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Aliases for TGFB2 Gene

Aliases for TGFB2 Gene

  • Transforming Growth Factor, Beta 2 2 3
  • Glioblastoma-Derived T-Cell Suppressor Factor 3 4
  • Prepro-Transforming Growth Factor Beta-2 2 3
  • BSC-1 Cell Growth Inhibitor 3 4
  • Polyergin 3 4
  • Cetermin 3 4
  • G-TSF 3 4
  • LDS4 3 6
  • Transforming Growth Factor Beta-2 3
  • TGF-Beta-2 4
  • TGF-Beta2 3

External Ids for TGFB2 Gene

Summaries for TGFB2 Gene

Entrez Gene Summary for TGFB2 Gene

  • This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

GeneCards Summary for TGFB2 Gene

TGFB2 (Transforming Growth Factor, Beta 2) is a Protein Coding gene. Diseases associated with TGFB2 include loeys-dietz syndrome, type 4 and tgfb2-related loeys-dietz syndrome. Among its related pathways are MAPK signaling pathway and Proteoglycans in cancer. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is INHBB.

UniProtKB/Swiss-Prot for TGFB2 Gene

  • TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth

Gene Wiki entry for TGFB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGFB2 Gene

Genomics for TGFB2 Gene

Genomic Location for TGFB2 Gene

Start:
218,345,334 bp from pter
End:
218,444,619 bp from pter
Size:
99,286 bases
Orientation:
Plus strand

Genomic View for TGFB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGFB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGFB2 Gene

Regulatory Elements for TGFB2 Gene

Proteins for TGFB2 Gene

  • Protein details for TGFB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61812-TGFB2_HUMAN
    Recommended name:
    Transforming growth factor beta-2
    Protein Accession:
    P61812
    Secondary Accessions:
    • B4DKC5
    • P08112
    • Q15579
    • Q15581
    • Q4VAV9

    Protein attributes for TGFB2 Gene

    Size:
    414 amino acids
    Molecular mass:
    47748 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (By similarity). Heterodimers with TGFB1 and with TGFB3 have been found in bone (By similarity). Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity). Latency-associated peptide interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (By similarity). Interacts with ASPN. Interacts with MFAP5 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TGFB2 Gene

    Alternative splice isoforms for TGFB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGFB2 Gene

Proteomics data for TGFB2 Gene at MOPED

Post-translational modifications for TGFB2 Gene

  • The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn72, Asn140, and Asn241

Other Protein References for TGFB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TGFB2 Gene

Domains for TGFB2 Gene

Gene Families for TGFB2 Gene

HGNC:

Suggested Antigen Peptide Sequences for TGFB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61812

UniProtKB/Swiss-Prot:

TGFB2_HUMAN
Family:
  • Belongs to the TGF-beta family.:
    • P61812
genes like me logo Genes that share domains with TGFB2: view

Function for TGFB2 Gene

Molecular function for TGFB2 Gene

GENATLAS Biochemistry: transforming growth factor,beta 2,152.6kDa,homodimerizing,expressed by fibroblast,platelet,monocyte,chondrocyte,osteoblasts,including the latency associated peptide (LAP),inhibitor of epithelial cell growth and inductor of extracellular matrix formation
UniProtKB/Swiss-Prot Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth

Gene Ontology (GO) - Molecular Function for TGFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IDA 16227582
GO:0004702 receptor signaling protein serine/threonine kinase activity IDA 12958365
GO:0005102 receptor binding IMP 16227582
GO:0005114 type II transforming growth factor beta receptor binding IPI 11157754
GO:0005125 cytokine activity TAS 9611771
genes like me logo Genes that share ontologies with TGFB2: view
genes like me logo Genes that share phenotypes with TGFB2: view

Animal Models for TGFB2 Gene

MGI Knock Outs for TGFB2:

miRNA for TGFB2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TGFB2 Gene

Localization for TGFB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGFB2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGFB2 Gene COMPARTMENTS Subcellular localization image for TGFB2 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TGFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 2119582
GO:0005615 extracellular space IDA 24263861
GO:0005768 endosome IEA --
GO:0030424 axon ISS --
GO:0031012 extracellular matrix IDA 18049952
genes like me logo Genes that share ontologies with TGFB2: view

Pathways for TGFB2 Gene

genes like me logo Genes that share pathways with TGFB2: view

Gene Ontology (GO) - Biological Process for TGFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IDA 15896309
GO:0001501 skeletal system development --
GO:0001502 cartilage condensation IEA --
GO:0001525 angiogenesis TAS 9611771
GO:0001568 blood vessel development --
genes like me logo Genes that share ontologies with TGFB2: view

Compounds for TGFB2 Gene

(74) Novoseek inferred chemical compound relationships for TGFB2 Gene

Compound -log(P) Hits PubMed IDs
tgf beta1 81.8 84
vegf 51.6 72
4-hydroxytamoxifen 40.9 3
ribonucleic acid 40 3
epsilon-(gamma-glutamyl)lysine 38.4 1
genes like me logo Genes that share compounds with TGFB2: view

Transcripts for TGFB2 Gene

Unigene Clusters for TGFB2 Gene

Transforming growth factor, beta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGFB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for TGFB2 Gene

GeneLoc Exon Structure for
TGFB2
ECgene alternative splicing isoforms for
TGFB2

Expression for TGFB2 Gene

mRNA expression in normal human tissues for TGFB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGFB2 Gene

This gene is overexpressed in Minor Salivary Gland (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGFB2 Gene

SOURCE GeneReport for Unigene cluster for TGFB2 Gene Hs.133379

genes like me logo Genes that share expressions with TGFB2: view

No data available for mRNA Expression by UniProt/SwissProt for TGFB2 Gene

Orthologs for TGFB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TGFB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGFB2 35
  • 99.85 (n)
  • 100 (a)
TGFB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TGFB2 35
  • 93.88 (n)
  • 98.31 (a)
TGFB2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TGFB2 35
  • 94.72 (n)
  • 99.32 (a)
TGFBETA2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgfb2 35
  • 89.21 (n)
  • 95.65 (a)
Tgfb2 16
Tgfb2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TGFB2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGFB2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgfb2 35
  • 89.06 (n)
  • 95.02 (a)
chicken
(Gallus gallus)
Aves TGFB2 35
  • 85.19 (n)
  • 90.29 (a)
TGFB2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TGFB2 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tgfb2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tgfb2 35
  • 76.8 (n)
  • 87.35 (a)
zebrafish
(Danio rerio)
Actinopterygii tgfb2 35
  • 71.61 (n)
  • 79.56 (a)
tgfb2 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta daw 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for TGFB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGFB2 Gene

ENSEMBL:
Gene Tree for TGFB2 (if available)
TreeFam:
Gene Tree for TGFB2 (if available)

Paralogs for TGFB2 Gene

Paralogs for TGFB2 Gene

Selected SIMAP similar genes for TGFB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TGFB2: view

Variants for TGFB2 Gene

Sequence variations from dbSNP and Humsavar for TGFB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs947711 -- 218,391,628(-) GTCCT(C/G)ATTTT intron-variant
rs947712 -- 218,391,539(-) GTTGT(A/G)TAATA intron-variant
rs1317681 -- 218,401,860(-) GAGAC(C/T)CAAAA intron-variant
rs1342586 -- 218,424,517(+) gcctc(C/T)acctc intron-variant
rs1343536 -- 218,369,431(+) CTTTA(C/G)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TGFB2 Gene

Variant ID Type Subtype PubMed ID
nsv873192 CNV Gain 21882294
nsv832603 CNV Gain 17160897
nsv873193 CNV Gain 21882294
esv2723040 CNV Deletion 23290073

Relevant External Links for TGFB2 Gene

HapMap Linkage Disequilibrium report
TGFB2
Human Gene Mutation Database (HGMD)
TGFB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGFB2 Gene

Disorders for TGFB2 Gene

(1) OMIM Diseases for TGFB2 Gene (190220)

UniProtKB/Swiss-Prot

TGFB2_HUMAN
  • Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.
  • Loeys-Dietz syndrome 4 (LDS4) [MIM:614816]: An aortic aneurysm syndrome with widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae. {ECO:0000269 PubMed:22772368}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features. {ECO:0000269 PubMed:25046559}.

(5) University of Copenhagen DISEASES for TGFB2 Gene

(95) Novoseek inferred disease relationships for TGFB2 Gene

Disease -log(P) Hits PubMed IDs
vitreoretinopathy proliferative 68.1 3
aqueous humor 67.3 42
macular holes 63.1 31
fuchs heterochromic cyclitis 59.4 1
breast cysts 56.6 4

Relevant External Links for TGFB2

Genetic Association Database (GAD)
TGFB2
Human Genome Epidemiology (HuGE) Navigator
TGFB2
genes like me logo Genes that share disorders with TGFB2: view

Publications for TGFB2 Gene

  1. Transforming growth factor-12 polymorphism and systemic lupus erythematosus. (PMID: 12064833) Alansari A. … Ollier W. (J. Rheumatol. 2002) 3 23 48
  2. Transforming growth factor-beta gene polymorphisms in sarcoidosis patients with and without fibrosis. (PMID: 16778279) Kruit A. … van den Bosch J.M. (Chest 2006) 3 23 48
  3. A novel functional polymorphism in the transforming growth factor-beta2 gene promoter and tumor progression in breast cancer. (PMID: 16885354) Beisner J. … Knabbe C. (Cancer Res. 2006) 3 23 48
  4. Sclera-related gene polymorphisms in high myopia. (PMID: 19710942) Lin H.J. … Tsai F.J. (Mol. Vis. 2009) 3 23 48
  5. Differential expression of transforming growth factor-beta isoforms in bullous keratopathy corneas. (PMID: 20142847) Strzalka-Mrozik B. … Mazurek U. (Mol. Vis. 2010) 3 23

Products for TGFB2 Gene

Sources for TGFB2 Gene

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