Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TEAD1 Gene

Aliases for TEAD1 Gene

  • TEA Domain Transcription Factor 1 2 3
  • TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) 2 3 5
  • Transcription Factor 13 3 4
  • Protein GT-IIC 3 4
  • NTEF-1 3 4
  • TCF-13 3 4
  • TEAD-1 3 4
  • TCF13 3 4
  • Atrophia Areata, Peripapillary Chorioretinal Degeneration 2
  • Transcriptional Enhancer Factor 1 3
  • TEA Domain Family Member 1 4
  • TEF-1 3
  • REF1 3
  • TEF1 4
  • AA 3

External Ids for TEAD1 Gene

Previous HGNC Symbols for TEAD1 Gene

  • TCF13
  • AA

Previous GeneCards Identifiers for TEAD1 Gene

  • GC11P014056
  • GC11P013515
  • GC11P012737
  • GC11P012730
  • GC11P012660
  • GC11P012652
  • GC11P012376

Summaries for TEAD1 Gene

Entrez Gene Summary for TEAD1 Gene

  • This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

GeneCards Summary for TEAD1 Gene

TEAD1 (TEA Domain Transcription Factor 1) is a Protein Coding gene. Diseases associated with TEAD1 include sveinsson choreoretinal atrophy and helicoid peripapillary chorioretinal degeneration. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TEAD2.

UniProtKB/Swiss-Prot for TEAD1 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC enhansons (5-GTGGAATGT-3) and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Gene Wiki entry for TEAD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEAD1 Gene

Genomics for TEAD1 Gene

Regulatory Elements for TEAD1 Gene

Promoters for TEAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TEAD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TEAD1 Gene

Chromosome:
11
Start:
12,674,422 bp from pter
End:
12,944,737 bp from pter
Size:
270,316 bases
Orientation:
Plus strand

Genomic View for TEAD1 Gene

Genes around TEAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEAD1 Gene

Proteins for TEAD1 Gene

  • Protein details for TEAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28347-TEAD1_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-1
    Protein Accession:
    P28347
    Secondary Accessions:
    • A4FUP2
    • E7EV65

    Protein attributes for TEAD1 Gene

    Size:
    426 amino acids
    Molecular mass:
    47946 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.
    SequenceCaution:
    • Sequence=AAB00791.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEAD1 Gene

    Alternative splice isoforms for TEAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEAD1 Gene

Proteomics data for TEAD1 Gene at MOPED

Post-translational modifications for TEAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEAD1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TEAD1 (TEAD1)

No data available for DME Specific Peptides for TEAD1 Gene

Domains & Families for TEAD1 Gene

Gene Families for TEAD1 Gene

Protein Domains for TEAD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28347

UniProtKB/Swiss-Prot:

TEAD1_HUMAN :
  • Contains 1 TEA DNA-binding domain.
Domain:
  • Contains 1 TEA DNA-binding domain.
genes like me logo Genes that share domains with TEAD1: view

Function for TEAD1 Gene

Molecular function for TEAD1 Gene

GENATLAS Biochemistry:
SV40-transcriptional enhancer factor 1,required for cardiac muscle specific genes expression
UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC enhansons (5-GTGGAATGT-3) and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Gene Ontology (GO) - Molecular Function for TEAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001159 core promoter proximal region DNA binding IMP 26045994
GO:0005515 protein binding IPI 9869635
genes like me logo Genes that share ontologies with TEAD1: view
genes like me logo Genes that share phenotypes with TEAD1: view

Human Phenotype Ontology for TEAD1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TEAD1 Gene

MGI Knock Outs for TEAD1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TEAD1 Gene

Localization for TEAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEAD1 Gene COMPARTMENTS Subcellular localization image for TEAD1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for TEAD1 Gene

Pathways & Interactions for TEAD1 Gene

genes like me logo Genes that share pathways with TEAD1: view

SIGNOR curated interactions for TEAD1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TEAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter IMP 26045994
genes like me logo Genes that share ontologies with TEAD1: view

Drugs & Compounds for TEAD1 Gene

(2) Drugs for TEAD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TEAD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TEAD1: view

Transcripts for TEAD1 Gene

Unigene Clusters for TEAD1 Gene

TEA domain family member 1 (SV40 transcriptional enhancer factor):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for TEAD1 Gene

GeneLoc Exon Structure for
TEAD1
ECgene alternative splicing isoforms for
TEAD1

Expression for TEAD1 Gene

mRNA expression in normal human tissues for TEAD1 Gene

Protein differential expression in normal tissues from HIPED for TEAD1 Gene

This gene is overexpressed in Breast (28.0) and Ovary (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TEAD1 Gene



SOURCE GeneReport for Unigene cluster for TEAD1 Gene Hs.655331

mRNA Expression by UniProt/SwissProt for TEAD1 Gene

P28347-TEAD1_HUMAN
Tissue specificity: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
genes like me logo Genes that share expression patterns with TEAD1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for TEAD1 Gene

Orthologs for TEAD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEAD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TEAD1 35
  • 95.7 (n)
  • 100 (a)
TEAD1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEAD1 35
  • 94.73 (n)
  • 99.51 (a)
TEAD1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tead1 35
  • 91.81 (n)
  • 99.27 (a)
Tead1 16
Tead1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TEAD1 35
  • 99.68 (n)
  • 100 (a)
TEAD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tead1 35
  • 92.3 (n)
  • 99.51 (a)
oppossum
(Monodelphis domestica)
Mammalia TEAD1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEAD1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEAD1 35
  • 87.66 (n)
  • 98.53 (a)
TEAD1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEAD1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6996 35
tead1 35
  • 81.33 (n)
  • 95.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29088 35
zebrafish
(Danio rerio)
Actinopterygii LOC100537467 35
  • 80.23 (n)
  • 91.67 (a)
TEAD1 (3 of 3) 36
  • 85 (a)
OneToMany
tead1a 36
  • 85 (a)
OneToMany
tead1b 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sd 37
  • 60 (a)
sd 35
  • 63.18 (n)
  • 69.63 (a)
sd 36
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000512 35
  • 65.13 (n)
  • 71.54 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-44 35
  • 51.04 (n)
  • 45.83 (a)
egl-44 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5470 35
Species with no ortholog for TEAD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEAD1 Gene

ENSEMBL:
Gene Tree for TEAD1 (if available)
TreeFam:
Gene Tree for TEAD1 (if available)

Paralogs for TEAD1 Gene

Paralogs for TEAD1 Gene

(3) SIMAP similar genes for TEAD1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TEAD1 Gene

genes like me logo Genes that share paralogs with TEAD1: view

Variants for TEAD1 Gene

Sequence variations from dbSNP and Humsavar for TEAD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11567847 Sveinsson chorioretinal atrophy (SCRA) 12,937,202(+) ATATT(C/T)ACAGG reference, missense
rs745361 -- 12,924,656(+) TAGTA(G/T)TATTC intron-variant
rs747113 -- 12,918,649(+) ggaac(A/G)tccaa intron-variant
rs747564 -- 12,919,023(-) gaaat(C/G)gaagt intron-variant
rs756425 -- 12,841,941(+) AATGT(A/G)TCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEAD1 Gene

Variant ID Type Subtype PubMed ID
nsv825769 CNV Gain 20364138
esv2671303 CNV Deletion 23128226
esv2744118 CNV Deletion 23290073
esv2744120 CNV Deletion 23290073
nsv519735 CNV Loss 19592680
dgv193e199 CNV Deletion 23128226
esv2422965 CNV Deletion 19546169
esv2744121 CNV Deletion 23290073
esv2139118 CNV Deletion 18987734
esv2744122 CNV Deletion 23290073
esv2483449 CNV Deletion 19546169
nsv38509 CNV Loss 16902084
esv9239 CNV Loss 19470904

Variation tolerance for TEAD1 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEAD1 Gene

HapMap Linkage Disequilibrium report
TEAD1
Human Gene Mutation Database (HGMD)
TEAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEAD1 Gene

Disorders for TEAD1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TEAD1 Gene - From: OMIM, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TEAD1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TEAD1_HUMAN
  • Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]: Characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid. {ECO:0000269 PubMed:15016762}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TEAD1

Genetic Association Database (GAD)
TEAD1
Human Genome Epidemiology (HuGE) Navigator
TEAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEAD1
genes like me logo Genes that share disorders with TEAD1: view

No data available for Genatlas for TEAD1 Gene

Publications for TEAD1 Gene

  1. Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1. (PMID: 1851669) Xiao J.H. … Chambon P. (Cell 1991) 2 3 4 23 67
  2. A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration). (PMID: 15016762) Fossdal R. … Stefansson K. (Hum. Mol. Genet. 2004) 2 3 23
  3. Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates activation of IFITM3 gene by BRGl. (PMID: 18177740) Cuddapah S. … Zhao K. (FEBS Lett. 2008) 3 23
  4. VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. (PMID: 14762206) GA1nther S. … Braun T. (Nucleic Acids Res. 2004) 3 23
  5. Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes. (PMID: 15140898) Chen H.H. … Stewart A.F. (J. Biol. Chem. 2004) 3 23

Products for TEAD1 Gene

Sources for TEAD1 Gene

Back to Top

Content