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Aliases for THRA Gene

Aliases for THRA Gene

  • Thyroid Hormone Receptor, Alpha 2 3
  • THRA1 3 4 6
  • ERBA1 3 4 6
  • Thyroid Hormone Receptor, Alpha (Erythroblastic Leukemia Viral (V-Erb-A) Oncogene Homolog, Avian) 2 3
  • Nuclear Receptor Subfamily 1 Group A Member 1 3 4
  • V-ErbA-Related Protein 7 3 4
  • C-ErbA-Alpha 3 4
  • C-ERBA-1 3 4
  • THRA2 3 4
  • CHNG6 3 6
  • EAR-7 3 4
  • NR1A1 3 4
  • EAR7 3 4
  • Thyroid Hormone Receptor, Alpha (Avian Erythroblastic Leukemia Viral (V-Erb-A) Oncogene Homolog) 2
  • Thyroid Normone Nuclear Receptor Alpha Variant 1 3
  • Thyroid Hormone Receptor Alpha 3
  • Triiodothyronine Receptor 3
  • ERBA-Related 7 3
  • ERB-T-1 3
  • ERBA 3
  • AR7 3

External Ids for THRA Gene

Previous Symbols for THRA Gene

  • THRA1
  • THRA2
  • ERBA1

Summaries for THRA Gene

Entrez Gene Summary for THRA Gene

  • The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for THRA Gene

THRA (Thyroid Hormone Receptor, Alpha) is a Protein Coding gene. Diseases associated with THRA include hypothyroidism, congenital, nongoitrous, 6 and peripheral resistance to thyroid hormones. Among its related pathways are Endochondral Ossification and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is NR1I2.

UniProtKB/Swiss-Prot for THRA Gene

  • Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Gene Wiki entry for THRA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THRA Gene

Genomics for THRA Gene

Genomic Location for THRA Gene

Start:
40,058,290 bp from pter
End:
40,093,867 bp from pter
Size:
35,578 bases
Orientation:
Plus strand

Genomic View for THRA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THRA Gene

Regulatory Elements for THRA Gene

Transcription factor binding sites by QIAGEN in the THRA gene promoter:

Proteins for THRA Gene

  • Protein details for THRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10827-THA_HUMAN
    Recommended name:
    Thyroid hormone receptor alpha
    Protein Accession:
    P10827
    Secondary Accessions:
    • A8K3B5
    • P21205
    • Q8N6A1
    • Q96H73

    Protein attributes for THRA Gene

    Size:
    490 amino acids
    Molecular mass:
    54816 Da
    Quaternary structure:
    • Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D. Interacts with AKAP13. Interacts with TP53INP2. Interacts with PER2.

    Three dimensional structures from OCA and Proteopedia for THRA Gene

    Alternative splice isoforms for THRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THRA Gene

Proteomics data for THRA Gene at MOPED

Post-translational modifications for THRA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys190

No data available for DME Specific Peptides for THRA Gene

Domains for THRA Gene

Gene Families for THRA Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

UniProtKB/Swiss-Prot:

THA_HUMAN
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain:
    • P10827
  • Contains 1 nuclear receptor DNA-binding domain.:
    • P10827
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.:
    • P10827
genes like me logo Genes that share domains with THRA: view

Function for THRA Gene

Molecular function for THRA Gene

GENATLAS Biochemistry: thyroid hormone receptor,alpha 1,ubiquitous,with two alternatively spliced isoforms THRA1,a hormone binding receptor and THRA2,not binding hormone but inhibiting THR transactivation,also encoding NR1D1 (alpha transcript) on the opposite strand (see symbol),steroid/thyroid hormone receptor superfamily
UniProtKB/Swiss-Prot Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Gene Ontology (GO) - Molecular Function for THRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002153 steroid receptor RNA activator RNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 18052923
GO:0003707 steroid hormone receptor activity IEA --
GO:0003727 single-stranded RNA binding --
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity --
genes like me logo Genes that share ontologies with THRA: view
genes like me logo Genes that share phenotypes with THRA: view

Animal Models for THRA Gene

MGI Knock Outs for THRA:
Targeting motifs for THRA Gene
HOMER Transcription Factor Regulatory Elements motif THRA
  • Consensus sequence: GGTCANYTGAGGWCA Submotif: canonical Cell Type: C17.2 GeoId: GSE38347

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for THRA Gene

Localization for THRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for THRA Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THRA Gene COMPARTMENTS Subcellular localization image for THRA gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for THRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19158403
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005829 cytosol IDA 19158403
genes like me logo Genes that share ontologies with THRA: view

Pathways for THRA Gene

genes like me logo Genes that share pathways with THRA: view

Pathways by source for THRA Gene

Gene Ontology (GO) - Biological Process for THRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0001503 ossification IEA --
GO:0002155 regulation of thyroid hormone mediated signaling pathway IEA --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with THRA: view

Compounds for THRA Gene

(1) HMDB Compounds for THRA Gene

Compound Synonyms Cas Number PubMed IDs
Liothyronine
  • 3,3',5-Triiodo-L-thyronine
6893-02-3

(5) Drugbank Compounds for THRA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
target
Dextrothyroxine
51-49-0 target agonist
Levothyroxine
  • (-)-Thyroxine
51-48-9 target agonist
Liothyronine
  • L-Liothyronine
6893-02-3 target agonist
Liotrix
8065-29-0 target agonist

(7) IUPHAR Ligand for THRA Gene

Ligand Type Action Affinity Pubmed IDs
T3 Agonist Agonist 10
GC-1 Agonist Agonist 9.36
NH-3 Antagonist Antagonist 7.62
KB-141 Agonist Agonist 7.6
reverse triiodothyronine Agonist Agonist
T4 Agonist Agonist
3,3,5-triiodothyroacetic acid Agonist Agonist

(11) Novoseek inferred chemical compound relationships for THRA Gene

Compound -log(P) Hits PubMed IDs
triiodothyronine 77.5 8
retinoic acid 64.5 14
thyroxine 48.6 1
estrogen 25.3 7
vitamin d 15.7 3

(1) PharmGKB related drug/compound annotations for THRA Gene

Drug/compound Annotation
lithium CA
genes like me logo Genes that share compounds with THRA: view

Transcripts for THRA Gene

Unigene Clusters for THRA Gene

Thyroid hormone receptor, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THRA Gene

No ASD Table

Relevant External Links for THRA Gene

GeneLoc Exon Structure for
THRA
ECgene alternative splicing isoforms for
THRA

Expression for THRA Gene

mRNA expression in normal human tissues for THRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for THRA Gene

SOURCE GeneReport for Unigene cluster for THRA Gene Hs.724

genes like me logo Genes that share expressions with THRA: view

Orthologs for THRA Gene

This gene was present in the common ancestor of chordates.

Orthologs for THRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THRA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THRA 36
  • 96.67 (n)
  • 99.19 (a)
THRA 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THRA 36
  • 96.75 (n)
  • 99.76 (a)
THRA 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thra 36
  • 95.93 (n)
  • 99.27 (a)
Thra 16
Thra 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THRA 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thra 36
  • 96.1 (n)
  • 99.27 (a)
chicken
(Gallus gallus)
Aves THRA 36
  • 84.97 (n)
  • 90.44 (a)
THRA 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THRA 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397942 36
tropical clawed frog
(Silurana tropicalis)
Amphibia thra 36
  • 79.98 (n)
  • 88.48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.164 36
zebrafish
(Danio rerio)
Actinopterygii thra 36
thraa 37
  • 72 (a)
OneToMany
thrab 36
  • 79.34 (n)
  • 86.67 (a)
thrab 37
  • 75 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6147 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4364 37
  • 27 (a)
OneToMany
Species with no ortholog for THRA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THRA Gene

ENSEMBL:
Gene Tree for THRA (if available)
TreeFam:
Gene Tree for THRA (if available)

Paralogs for THRA Gene

genes like me logo Genes that share paralogs with THRA: view

Variants for THRA Gene

Sequence variations from dbSNP and Humsavar for THRA Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs868343 -- 40,061,702(+) AGCAG(C/T)TCCCC upstream-variant-2KB
rs879091 -- 40,075,757(+) AAGCC(A/G)CTAGC intron-variant
rs939345 -- 40,061,097(-) CTTGG(A/G)ATTGG upstream-variant-2KB
rs939348 -- 40,075,600(+) TGTGC(C/T)TAATG intron-variant
rs1109976 -- 40,061,708(+) TCCCC(C/G/T)TAaca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for THRA Gene

Variant ID Type Subtype PubMed ID
nsv908221 CNV Loss 21882294
nsv833444 CNV Loss 17160897

Relevant External Links for THRA Gene

HapMap Linkage Disequilibrium report
THRA
Human Gene Mutation Database (HGMD)
THRA

Disorders for THRA Gene

(1) OMIM Diseases for THRA Gene (190120)

UniProtKB/Swiss-Prot

THA_HUMAN
  • Hypothyroidism, congenital, non-goitrous, 6 (CHNG6) [MIM:614450]: A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance. {ECO:0000269 PubMed:22168587}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for THRA Gene

(12) Novoseek inferred disease relationships for THRA Gene

Disease -log(P) Hits PubMed IDs
osteoclastoma 58.9 2
thyroid cancer 31.5 4
erythroleukemia 30.8 1
hypertrophy 15.3 1
breast carcinoma 0 1

Genatlas disease for THRA Gene

hyperthyroxinemia,euthyroidal

Relevant External Links for THRA

Genetic Association Database (GAD)
THRA
Human Genome Epidemiology (HuGE) Navigator
THRA
Tumor Gene Database (TGDB):
THRA
genes like me logo Genes that share disorders with THRA: view

Publications for THRA Gene

  1. Genomic organization of the human thyroid hormone receptor alpha (c- erbA-1) gene. (PMID: 1850510) Laudet V. … Saule S. (Nucleic Acids Res. 1991) 3 4 23
  2. Identification and consequences of polymorphisms in the thyroid hormone receptor alpha and beta genes. (PMID: 18844476) SA … Visser T.J. (Thyroid 2008) 3 23 49
  3. Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues. (PMID: 2464749) Nakai A. … Degroot L.J. (Mol. Endocrinol. 1988) 3 4
  4. Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. (PMID: 2539258) Miyajima N. … Yamamoto T. (Cell 1989) 3 4
  5. Subcutaneous fat shows higher thyroid hormone receptor-alpha1 gene expression than omental fat. (PMID: 19360007) Ortega F.J. … FernA!ndez-Real J.M. (Obesity (Silver Spring) 2009) 3 23

Products for THRA Gene

Sources for THRA Gene

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