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Aliases for TF Gene

Aliases for TF Gene

  • Transferrin 2 3 4
  • Beta-1 Metal-Binding Globulin 3 4
  • Siderophilin 3 4
  • EC 3.4.21 63
  • PRO1557 3
  • PRO2086 3
  • TFQTL1 3

External Ids for TF Gene

Previous GeneCards Identifiers for TF Gene

  • GC03P130424
  • GC03P134209
  • GC03P134746
  • GC03P134786
  • GC03P134727
  • GC03P134947
  • GC03P133419
  • GC03P130844
  • GC03P133464
  • GC03P133745

Summaries for TF Gene

Entrez Gene Summary for TF Gene

  • This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

GeneCards Summary for TF Gene

TF (Transferrin) is a Protein Coding gene. Diseases associated with TF include congenital atransferrinemia and atransferrinemia. Among its related pathways are Hemostasis and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include ubiquitin protein ligase binding and ferric iron transmembrane transporter activity. An important paralog of this gene is MFI2.

UniProtKB/Swiss-Prot for TF Gene

  • Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation

Gene Wiki entry for TF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TF Gene

Genomics for TF Gene

Regulatory Elements for TF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TF Gene

Chromosome:
3
Start:
133,661,998 bp from pter
End:
133,779,006 bp from pter
Size:
117,009 bases
Orientation:
Plus strand

Genomic View for TF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TF Gene

Proteins for TF Gene

  • Protein details for TF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02787-TRFE_HUMAN
    Recommended name:
    Serotransferrin
    Protein Accession:
    P02787
    Secondary Accessions:
    • O43890
    • Q1HBA5
    • Q9NQB8
    • Q9UHV0

    Protein attributes for TF Gene

    Size:
    698 amino acids
    Molecular mass:
    77064 Da
    Quaternary structure:
    • Monomer
    SequenceCaution:
    • Sequence=AAF22007.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TF Gene

neXtProt entry for TF Gene

Proteomics data for TF Gene at MOPED

Selected DME Specific Peptides for TF Gene

Post-translational modifications for TF Gene

  • Glycosylation at Ser 51, Asn 432, Asn 491, and Asn 630
  • Modification sites at PhosphoSitePlus

Other Protein References for TF Gene

Antibody Products

Domains & Families for TF Gene

Gene Families for TF Gene

HGNC:

Protein Domains for TF Gene

Suggested Antigen Peptide Sequences for TF Gene

Graphical View of Domain Structure for InterPro Entry

P02787

UniProtKB/Swiss-Prot:

TRFE_HUMAN :
  • Contains 2 transferrin-like domains.
  • Belongs to the transferrin family.
Domain:
  • Contains 2 transferrin-like domains.
Family:
  • Belongs to the transferrin family.
genes like me logo Genes that share domains with TF: view

Function for TF Gene

Molecular function for TF Gene

GENATLAS Biochemistry:
transferrin with three predominant variants Tfc1,Tfc2 (P570S),TFC3
UniProtKB/Swiss-Prot Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation

Enzyme Numbers (IUBMB) for TF Gene

LifeMap Function Summary for TF Gene

TF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15880641
GO:0008198 ferrous iron binding IDA 18353247
GO:0008199 ferric iron binding IEA --
GO:0015091 ferric iron transmembrane transporter activity IEA --
GO:1990459 transferrin receptor binding TAS 9465039
genes like me logo Genes that share ontologies with TF: view
genes like me logo Genes that share phenotypes with TF: view

Animal Model Products

miRNA for TF Gene

miRTarBase miRNAs that target TF

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TF Gene

Localization for TF Gene

Subcellular locations from UniProtKB/Swiss-Prot for TF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TF Gene COMPARTMENTS Subcellular localization image for TF gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytosol 3
lysosome 3
vacuole 3
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005769 early endosome IDA 15880641
GO:0005770 late endosome IDA 15880641
GO:0005905 coated pit IDA 12857860
genes like me logo Genes that share ontologies with TF: view

Pathways & Interactions for TF Gene

genes like me logo Genes that share pathways with TF: view

Gene Ontology (GO) - Biological Process for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0002576 platelet degranulation TAS --
GO:0006826 iron ion transport --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with TF: view

No data available for SIGNOR curated interactions for TF Gene

Drugs & Compounds for TF Gene

(67) Drugs for TF Gene - From: NovoSeek, DrugBank, HMDB, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aluminium Approved Pharma Target 0
Iron Dextran Approved Pharma Carrier, substrate 0
Bismuth Subsalicylate Approved Pharma Carrier 23
Gallium nitrate Approved, Investigational Pharma Carrier, substrate 6
Antipyrine Approved Pharma 4

(67) Additional Compounds for TF Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Aluminum
  • Al
  • Alloy
  • ALN
  • Alugel
  • Alum
7429-90-5
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
8-isoprostane
  • 8-beta-Prostane
  • 8-Isoprostane
155976-51-5
Adriamycin
genes like me logo Genes that share compounds with TF: view

Transcripts for TF Gene

Unigene Clusters for TF Gene

Transferrin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TF Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^
SP1: - - - - -
SP2: - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - -
SP4: -
SP5: - -
SP6:
SP7: - - -
SP8:

ExUns: 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TF Gene

GeneLoc Exon Structure for
TF
ECgene alternative splicing isoforms for
TF

Expression for TF Gene

mRNA expression in normal human tissues for TF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TF Gene

This gene is overexpressed in Liver (x19.0), Brain - Spinal cord (cervical c-1) (x13.3), and Brain - Substantia nigra (x5.4).

Protein differential expression in normal tissues from HIPED for TF Gene

This gene is overexpressed in Vitreous humor (10.4), Plasma (7.7), and Cerebrospinal fluid (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TF Gene



SOURCE GeneReport for Unigene cluster for TF Gene Hs.518267

mRNA Expression by UniProt/SwissProt for TF Gene

P02787-TRFE_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expression patterns with TF: view

Protein tissue co-expression partners for TF Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TF Gene

This gene was present in the common ancestor of animals.

Orthologs for TF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TF 35
  • 77.7 (n)
  • 69.93 (a)
TF 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TF 35
  • 80.32 (n)
  • 73.23 (a)
TF 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trf 35
  • 78.15 (n)
  • 74.1 (a)
Trf 16
Gm20425 36
  • 51 (a)
OneToMany
Trf 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TF 35
  • 99.38 (n)
  • 99.43 (a)
TF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tf 35
  • 77.28 (n)
  • 73.63 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves TF 35
  • 60.26 (n)
  • 53.67 (a)
TF 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tf 35
  • 59.25 (n)
  • 51.49 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28538 35
tfa 35
  • 53.8 (n)
  • 48.28 (a)
tfa 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsf2 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4617 36
  • 31 (a)
ManyToMany
Species with no ortholog for TF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TF Gene

ENSEMBL:
Gene Tree for TF (if available)
TreeFam:
Gene Tree for TF (if available)

Paralogs for TF Gene

Paralogs for TF Gene

Pseudogenes.org Pseudogenes for TF Gene

genes like me logo Genes that share paralogs with TF: view

Variants for TF Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TF Gene

P02787-TRFE_HUMAN
Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1)

Sequence variations from dbSNP and Humsavar for TF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7845 -- 133,768,144(+) TACTA(C/G/T)GGCTA reference, synonymous-codon
rs8649 -- 133,768,114(+) AACCT(C/G)TGTGA synonymous-codon, reference
rs11553 -- 133,778,591(+) CACTC(C/T)TGGAA reference, synonymous-codon
rs11877 -- 133,778,668(+) CAGAT(G/T)ATCCA utr-variant-3-prime
rs12595 -- 133,777,709(-) CAAAC(A/C/G)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TF Gene

Variant ID Type Subtype PubMed ID
nsv877506 CNV Gain 21882294
nsv829729 CNV Loss 17160897
nsv877507 CNV Loss 21882294
nsv877508 CNV Loss 21882294
nsv4018 CNV Loss 18451855

Variation tolerance for TF Gene

Residual Variation Intolerance Score: 50.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TF Gene

HapMap Linkage Disequilibrium report
TF
Human Gene Mutation Database (HGMD)
TF

Disorders for TF Gene

MalaCards: The human disease database

(73) MalaCards diseases for TF Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
congenital atransferrinemia
  • congenital hypotransferrinemia
atransferrinemia
  • familial hypotransferrinemia
alcohol abuse
  • ethanol abuse
dysentery
  • infectious diarrhea
substance abuse
  • substance abuse problem
- elite association
Search TF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRFE_HUMAN
  • Atransferrinemia (ATRAF) [MIM:209300]: A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. {ECO:0000269 PubMed:11110675, ECO:0000269 PubMed:15466165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for TF Gene

hypotransferrinemia,familial

Relevant External Links for TF

Genetic Association Database (GAD)
TF
Human Genome Epidemiology (HuGE) Navigator
TF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TF
genes like me logo Genes that share disorders with TF: view

Publications for TF Gene

  1. A systems biology approach to the blood-aluminium problem: the application and testing of a computational model. (PMID: 17629565) Beardmore J. … Exley C. (J. Inorg. Biochem. 2007) 23 25 26 67
  2. Binding affinity of aluminium to human serum transferrin and effects of carbohydrate chain modification as studied by HPLC/high-resolution ICP-MS--speciation of aluminium in human serum. (PMID: 16139893) Nagaoka M.H. … Maitani T. (J. Inorg. Biochem. 2005) 23 25 26 67
  3. The serum protein binding of pharmacologically active gallium(III) compounds assessed by hyphenated CE-MS techniques. (PMID: 19621374) Groessl M. … Hartinger C.G. (Electrophoresis 2009) 23 25 67
  4. Comparison of oxidative stress markers after intravenous administration of iron dextran, sodium ferric gluconate, and iron sucrose in patients undergoing hemodialysis. (PMID: 17316146) Pai A.B. … Zager P.G. (Pharmacotherapy 2007) 23 25 67
  5. Indirect detection of protein-metal binding: interaction of serum transferrin with In3+ and Bi3+. (PMID: 15519234) Zhang M. … Mason A.B. (J. Am. Soc. Mass Spectrom. 2004) 23 25 67

Products for TF Gene

Sources for TF Gene

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