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Aliases for TF Gene

Aliases for TF Gene

  • Transferrin 2 3 4 5
  • Beta-1 Metal-Binding Globulin 3 4
  • Siderophilin 3 4
  • Epididymis Secretory Sperm Binding Protein Li 71p 3
  • HEL-S-71p 3
  • EC 3.4.21 63
  • PRO1557 3
  • PRO2086 3
  • TFQTL1 3

External Ids for TF Gene

Previous GeneCards Identifiers for TF Gene

  • GC03P130424
  • GC03P134209
  • GC03P134746
  • GC03P134786
  • GC03P134727
  • GC03P134947
  • GC03P133419
  • GC03P130844
  • GC03P133464
  • GC03P133745

Summaries for TF Gene

Entrez Gene Summary for TF Gene

  • This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

GeneCards Summary for TF Gene

TF (Transferrin) is a Protein Coding gene. Diseases associated with TF include atransferrinemia and congenital atransferrinemia. Among its related pathways are Platelet activation, signaling and aggregation and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ubiquitin protein ligase binding and ferric iron transmembrane transporter activity. An important paralog of this gene is MELTF.

UniProtKB/Swiss-Prot for TF Gene

  • Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Gene Wiki entry for TF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TF Gene

Genomics for TF Gene

Regulatory Elements for TF Gene

Promoters for TF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TF on UCSC Golden Path with GeneCards custom track

Genomic Location for TF Gene

Chromosome:
3
Start:
133,661,998 bp from pter
End:
133,779,006 bp from pter
Size:
117,009 bases
Orientation:
Plus strand

Genomic View for TF Gene

Genes around TF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TF Gene

Proteins for TF Gene

  • Protein details for TF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02787-TRFE_HUMAN
    Recommended name:
    Serotransferrin
    Protein Accession:
    P02787
    Secondary Accessions:
    • O43890
    • Q1HBA5
    • Q9NQB8
    • Q9UHV0

    Protein attributes for TF Gene

    Size:
    698 amino acids
    Molecular mass:
    77064 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAF22007.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TF Gene

neXtProt entry for TF Gene

Proteomics data for TF Gene at MOPED

Selected DME Specific Peptides for TF Gene

Post-translational modifications for TF Gene

  • Glycosylation at Ser 51, Asn 432, Asn 491, and Asn 630
  • Modification sites at PhosphoSitePlus

Other Protein References for TF Gene

Antibody Products

Domains & Families for TF Gene

Gene Families for TF Gene

Protein Domains for TF Gene

Suggested Antigen Peptide Sequences for TF Gene

Graphical View of Domain Structure for InterPro Entry

P02787

UniProtKB/Swiss-Prot:

TRFE_HUMAN :
  • Contains 2 transferrin-like domains.
  • Belongs to the transferrin family.
Domain:
  • Contains 2 transferrin-like domains.
Family:
  • Belongs to the transferrin family.
genes like me logo Genes that share domains with TF: view

Function for TF Gene

Molecular function for TF Gene

GENATLAS Biochemistry:
transferrin with three predominant variants Tfc1,Tfc2 (P570S),TFC3
UniProtKB/Swiss-Prot Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Enzyme Numbers (IUBMB) for TF Gene

LifeMap Function Summary for TF Gene

TF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990459 transferrin receptor binding TAS 9465039
genes like me logo Genes that share ontologies with TF: view
genes like me logo Genes that share phenotypes with TF: view

Human Phenotype Ontology for TF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for TF Gene

miRTarBase miRNAs that target TF

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TF Gene

Localization for TF Gene

Subcellular locations from UniProtKB/Swiss-Prot for TF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TF Gene COMPARTMENTS Subcellular localization image for TF gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytosol 3
lysosome 3
vacuole 3
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,IDA 16502470
GO:0005769 early endosome IDA 15880641
GO:0005770 late endosome IDA 15880641
GO:0009925 basal plasma membrane IDA 15880641
GO:0009986 cell surface IDA 16195351
genes like me logo Genes that share ontologies with TF: view

Pathways & Interactions for TF Gene

genes like me logo Genes that share pathways with TF: view

Gene Ontology (GO) - Biological Process for TF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0002576 platelet degranulation TAS --
GO:0006879 cellular iron ion homeostasis IEA,TAS --
GO:0007596 blood coagulation TAS --
GO:0031647 regulation of protein stability TAS 25635054
genes like me logo Genes that share ontologies with TF: view

No data available for SIGNOR curated interactions for TF Gene

Drugs & Compounds for TF Gene

(67) Drugs for TF Gene - From: Novoseek, DrugBank, HMDB, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aluminium Approved Pharma Target 0
Iron Dextran Approved Pharma Carrier, substrate 0
Bismuth Subsalicylate Approved Pharma Carrier 24
Gallium nitrate Approved, Investigational Pharma Carrier, substrate 6
Thromboplastin Pharma 54

(67) Additional Compounds for TF Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Aluminum
  • Al
  • Alloy
  • ALN
  • Alugel
  • Alum
7429-90-5
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
genes like me logo Genes that share compounds with TF: view

Transcripts for TF Gene

Unigene Clusters for TF Gene

Transferrin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TF Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^
SP1: - - - - -
SP2: - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - -
SP4: -
SP5: - -
SP6:
SP7: - - -
SP8:

ExUns: 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TF Gene

GeneLoc Exon Structure for
TF
ECgene alternative splicing isoforms for
TF

Expression for TF Gene

mRNA expression in normal human tissues for TF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TF Gene

This gene is overexpressed in Liver (x19.0), Brain - Spinal cord (cervical c-1) (x13.3), and Brain - Substantia nigra (x5.4).

Protein differential expression in normal tissues from HIPED for TF Gene

This gene is overexpressed in Vitreous humor (10.4), Plasma (7.7), and Cerebrospinal fluid (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TF Gene



SOURCE GeneReport for Unigene cluster for TF Gene Hs.518267

mRNA Expression by UniProt/SwissProt for TF Gene

P02787-TRFE_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expression patterns with TF: view

Protein tissue co-expression partners for TF Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TF Gene

This gene was present in the common ancestor of animals.

Orthologs for TF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TF 35
  • 77.7 (n)
  • 69.93 (a)
TF 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TF 35
  • 80.32 (n)
  • 73.23 (a)
TF 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trf 35
  • 78.15 (n)
  • 74.1 (a)
Trf 16
Gm20425 36
  • 51 (a)
OneToMany
Trf 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TF 35
  • 99.38 (n)
  • 99.43 (a)
TF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tf 35
  • 77.28 (n)
  • 73.63 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves TF 35
  • 60.26 (n)
  • 53.67 (a)
TF 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tf 35
  • 59.25 (n)
  • 51.49 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28538 35
tfa 35
  • 53.8 (n)
  • 48.28 (a)
tfa 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsf2 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4617 36
  • 31 (a)
ManyToMany
Species with no ortholog for TF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TF Gene

ENSEMBL:
Gene Tree for TF (if available)
TreeFam:
Gene Tree for TF (if available)

Paralogs for TF Gene

Paralogs for TF Gene

Pseudogenes.org Pseudogenes for TF Gene

genes like me logo Genes that share paralogs with TF: view

Variants for TF Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TF Gene

P02787-TRFE_HUMAN
Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1).

Sequence variations from dbSNP and Humsavar for TF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs8177238 - 133,757,785(+) CAAAG(A/G)CAAAT reference, missense
rs41295774 - 133,757,854(+) TGCCC(A/G)CGGGT reference, missense
rs1799830 - 133,754,593(+) GTCTA(A/G)GCAGG reference, missense
rs1799899 - 133,756,968(+) TGGGC(A/G)GCAAG reference, missense
rs1804498 - 133,759,257(+) GAGTG(C/G)AGTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TF Gene

Variant ID Type Subtype PubMed ID
nsv877506 CNV Gain 21882294
nsv829729 CNV Loss 17160897
nsv877507 CNV Loss 21882294
nsv877508 CNV Loss 21882294
nsv4018 CNV Loss 18451855

Variation tolerance for TF Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TF Gene

HapMap Linkage Disequilibrium report
TF
Human Gene Mutation Database (HGMD)
TF

Disorders for TF Gene

MalaCards: The human disease database

(71) MalaCards diseases for TF Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
atransferrinemia
  • familial hypotransferrinemia
congenital atransferrinemia
  • congenital hypotransferrinemia
nutritional deficiency disease
  • carbamoyl-phosphate synthase i deficiency disease
iron metabolism disease
  • disorder of iron metabolism
alcohol abuse
  • alcoholism
- elite association - COSMIC cancer census association via MalaCards
Search TF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRFE_HUMAN
  • Atransferrinemia (ATRAF) [MIM:209300]: A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. {ECO:0000269 PubMed:11110675, ECO:0000269 PubMed:15466165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for TF Gene

hypotransferrinemia,familial

Relevant External Links for TF

Genetic Association Database (GAD)
TF
Human Genome Epidemiology (HuGE) Navigator
TF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TF
genes like me logo Genes that share disorders with TF: view

Publications for TF Gene

  1. Human transferrin G277S mutation: a risk factor for iron deficiency anaemia. (PMID: 11703331) Lee P.L. … Beutler E. (Br. J. Haematol. 2001) 3 4 48 67
  2. A systems biology approach to the blood-aluminium problem: the application and testing of a computational model. (PMID: 17629565) Beardmore J. … Exley C. (J. Inorg. Biochem. 2007) 23 25 26
  3. Binding affinity of aluminium to human serum transferrin and effects of carbohydrate chain modification as studied by HPLC/high-resolution ICP-MS--speciation of aluminium in human serum. (PMID: 16139893) Nagaoka M.H. … Maitani T. (J. Inorg. Biochem. 2005) 23 25 26
  4. The unique kinetics of iron release from transferrin: the role of receptor, lobe-lobe interactions, and salt at endosomal pH. (PMID: 19917294) Byrne S.L. … Mason A.B. (J. Mol. Biol. 2010) 3 23
  5. Levels of transferrin in bronchoalveolar lavage fluid in sarcoidosis. (PMID: 20066543) Shigemura M. … Nishimura M. (Lung 2010) 3 23

Products for TF Gene

Sources for TF Gene

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