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Aliases for TFPI Gene

Aliases for TFPI Gene

  • Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) 2 3
  • Extrinsic Pathway Inhibitor 2 3 4
  • LACI 3 4 6
  • TFPI1 3 4
  • EPI 3 4
  • Lipoprotein-Associated Coagulation Inhibitor 4
  • Tissue Factor Pathway Inhibitor 3
  • Anti-Convertin 3
  • TFI 3

External Ids for TFPI Gene

Previous HGNC Symbols for TFPI Gene

  • LACI

Previous GeneCards Identifiers for TFPI Gene

  • GC02M186541
  • GC02M187014
  • GC02M188295
  • GC02M188534
  • GC02M188533
  • GC02M188156
  • GC02M188039
  • GC02M180188
  • GC02M188328

Summaries for TFPI Gene

Entrez Gene Summary for TFPI Gene

  • This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]

GeneCards Summary for TFPI Gene

TFPI (Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor)) is a Protein Coding gene. Diseases associated with TFPI include crescentic glomerulonephritis. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is SPINT3.

UniProtKB/Swiss-Prot for TFPI Gene

  • Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma

Gene Wiki entry for TFPI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFPI Gene

Genomics for TFPI Gene

Regulatory Elements for TFPI Gene

Genomic Location for TFPI Gene

187,464,230 bp from pter
187,565,760 bp from pter
101,531 bases
Minus strand

Genomic View for TFPI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFPI Gene

Proteins for TFPI Gene

  • Protein details for TFPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tissue factor pathway inhibitor
    Protein Accession:
    Secondary Accessions:
    • O95103
    • Q53TS4

    Protein attributes for TFPI Gene

    304 amino acids
    Molecular mass:
    35015 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TFPI Gene

    Alternative splice isoforms for TFPI Gene


neXtProt entry for TFPI Gene

Proteomics data for TFPI Gene at MOPED

Post-translational modifications for TFPI Gene

  • O-glycosylated.
  • Glycosylation at Thr42, Thr115, Thr116, Asn145, Asn195, Ser202, and Thr203
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TFPI Gene

Domains for TFPI Gene

Protein Domains for TFPI Gene

Suggested Antigen Peptide Sequences for TFPI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P10646
  • This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa
  • Contains 3 BPTI/Kunitz inhibitor domains.
genes like me logo Genes that share domains with TFPI: view

No data available for Gene Families for TFPI Gene

Function for TFPI Gene

Molecular function for TFPI Gene

GENATLAS Biochemistry:
tissue factor pathway inhibitor,serine proteinase inhibitor,susceptibility gene for venous thrombosis (536GC->T)
UniProtKB/Swiss-Prot Function:
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma

Gene Ontology (GO) - Molecular Function for TFPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 9252393
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with TFPI: view
genes like me logo Genes that share phenotypes with TFPI: view

Animal Models for TFPI Gene

MGI Knock Outs for TFPI:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TFPI Gene

Localization for TFPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFPI Gene

Isoform Alpha: Secreted.
Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for TFPI Gene COMPARTMENTS Subcellular localization image for TFPI gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 3
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TFPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 19065458
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 19581412
genes like me logo Genes that share ontologies with TFPI: view

Pathways for TFPI Gene

genes like me logo Genes that share pathways with TFPI: view

Pathways by source for TFPI Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TFPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0007598 blood coagulation, extrinsic pathway TAS --
GO:0010466 negative regulation of peptidase activity --
GO:0010951 negative regulation of endopeptidase activity TAS 9252393
genes like me logo Genes that share ontologies with TFPI: view

Compounds for TFPI Gene

(2) Drugbank Compounds for TFPI Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Coagulation factor VIIa
  • Coagulation factor VII precursor
9001-25-6 target
  • Daltepariininatrium
9041-08-1 target inhibitor

(15) Novoseek inferred chemical compound relationships for TFPI Gene

Compound -log(P) Hits PubMed IDs
iptg 53.6 1
phip 51.3 4
n-methyl-n-nitrosourea 42.4 1
heparin 39.4 19
1,3-butadiene 37.2 2
genes like me logo Genes that share compounds with TFPI: view

Transcripts for TFPI Gene

Unigene Clusters for TFPI Gene

Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TFPI

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFPI Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - -
SP3: - - - -

Relevant External Links for TFPI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TFPI Gene

mRNA expression in normal human tissues for TFPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFPI Gene

This gene is overexpressed in Liver (6.1) and Lung (4.7).

Protein differential expression in normal tissues for TFPI Gene

This gene is overexpressed in Amniocyte (29.3), Serum (15.8), and Liver (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFPI Gene

SOURCE GeneReport for Unigene cluster for TFPI Gene Hs.516578

mRNA Expression by UniProt/SwissProt for TFPI Gene

Tissue specificity: Mostly in endothelial cells
genes like me logo Genes that share expressions with TFPI: view

Expression partners for TFPI Gene

In Situ Assay Products

Orthologs for TFPI Gene

This gene was present in the common ancestor of animals.

Orthologs for TFPI Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TFPI 35
  • 81.38 (n)
  • 74.92 (a)
(Mus musculus)
Mammalia Tfpi 35
  • 74.33 (n)
  • 62.77 (a)
Tfpi 16
Tfpi 36
  • 58 (a)
(Pan troglodytes)
Mammalia TFPI 35
  • 99.34 (n)
  • 99.01 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tfpi 35
  • 75.24 (n)
  • 63.41 (a)
(Canis familiaris)
Mammalia TFPI 36
  • 52 (a)
(Monodelphis domestica)
Mammalia TFPI 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia TFPI 36
  • 60 (a)
(Gallus gallus)
Aves TFPI 35
  • 60.98 (n)
  • 54.37 (a)
  • 48 (a)
(Anolis carolinensis)
Reptilia TFPI 36
  • 48 (a)
(Danio rerio)
Actinopterygii tfpia 35
  • 52.1 (n)
  • 38.83 (a)
tfpia 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea F22E12.1 36
  • 7 (a)
mec-1 36
  • 4 (a)
mec-9 36
  • 10 (a)
ZK287.4 36
  • 6 (a)
Species with no ortholog for TFPI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TFPI Gene

Gene Tree for TFPI (if available)
Gene Tree for TFPI (if available)

Paralogs for TFPI Gene

Paralogs for TFPI Gene

Selected SIMAP similar genes for TFPI Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TFPI: view

Variants for TFPI Gene

Sequence variations from dbSNP and Humsavar for TFPI Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs5940 - 187,466,977(-) AGAGA(A/G)TGAAA missense, reference
rs727508 -- 187,505,208(+) CAGAG(A/T)GTACT intron-variant
rs763684 -- 187,469,496(-) CCTCA(A/C)ATATA intron-variant
rs978044 -- 187,485,545(+) ATCCT(C/T)TACTG intron-variant
rs1160911 -- 187,505,128(+) AACAC(-/AT)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFPI Gene

Variant ID Type Subtype PubMed ID
nsv834487 CNV Gain 17160897
dgv4393n71 CNV Loss 21882294
nsv875560 CNV Loss 21882294
dgv4394n71 CNV Loss 21882294
dgv4395n71 CNV Loss 21882294
dgv4396n71 CNV Loss 21882294
nsv834488 CNV Gain+Loss 17160897
dgv4397n71 CNV Loss 21882294
nsv875572 CNV Loss 21882294
nsv875574 CNV Loss 21882294
nsv875575 CNV Gain 21882294
dgv4398n71 CNV Loss 21882294
nsv875579 CNV Loss 21882294
dgv4399n71 CNV Loss 21882294
dgv1281e1 CNV Complex 17122850
esv28153 CNV Loss 19812545
esv2660083 CNV Deletion 23128226
nsv875584 CNV Loss 21882294

Relevant External Links for TFPI Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFPI Gene

Disorders for TFPI Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TFPI Gene in MalaCards »

(1) Diseases for TFPI Gene including...

(11) Novoseek inferred disease relationships for TFPI Gene

Disease -log(P) Hits PubMed IDs
atherosclerotic plaque 25.6 4
cell damage 12 2
thrombosis 9.7 4
atherosclerosis 5.36 1
sepsis 0 1

Relevant External Links for TFPI

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TFPI: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for TFPI Gene

Publications for TFPI Gene

  1. Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation. (PMID: 1993173) van der Logt C.P.E. … Bertina R.M. (Biochemistry 1991) 2 3 4
  2. Association analysis of tissue factor pathway inhibitor polymorphisms and haplotypes with osteonecrosis of the femoral head in the Korean population. (PMID: 18695356) Dai X.L. … Kim T.H. (Mol. Cells 2008) 3 23 48
  3. Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor. (PMID: 11772005) Mine S. … Kato H. (Biochemistry 2002) 3 4 25
  4. The C536T transition in the tissue factor pathway inhibitor (TFPI) gene does not contribute to risk of venous thrombosis among carriers of factor V Leiden. (PMID: 11057878) Hessner M.J. … Luhm R.A. (Thromb. Haemost. 2000) 3 48
  5. Analysis of the tissue factor pathway inhibitor gene and antigen levels in relation to venous thrombosis. (PMID: 11380428) Amini-Nekoo A. … AriAns R.A. (Br. J. Haematol. 2001) 3 48

Products for TFPI Gene

Sources for TFPI Gene

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