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Aliases for TSPO Gene

Aliases for TSPO Gene

  • Translocator Protein (18kDa) 2 3
  • BZRP 3 4 6
  • PBR 3 4 6
  • Peripheral-Type Benzodiazepine Receptor 3 4
  • Mitochondrial Benzodiazepine Receptor 3 4
  • BPBS 3 6
  • PKBS 3 4
  • PBS 3 6
  • MBR 3 4
  • Peripheral-Type Benzodiazepine Receptor/Recognition Site 2
  • Benzodiazepine Peripheral Binding Site 3
  • Benzodiazapine Receptor (Peripheral) 2
  • Translocator Protein 3
  • PTBR 3
  • MDRC 3
  • Pk18 3
  • PBRS 4
  • IBP 3
  • DBI 3

External Ids for TSPO Gene

Previous Symbols for TSPO Gene

  • BZRP

Summaries for TSPO Gene

Entrez Gene Summary for TSPO Gene

  • Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]

GeneCards Summary for TSPO Gene

TSPO (Translocator Protein (18kDa)) is a Protein Coding gene. Diseases associated with TSPO include first-degree atrioventricular block and wernicke encephalopathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include cholesterol binding and androgen binding. An important paralog of this gene is TSPO2.

UniProtKB/Swiss-Prot for TSPO Gene

  • Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).

Gene Wiki entry for TSPO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPO Gene

Genomics for TSPO Gene

Genomic Location for TSPO Gene

Start:
43,151,514 bp from pter
End:
43,163,242 bp from pter
Size:
11,729 bases
Orientation:
Plus strand

Genomic View for TSPO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPO Gene

Regulatory Elements for TSPO Gene

Proteins for TSPO Gene

  • Protein details for TSPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B1AH88-TSPOB_HUMAN
    Recommended name:
    Putative peripheral benzodiazepine receptor-related protein
    Protein Accession:
    B1AH88
    Secondary Accessions:
    • Q13849
    • Q6IAZ7

    Protein attributes for TSPO Gene

    Size:
    102 amino acids
    Molecular mass:
    10537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPO Gene

    UniProtKB/Swiss-Prot:
  • Protein details for TSPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30536-TSPOA_HUMAN
    Recommended name:
    Translocator protein
    Protein Accession:
    P30536
    Secondary Accessions:
    • Q53Y59
    • Q6ICF9
    • Q96TF6

    Protein attributes for TSPO Gene

    Size:
    169 amino acids
    Molecular mass:
    18828 Da
    Quaternary structure:
    • Interacts with BZRAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1.

    Alternative splice isoforms for TSPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPO Gene

Proteomics data for TSPO Gene at MOPED

Post-translational modifications for TSPO Gene

No Post-translational modifications

Other Protein References for TSPO Gene

No data available for DME Specific Peptides for TSPO Gene

Domains for TSPO Gene

Protein Domains for TSPO Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TSPO Gene

Graphical View of Domain Structure for InterPro Entry

P30536

UniProtKB/Swiss-Prot:

TSPOA_HUMAN
Family:
  • Belongs to the TspO/BZRP family.:
    • P30536
genes like me logo Genes that share domains with TSPO: view

No data available for Gene Families for TSPO Gene

Function for TSPO Gene

Molecular function for TSPO Gene

UniProtKB/Swiss-Prot Function: Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).

Gene Ontology (GO) - Molecular Function for TSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005497 androgen binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008503 benzodiazepine receptor activity IEA --
GO:0015485 cholesterol binding TAS 16822554
genes like me logo Genes that share ontologies with TSPO: view

Phenotypes for TSPO Gene

GenomeRNAi human phenotypes for TSPO:
genes like me logo Genes that share phenotypes with TSPO: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSPO Gene

Localization for TSPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPO Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPO Gene COMPARTMENTS Subcellular localization image for TSPO gene
Compartment Confidence
mitochondrion 5
extracellular 3
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
vacuole 2
chloroplast 1
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with TSPO: view

Pathways for TSPO Gene

genes like me logo Genes that share pathways with TSPO: view

Pathways by source for TSPO Gene

1 BioSystems pathway for TSPO Gene
1 PharmGKB pathway for TSPO Gene

Gene Ontology (GO) - Biological Process for TSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 1326278
GO:0006694 steroid biosynthetic process IEA --
GO:0006783 heme biosynthetic process TAS 16822554
GO:0006811 ion transport --
GO:0006820 anion transport TAS 16822554
genes like me logo Genes that share ontologies with TSPO: view

Compounds for TSPO Gene

(2) HMDB Compounds for TSPO Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
Zolpidem
  • Ambien
82626-48-0

(13) Drugbank Compounds for TSPO Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alprazolam
28981-97-7 target other
Chlormezanone
  • Chlormethazanone
80-77-3 target agonist
Clonazepam
  • Chlonazepam
1622-61-3 target other/unknown
Clorazepate
23887-31-2 target agonist
Diazepam
439-14-5 target potentiator

(119) Novoseek inferred chemical compound relationships for TSPO Gene

Compound -log(P) Hits PubMed IDs
benzodiazepine 98.6 405
pk 11195 94.4 62
iomazenil 93.1 16
flumazenil 92.6 84
benzodiazepines 86.6 71
genes like me logo Genes that share compounds with TSPO: view

Transcripts for TSPO Gene

Unigene Clusters for TSPO Gene

Translocator protein (18kDa):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPO Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - -
SP5:

Relevant External Links for TSPO Gene

GeneLoc Exon Structure for
TSPO
ECgene alternative splicing isoforms for
TSPO

Expression for TSPO Gene

mRNA expression in normal human tissues for TSPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPO Gene

This gene is overexpressed in Whole Blood (13.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPO Gene

SOURCE GeneReport for Unigene cluster for TSPO Gene Hs.202

mRNA Expression by UniProt/SwissProt for TSPO Gene

B1AH88-TSPOB_HUMAN
Tissue specificity: Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.
genes like me logo Genes that share expressions with TSPO: view

Orthologs for TSPO Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPO 35
  • 98.82 (n)
  • 97.63 (a)
TSPO 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSPO 35
  • 82.45 (n)
  • 74.56 (a)
TSPO 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPO 35
  • 85.8 (n)
  • 81.66 (a)
TSPO 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspo 35
  • 81.66 (n)
  • 81.07 (a)
Tspo 16
Tspo 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSPO 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspo 35
  • 81.26 (n)
  • 79.88 (a)
chicken
(Gallus gallus)
Aves TSPO 35
  • 63.33 (n)
  • 61.87 (a)
TSPO 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPO 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia bzrp-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1193 35
tspo 35
  • 67.94 (n)
  • 60.51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7981 35
zebrafish
(Danio rerio)
Actinopterygii tspo 35
  • 60.61 (n)
  • 57.14 (a)
tspo 36
  • 54 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000426 35
  • 57.33 (n)
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2789 35
  • 56.82 (n)
  • 46.98 (a)
CG2789 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C41G7.9 36
  • 25 (a)
OneToMany
Species with no ortholog for TSPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPO Gene

ENSEMBL:
Gene Tree for TSPO (if available)
TreeFam:
Gene Tree for TSPO (if available)

Paralogs for TSPO Gene

Paralogs for TSPO Gene

Selected SIMAP similar genes for TSPO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSPO: view

Variants for TSPO Gene

Sequence variations from dbSNP and Humsavar for TSPO Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs6971 -, - 43,162,920(-) GGTCG(C/T)GAAGG reference, missense, nc-transcript-variant
rs6972 - 43,162,966(+) CTGGC(A/G)TGGGG missense, reference, nc-transcript-variant
rs6973 -- 43,163,131(+) GAGGT(G/T)GCCCC utr-variant-3-prime, nc-transcript-variant
rs105585 -- 43,161,486(+) TAACA(A/G)Cttct intron-variant
rs113515 -- 43,160,916(+) ccaga(C/G)aggtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPO Gene

Variant ID Type Subtype PubMed ID
nsv834214 CNV Gain 17160897
esv33816 CNV Gain 17666407
dgv4986n71 CNV Loss 21882294
dgv4987n71 CNV Loss 21882294
nsv915201 CNV Loss 21882294
dgv4988n71 CNV Loss 21882294
nsv915215 CNV Loss 21882294
nsv459890 CNV Gain 19166990
esv2671621 CNV Deletion 23128226
esv1998181 CNV Deletion 18987734
esv2724299 CNV Deletion 23290073
esv3468 CNV Deletion 18987735
esv8520 CNV Loss 19470904
nsv520927 CNV Loss 19592680
nsv915217 CNV Gain 21882294
dgv4989n71 CNV Loss 21882294

Relevant External Links for TSPO Gene

HapMap Linkage Disequilibrium report
TSPO
Human Gene Mutation Database (HGMD)
TSPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPO Gene

Disorders for TSPO Gene

(93) Novoseek inferred disease relationships for TSPO Gene

Disease -log(P) Hits PubMed IDs
hepatic encephalopathy 78.4 48
hepatic coma 60.7 5
chronic insomnia 60.3 1
epilepsy temporal lobe 57.7 17
panic disorder 53.6 27

Relevant External Links for TSPO

Genetic Association Database (GAD)
TSPO
Human Genome Epidemiology (HuGE) Navigator
TSPO
genes like me logo Genes that share disorders with TSPO: view

No data available for UniProtKB/Swiss-Prot for TSPO Gene

Publications for TSPO Gene

  1. The human "peripheral-type" benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA. (PMID: 1326278) Chang Y.J. … Strauss J.F. (DNA Cell Biol. 1992) 2 3 23
  2. The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia. (PMID: 8307574) Lin D. … Miller W.L. (Genomics 1993) 3 4 23
  3. Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder. (PMID: 16511838) Nakamura K. … Mori N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 23 48
  4. Immunohistochemical expression of peripheral benzodiazepine receptors in human astrocytomas and its correlation with grade of malignancy, proliferation, apoptosis and survival. (PMID: 16868661) Vlodavsky E. … Soustiel J.F. (J. Neurooncol. 2007) 3 23
  5. Platelet 18 kDa Translocator Protein density is reduced in depressed patients with adult separation anxiety. (PMID: 18054208) Chelli B. … Martini C. (Eur Neuropsychopharmacol 2008) 3 23

Products for TSPO Gene

Sources for TSPO Gene

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