Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TEAD1 Gene

Aliases for TEAD1 Gene

  • TEA Domain Transcription Factor 1 2 3 5
  • TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) 2 3
  • Transcription Factor 13 3 4
  • Protein GT-IIC 3 4
  • NTEF-1 3 4
  • TCF-13 3 4
  • TEAD-1 3 4
  • TCF13 3 4
  • Atrophia Areata, Peripapillary Chorioretinal Degeneration 2
  • Transcriptional Enhancer Factor TEF-1 3
  • Transcriptional Enhancer Factor 1 3
  • TEA Domain Family Member 1 4
  • TEF-1 3
  • REF1 3
  • TEF1 4
  • AA 3

External Ids for TEAD1 Gene

Previous HGNC Symbols for TEAD1 Gene

  • TCF13
  • AA

Previous GeneCards Identifiers for TEAD1 Gene

  • GC11P014056
  • GC11P013515
  • GC11P012737
  • GC11P012730
  • GC11P012660
  • GC11P012652
  • GC11P012376

Summaries for TEAD1 Gene

Entrez Gene Summary for TEAD1 Gene

  • This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

GeneCards Summary for TEAD1 Gene

TEAD1 (TEA Domain Transcription Factor 1) is a Protein Coding gene. Diseases associated with TEAD1 include Sveinsson Choreoretinal Atrophy and Aicardi Syndrome. Among its related pathways are Mesodermal Commitment Pathway and ERK Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TEAD4.

UniProtKB/Swiss-Prot for TEAD1 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC enhansons (5-GTGGAATGT-3) and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Gene Wiki entry for TEAD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEAD1 Gene

Genomics for TEAD1 Gene

Regulatory Elements for TEAD1 Gene

Enhancers for TEAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G012862 2.4 Ensembl ENCODE dbSUPER 11.1 +189.5 189519 3.5 FOXA2 FEZF1 ETS1 ZNF121 FOS ETV6 NR2F2 NFIC MAFF SMARCA4 ENSG00000254688 TEAD1 ENSG00000255067 GC11M012886
GH11G012798 2 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +128.3 128275 8.8 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TEAD1 ENSG00000254688 ENSG00000252329 GC11P012801 GC11P012807
GH11G012843 2.1 VISTA Ensembl ENCODE dbSUPER 11.7 +171.7 171694 4.7 HDGF PKNOX1 FOXA2 MLX SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 ENSG00000254688 TEAD1 ENSG00000252329 ENSG00000255067
GH11G012852 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +180.1 180149 4.5 HDGF ATF1 PKNOX1 YY1 TCF12 ZNF766 GATA2 CAVIN1 JUNB NCOA1 ENSG00000254688 TEAD1 ENSG00000252329 ENSG00000255067 GC11M012886
GH11G012832 2 ENCODE dbSUPER 9.9 +158.5 158547 0.2 HDGF PKNOX1 INSM2 ZEB1 POLR2A KLF8 TCF7L2 ZNF639 ZNF10 ZEB2 TEAD1 ENSG00000254688 ENSG00000255067
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEAD1 on UCSC Golden Path with GeneCards custom track

Promoters for TEAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000037085 1178 4401 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 FOS KLF13 ZNF263

Genomic Location for TEAD1 Gene

Chromosome:
11
Start:
12,674,422 bp from pter
End:
12,944,737 bp from pter
Size:
270,316 bases
Orientation:
Plus strand

Genomic View for TEAD1 Gene

Genes around TEAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEAD1 Gene

Proteins for TEAD1 Gene

  • Protein details for TEAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28347-TEAD1_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-1
    Protein Accession:
    P28347
    Secondary Accessions:
    • A4FUP2
    • E7EV65

    Protein attributes for TEAD1 Gene

    Size:
    426 amino acids
    Molecular mass:
    47946 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.
    SequenceCaution:
    • Sequence=AAB00791.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEAD1 Gene

    Alternative splice isoforms for TEAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEAD1 Gene

Post-translational modifications for TEAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEAD1 Gene

No data available for DME Specific Peptides for TEAD1 Gene

Domains & Families for TEAD1 Gene

Gene Families for TEAD1 Gene

Protein Domains for TEAD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEAD1: view

No data available for UniProtKB/Swiss-Prot for TEAD1 Gene

Function for TEAD1 Gene

Molecular function for TEAD1 Gene

GENATLAS Biochemistry:
SV40-transcriptional enhancer factor 1,required for cardiac muscle specific genes expression
UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC enhansons (5-GTGGAATGT-3) and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Gene Ontology (GO) - Molecular Function for TEAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 26045994
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0001085 RNA polymerase II transcription factor binding IBA --
GO:0001134 transcription factor activity, transcription factor recruiting IMP 20123905
GO:0001159 core promoter proximal region DNA binding IMP 26045994
genes like me logo Genes that share ontologies with TEAD1: view
genes like me logo Genes that share phenotypes with TEAD1: view

Human Phenotype Ontology for TEAD1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TEAD1 Gene

MGI Knock Outs for TEAD1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TEAD1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TEAD1 Gene

Localization for TEAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEAD1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TEAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA --
GO:0071148 TEAD-1-YAP complex IDA 20123905
genes like me logo Genes that share ontologies with TEAD1: view

Pathways & Interactions for TEAD1 Gene

genes like me logo Genes that share pathways with TEAD1: view

SIGNOR curated interactions for TEAD1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TEAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006461 protein complex assembly IMP 20123905
genes like me logo Genes that share ontologies with TEAD1: view

Drugs & Compounds for TEAD1 Gene

(2) Drugs for TEAD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TEAD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TEAD1: view

Transcripts for TEAD1 Gene

Unigene Clusters for TEAD1 Gene

TEA domain family member 1 (SV40 transcriptional enhancer factor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TEAD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for TEAD1 Gene

GeneLoc Exon Structure for
TEAD1
ECgene alternative splicing isoforms for
TEAD1

Expression for TEAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEAD1 Gene

Protein differential expression in normal tissues from HIPED for TEAD1 Gene

This gene is overexpressed in Breast (28.0) and Ovary (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TEAD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TEAD1 Gene:

TEAD1

SOURCE GeneReport for Unigene cluster for TEAD1 Gene:

Hs.655331

mRNA Expression by UniProt/SwissProt for TEAD1 Gene:

P28347-TEAD1_HUMAN
Tissue specificity: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Evidence on tissue expression from TISSUES for TEAD1 Gene

  • Muscle(2.5)
  • Heart(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TEAD1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
Organs:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • eyelid
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TEAD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for TEAD1 Gene

Orthologs for TEAD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEAD1 34 35
  • 99.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TEAD1 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEAD1 34 35
  • 95.7 (n)
dog
(Canis familiaris)
Mammalia TEAD1 34 35
  • 94.73 (n)
oppossum
(Monodelphis domestica)
Mammalia TEAD1 35
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tead1 34
  • 92.3 (n)
mouse
(Mus musculus)
Mammalia Tead1 34 16 35
  • 91.81 (n)
chicken
(Gallus gallus)
Aves TEAD1 34 35
  • 87.66 (n)
lizard
(Anolis carolinensis)
Reptilia TEAD1 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tead1 34
  • 81.33 (n)
Str.6996 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.29088 34
zebrafish
(Danio rerio)
Actinopterygii TEAD1 (3 of 3) 35
  • 85 (a)
OneToMany
tead1a 35
  • 85 (a)
OneToMany
tead1b 35
  • 85 (a)
OneToMany
LOC100537467 34
  • 80.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000512 34
  • 65.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta sd 36 34 35
  • 63.18 (n)
worm
(Caenorhabditis elegans)
Secernentea egl-44 34 35
  • 51.04 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5470 34
Species where no ortholog for TEAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEAD1 Gene

ENSEMBL:
Gene Tree for TEAD1 (if available)
TreeFam:
Gene Tree for TEAD1 (if available)

Paralogs for TEAD1 Gene

Paralogs for TEAD1 Gene

(3) SIMAP similar genes for TEAD1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TEAD1 Gene

genes like me logo Genes that share paralogs with TEAD1: view

Variants for TEAD1 Gene

Sequence variations from dbSNP and Humsavar for TEAD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11567847 Pathogenic, Sveinsson chorioretinal atrophy (SCRA) [MIM:108985] 12,937,202(+) ATATT(C/T)ACAGG reference
rs1000017292 -- 12,879,112(+) CATGC(A/C)CCCCG intron-variant
rs1000050539 -- 12,719,548(+) CTCTC(C/T)CCTTT intron-variant
rs1000056868 -- 12,839,382(+) CTCCA(C/G)CCTCG intron-variant
rs1000062936 -- 12,819,658(+) ATGTT(A/G)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEAD1 Gene

Variant ID Type Subtype PubMed ID
dgv1059n100 CNV gain 25217958
dgv193e199 CNV deletion 23128226
dgv323e212 CNV loss 25503493
esv2139118 CNV deletion 18987734
esv2422965 CNV deletion 19546169
esv2483449 CNV deletion 19546169
esv2671303 CNV deletion 23128226
esv2744118 CNV deletion 23290073
esv2744120 CNV deletion 23290073
esv2744121 CNV deletion 23290073
esv2744122 CNV deletion 23290073
esv3547338 CNV deletion 23714750
esv3547339 CNV deletion 23714750
esv3625395 CNV gain 21293372
esv3625401 CNV gain 21293372
esv3625402 CNV gain 21293372
esv3625403 CNV loss 21293372
esv3625404 CNV loss 21293372
esv9239 CNV loss 19470904
nsv1070939 CNV deletion 25765185
nsv1077839 CNV deletion 25765185
nsv1122584 CNV deletion 24896259
nsv1134093 CNV deletion 24896259
nsv1136123 CNV deletion 24896259
nsv1136124 CNV deletion 24896259
nsv1143534 CNV deletion 24896259
nsv1150574 CNV deletion 26484159
nsv38509 CNV deletion 16902084
nsv476323 CNV novel sequence insertion 20440878
nsv483000 CNV loss 15286789
nsv519735 CNV loss 19592680
nsv825769 CNV gain 20364138
nsv951308 CNV deletion 24416366
nsv957167 CNV deletion 24416366

Variation tolerance for TEAD1 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEAD1 Gene

Human Gene Mutation Database (HGMD)
TEAD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEAD1 Gene

Disorders for TEAD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TEAD1 Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
sveinsson choreoretinal atrophy
  • sveinsson chorioretinal atrophy
aicardi syndrome
  • aic
- elite association - COSMIC cancer census association via MalaCards
Search TEAD1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TEAD1_HUMAN
  • Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]: Characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid. {ECO:0000269 PubMed:15016762, ECO:0000269 PubMed:18579750, ECO:0000269 PubMed:20123905}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TEAD1

Genetic Association Database (GAD)
TEAD1
Human Genome Epidemiology (HuGE) Navigator
TEAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEAD1
genes like me logo Genes that share disorders with TEAD1: view

No data available for Genatlas for TEAD1 Gene

Publications for TEAD1 Gene

  1. A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration). (PMID: 15016762) Fossdal R. … Stefansson K. (Hum. Mol. Genet. 2004) 2 3 4 22 64
  2. Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1. (PMID: 1851669) Xiao J.H. … Chambon P. (Cell 1991) 2 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
  5. Structural insights into the YAP and TEAD complex. (PMID: 20123905) Li Z. … Xu Y. (Genes Dev. 2010) 3 4 64

Products for TEAD1 Gene

Sources for TEAD1 Gene

Content
Loading form....