
  • 70.81 (a)
oppossum
(Monodelphis domestica)
Mammalia THY1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THY1 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves THY1 35
  • 65.83 (n)
  • 54.37 (a)
gga-mir-1466 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THY1 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thy1 35
  • 45.76 (n)
  • 36.02 (a)
Species with no ortholog for THY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THY1 Gene

ENSEMBL:
Gene Tree for THY1 (if available)
TreeFam:
Gene Tree for THY1 (if available)

Paralogs for THY1 Gene

No data available for Paralogs for THY1 Gene

Variants for THY1 Gene

Structural Variations from Database of Genomic Variants (DGV) for THY1 Gene

Variant ID Type Subtype PubMed ID
nsv898418 CNV Loss 21882294
nsv832284 CNV Gain 17160897

Variation tolerance for THY1 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for THY1 Gene

Disorders for THY1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for THY1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thymoma
  • primary thymic epithelial neoplasm
nasopharyngeal carcinoma
  • malignant neoplasm of nasopharynx
warthin tumor
  • papillary cystadenoma lymphomatosum
fiedler's myocarditis
  • fiedler myocarditis
gerstmann-straussler disease
  • cerebral amyloid angiopathy, prnp-related
- elite association - COSMIC cancer census association via MalaCards
Search THY1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for THY1

Genetic Association Database (GAD)
THY1
Human Genome Epidemiology (HuGE) Navigator
THY1
Tumor Gene Database (TGDB):
THY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THY1
genes like me logo Genes that share disorders with THY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THY1 Gene

Publications for THY1 Gene

  1. The human Thy-1 gene: structure and chromosomal location. (PMID: 2864690) Seki T. … Silver J. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4 67
  2. A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs. (PMID: 18985728) Campioni D. … Lanza F. (Cytometry B Clin Cytom 2009) 3 23
  3. Loss of Thy-1 (CD90) antigen expression on mesenchymal stromal cells from hematologic malignancies is induced by in vitro angiogenic stimuli and is associated with peculiar functional and phenotypic characteristics. (PMID: 18202976) Campioni D. … Cuneo A. (Cytotherapy 2008) 3 23
  4. Evidence for enhanced Thy-1 (CD90) expression in orbital fibroblasts of patients with Graves' ophthalmopathy. (PMID: 18976167) Khoo T.K. … Bahn R.S. (Thyroid 2008) 3 23
  5. Increased neutrophil adherence in psoriasis: role of the human endothelial cell receptor Thy-1 (CD90). (PMID: 16374458) Wetzel A. … Saalbach A. (J. Invest. Dermatol. 2006) 3 23

Products for THY1 Gene

Sources for THY1 Gene

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