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Aliases for TEAD4 Gene

Aliases for TEAD4 Gene

  • TEA Domain Family Member 4 2 3 4
  • TCF13L1 3 4 6
  • RTEF1 3 4 6
  • Transcription Factor 13-Like 1 3 4
  • Transcription Factor RTEF-1 3 4
  • TEF3 3 4
  • Transcriptional Enhancer Factor 1-Related 3
  • Related Transcription Enhancer Factor 1B 3
  • Transcriptional Enhancer Factor TEF-3 3
  • Transcriptional Enhancer Factor 3 3
  • HRTEF-1B 3
  • EFTR-2 3
  • TEFR-1 3
  • TEAD-4 4
  • TEF-3 3

External Ids for TEAD4 Gene

Previous HGNC Symbols for TEAD4 Gene

  • TCF13L1

Previous GeneCards Identifiers for TEAD4 Gene

  • GC12U990098
  • GC12M123588
  • GC12P002947
  • GC12P002938
  • GC12P003068

Summaries for TEAD4 Gene

Entrez Gene Summary for TEAD4 Gene

  • This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEAD4 Gene

TEAD4 (TEA Domain Family Member 4) is a Protein Coding gene. Diseases associated with TEAD4 include cardiac conduction defect. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot for TEAD4 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC enhansons (5-GTGGAATGT-3) and activates transcription. Binds to the M-CAT motif.

Gene Wiki entry for TEAD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEAD4 Gene

Genomics for TEAD4 Gene

Regulatory Elements for TEAD4 Gene

Genomic Location for TEAD4 Gene

Start:
2,959,312 bp from pter
End:
3,040,676 bp from pter
Size:
81,365 bases
Orientation:
Plus strand

Genomic View for TEAD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEAD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEAD4 Gene

Proteins for TEAD4 Gene

  • Protein details for TEAD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15561-TEAD4_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-3
    Protein Accession:
    Q15561
    Secondary Accessions:
    • H0Y308
    • Q6MZR9
    • Q8NEV5
    • Q92883
    • Q96BK2

    Protein attributes for TEAD4 Gene

    Size:
    434 amino acids
    Molecular mass:
    48329 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.
    SequenceCaution:
    • Sequence=CAA64212.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for TEAD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEAD4 Gene

Proteomics data for TEAD4 Gene at MOPED

Post-translational modifications for TEAD4 Gene

  • Ubiquitination at Lys73
  • Modification sites at PhosphoSitePlus

Other Protein References for TEAD4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TEAD4 (TEAD4)

No data available for DME Specific Peptides for TEAD4 Gene

Domains for TEAD4 Gene

Protein Domains for TEAD4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEAD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q15561

UniProtKB/Swiss-Prot:

TEAD4_HUMAN :
  • Q15561
Domain:
  • Contains 1 TEA DNA-binding domain.
genes like me logo Genes that share domains with TEAD4: view

No data available for Gene Families for TEAD4 Gene

Function for TEAD4 Gene

Molecular function for TEAD4 Gene

GENATLAS Biochemistry: SV40-transcriptional enhancer factor 4 (TEF4)
UniProtKB/Swiss-Prot Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC enhansons (5-GTGGAATGT-3) and activates transcription. Binds to the M-CAT motif.

Gene Ontology (GO) - Molecular Function for TEAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 18579750
GO:0005515 protein binding IPI 16189514
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with TEAD4: view

Phenotypes for TEAD4 Gene

genes like me logo Genes that share phenotypes with TEAD4: view

Animal Models for TEAD4 Gene

MGI Knock Outs for TEAD4:

Animal Model Products

CRISPR Products

miRNA for TEAD4 Gene

miRTarBase miRNAs that target TEAD4
Targeting motifs for TEAD4 Gene
HOMER Transcription Factor Regulatory Elements motif TEAD4
  • Consensus sequence: CCWGGAATGY Submotif: canonical Cell Type: Tropoblast GeoId: GSE37350

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEAD4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for TEAD4 Gene

Localization for TEAD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEAD4 Gene COMPARTMENTS Subcellular localization image for TEAD4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TEAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex --
GO:0005737 cytoplasm --
GO:0032993 protein-DNA complex --
genes like me logo Genes that share ontologies with TEAD4: view

Pathways for TEAD4 Gene

genes like me logo Genes that share pathways with TEAD4: view

Gene Ontology (GO) - Biological Process for TEAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8662936
GO:0001701 in utero embryonic development --
GO:0001708 cell fate specification --
GO:0001825 blastocyst formation --
GO:0001830 trophectodermal cell fate commitment --
genes like me logo Genes that share ontologies with TEAD4: view

Transcripts for TEAD4 Gene

Unigene Clusters for TEAD4 Gene

TEA domain family member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEAD4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TEAD4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - - -
SP6:
SP7: -
SP8: - -

Relevant External Links for TEAD4 Gene

GeneLoc Exon Structure for
TEAD4
ECgene alternative splicing isoforms for
TEAD4

Expression for TEAD4 Gene

mRNA expression in normal human tissues for TEAD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEAD4 Gene

This gene is overexpressed in Muscle - Skeletal (10.7) and Pancreas (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TEAD4 Gene

SOURCE GeneReport for Unigene cluster for TEAD4 Gene Hs.94865

mRNA Expression by UniProt/SwissProt for TEAD4 Gene

Q15561-TEAD4_HUMAN
Tissue specificity: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart
genes like me logo Genes that share expressions with TEAD4: view

In Situ Assay Products

Orthologs for TEAD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEAD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEAD4 35
  • 99.35 (n)
  • 99.72 (a)
TEAD4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEAD4 35
  • 90.19 (n)
  • 94.72 (a)
TEAD4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEAD4 35
  • 93.26 (n)
  • 97.51 (a)
TEAD4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tead4 35
  • 88.84 (n)
  • 93.91 (a)
Tead4 16
Tead4 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEAD4 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEAD4 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tead4 35
  • 88.86 (n)
  • 93.55 (a)
chicken
(Gallus gallus)
Aves TEAD4 35
  • 78.6 (n)
  • 88.45 (a)
TEAD4 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tead4 35
  • 70.25 (n)
  • 75.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5943 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01090021.1 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sd 36
  • 43 (a)
OneToMany
sd 37
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-44 36
  • 37 (a)
OneToMany
egl-44 37
  • 40 (a)
Species with no ortholog for TEAD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEAD4 Gene

ENSEMBL:
Gene Tree for TEAD4 (if available)
TreeFam:
Gene Tree for TEAD4 (if available)

Paralogs for TEAD4 Gene

Paralogs for TEAD4 Gene

Selected SIMAP similar genes for TEAD4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TEAD4: view

Variants for TEAD4 Gene

Sequence variations from dbSNP and Humsavar for TEAD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs885201 -- 3,003,212(-) CCCCA(A/C)CCAAG intron-variant
rs933418 -- 3,001,248(+) CATTA(C/T)GTAAA intron-variant
rs933419 -- 3,002,569(+) ATCTC(A/G)TGGTT intron-variant
rs933420 -- 3,016,874(+) TTACA(C/T)TCTGA intron-variant
rs933421 -- 3,020,259(+) GTGGA(C/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEAD4 Gene

Variant ID Type Subtype PubMed ID
nsv832311 CNV Loss 17160897
nsv470261 CNV Loss 18288195
esv2673655 CNV Deletion 23128226
nsv468974 CNV Loss 19166990
nsv528500 CNV Loss 19592680
esv275406 CNV Gain+Loss 21479260
nsv898610 CNV Loss 21882294
dgv1345n71 CNV Loss 21882294
nsv523615 CNV Loss 19592680
nsv468975 CNV Loss 19166990
nsv898613 CNV Loss 21882294
esv2662595 CNV Deletion 23128226

Relevant External Links for TEAD4 Gene

HapMap Linkage Disequilibrium report
TEAD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEAD4 Gene

Disorders for TEAD4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TEAD4 Gene including...

Search for TEAD4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TEAD4 Gene

genes like me logo Genes that share disorders with TEAD4: view

No data available for UniProtKB/Swiss-Prot for TEAD4 Gene

Publications for TEAD4 Gene

  1. Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family. (PMID: 8921372) Stewart A.F.R. … Adra C.N. (Genomics 1996) 2 3 4
  2. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PMID: 9889009) Jacquemin P. … Davidson I. (Genomics 1999) 2 3
  3. Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation. (PMID: 15520314) Chen H.H. … Stewart A.F. (Circulation 2004) 3 23
  4. Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells. (PMID: 18840614) Liu X. … Zeng H. (J. Biol. Chem. 2008) 3 23
  5. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. (PMID: 8702974) Jacquemin P. … Davidson I. (J. Biol. Chem. 1996) 3 4

Products for TEAD4 Gene

  • Addgene plasmids for TEAD4

Sources for TEAD4 Gene

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