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Aliases for TGM2 Gene

Aliases for TGM2 Gene

  • Transglutaminase 2 2 3
  • Protein-Glutamine-Gamma-Glutamyltransferase 2 3
  • Tissue Transglutaminase 3 4
  • Transglutaminase C 3 4
  • Transglutaminase H 3 4
  • Transglutaminase-2 3 4
  • EC 2.3.2.13 4 64
  • TGase C 3 4
  • TGase H 3 4
  • TGase-2 3 4
  • TG(C) 3 4
  • TGC 3 4
  • Transglutaminase 2 (C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase) 2
  • C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase 3
  • Protein-Glutamine Gamma-Glutamyltransferase 2 3
  • Epididymis Secretory Protein Li 45 3
  • C Polypeptide 2
  • G-ALPHA-H 3
  • HEL-S-45 3
  • TGase-H 3
  • GNAH 3
  • TG2 3

External Ids for TGM2 Gene

Summaries for TGM2 Gene

Entrez Gene Summary for TGM2 Gene

  • Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TGM2 Gene

TGM2 (Transglutaminase 2) is a Protein Coding gene. Diseases associated with TGM2 include focal myositis and celiac disease. Among its related pathways are CREB Pathway and Phospholipase-C Pathway. GO annotations related to this gene include GTP binding and protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is F13A1.

UniProtKB/Swiss-Prot for TGM2 Gene

  • Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins

Gene Wiki entry for TGM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGM2 Gene

Genomics for TGM2 Gene

Genomic Location for TGM2 Gene

Start:
38,127,387 bp from pter
End:
38,166,578 bp from pter
Size:
39,192 bases
Orientation:
Minus strand

Genomic View for TGM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGM2 Gene

Regulatory Elements for TGM2 Gene

Proteins for TGM2 Gene

  • Protein details for TGM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21980-TGM2_HUMAN
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 2
    Protein Accession:
    P21980
    Secondary Accessions:
    • E1P5V9
    • Q16436
    • Q6B838
    • Q9BTN7
    • Q9UH35

    Protein attributes for TGM2 Gene

    Size:
    687 amino acids
    Molecular mass:
    77329 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for TGM2 Gene

    Alternative splice isoforms for TGM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGM2 Gene

Proteomics data for TGM2 Gene at MOPED

Post-translational modifications for TGM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGM2 Gene

Domains for TGM2 Gene

Gene Families for TGM2 Gene

HGNC:
  • TGM :Transglutaminases

UniProtKB/Swiss-Prot:

TGM2_HUMAN
Family:
  • Belongs to the transglutaminase superfamily. Transglutaminase family.:
    • P21980
genes like me logo Genes that share domains with TGM2: view

Function for TGM2 Gene

Molecular function for TGM2 Gene

GENATLAS Biochemistry: transglutaminase,C polypeptide,tissue,type II (80kDa),cytoplasmic,ubiquitous,interacting with huntingtin
UniProtKB/Swiss-Prot CatalyticActivity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
UniProtKB/Swiss-Prot Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins
UniProtKB/Swiss-Prot Induction: By retinoic acid

Enzyme Numbers (IUBMB) for TGM2 Gene

Gene Ontology (GO) - Molecular Function for TGM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003810 protein-glutamine gamma-glutamyltransferase activity ISS --
GO:0005515 protein binding IPI 16301118
GO:0005525 GTP binding IEA --
GO:0019904 protein domain specific binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TGM2: view
genes like me logo Genes that share phenotypes with TGM2: view

Animal Models for TGM2 Gene

MGI Knock Outs for TGM2:

No data available for Transcription Factor Targeting and HOMER Transcription for TGM2 Gene

Localization for TGM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGM2 Gene COMPARTMENTS Subcellular localization image for TGM2 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 3
cytoskeleton 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TGM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IDA 24349085
GO:0005829 cytosol IDA 24349085
GO:0005886 plasma membrane --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with TGM2: view

Pathways for TGM2 Gene

genes like me logo Genes that share pathways with TGM2: view

Pathways by source for TGM2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for TGM2 Gene
1 Cell Signaling Technology pathway for TGM2 Gene
1 BioSystems pathway for TGM2 Gene
1 KEGG pathway for TGM2 Gene

Gene Ontology (GO) - Biological Process for TGM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway --
GO:0018149 peptide cross-linking --
GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine IEA --
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IMP 24349085
genes like me logo Genes that share ontologies with TGM2: view

Compounds for TGM2 Gene

(3) HMDB Compounds for TGM2 Gene

Compound Synonyms Cas Number PubMed IDs
Ammonia
  • NH3
7664-41-7
Calcium
  • Ca
7440-70-2
L-Glutamine
  • (2S)-2,5-diamino-5-oxopentanoic acid
56-85-9

(2) Drugbank Compounds for TGM2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target
L-Glutamine
  • (S)-2,5-diamino-5-oxopentanoic acid
56-85-9 enzyme substrate

(32) Novoseek inferred chemical compound relationships for TGM2 Gene

Compound -log(P) Hits PubMed IDs
tgm 2 93.2 66
gliadin 87.4 37
gluten 86.5 39
epsilon-(gamma-glutamyl)lysine 83.9 4
cystamine 82.2 16
genes like me logo Genes that share compounds with TGM2: view

Transcripts for TGM2 Gene

Unigene Clusters for TGM2 Gene

Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGM2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - -
SP14: - -
SP15: - -
SP16: - - - - - -
SP17:
SP18:
SP19: - -

ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for TGM2 Gene

GeneLoc Exon Structure for
TGM2
ECgene alternative splicing isoforms for
TGM2

Expression for TGM2 Gene

mRNA expression in normal human tissues for TGM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGM2 Gene

This gene is overexpressed in Artery - Coronary (8.6) and Artery - Tibial (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGM2 Gene

SOURCE GeneReport for Unigene cluster for TGM2 Gene Hs.517033

genes like me logo Genes that share expressions with TGM2: view

Orthologs for TGM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TGM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGM2 36
  • 98.25 (n)
  • 98.25 (a)
TGM2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TGM2 36
  • 87.97 (n)
  • 88.36 (a)
TGM2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TGM2 36
  • 86.51 (n)
  • 84.57 (a)
TGM2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgm2 36
  • 83.04 (n)
  • 84.26 (a)
Tgm2 16
Tgm2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TGM2 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGM2 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgm2 36
  • 83.28 (n)
  • 83.24 (a)
chicken
(Gallus gallus)
Aves TGM2 36
  • 69.39 (n)
  • 64.82 (a)
TGM2 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 61 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia tgm2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tgm2 36
  • 64.43 (n)
  • 62.04 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8978 36
zebrafish
(Danio rerio)
Actinopterygii Dr.16524 36
tgm2a 37
  • 48 (a)
OneToMany
tgm2b 36
  • 60.31 (n)
  • 55.41 (a)
tgm2b 37
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tg 37
  • 29 (a)
OneToMany
CG7356 38
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2702 36
Species with no ortholog for TGM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGM2 Gene

ENSEMBL:
Gene Tree for TGM2 (if available)
TreeFam:
Gene Tree for TGM2 (if available)

Paralogs for TGM2 Gene

Paralogs for TGM2 Gene

Selected SIMAP similar genes for TGM2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TGM2: view

Variants for TGM2 Gene

Sequence variations from dbSNP and Humsavar for TGM2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs11387 -- 38,128,697(+) GCCCT(A/G)GAGGC utr-variant-3-prime
rs1044857 -- 38,128,514(-) TGCTT(C/T)TGAAC utr-variant-3-prime
rs1044932 -- 38,128,494(-) CAAAC(A/C)CTGAA utr-variant-3-prime
rs1062735 -- 38,161,459(-) ACTAC(C/G)AGGCC missense, reference
rs1062736 -- 38,130,136(-) CCCTT(A/C)TTGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TGM2 Gene

Variant ID Type Subtype PubMed ID
nsv833972 CNV Loss 17160897
esv29167 CNV Gain 19812545

Relevant External Links for TGM2 Gene

HapMap Linkage Disequilibrium report
TGM2
Human Gene Mutation Database (HGMD)
TGM2

Disorders for TGM2 Gene

(3) University of Copenhagen DISEASES for TGM2 Gene

(48) Novoseek inferred disease relationships for TGM2 Gene

Disease -log(P) Hits PubMed IDs
celiac disease 88.6 55
dermatitis herpetiformis 65.1 3
carcinoma pancreatic ductal 62.7 1
huntington disease 57.3 7
neurodegenerative diseases 48.8 12

Relevant External Links for TGM2

Genetic Association Database (GAD)
TGM2
Human Genome Epidemiology (HuGE) Navigator
TGM2
genes like me logo Genes that share disorders with TGM2: view

No data available for UniProtKB/Swiss-Prot for TGM2 Gene

Publications for TGM2 Gene

  1. Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. (PMID: 17939176) Porzio O. … Barbetti F. (Hum. Mutat. 2007) 3 4 23 49
  2. Transglutaminase 2 undergoes a large conformational change upon activation. (PMID: 18092889) Pinkas D.M. … Khosla C. (PLoS Biol. 2007) 3 4 23
  3. The TGM2 gene is associated with schizophrenia in a British population. (PMID: 18561261) Bradford M. … Wei J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23 49
  4. A third human tissue transglutaminase homologue as a result of alternative gene transcripts. (PMID: 8611626) Fraij B.M. … Gonzales R.A. (Biochim. Biophys. Acta 1996) 3 4 23
  5. Germline mutations in TGM2 do not contribute to coeliac disease susceptibility in the Swedish population. (PMID: 11742196) Popat S. … Houlston R.S. (Eur J Gastroenterol Hepatol 2001) 3 23 49

Products for TGM2 Gene

Sources for TGM2 Gene

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