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Aliases for TGM2 Gene

Aliases for TGM2 Gene

  • Transglutaminase 2 2 3 5
  • Tissue Transglutaminase 3 4
  • Transglutaminase C 3 4
  • Transglutaminase H 3 4
  • Transglutaminase-2 3 4
  • EC 2.3.2.13 4 63
  • TGase C 3 4
  • TGase H 3 4
  • TGase-2 3 4
  • TG(C) 3 4
  • TGC 3 4
  • Transglutaminase 2 (C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase) 2
  • C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase 3
  • Protein-Glutamine-Gamma-Glutamyltransferase 2
  • C Polypeptide 2

External Ids for TGM2 Gene

Previous GeneCards Identifiers for TGM2 Gene

  • GC20M036486
  • GC20M037395
  • GC20M037442
  • GC20M036190
  • GC20M036756
  • GC20M033493

Summaries for TGM2 Gene

Entrez Gene Summary for TGM2 Gene

  • Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TGM2 Gene

TGM2 (Transglutaminase 2) is a Protein Coding gene. Diseases associated with TGM2 include Celiac Disease and Autoimmune Disease Of Gastrointestinal Tract. Among its related pathways are Ca, cAMP and Lipid Signaling and Phospholipase-C Pathway. GO annotations related to this gene include GTP binding and protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is F13A1.

UniProtKB/Swiss-Prot for TGM2 Gene

  • Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Gene Wiki entry for TGM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGM2 Gene

Genomics for TGM2 Gene

Regulatory Elements for TGM2 Gene

Enhancers for TGM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TGM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TGM2 Gene

Chromosome:
20
Start:
38,127,387 bp from pter
End:
38,166,578 bp from pter
Size:
39,192 bases
Orientation:
Minus strand

Genomic View for TGM2 Gene

Genes around TGM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGM2 Gene

Proteins for TGM2 Gene

  • Protein details for TGM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21980-TGM2_HUMAN
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 2
    Protein Accession:
    P21980
    Secondary Accessions:
    • E1P5V9
    • Q16436
    • Q6B838
    • Q9BTN7
    • Q9UH35

    Protein attributes for TGM2 Gene

    Size:
    687 amino acids
    Molecular mass:
    77329 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for TGM2 Gene

    Alternative splice isoforms for TGM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGM2 Gene

Proteomics data for TGM2 Gene at MOPED

Post-translational modifications for TGM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGM2 Gene

Antibody Products

  • R&D Systems Antibodies for TGM2 (Transglutaminase 2/TGM2)
  • Cell Signaling Technology (CST) Antibodies for TGM2 (TGM2)

Domains & Families for TGM2 Gene

Gene Families for TGM2 Gene

Graphical View of Domain Structure for InterPro Entry

P21980

UniProtKB/Swiss-Prot:

TGM2_HUMAN :
  • Belongs to the transglutaminase superfamily. Transglutaminase family.
Family:
  • Belongs to the transglutaminase superfamily. Transglutaminase family.
genes like me logo Genes that share domains with TGM2: view

Function for TGM2 Gene

Molecular function for TGM2 Gene

GENATLAS Biochemistry:
transglutaminase,C polypeptide,tissue,type II (80kDa),cytoplasmic,ubiquitous,interacting with huntingtin
UniProtKB/Swiss-Prot CatalyticActivity:
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
UniProtKB/Swiss-Prot Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Enzyme Numbers (IUBMB) for TGM2 Gene

genes like me logo Genes that share phenotypes with TGM2: view

Animal Models for TGM2 Gene

MGI Knock Outs for TGM2:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TGM2 Gene

Localization for TGM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGM2 Gene COMPARTMENTS Subcellular localization image for TGM2 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
plasma membrane 5
endoplasmic reticulum 4
nucleus 3
cytoskeleton 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TGM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0031226 intrinsic component of plasma membrane IMP 8105889
genes like me logo Genes that share ontologies with TGM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TGM2 Gene

Pathways & Interactions for TGM2 Gene

genes like me logo Genes that share pathways with TGM2: view

Pathways by source for TGM2 Gene

1 GeneTex pathway for TGM2 Gene
1 Cell Signaling Technology pathway for TGM2 Gene
1 BioSystems pathway for TGM2 Gene
1 KEGG pathway for TGM2 Gene
1 GeneGo (Thomson Reuters) pathway for TGM2 Gene

SIGNOR curated interactions for TGM2 Gene

Activates:

Gene Ontology (GO) - Biological Process for TGM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018149 peptide cross-linking IEA --
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IEA,IMP 24349085
GO:0060445 branching involved in salivary gland morphogenesis IEA --
genes like me logo Genes that share ontologies with TGM2: view

Drugs & Compounds for TGM2 Gene

(14) Drugs for TGM2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Guanosine diphosphate Experimental Pharma Target 0
calcium Nutra 0

(21) Additional Compounds for TGM2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with TGM2: view

Transcripts for TGM2 Gene

Unigene Clusters for TGM2 Gene

Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGM2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - -
SP14: - -
SP15: - -
SP16: - - - - - -
SP17:
SP18:
SP19: - -

ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for TGM2 Gene

GeneLoc Exon Structure for
TGM2
ECgene alternative splicing isoforms for
TGM2

Expression for TGM2 Gene

mRNA expression in normal human tissues for TGM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGM2 Gene

This gene is overexpressed in Artery - Coronary (x8.6) and Artery - Tibial (x6.7).

Protein differential expression in normal tissues from HIPED for TGM2 Gene

This gene is overexpressed in Urinary Bladder (9.5), Gallbladder (9.1), and Placenta (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGM2 Gene



SOURCE GeneReport for Unigene cluster for TGM2 Gene Hs.517033

genes like me logo Genes that share expression patterns with TGM2: view

Protein tissue co-expression partners for TGM2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TGM2 Gene

Orthologs for TGM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TGM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TGM2 35
  • 87.97 (n)
  • 88.36 (a)
TGM2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TGM2 35
  • 86.51 (n)
  • 84.57 (a)
TGM2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgm2 35
  • 83.04 (n)
  • 84.26 (a)
Tgm2 16
Tgm2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TGM2 35
  • 98.25 (n)
  • 98.25 (a)
TGM2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgm2 35
  • 83.28 (n)
  • 83.24 (a)
oppossum
(Monodelphis domestica)
Mammalia TGM2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGM2 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves TGM2 35
  • 69.39 (n)
  • 64.82 (a)
TGM2 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tgm2 35
  • 64.43 (n)
  • 62.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia tgm2-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16524 35
tgm2b 35
  • 60.31 (n)
  • 55.41 (a)
tgm2a 36
  • 48 (a)
OneToMany
tgm2b 36
  • 53 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8978 35
fruit fly
(Drosophila melanogaster)
Insecta CG7356 37
  • 34 (a)
Tg 36
  • 29 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2702 35
Species with no ortholog for TGM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGM2 Gene

ENSEMBL:
Gene Tree for TGM2 (if available)
TreeFam:
Gene Tree for TGM2 (if available)

Paralogs for TGM2 Gene

Paralogs for TGM2 Gene

(10) SIMAP similar genes for TGM2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TGM2: view

Variants for TGM2 Gene

Sequence variations from dbSNP and Humsavar for TGM2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036554 A colorectal cancer sample
VAR_037998 -
VAR_037999 -
rs41274720 - 38,156,053(+) GAAAA(C/T)GGGCC reference, missense
rs45556333 - 38,138,122(-) TGGAG(C/T)CTTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TGM2 Gene

Variant ID Type Subtype PubMed ID
nsv833972 CNV Loss 17160897
esv29167 CNV Gain 19812545

Variation tolerance for TGM2 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGM2 Gene

Human Gene Mutation Database (HGMD)
TGM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGM2 Gene

Disorders for TGM2 Gene

MalaCards: The human disease database

(20) MalaCards diseases for TGM2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
celiac disease
  • celiac sprue
autoimmune disease of gastrointestinal tract
dermatitis herpetiformis
  • dermatitis herpetiformis [dup]
spinocerebellar ataxia 35
  • spinocerebellar ataxia type 35
nephrogenic systemic fibrosis
  • nephrogenic fibrosing dermopathy
- elite association - COSMIC cancer census association via MalaCards
Search TGM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TGM2

Genetic Association Database (GAD)
TGM2
Human Genome Epidemiology (HuGE) Navigator
TGM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TGM2
genes like me logo Genes that share disorders with TGM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TGM2 Gene

Publications for TGM2 Gene

  1. Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. (PMID: 17939176) Porzio O. … Barbetti F. (Hum. Mutat. 2007) 3 4 23 48 67
  2. Transglutaminase 2 mediates polymer formation of I-kappaBalpha through C-terminal glutamine cluster. (PMID: 16987813) Park S.S. … Kim S.Y. (J. Biol. Chem. 2006) 23 25 26
  3. Phage display selection of efficient glutamine-donor substrate peptides for transglutaminase 2. (PMID: 17075129) Keresztessy Z. … FAcsA1s L. (Protein Sci. 2006) 23 25 26
  4. Transglutaminase 2 expression levels regulate sensitivity to cystamine plus TRAIL-mediated apoptosis. (PMID: 19632032) Jang J.H. … Kwon T.K. (Cancer Lett. 2010) 3 23
  5. Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression. (PMID: 19937343) Gupta R. … Suri V. (Virchows Arch. 2010) 3 23

Products for TGM2 Gene

Sources for TGM2 Gene

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