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Aliases for THBS1 Gene

Aliases for THBS1 Gene

  • Thrombospondin 1 2 3
  • Thrombospondin-1p180 2 3
  • TSP1 3 4
  • TSP 3 4
  • Thrombospondin-1 3
  • THBS-1 3
  • TSP-1 3
  • THBS 3

External Ids for THBS1 Gene

Summaries for THBS1 Gene

Entrez Gene Summary for THBS1 Gene

  • The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for THBS1 Gene

THBS1 (Thrombospondin 1) is a Protein Coding gene. Diseases associated with THBS1 include cerebral arteriovenous malformation and uveal melanoma. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for THBS1 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

Gene Wiki entry for THBS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS1 Gene

Genomics for THBS1 Gene

Genomic Location for THBS1 Gene

Start:
39,581,079 bp from pter
End:
39,599,466 bp from pter
Size:
18,388 bases
Orientation:
Plus strand

Genomic View for THBS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THBS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS1 Gene

Regulatory Elements for THBS1 Gene

Proteins for THBS1 Gene

  • Protein details for THBS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07996-TSP1_HUMAN
    Recommended name:
    Thrombospondin-1
    Protein Accession:
    P07996
    Secondary Accessions:
    • A8K6H4
    • B4E3J7
    • B9EGH6
    • Q15667
    • Q59E99

    Protein attributes for THBS1 Gene

    Size:
    1170 amino acids
    Molecular mass:
    129383 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts with ATF6 (via lumenal domain) (By similarity).
    SequenceCaution:
    • Sequence=BAD93149.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for THBS1 Gene

    Alternative splice isoforms for THBS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THBS1 Gene

Proteomics data for THBS1 Gene at MOPED

Post-translational modifications for THBS1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn248, Thr289, Thr292, Thr293, Thr302, Asn360, Trp385, Ser394, Trp438, Trp441, Thr450, Trp498, Thr507, Thr638, Asn708, and Asn1067

Other Protein References for THBS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for THBS1 Gene

Domains for THBS1 Gene

UniProtKB/Swiss-Prot:

TSP1_HUMAN
Domain:
  • Contains 2 EGF-like domains.:
    • P07996
  • Contains 1 laminin G-like domain.:
    • P07996
  • Contains 1 TSP C-terminal (TSPC) domain.:
    • P07996
  • Contains 3 TSP type-1 domains.:
    • P07996
  • Contains 1 VWFC domain.:
    • P07996
Family:
  • Belongs to the thrombospondin family.:
    • P07996
Similarity:
  • Contains 8 TSP type-3 repeats.:
    • P07996
genes like me logo Genes that share domains with THBS1: view

No data available for Gene Families for THBS1 Gene

Function for THBS1 Gene

Molecular function for THBS1 Gene

GENATLAS Biochemistry: thrombospondin I (140kDa),glycoprotein expressed in extracellular matrix protein involved in platelet aggregation,embryogenesis,morphogenesis,cell adhesion molecule,major activator of TGFB1
UniProtKB/Swiss-Prot Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

Gene Ontology (GO) - Molecular Function for THBS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 18940719
GO:0001948 glycoprotein binding NAS 6438154
GO:0001968 fibronectin binding IDA 6693501
GO:0005178 integrin binding IMP 17413041
GO:0005509 calcium ion binding NAS 9304800
genes like me logo Genes that share ontologies with THBS1: view
genes like me logo Genes that share phenotypes with THBS1: view

Animal Models for THBS1 Gene

MGI Knock Outs for THBS1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for THBS1 Gene

Localization for THBS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THBS1 Gene

Endoplasmic reticulum. Sarcoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THBS1 Gene COMPARTMENTS Subcellular localization image for THBS1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for THBS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005577 fibrinogen complex IDA 3997886
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with THBS1: view

Pathways for THBS1 Gene

genes like me logo Genes that share pathways with THBS1: view

Gene Ontology (GO) - Biological Process for THBS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IMP 17413041
GO:0001666 response to hypoxia NAS 9304800
GO:0001937 negative regulation of endothelial cell proliferation IMP 17413041
GO:0001953 negative regulation of cell-matrix adhesion IDA 16150726
GO:0002040 sprouting angiogenesis IMP 17879962
genes like me logo Genes that share ontologies with THBS1: view

Compounds for THBS1 Gene

(103) Novoseek inferred chemical compound relationships for THBS1 Gene

Compound -log(P) Hits PubMed IDs
vegf 74.6 230
grgdsp 60.4 6
heparin 51.7 83
grgesp 47 2
dauricine 45.4 3
genes like me logo Genes that share compounds with THBS1: view

Transcripts for THBS1 Gene

Unigene Clusters for THBS1 Gene

Thrombospondin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THBS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1: - - - -
SP2:
SP3: -
SP4:
SP5:
SP6:

ExUns: 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for THBS1 Gene

GeneLoc Exon Structure for
THBS1
ECgene alternative splicing isoforms for
THBS1

Expression for THBS1 Gene

mRNA expression in normal human tissues for THBS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THBS1 Gene

SOURCE GeneReport for Unigene cluster for THBS1 Gene Hs.164226

genes like me logo Genes that share expressions with THBS1: view

Orthologs for THBS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THBS1 36
  • 99.69 (n)
  • 99.74 (a)
THBS1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THBS1 36
  • 92.13 (n)
  • 96.75 (a)
THBS1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THBS1 36
  • 91.3 (n)
  • 97.26 (a)
THBS1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thbs1 36
  • 89.05 (n)
  • 94.78 (a)
Thbs1 16
Thbs1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THBS1 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THBS1 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thbs1 36
  • 88.99 (n)
  • 95.3 (a)
chicken
(Gallus gallus)
Aves THBS1 36
  • 78.8 (n)
  • 85.7 (a)
THBS1 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THBS1 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs1 36
  • 75.06 (n)
  • 81.93 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
thbs1 36
  • 71.94 (n)
  • 75.77 (a)
THBS1 (2 of 2) 37
  • 80 (a)
OneToMany
thbs1b 37
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp 37
  • 36 (a)
OneToMany
Tsp 38
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToMany
Species with no ortholog for THBS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS1 Gene

ENSEMBL:
Gene Tree for THBS1 (if available)
TreeFam:
Gene Tree for THBS1 (if available)

Paralogs for THBS1 Gene

Paralogs for THBS1 Gene

Selected SIMAP similar genes for THBS1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with THBS1: view

Variants for THBS1 Gene

Sequence variations from dbSNP and Humsavar for THBS1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs753598 -- 39,586,066(+) GATAT(C/T)GTTCC intron-variant
rs753599 -- 39,586,074(+) TCCAT(A/G)GCACG intron-variant
rs1134485 -- 39,587,780(-) ACTCA(A/G)TGCTA intron-variant
rs1134486 -- 39,587,696(-) CAAAT(C/G)AGGAA intron-variant
rs1478604 -- 39,581,120(-) GAGCG(A/G)CAGGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for THBS1 Gene

Variant ID Type Subtype PubMed ID
nsv904094 CNV Gain 21882294
nsv832977 CNV Gain 17160897
nsv1502 CNV Loss 18451855

Relevant External Links for THBS1 Gene

HapMap Linkage Disequilibrium report
THBS1
Human Gene Mutation Database (HGMD)
THBS1

Disorders for THBS1 Gene

(2) University of Copenhagen DISEASES for THBS1 Gene

(98) Novoseek inferred disease relationships for THBS1 Gene

Disease -log(P) Hits PubMed IDs
purpura thrombotic thrombocytopenic 66.3 8
neovascularization 64 24
tumors 62.5 328
metastasis 51.5 81
cancer 48.3 99

Relevant External Links for THBS1

Genetic Association Database (GAD)
THBS1
Human Genome Epidemiology (HuGE) Navigator
THBS1
genes like me logo Genes that share disorders with THBS1: view

No data available for UniProtKB/Swiss-Prot for THBS1 Gene

Publications for THBS1 Gene

  1. Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. (PMID: 11134179) Simantov R. … Silverstein R.L. (J. Clin. Invest. 2001) 3 4 23
  2. Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. (PMID: 12391027) Tan K. … Wang J.-H. (J. Cell Biol. 2002) 3 4 23
  3. Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population. (PMID: 15140581) Zhou X. … Gu D. (Thromb. Res. 2004) 3 23 49
  4. [Correlation of thrombospondin-1 G1678A polymorphism to stroke: a study in Chinese population]. (PMID: 15730804) Liu X.N. … Hui R.T. (Zhonghua Yi Xue Za Zhi 2004) 3 23 49
  5. TSP1 and MMP9 genetic variants in sporadic prostate cancer. (PMID: 17175378) Sfar S. … Chouchane L. (Cancer Genet. Cytogenet. 2007) 3 23 49

Products for THBS1 Gene

  • Addgene plasmids for THBS1

Sources for THBS1 Gene

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