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Aliases for TGFB1I1 Gene

Aliases for TGFB1I1 Gene

  • Transforming Growth Factor Beta 1 Induced Transcript 1 2 3
  • ARA55 3 4 6
  • Androgen Receptor-Associated Protein Of 55 KDa 3 4
  • Androgen Receptor Coactivator 55 KDa Protein 3 4
  • Hydrogen Peroxide-Inducible Clone 5 Protein 3 4
  • Hydrogen Peroxide-Inducible Clone-5 2 3
  • HIC-5 3 4
  • HIC5 3 6
  • Transforming Growth Factor Beta-1-Induced Transcript 1 Protein 3
  • Androgen Receptor Coactivator ARA55 3
  • TSC-5 3

External Ids for TGFB1I1 Gene

Summaries for TGFB1I1 Gene

Entrez Gene Summary for TGFB1I1 Gene

  • This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for TGFB1I1 Gene

TGFB1I1 (Transforming Growth Factor Beta 1 Induced Transcript 1) is a Protein Coding gene. Diseases associated with TGFB1I1 include prostate cancer and mesangial proliferative glomerulonephritis. Among its related pathways are ERK Signaling and Adhesion. GO annotations related to this gene include transcription coactivator activity and I-SMAD binding. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for TGFB1I1 Gene

  • Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.

Gene Wiki entry for TGFB1I1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGFB1I1 Gene

Genomics for TGFB1I1 Gene

Genomic Location for TGFB1I1 Gene

Start:
31,471,585 bp from pter
End:
31,477,960 bp from pter
Size:
6,376 bases
Orientation:
Plus strand

Genomic View for TGFB1I1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGFB1I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGFB1I1 Gene

Regulatory Elements for TGFB1I1 Gene

Proteins for TGFB1I1 Gene

  • Protein details for TGFB1I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43294-TGFI1_HUMAN
    Recommended name:
    Transforming growth factor beta-1-induced transcript 1 protein
    Protein Accession:
    O43294
    Secondary Accessions:
    • B2R8D5
    • Q9BPW3
    • Q9Y2V5

    Protein attributes for TGFB1I1 Gene

    Size:
    461 amino acids
    Molecular mass:
    49814 Da
    Quaternary structure:
    • Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity.
    SequenceCaution:
    • Sequence=AAH32545.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TGFB1I1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGFB1I1 Gene

Proteomics data for TGFB1I1 Gene at MOPED

Post-translational modifications for TGFB1I1 Gene

  • Phosphorylated by gonadotropin-releasing hormone-activated SRC.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TGFB1I1 Gene

Domains for TGFB1I1 Gene

Protein Domains for TGFB1I1 Gene

UniProtKB/Swiss-Prot:

TGFI1_HUMAN
Domain:
  • The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12:
    • O43294
  • The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal:
    • O43294
  • Contains 4 LIM zinc-binding domains.:
    • O43294
Family:
  • Belongs to the paxillin family.:
    • O43294
genes like me logo Genes that share domains with TGFB1I1: view

No data available for Gene Families for TGFB1I1 Gene

Function for TGFB1I1 Gene

Molecular function for TGFB1I1 Gene

UniProtKB/Swiss-Prot Function: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
UniProtKB/Swiss-Prot Induction: Up-regulated by TNF and hydrogen peroxide.

Gene Ontology (GO) - Molecular Function for TGFB1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding IPI 10604475
GO:0008270 zinc ion binding IEA --
GO:0048495 Roundabout binding IPI 19855388
GO:0050681 androgen receptor binding NAS 15572661
genes like me logo Genes that share ontologies with TGFB1I1: view

Phenotypes for TGFB1I1 Gene

GenomeRNAi human phenotypes for TGFB1I1:
genes like me logo Genes that share phenotypes with TGFB1I1: view

miRNA for TGFB1I1 Gene

miRTarBase miRNAs that target TGFB1I1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TGFB1I1 Gene

Localization for TGFB1I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGFB1I1 Gene

Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGFB1I1 Gene COMPARTMENTS Subcellular localization image for TGFB1I1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TGFB1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 10075738
GO:0005634 nucleus --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with TGFB1I1: view

Pathways for TGFB1I1 Gene

genes like me logo Genes that share pathways with TGFB1I1: view

Pathways by source for TGFB1I1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for TGFB1I1 Gene
2 Qiagen pathways for TGFB1I1 Gene
1 Cell Signaling Technology pathway for TGFB1I1 Gene

Gene Ontology (GO) - Biological Process for TGFB1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS 10075738
GO:0007155 cell adhesion TAS 9422762
GO:0008285 negative regulation of cell proliferation TAS 7929412
GO:0009408 response to heat IEA --
GO:0010718 positive regulation of epithelial to mesenchymal transition IDA 18762808
genes like me logo Genes that share ontologies with TGFB1I1: view

Compounds for TGFB1I1 Gene

(9) Novoseek inferred chemical compound relationships for TGFB1I1 Gene

Compound -log(P) Hits PubMed IDs
hydroxyflutamide 73.2 3
testosterone 56.9 18
roxithromycin 51.4 3
tyrosine 33.4 16
hydrogen 13.7 5
genes like me logo Genes that share compounds with TGFB1I1: view

Transcripts for TGFB1I1 Gene

Unigene Clusters for TGFB1I1 Gene

Transforming growth factor beta 1 induced transcript 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGFB1I1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: -
SP8: - -
SP9: -
SP10: -
SP11:

Relevant External Links for TGFB1I1 Gene

GeneLoc Exon Structure for
TGFB1I1
ECgene alternative splicing isoforms for
TGFB1I1

Expression for TGFB1I1 Gene

mRNA expression in normal human tissues for TGFB1I1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGFB1I1 Gene

This gene is overexpressed in Colon - Sigmoid (4.2) and Esophagus - Muscularis (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGFB1I1 Gene

SOURCE GeneReport for Unigene cluster for TGFB1I1 Gene Hs.513530

mRNA Expression by UniProt/SwissProt for TGFB1I1 Gene

O43294-TGFI1_HUMAN
Tissue specificity: Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).
genes like me logo Genes that share expressions with TGFB1I1: view

Orthologs for TGFB1I1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGFB1I1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGFB1I1 36
  • 99.57 (n)
  • 100 (a)
TGFB1I1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TGFB1I1 36
  • 90.13 (n)
  • 94.31 (a)
TGFB1I1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TGFB1I1 36
  • 89.73 (n)
  • 93.28 (a)
TGFB1I1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgfb1i1 36
  • 87.16 (n)
  • 90.99 (a)
Tgfb1i1 16
Tgfb1i1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TGFB1I1 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGFB1I1 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgfb1i1 36
  • 87.06 (n)
  • 91.54 (a)
lizard
(Anolis carolinensis)
Reptilia TGFB1I1 37
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ldb3a 37
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Pax 37
  • 35 (a)
OneToMany
Pax 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea pxl-1 37
  • 38 (a)
OneToMany
C28H8.6 38
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9134 37
  • 42 (a)
OneToMany
Species with no ortholog for TGFB1I1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TGFB1I1 Gene

ENSEMBL:
Gene Tree for TGFB1I1 (if available)
TreeFam:
Gene Tree for TGFB1I1 (if available)

Paralogs for TGFB1I1 Gene

Paralogs for TGFB1I1 Gene

Selected SIMAP similar genes for TGFB1I1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TGFB1I1: view

Variants for TGFB1I1 Gene

Sequence variations from dbSNP and Humsavar for TGFB1I1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10596 -- 31,477,595(+) TCGCC(C/G)TCTCC utr-variant-3-prime
rs13143 -- 31,477,712(+) TGAGT(C/T)CTCAG utr-variant-3-prime
rs3813003 -- 31,472,824(+) CCGGA(A/G)GGGGG intron-variant, upstream-variant-2KB
rs4073483 -- 31,476,032(+) GGCCG(C/G)GCCTG reference, synonymous-codon
rs4073484 -- 31,476,196(+) CCCCG(C/G)CCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TGFB1I1 Gene

Variant ID Type Subtype PubMed ID
nsv833194 CNV Loss 17160897
nsv905747 CNV Gain 21882294
dgv2673n71 CNV Loss 21882294
nsv905751 CNV Loss 21882294

Relevant External Links for TGFB1I1 Gene

HapMap Linkage Disequilibrium report
TGFB1I1

Disorders for TGFB1I1 Gene

(4) Novoseek inferred disease relationships for TGFB1I1 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 48 18
necrosis 0 2
tumors 0 6
cancer 0 2
genes like me logo Genes that share disorders with TGFB1I1: view

No data available for UniProtKB/Swiss-Prot for TGFB1I1 Gene

Publications for TGFB1I1 Gene

  1. Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. (PMID: 9422762) Matsuya M. … Sasaki T. (J. Biol. Chem. 1998) 2 3 4 23
  2. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. (PMID: 10075738) Fujimoto N. … Chang C. (J. Biol. Chem. 1999) 2 3 4 23
  3. Induction of senescence-like phenotypes by forced expression of hic- 5, which encodes a novel LIM motif protein, in immortalized human fibroblasts. (PMID: 9032249) Shibanuma M. … Nose K. (Mol. Cell. Biol. 1997) 3 4 23
  4. Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator. (PMID: 11856738) Wang X. … Chang C. (J. Biol. Chem. 2002) 3 4 23
  5. Transcriptional activation of the c-fos gene by a LIM protein, Hic- 5. (PMID: 12445807) Kim-Kaneyama J.-R. … Nose K. (Biochem. Biophys. Res. Commun. 2002) 3 4 23

Products for TGFB1I1 Gene

Sources for TGFB1I1 Gene

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