Aliases for TGFB3 Gene
Aliases for TGFB3 Gene
External Ids for TGFB3 Gene
- HGNC: 11769
- Entrez Gene: 7043
- Ensembl: ENSG00000119699
- OMIM: 190230
- UniProtKB: P10600
Previous HGNC Symbols for TGFB3 Gene
- ARVD1
- ARVD
Previous GeneCards Identifiers for TGFB3 Gene
- GC14M073930
- GC14M070241
- GC14M074414
- GC14M075494
- GC14M076424
- GC14M056593
Summaries for TGFB3 Gene
-
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]
GeneCards Summary for TGFB3 Gene
TGFB3 (Transforming Growth Factor Beta 3) is a Protein Coding gene. Diseases associated with TGFB3 include Loeys-Dietz Syndrome 5 and Arrhythmogenic Right Ventricular Dysplasia, Familial, 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and cytokine activity. An important paralog of this gene is TGFB2.
UniProtKB/Swiss-Prot for TGFB3 Gene
-
Involved in embryogenesis and cell differentiation.
Additional gene information for TGFB3 Gene
- Monarch Initiative
- Search for TGFB3 at DataMed
- Search for TGFB3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGFB3 Gene
Genomics for TGFB3 Gene
GeneHancer (GH) Regulatory Elements for TGFB3 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH14I075979 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 557.2 | +1.6 | 1603 | 4.1 | HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B | TGFB3 IFT43 TGFB3-AS1 | |
GH14I075983 | Enhancer | 0.3 | dbSUPER | 550.8 | -1.0 | -1004 | 0.9 | NONO | TGFB3 RPL22P2 NEK9 LOC100506576 IFT43 | |
GH14I075904 | Enhancer | 0.9 | Ensembl ENCODE | 16.6 | +77.2 | 77213 | 1.7 | CTCF NFIB FEZF1 OSR2 ZNF664 ZNF707 NFIC PRDM6 ZNF316 SKIL | TGFB3 LOC102724153 IFT43 TGFB3-AS1 TTLL5 | |
GH14I075906 | Enhancer | 0.6 | ENCODE | 11.7 | +76.1 | 76118 | 0.2 | CTCF ZNF654 RXRA TRIM22 REST PPARG RAD21 SMC3 ZNF143 RXRB | TGFB3 IFT43 TGFB3-AS1 TTLL5 | |
GH14I075977 | Enhancer | 0.8 | ENCODE dbSUPER | 6 | +4.9 | 4900 | 0.4 | MAX CEBPG EP300 RFX5 GATA3 JUND ATF3 HNF4A ZBTB33 RCOR1 | IFT43 TGFB3 TGFB3-AS1 |
Regulatory Element Products
Genomic Locations for TGFB3 Gene
- chr14:75,958,097-75,982,991
- (GRCh38/hg38)
- Size:
- 24,895 bases
- Orientation:
- Minus strand
- chr14:76,424,442-76,449,334
- (GRCh37/hg19)
Genomic View for TGFB3 Gene
- Cytogenetic band:
-
- 14q24.3 by Ensembl
- 14q24.3 by Entrez Gene
- 14q24 by HGNC


RefSeq DNA sequence for TGFB3 Gene
Proteins for TGFB3 Gene
-
Protein details for TGFB3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10600-TGFB3_HUMAN
- Recommended name:
- Transforming growth factor beta-3
- Protein Accession:
- P10600
- Q8WV88
Protein attributes for TGFB3 Gene
- Size:
- 412 amino acids
- Molecular mass:
- 47328 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Interacts with ASPN.
- SequenceCaution:
-
- Sequence=CAA33024.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for TGFB3 Gene
Post-translational modifications for TGFB3 Gene
- The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive.
- Glycosylation at posLast=7474, posLast=135135, and isoforms=2142
Other Protein References for TGFB3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TGFB3 (TGF-beta 3)
- Cell Signaling Technology (CST) Antibodies for TGFB3 (TGFB3)
-
Custom Antibody ServicesOriGene Antibodies for TGFB3
- Novus Biologicals Antibodies for TGFB3
-
Abcam antibodies for TGFB3
-
Cloud-Clone Corp. Antibodies for TGFB3
- Invitrogen Antibodies for TGFB3
- antibodies-online: Search results for 92 available TGFB3 Antibodies ranked by validation data
- Compare Top TGFB3 Antibodies
-
Recommended
- 2 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 38 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 36 WB Antibodies (anti-mouse)
- 1 IF Antibody (anti-human)
- 2 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 70 WB Antibodies (anti-human)
- GeneTex TGFB3 antibody for TGFB3
-
Santa Cruz Biotechnology (SCBT) Antibodies for TGFB3
Protein Products
- R&D Systems Proteins and Enzymes for TGFB3 (TGF-beta 3)
- Search Origene for MassSpec and Protein Over-expression Lysates for TGFB3
- Origene Custom Protein Services for TGFB3
- ProSpec Recombinant Proteins for TGFB3
-
Cloud-Clone Corp. Proteins for TGFB3
- GeneTex Proteins for TGFB3
-
Abcam proteins for TGFB3
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for TGFB3
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for TGFB3 (TGF-beta 3)
- antibodies-online: Search results for 99 available TGFB3 Elisa Kits ranked by validation data
- Compare Top TGFB3 Elisa Kits
-
Recommended
- 3 Wild boar (Sus scrofa) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 20 Rat (Rattus) ELISA Kits
- 3 Rabbit ELISA Kits
- 10 Pig (Porcine) ELISA Kits
- 22 Mouse (Murine) ELISA Kits
- 4 Monkey ELISA Kits
- 24 Human ELISA Kits
- 4 Horse (Equine) ELISA Kits
- 3 Guinea Pig ELISA Kits
- 1 Goat ELISA Kit
- 4 Dog (Canine) ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 5 Chicken ELISA Kits
No data available for DME Specific Peptides for TGFB3 Gene
Domains & Families for TGFB3 Gene
Gene Families for TGFB3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted secreted proteins
Protein Domains for TGFB3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TGFB3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P10600- Family:
-
- Belongs to the TGF-beta family.
Function for TGFB3 Gene
Molecular function for TGFB3 Gene
- GENATLAS Biochemistry:
- transforming growth factor,beta 3,152.6kDa,homodimerizing,expressed by fibroblast,platelet,monocyte,chondrocyte,osteoblasts,including the latency associated peptide (LAP),involved in the pathogenesis of cleft lip and palate
- UniProtKB/Swiss-Prot Function:
- Involved in embryogenesis and cell differentiation.
LifeMap Function Summary for TGFB3 Gene
- Brain
- Cartilage
- Cartilage
-
Cartilage
- Articular chondrocyte-like cells
- Cartilage Constructs
- Chondrocyte pellets
- Chondrocyte-like cells
- Chondrocyte-like cells
- Hypertrophic chondrocytes like cells
- HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
- HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
- HyStem+TGFbeta3+GDF5-induced E15 cells
- HyStem+TGFbeta3+GDF5-induced MEL2 cells
- HyStem+TGFbeta3+GDF5-induced SK11 cells
- HyStem+TGFbeta3+GDF5-induced SM30 cells
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Pelleted mesenchymal stem cells
- Scaffold-embedded chondrocyte-like cells
- TGFbeta3- and IGF1-induced embryoid bodies
- TGFbeta3+BMP7-induced chondrocytes
- TGFbeta3+BMP7-induced chondrocytes
- Brain
- Neurons
-
Bone
- Articular chondrocyte-like cells
- Chondrocyte-like cells
- Hypertrophic chondrocytes like cells
- HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
- HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
- HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
- HyStem+TGFbeta3+GDF5-induced E15 cells
- HyStem+TGFbeta3+GDF5-induced MEL2 cells
- HyStem+TGFbeta3+GDF5-induced SK11 cells
- HyStem+TGFbeta3+GDF5-induced SM30 cells
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Micromass-induced chondrocytes
- Pelleted mesenchymal stem cells
- TGFbeta3+BMP7-induced chondrocytes
- TGFbeta3+BMP7-induced chondrocytes
- Neural Tube
-
and also in
- Articular chondrocyte-like cells
- Cartilage Constructs
- Cartilaginous aggregates
- Chondrocyte pellets
- Chondrocyte-like cells
- Chondrocyte-like cells
- Dorsal forebrain-like precursor cells
- Engineered articular cartilage
- HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
- Midbrain dopaminergic-like precursor cells
- Midbrain neural progenitor-like cells
- Scaffold-embedded chondrocyte-like cells
- Specified dopaminergic neuron precursors cells
- TGFbeta3- and IGF1-induced embryoid bodies
- TGFbeta3-induced embryoid bodies
- Ventral/hypothalamic-like precursor cells
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005114 | type II transforming growth factor beta receptor binding | IPI | 1333888 |
GO:0005125 | cytokine activity | IBA | -- |
GO:0005160 | transforming growth factor beta receptor binding | IEA | -- |
GO:0005515 | protein binding | IPI | 1326540 |
GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for TGFB3 Gene
- MGI mutant phenotypes for TGFB3:
-
inferred from 7 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- vision/eye phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for TGFB3:
Animal Models for TGFB3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TGFB3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TGFB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TGFB3 gene
- Search ViGene Biosciences for TGFB3
CRISPR Products
-
OriGene CRISPR knockouts for TGFB3
- genomics-online: gRNA clones - Search results for 140 available TGFB3 gene related products
- Overview of 140 available TGFB3 gene related products
- Applied Biological Materials CRISPR for TGFB3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGFB3
- GenScript: Design CRISPR guide RNA sequences for TGFB3
miRNA for TGFB3 Gene
- miRTarBase miRNAs that target TGFB3
miRNA Products
- Search ViGene Biosciences for TGFB3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TGFB3
- Browse OriGene Inhibitory RNA Products For TGFB3
- genomics-online: shRNA clones - Search results for 140 available TGFB3 gene related products
- Overview of 140 available TGFB3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TGFB3 gene
Clone Products
- Sino Biological Human cDNA Clone for TGFB3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TGFB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TGFB3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TGFB3
- Applied Biological Materials Clones for TGFB3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor and PureStem SK11, NCr-fac & Meso-prx Progenitor for TGFB3
-
Horizon Cell Lines for TGFB3
-
ViGene Biosciences adenoviral particle packaged cDNA for TGFB3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TGFB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TGFB3 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for TGFB3 Gene
Localization for TGFB3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TGFB3 Gene
- Secreted.
- Vesicles (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | IC | 11157754 |
Pathways & Interactions for TGFB3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
2 | PEDF Induced Signaling |
.61
.47
|
|
3 | GPCR Pathway |
.73
.62
|
.55
|
4 | ERK Signaling |
.61
.58
|
.49
|
5 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
Pathways by source for TGFB3 Gene
1 Sino Biological pathway for TGFB3 Gene
2 Cell Signaling Technology pathways for TGFB3 Gene
8 BioSystems pathways for TGFB3 Gene
8 Reactome pathways for TGFB3 Gene
27 KEGG pathways for TGFB3 Gene
2 R&D Systems pathways for TGFB3 Gene
Interacting Proteins for TGFB3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000187 | activation of MAPK activity | IEA | -- |
GO:0001666 | response to hypoxia | IDA | 18156205 |
GO:0001701 | in utero embryonic development | ISS | -- |
GO:0002576 | platelet degranulation | TAS | -- |
GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 11157754 |
Drugs & Compounds for TGFB3 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
(1) ApexBio Compounds for TGFB3 Gene
Compound | Action | Cas Number |
---|---|---|
ITD 1 | The first selective TGFβ inhibitor | 1099644-42-4 |
Transcripts for TGFB3 Gene
mRNA/cDNA for TGFB3 Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (115) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TGFB3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TGFB3
- genomics-online: gRNA clones - Search results for 140 available TGFB3 gene related products
- Overview of 140 available TGFB3 gene related products
- Applied Biological Materials CRISPR for TGFB3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TGFB3
- GenScript: Design CRISPR guide RNA sequences for TGFB3
miRNA Products
- Search ViGene Biosciences for TGFB3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TGFB3
- Browse OriGene Inhibitory RNA Products For TGFB3
- genomics-online: shRNA clones - Search results for 140 available TGFB3 gene related products
- Overview of 140 available TGFB3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TGFB3 gene
Clone Products
- Sino Biological Human cDNA Clone for TGFB3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TGFB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TGFB3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TGFB3
- Applied Biological Materials Clones for TGFB3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TGFB3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Endochondral Preosteoblasts Stylopod Perichondrium
- Endochondral Preosteoblasts Zeugopod Perichondrium
- Endochondral Preosteoblasts Rib
- Endochondral Preosteoblasts Vertebrae
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Acinar Progenitor Cells Dorsal Pancreatic Bud
- Pancreatic Progenitor Cells Ventral Pancreatic Bud
- Mature Choroid Plexus Cells Choroid Plexus
- Pancreatic Progenitor Cells Dorsal Pancreatic Bud
-
Cartilage (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Annulus Fibrosus
- Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
- Hypertrophic Chondrocytes Rib
- HyStem+BMP4-induced SK11 cells
-
Pancreas (Endocrine System)
- Acinar Progenitor Cells Dorsal Pancreatic Bud
- Pancreatic Progenitor Cells Ventral Pancreatic Bud
- Pancreatic Progenitor Cells Dorsal Pancreatic Bud
- Acinar Progenitor Cells Ventral Pancreatic Bud
- Acinar Cells Pancreatic Acini
-
Tendon & Ligament (Muscoskeletal System)
- Tenocytes Limb Tendons and Ligaments
- Early Tenocyte Cells Axial Tendon Primordia
- Tenocytes Axial Tendons and Ligamnets
- Early Tenocyte Cells Limb Tendon Primordia
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Odontoblasts Dentin
- Stellate Reticulum Cells Dental Core
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Choroid Plexus Progenitor Cells Choroid Plexus
- Fibroblasts (Uncategorized)
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
-
Heart (Cardiovascular System)
- Endocardial Cells Endocardium
- Neural Tube (Nervous System)
- Esophagus
- Dermis (Integumentary System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
NURSA nuclear receptor signaling pathways regulating expression of TGFB3 Gene:
TGFB3SOURCE GeneReport for Unigene cluster for TGFB3 Gene:
Hs.592317Evidence on tissue expression from TISSUES for TGFB3 Gene
- Muscle(2.9)
- Heart(2.6)
- Lung(2.5)
- Skin(2.3)
- Nervous system(2.3)
- Bone marrow(2.2)
- Bone(2.1)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TGFB3 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- brain
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- head
- jaw
- mandible
- maxilla
- mouth
- pharynx
- skull
- chest wall
- diaphragm
- esophagus
- heart
- heart valve
- lung
- rib
- rib cage
- sternum
- abdominal wall
- intestine
- stomach
- pelvis
- ankle
- arm
- digit
- elbow
- femur
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- thigh
- toe
- upper limb
- wrist
- blood
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for TGFB3
-
OriGene qPCR primer pairs and template standards for TGFB3
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TGFB3 Gene
Orthologs for TGFB3 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TGFB3 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | TGFB3 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | TGFB3 33 |
|
||
TGFBETA3 34 |
|
OneToOne | |||
rat (Rattus norvegicus) |
Mammalia | Tgfb3 33 |
|
||
mouse (Mus musculus) |
Mammalia | Tgfb3 33 16 34 |
|
||
cow (Bos Taurus) |
Mammalia | TGFB3 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | TGFB3 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TGFB3 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | TGFB3 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | tgfb3 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | daw 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for TGFB3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TGFB3 Gene
Paralogs for TGFB3 Gene
(8) SIMAP similar genes for TGFB3 Gene using alignment to 7 proteins:
Variants for TGFB3 Gene
SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10129478 | likely-benign, Cardiomyopathy, ARVC | 75,958,491(-) | A/G | 3_prime_UTR_variant | |
rs1060502826 | pathogenic, Loeys-Dietz syndrome 4 | 75,963,358(-) | CCCCCC/CCCC | coding_sequence_variant, frameshift | |
rs1060502827 | pathogenic, likely-pathogenic, Loeys-Dietz syndrome 4, not provided | 75,960,969(-) | G/A/C | coding_sequence_variant, missense_variant, stop_gained | |
rs1060502828 | uncertain-significance, Loeys-Dietz syndrome 4 | 75,959,296(-) | C/T | coding_sequence_variant, missense_variant | |
rs1060504730 | likely-benign, Loeys-Dietz syndrome 4 | 75,980,549(-) | C/T | coding_sequence_variant, synonymous_variant |
Additional Variant Information for TGFB3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGFB3 Gene
Disorders for TGFB3 Gene

(41) MalaCards diseases for TGFB3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
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loeys-dietz syndrome 5 |
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arrhythmogenic right ventricular dysplasia, familial, 1 |
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loeys-dietz syndrome 4 |
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familial isolated arrhythmogenic ventricular dysplasia, right dominant form |
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familial isolated arrhythmogenic ventricular dysplasia, biventricular form |
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UniProtKB/Swiss-Prot
TGFB3_HUMAN- Arrhythmogenic right ventricular dysplasia, familial, 1 (ARVD1) [MIM:107970]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. {ECO:0000269 PubMed:15639475}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Loeys-Dietz syndrome 5 (LDS5) [MIM:615582]: A form of Loeys-Dietz syndrome, a syndrome with widespread systemic involvement characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. LDS5 additional variable features include mitral valve disease, skeletal overgrowth, cervical spine instability, and clubfoot deformity. LDS5 patients do not manifest remarkable aortic or arterial tortuosity, and there is no strong evidence for early aortic dissection. {ECO:0000269 PubMed:23824657}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TGFB3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for TGFB3 Gene
Publications for TGFB3 Gene
- Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1. (PMID: 15639475) Beffagna G … Rampazzo A (Cardiovascular research 2005) 2 3 4 22 58
- Maternal and fetal variants in the TGF-beta3 gene and risk of pregnancy-induced hypertension in a predominantly Latino population. (PMID: 19628198) Wilson ML … Ingles SA (American journal of obstetrics and gynecology 2009) 3 22 44 58
- [No association between 3 polymorphisms of transforming growth factor beta3 gene and essential hypertension in Chinese]. (PMID: 15924806) Hu BC … Zhu DL (Zhonghua xin xue guan bing za zhi 2005) 3 22 44 58
- Genetic susceptibility to keloid disease: mutation screening of the TGFbeta3 gene. (PMID: 16043141) Bayat A … Ferguson MW (British journal of plastic surgery 2005) 3 22 44 58
- Transforming growth factor-beta3 gene SfaN1 polymorphism in Korean nonsyndromic cleft lip and palate patients. (PMID: 14659070) Kim MH … Nahm DS (Journal of biochemistry and molecular biology 2003) 3 22 44 58
Products for TGFB3 Gene
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- Mammalian expression: PiggyBac
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Sources for TGFB3 Gene
- (1) GeneCards
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- (3) EntrezGene
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- (47) Atlas
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- (54) Leiden
- (55) miRBase
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- (65) Sino Biological
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- (68) Cloud-Clone Corp.
- (69) OCA
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- (74) GeneGo (Thomson Reuters)
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